PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 18784074-5 2008 Here we report that inhibition of cyclin-dependent kinases (Cdks) by kenpaullone and roscovitine (two small molecule inhibitors of Cdks that we identified in a screen for compounds that activate hPXR) leads to activation of hPXR-mediated CYP3A4 gene expression in HepG2 human liver carcinoma cells. kenpaullone 69-80 nuclear receptor subfamily 1 group I member 2 Homo sapiens 195-199 18784074-5 2008 Here we report that inhibition of cyclin-dependent kinases (Cdks) by kenpaullone and roscovitine (two small molecule inhibitors of Cdks that we identified in a screen for compounds that activate hPXR) leads to activation of hPXR-mediated CYP3A4 gene expression in HepG2 human liver carcinoma cells. kenpaullone 69-80 nuclear receptor subfamily 1 group I member 2 Homo sapiens 224-228 35053380-10 2022 As well-known CDK inhibitors, dinaciclib and kenpaullone stabilize PXR and result in elevated expression and activity of PXR-targeted DMETs, including carboxylesterases, CYP3A4 and P-gp. kenpaullone 45-56 nuclear receptor subfamily 1 group I member 2 Homo sapiens 67-70 35053380-10 2022 As well-known CDK inhibitors, dinaciclib and kenpaullone stabilize PXR and result in elevated expression and activity of PXR-targeted DMETs, including carboxylesterases, CYP3A4 and P-gp. kenpaullone 45-56 nuclear receptor subfamily 1 group I member 2 Homo sapiens 121-124