PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 24900456-4 2012 In this letter, we describe the discovery of a potent tetrahydroisoquinoline (THIQ)-derived LFA-1/ICAM-1 antagonist (SAR 1118) and its development as an ophthalmic solution for treating dry eye. 1,2,3,4-tetrahydroisoquinoline 54-76 intercellular adhesion molecule 1 Homo sapiens 98-104 24900456-4 2012 In this letter, we describe the discovery of a potent tetrahydroisoquinoline (THIQ)-derived LFA-1/ICAM-1 antagonist (SAR 1118) and its development as an ophthalmic solution for treating dry eye. 1,2,3,4-tetrahydroisoquinoline 78-82 intercellular adhesion molecule 1 Homo sapiens 98-104 20655213-1 2010 This letter describes the discovery of a novel series of tetrahydroisoquinoline (THIQ)-derived small molecules that potently inhibit both human T-cell migration and super-antigen induced T-cell activation through disruption of the binding of integrin LFA-1 to its receptor, ICAM-1. 1,2,3,4-tetrahydroisoquinoline 57-79 intercellular adhesion molecule 1 Homo sapiens 274-280 20655213-1 2010 This letter describes the discovery of a novel series of tetrahydroisoquinoline (THIQ)-derived small molecules that potently inhibit both human T-cell migration and super-antigen induced T-cell activation through disruption of the binding of integrin LFA-1 to its receptor, ICAM-1. 1,2,3,4-tetrahydroisoquinoline 81-85 intercellular adhesion molecule 1 Homo sapiens 274-280 21109434-0 2011 Structure-activity relationship (SAR) of the alpha-amino acid residue of potent tetrahydroisoquinoline (THIQ)-derived LFA-1/ICAM-1 antagonists. 1,2,3,4-tetrahydroisoquinoline 80-102 intercellular adhesion molecule 1 Homo sapiens 124-130 21109434-0 2011 Structure-activity relationship (SAR) of the alpha-amino acid residue of potent tetrahydroisoquinoline (THIQ)-derived LFA-1/ICAM-1 antagonists. 1,2,3,4-tetrahydroisoquinoline 104-108 intercellular adhesion molecule 1 Homo sapiens 124-130 21109434-1 2011 This letter describes the structure-activity relationship (SAR) of the "right-wing" alpha-amino acid residue of potent tetrahydroisoquinoline (THIQ)-derived LFA-1/ICAM-1 antagonists. 1,2,3,4-tetrahydroisoquinoline 119-141 intercellular adhesion molecule 1 Homo sapiens 163-169 21109434-1 2011 This letter describes the structure-activity relationship (SAR) of the "right-wing" alpha-amino acid residue of potent tetrahydroisoquinoline (THIQ)-derived LFA-1/ICAM-1 antagonists. 1,2,3,4-tetrahydroisoquinoline 143-147 intercellular adhesion molecule 1 Homo sapiens 163-169