PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 29454840-4 2018 In this work, we tested the acute effects of THIQ, a selective melanocortin 4 receptor (MC4R) agonist. 1,2,3,4-tetrahydroisoquinoline 45-49 melanocortin 4 receptor Mus musculus 63-86 29454840-4 2018 In this work, we tested the acute effects of THIQ, a selective melanocortin 4 receptor (MC4R) agonist. 1,2,3,4-tetrahydroisoquinoline 45-49 melanocortin 4 receptor Mus musculus 88-92 26418335-8 2015 Similar to MTII, the synthetic MC4R agonists, THIQ and BIM-22511, but not LY2112688, induced prolonged cAMP signaling after agonist withdrawal. 1,2,3,4-tetrahydroisoquinoline 46-50 melanocortin 4 receptor Mus musculus 31-35 18028105-0 2007 Functional evaluation of THIQ, a melanocortin 4 receptor agonist, in models of food intake and inflammation. 1,2,3,4-tetrahydroisoquinoline 25-29 melanocortin 4 receptor Mus musculus 33-56 18028105-2 2007 In the present study, we evaluated the in vivo activities of food intake suppression and anti-inflammatory activity of THIQ, which has been proposed to possess high and selective melanocortin-4 receptor agonistic activity in vitro. 1,2,3,4-tetrahydroisoquinoline 119-123 melanocortin 4 receptor Mus musculus 179-202 18028105-6 2007 Our findings provide new insight into the in vivo pharmacological profile of the in vitro selective melanocortin-4 receptor agonist THIQ and give grounds for caution when interpreting and predicting melanocortin receptor selective agonist activity in vivo. 1,2,3,4-tetrahydroisoquinoline 132-136 melanocortin 4 receptor Mus musculus 100-123