PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
11792648-8	2002	Basal and ACh-induced nitrite/nitrate production was less in TNF-alpha-infused than in control pregnant rats.	Nitrates	30-37	tumor necrosis factor	Rattus norvegicus	61-70	
16133968-10	2005	The downregulation of nitrate/nitrite by these inhibitors suggests that TNF-alpha modulates iNOS expression.	Nitrates	22-29	tumor necrosis factor	Rattus norvegicus	72-81	
12069938-6	2002	TNF-alpha caused significant inhibition of ACh- and bradykinin-induced vascular relaxation and nitrite/nitrate production that were more prominent in pregnant than virgin rats.	Nitrates	103-110	tumor necrosis factor	Rattus norvegicus	0-9	
11863253-6	2002	RESULTS: A twofold increase in plasma TNF-alpha levels in pregnant rats resulted in a significant increase in arterial pressure (97 +/- 3.6 v 116 +/- 2.1 mm Hg, pregnant versus TNF-alpha pregnant, respectively, P < .05), but no significant change in urinary nitrite/nitrate excretion (22.0 +/- 1.9 v 20.8 +/- 2.5 micromol/24 h, pregnant versus TNF-alpha pregnant, respectively), a measure of whole body NO production.	Nitrates	269-276	tumor necrosis factor	Rattus norvegicus	38-47	
11131279-5	2000	Nitrite/nitrate (NOx) production stimulated by interleukin (IL)-1beta or tumor necrosis factor (TNF)-alpha in VSMCs was markedly suppressed by inhibiting MAP kinase by pretreatment with a p42/p44 MAP kinase kinase (MAPKK)-1 inhibitor (PD98059) or by transfecting the dominant-interfering form of the nonphosphorylated MAPKK-1 expressing construct (MAPKK S222A).	Nitrates	8-15	tumor necrosis factor	Rattus norvegicus	73-106	
11755929-4	2002	Both IL-1beta and TNF-alpha stimulated NF-kappaB activity, iNOS mRNA and protein expression with massive nitrite/nitrate (NOx) production in rat VSMCs.	Nitrates	113-120	tumor necrosis factor	Rattus norvegicus	18-27	
10218970-4	1999	Both interleukin (IL)-1beta and tumor necrosis factor (TNF)-alpha potently stimulated nitrite/nitrate (NOx) production with a concomitant expression of iNOS mRNA and protein as demonstrated by Northern and Western blot analysis, respectively.	Nitrates	94-101	tumor necrosis factor	Rattus norvegicus	32-65	
7536714-2	1995	A combination of interleukin-1 alpha (100 U/mL) and tumor necrosis factor--alpha (5000 U/mL) induced accumulation of nitrite/nitrate, the stable end products of nitric oxide, in culture media within 48 hours.	Nitrates	125-132	tumor necrosis factor	Rattus norvegicus	17-80	
8760140-2	1996	Stimulation of rat pleural mesothelial cells with combinations of interleukin-1 beta (IL-1 beta), tumor necrosis factor-alpha (TNF-alpha), interferon-gamma (IFN-gamma), and LPS induced the synthesis of nitric oxide as measured by the oxidation products nitrite (NO2-) and nitrate (NO3-).	Nitrates	272-279	tumor necrosis factor	Rattus norvegicus	98-125	
9227507-6	1997	In the current study, we demonstrate that L2 cells generate the oxidative products of NO., nitrite and nitrate, after exposure to tumor necrosis factor-alpha, lipopolysaccharide, and interferon-gamma.	Nitrates	103-110	tumor necrosis factor	Rattus norvegicus	130-157	
7536714-6	1995	Induction of nitrite/nitrate production by the combination of tumor necrosis factor-alpha and bacterial lipopolysaccharide or that of interleukin-1 alpha and interferon gamma (100 U/mL) was also inhibited by cyclosporin A cotreatment.	Nitrates	21-28	tumor necrosis factor	Rattus norvegicus	62-89	
7509009-2	1993	The combination of interferon-gamma (100 U/ml) and tumor necrosis factor-alpha (5000 U/ml) evoked a time-dependent increase in nitric oxide synthase mRNA and nitrite/nitrate production, both of which were inhibited by dexamethasone.	Nitrates	166-173	tumor necrosis factor	Rattus norvegicus	19-78	
3142779-2	1988	Recombinant interferon-gamma (rIFN-gamma) and recombinant tumor necrosis factor (rTNF) synergize to induce nitrite (NO2-) and nitrate (NO3-) synthesis from L-arginine as well as to cause inhibition of the iron-dependent enzyme aconitase in macrophages.	Nitrates	126-133	tumor necrosis factor	Rattus norvegicus	81-85