PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
28223128-10	2017	Looking at individual substances, kenpaullone, a GSK-3beta and Cdk inhibitor, had the highest selective index of 3.44.	kenpaullone	34-45	glycogen synthase kinase 3 beta	Homo sapiens	49-58	
25591548-6	2015	IL-18 expression upregulated the expression and phosphorylation of glycogen synthase kinase (GSK)-3beta protein in CRL1623 cells, whereas the selective GSK-3beta inhibitor kenpaullone antagonized the effects of IL-18 protein on TSCC cells in vitro.	kenpaullone	172-183	glycogen synthase kinase 3 beta	Homo sapiens	152-161	
27977752-8	2016	GSK-3beta inhibition with 1-azakenpaullone or a GSK-3beta-targeting siRNA increased NFAT-Luc activity, whereas overexpression of a constitutively active GSK-3beta mutant (GSK-3betaS9A) inhibited NFAT-Luc activation mediated by testosterone.	kenpaullone	26-42	glycogen synthase kinase 3 beta	Homo sapiens	0-9	
22700489-9	2012	Prominent rescue was also observed by inhibitors of GSK-3beta (e.g. GSK-3beta Inhibitor II and Kenpaullone).	kenpaullone	95-106	glycogen synthase kinase 3 beta	Homo sapiens	52-61	
21111724-10	2011	Kenpaullone (1, 3 muM) decreased the active- and increased the inactive form of cytoplasmic GSK-3beta, and increased nuclear AR and beta-catenin accumulation.	kenpaullone	0-11	glycogen synthase kinase 3 beta	Homo sapiens	92-101	
19430525-9	2009	Inhibition of GSK-3beta activity using well-characterized inhibitors, LiCl and kenpaullone, and RNA interference, prevented MPP(+)-induced cell death by blocking mitochondrial membrane potential changes and subsequent caspase-9 and -3 activation.	kenpaullone	79-90	glycogen synthase kinase 3 beta	Homo sapiens	14-23	
14698171-2	2004	Among the novel structures, 1-azakenpaullone was found to act as a selective GSK-3beta versus CDK1 inhibitor.	kenpaullone	28-44	glycogen synthase kinase 3 beta	Homo sapiens	77-86	
14698171-3	2004	The charge distribution within the 1-azakenpaullone molecule is discussed as a possible explanation for the enhanced GSK-3beta selectivity of 1-azakenpaullone compared to other paullone derivatives.	kenpaullone	35-51	glycogen synthase kinase 3 beta	Homo sapiens	117-126	
14698171-3	2004	The charge distribution within the 1-azakenpaullone molecule is discussed as a possible explanation for the enhanced GSK-3beta selectivity of 1-azakenpaullone compared to other paullone derivatives.	kenpaullone	142-158	glycogen synthase kinase 3 beta	Homo sapiens	117-126