PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 33178594-8 2020 Inhibition of GSK-3beta by 1-Azakenpaullone could partially reverse the effects of BYSL downregulation on the transcriptional activity of beta-catenin, the expression of EMT markers, and GBM cell migration/invasion. kenpaullone 27-43 glycogen synthase kinase 3 alpha Homo sapiens 14-23 34635948-4 2021 Here, we investigate the morphological effects of 1-azakenpaullone, a pharmacological inhibitor of GSK3beta that is supposed to over-activate the Wnt/beta-catenin pathway, during the anterior and posterior regeneration of the annelid Syllis malaquini. kenpaullone 50-66 glycogen synthase kinase 3 alpha Homo sapiens 99-107 15522889-3 2004 Two chemical inhibitors of glycogen synthase kinase (GSK)-3beta, indirubin-3-monoxime and kenpaullone, were found to increase neuronal differentiation in ventral mesencephalon precursor cultures. kenpaullone 90-101 glycogen synthase kinase 3 alpha Homo sapiens 27-63 15522889-4 2004 In addition, the GSK-3beta-specific inhibitor kenpaullone increased the size of the DA neuron population through conversion of precursors expressing the orphan nuclear receptor-related factor 1 into tyrosine hydroxylase positive neurons, thereby mimicking an effect of Wnts. kenpaullone 46-57 glycogen synthase kinase 3 alpha Homo sapiens 17-26 23565238-4 2013 CG0009 enhanced the inactivating phosphorylation of GSK3alpha at Ser21 and GSK3beta at Ser9 and simultaneously decreased activating phosphorylation of GSK3beta at Tyr216, and induced caspase-dependent apoptosis independently of estrogen receptor alpha (ERalpha) expression status, which was not observed with the other GSK3 inhibitors examined, including SB216763, kenpaullone and LiCl. kenpaullone 365-376 glycogen synthase kinase 3 alpha Homo sapiens 52-61