PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 16603448-0 2006 Bcl-2 siRNA induced apoptosis and increased sensitivity to 5-fluorouracil and HCPT in HepG2 cells. 10-hydroxycamptothecin 78-82 BCL2 apoptosis regulator Homo sapiens 0-5 17439414-10 2007 The MTT results demonstrated that Bcl-2 and Bcl-xl transfected cells exhibited increased sensitivity to 5-FU or HCPT. 10-hydroxycamptothecin 112-116 BCL2 apoptosis regulator Homo sapiens 34-39 16603448-7 2006 Accordingly, Bax protein expression had no change and caspase-3 protein expression showed significantly be up regulated; (2) MTT results showed that Bcl-2 siRNA transfectants had higher cell inhibitory rates after treated with 5-FU or HCPT; (3) flow cytometry results demonstrated that sub G1 population increased in Bcl-2 siRNA transfected cells compared with negative siRNA or untreated cells. 10-hydroxycamptothecin 235-239 BCL2 apoptosis regulator Homo sapiens 149-154 16603448-8 2006 After addition 5-FU (1300 mg/l) and HCPT (0.72 mg/l), Bcl-2 siRNA cells showed higher sub G1 population than negative siRNA or untreated cells. 10-hydroxycamptothecin 36-40 BCL2 apoptosis regulator Homo sapiens 54-59 16603448-9 2006 siRNA targeting Bcl-2 gene can specifically down-regulate Bcl-2 expression, increased Bax/Bcl-2 ratio expression and caspase-3 activity in HepG2 cells, which lead to increase cells spontaneous apoptosis and sensitize cells to 5-FU or HCPT. 10-hydroxycamptothecin 234-238 BCL2 apoptosis regulator Homo sapiens 16-21 11129738-3 2000 It showed that HCPT at a dose of 0.1 microg/ml increased the expression of P53, c-Myc and Bax protein, and decreased the expression of Bcl-2 and AFP. 10-hydroxycamptothecin 15-19 BCL2 apoptosis regulator Homo sapiens 135-140 29434958-6 2018 The anticancer effects of HCPT were demonstrated to significantly activate the protein expression of p53, PARP-1 and cytochrome c, and suppress Bcl-2 protein expression and promote the activity of caspase-9 and caspase-3 in human osteosarcoma cells. 10-hydroxycamptothecin 26-30 BCL2 apoptosis regulator Homo sapiens 144-149