PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
35053380-10	2022	As well-known CDK inhibitors, dinaciclib and kenpaullone stabilize PXR and result in elevated expression and activity of PXR-targeted DMETs, including carboxylesterases, CYP3A4 and P-gp.	kenpaullone	45-56	nuclear receptor subfamily 1 group I member 2	Homo sapiens	67-70	
35053380-10	2022	As well-known CDK inhibitors, dinaciclib and kenpaullone stabilize PXR and result in elevated expression and activity of PXR-targeted DMETs, including carboxylesterases, CYP3A4 and P-gp.	kenpaullone	45-56	nuclear receptor subfamily 1 group I member 2	Homo sapiens	121-124	
18784074-5	2008	Here we report that inhibition of cyclin-dependent kinases (Cdks) by kenpaullone and roscovitine (two small molecule inhibitors of Cdks that we identified in a screen for compounds that activate hPXR) leads to activation of hPXR-mediated CYP3A4 gene expression in HepG2 human liver carcinoma cells.	kenpaullone	69-80	nuclear receptor subfamily 1 group I member 2	Homo sapiens	195-199	
18784074-5	2008	Here we report that inhibition of cyclin-dependent kinases (Cdks) by kenpaullone and roscovitine (two small molecule inhibitors of Cdks that we identified in a screen for compounds that activate hPXR) leads to activation of hPXR-mediated CYP3A4 gene expression in HepG2 human liver carcinoma cells.	kenpaullone	69-80	nuclear receptor subfamily 1 group I member 2	Homo sapiens	224-228