PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
29434958-6	2018	The anticancer effects of HCPT were demonstrated to significantly activate the protein expression of p53, PARP-1 and cytochrome c, and suppress Bcl-2 protein expression and promote the activity of caspase-9 and caspase-3 in human osteosarcoma cells.	10-hydroxycamptothecin	26-30	BCL2 apoptosis regulator	Homo sapiens	144-149	
17439414-10	2007	The MTT results demonstrated that Bcl-2 and Bcl-xl transfected cells exhibited increased sensitivity to 5-FU or HCPT.	10-hydroxycamptothecin	112-116	BCL2 apoptosis regulator	Homo sapiens	34-39	
16603448-0	2006	Bcl-2 siRNA induced apoptosis and increased sensitivity to 5-fluorouracil and HCPT in HepG2 cells.	10-hydroxycamptothecin	78-82	BCL2 apoptosis regulator	Homo sapiens	0-5	
16603448-7	2006	Accordingly, Bax protein expression had no change and caspase-3 protein expression showed significantly be up regulated; (2) MTT results showed that Bcl-2 siRNA transfectants had higher cell inhibitory rates after treated with 5-FU or HCPT; (3) flow cytometry results demonstrated that sub G1 population increased in Bcl-2 siRNA transfected cells compared with negative siRNA or untreated cells.	10-hydroxycamptothecin	235-239	BCL2 apoptosis regulator	Homo sapiens	149-154	
16603448-8	2006	After addition 5-FU (1300 mg/l) and HCPT (0.72 mg/l), Bcl-2 siRNA cells showed higher sub G1 population than negative siRNA or untreated cells.	10-hydroxycamptothecin	36-40	BCL2 apoptosis regulator	Homo sapiens	54-59	
16603448-9	2006	siRNA targeting Bcl-2 gene can specifically down-regulate Bcl-2 expression, increased Bax/Bcl-2 ratio expression and caspase-3 activity in HepG2 cells, which lead to increase cells spontaneous apoptosis and sensitize cells to 5-FU or HCPT.	10-hydroxycamptothecin	234-238	BCL2 apoptosis regulator	Homo sapiens	16-21	
11129738-3	2000	It showed that HCPT at a dose of 0.1 microg/ml increased the expression of P53, c-Myc and Bax protein, and decreased the expression of Bcl-2 and AFP.	10-hydroxycamptothecin	15-19	BCL2 apoptosis regulator	Homo sapiens	135-140