PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
12087347-8	2002	CONCLUSION: Our results suggest that angiotensin II may attenuate the arterial vasodilating effect of glyceryl trinitrate through angiotensin type 1 receptors and presumably through receptor-mediated superoxide production, which may be relevant to the development of nitrate tolerance.	Nitrates	114-121	angiotensinogen	Homo sapiens	37-51	
8638526-7	1996	Recent information suggests that nitrate tolerance is caused by increased levels of superoxide at the vascular wall, which leads to reduced nitric oxide level and to increased sensitivity to vasoconstrictive mechanisms, such as endothelin and angiotensin II.	Nitrates	33-40	angiotensinogen	Homo sapiens	228-257	
7867440-3	1994	However, when captopril (CPT, 12.5-25mg, 3 times daily) was combined with nitrates, the clinical effects were enhanced and maintained throughout the study, along with a decrease in the level of AII and body weight.	Nitrates	74-82	angiotensinogen	Homo sapiens	194-197	
25312438-0	2015	Nitrate, nitrite, and nitric oxide find a home in the kidney by offsetting angiotensin II-mediated hypertension.	Nitrates	0-7	angiotensinogen	Homo sapiens	75-89	
25312440-3	2015	We investigated the hypothesis that inorganic nitrate and nitrite attenuate reactivity of renal microcirculation and blood pressure responses to angiotensin II (ANG II) by modulating nicotinamide adenine dinucleotide phosphate (NADPH) oxidase activity and NO bioavailability.	Nitrates	46-53	angiotensinogen	Homo sapiens	145-159	
25312440-3	2015	We investigated the hypothesis that inorganic nitrate and nitrite attenuate reactivity of renal microcirculation and blood pressure responses to angiotensin II (ANG II) by modulating nicotinamide adenine dinucleotide phosphate (NADPH) oxidase activity and NO bioavailability.	Nitrates	46-53	angiotensinogen	Homo sapiens	161-167	
25312440-12	2015	Moreover, supplementation with dietary nitrate (10(-2) mol/L) reduced renal NADPH oxidase activity and attenuated ANG II-mediated arteriolar contractions and hypertension (99+-2-146+-2 mm Hg) compared with placebo (100+-3-168+-3 mm Hg).	Nitrates	39-46	angiotensinogen	Homo sapiens	114-120	
12952843-0	2003	Attenuation of nitrate tolerance and oxidative stress by an angiotensin II receptor blocker in patients with coronary spastic angina.	Nitrates	15-22	angiotensinogen	Homo sapiens	60-74	
12952843-11	2003	These results suggest that increased oxidative stress induced by activation of angiotensin II may play an important role in the development of nitrate tolerance.	Nitrates	143-150	angiotensinogen	Homo sapiens	79-93	
11026644-7	2000	N(G)-nitro-L-arginine methyl ester (L-NAME) lowered the basal concentration of plasma nitrate, abolished the increase in plasma nitrate elicited by angiotensin II and norepinephrine, and potentiated the pressor effect of the low dose of angiotensin II, although this dose did not increase NO production.	Nitrates	128-135	angiotensinogen	Homo sapiens	148-162	
11240977-1	2001	OBJECTIVE: An enhanced circulatory angiotensin II level that results from the administration of nitroglycerin may contribute to the development of nitrate tolerance.	Nitrates	147-154	angiotensinogen	Homo sapiens	35-49	
11001767-5	2000	Angiotensin II (ANG II, 100 nM) increased EC production of nitrate/nitrite by 2.4-fold.	Nitrates	59-66	angiotensinogen	Homo sapiens	0-14	
11001767-5	2000	Angiotensin II (ANG II, 100 nM) increased EC production of nitrate/nitrite by 2.4-fold.	Nitrates	59-66	angiotensinogen	Homo sapiens	16-22	
11026644-2	2000	This study intended to determine first, whether NO-derived plasma nitrate varies in response to increases in blood pressure induced by different mechanical and pharmacologic stimuli, including angiotensin II and catecholamines; and second, specifically to study the interaction between angiotensin II and NO production.	Nitrates	66-73	angiotensinogen	Homo sapiens	193-207	
11026644-6	2000	The intermediate and high dose, but not the low dose, of angiotensin II increased plasma nitrate concentration.	Nitrates	89-96	angiotensinogen	Homo sapiens	57-71	
10981145-6	2000	ANG II-induced ROS play a pivotal role in several pathophysiologic situations of vascular and renal cells such as hypertension, endothelial dysfunction, nitrate tolerance, atherosclerosis, and cellular remodeling.	Nitrates	153-160	angiotensinogen	Homo sapiens	0-6	
10642319-4	2000	Nitrate/nitrite production in AdeNOS-transduced ZG cells increased from 0.15+/-0.01 to 0.27+/-0.01 micromol/L after stimulation with 1 nmol/L angiotensin II.	Nitrates	0-7	angiotensinogen	Homo sapiens	142-156