PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
28462839-0	2017	Synthesis of both enantiomers of 1,2,3,4-tetrahydroisoquinoline derivative IPPAM-1 and enantio-dependency of its positive allosteric modulation of prostacyclin receptor.	1,2,3,4-tetrahydroisoquinoline	33-63	prostaglandin I2 receptor	Homo sapiens	147-168	
28462839-1	2017	We present a practical synthesis of both enantiomers of 1,2,3,4-tetrahydroisoquinoline derivative IPPAM-1 (1), which is a positive allosteric modulator (PAM) of prostacyclin receptor (IP) and a candidate for treatment of pulmonary arterial hypertension without the side effects caused by IP agonists.	1,2,3,4-tetrahydroisoquinoline	56-86	prostaglandin I2 receptor	Homo sapiens	161-182	
28587821-0	2017	Structural development of 1,2,3,4-tetrahydroisoquinoline-type positive allosteric modulators of prostacyclin receptor (IPPAMs) to improve metabolic stability, and investigation of metabolic fate.	1,2,3,4-tetrahydroisoquinoline	26-56	prostaglandin I2 receptor	Homo sapiens	96-117	
28587821-1	2017	We synthesized a series of 1,2,3,4-tetrahydroisoquinoline-type positive allosteric modulators of prostacyclin receptor (IPPAMs), aiming to improve the metabolic stability of the previously identified hit compound IPPAM-3 (2).	1,2,3,4-tetrahydroisoquinoline	27-57	prostaglandin I2 receptor	Homo sapiens	97-118