PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 26435258-3 2016 The aim of the study was to measure and correlate plasma nitrite/nitrate levels with tissue specific expression of iNOS mRNA among women with different grades of cervical lesions and cervical cancer. Nitrates 65-72 nitric oxide synthase 2 Homo sapiens 115-119 28798125-3 2017 Nitrate levels increased in the colonic lumen because epithelial expression of Nos2, the gene encoding inducible nitric oxide synthase, was elevated in the absence of PPAR-gamma signaling. Nitrates 0-7 nitric oxide synthase 2 Homo sapiens 79-83 28617311-1 2017 This study aimed to investigate whether the -1026(A>C)(rs2779249) and +2087(A>G)(2297518) polymorphisms in the NOS2 gene were associated with chronic periodontitis (CP) and with salivary levels of nitrite (NO2-) and/or nitrate + nitrite (NOx). Nitrates 225-232 nitric oxide synthase 2 Homo sapiens 117-121 25554360-1 2015 Nitrate supplementation in the form of beetroot juice has been shown to increase nitric oxide (NO) where nitrate can be reduced to nitrite and, subsequently, to NO through both nitric oxide synthase (NOS)-dependent and -independent pathways. Nitrates 0-7 nitric oxide synthase 2 Homo sapiens 177-198 25826741-7 2015 Nitrate supplementation has been shown to increase NO-dependent vasodilatation through both NO synthase (NOS)-dependent and NOS-independent pathways. Nitrates 0-7 nitric oxide synthase 2 Homo sapiens 92-103 25554360-1 2015 Nitrate supplementation in the form of beetroot juice has been shown to increase nitric oxide (NO) where nitrate can be reduced to nitrite and, subsequently, to NO through both nitric oxide synthase (NOS)-dependent and -independent pathways. Nitrates 105-112 nitric oxide synthase 2 Homo sapiens 177-198 25239655-2 2014 NOS3 and NOS2 SNPs might modify plasma nitrite/nitrate (NOx) levels, sepsis development, hemodynamics and survival. Nitrates 47-54 nitric oxide synthase 2 Homo sapiens 9-13 18572022-6 2008 Both LPS and IFN-gamma induce iNOS with generation of nitrate up to 9 muM in the media after a 24-h stimulation, while native RAW 264.7 macrophages neither express iNOS nor generate nitrate. Nitrates 54-61 nitric oxide synthase 2 Homo sapiens 30-34 22363694-4 2012 In marked contrast, the expressions of both mRNA and protein levels of inducible nitrate oxide synthase (iNOS) increased, and were accompanied by increased extracellular nitrate/nitrite production by Griess reaction. Nitrates 81-88 nitric oxide synthase 2 Homo sapiens 105-109 20006999-8 2010 Computer simulations that utilized the measured kinetic values confirmed this interpretation, and revealed that the V346I iNOS has an enhanced NADPH-dependent NO dioxygenase activity that converts almost 1 NO to nitrate for every NO that the enzyme releases into solution. Nitrates 212-219 nitric oxide synthase 2 Homo sapiens 122-126 18830972-8 2009 We confirmed that reduction of Nitrate levels in Jurkat cells was due to down-regulation of inducible nitric oxide synthase (iNOS), not endothelial nitric oxide synthase (eNOS). Nitrates 31-38 nitric oxide synthase 2 Homo sapiens 92-123 18830972-8 2009 We confirmed that reduction of Nitrate levels in Jurkat cells was due to down-regulation of inducible nitric oxide synthase (iNOS), not endothelial nitric oxide synthase (eNOS). Nitrates 31-38 nitric oxide synthase 2 Homo sapiens 125-129 12390892-1 2002 Recently, we have found that the nitrate/nitrite concentrations in preovulatory follicles significantly decrease after hCG injection and that inducible nitric oxide synthase (iNOS) plays a main role in the decrease of the intrafollicular nitric oxide (NO) concentration. Nitrates 33-40 nitric oxide synthase 2 Homo sapiens 142-173 17709521-8 2007 The NOS2 genotype observed in healthy controls was correlated with an increase in NOS2 expression and higher concentrations of nitrate and nitrite in control serum. Nitrates 127-134 nitric oxide synthase 2 Homo sapiens 4-8 16223957-5 2006 Inhibition of cellular nitrate/nitrite synthesis in RAW, rat mesangium, and human embryonic kidney 293 cells after iNOS induction showed 40- to 100-fold higher IC(50) values than at the isolated enzyme, in agreement with the much higher l-arginine concentrations in cell culture media and inside intact cells. Nitrates 23-30 nitric oxide synthase 2 Homo sapiens 115-119 17003285-6 2006 In addition, two specific inducible NO synthase (iNOS) inhibitors, l-N6-(1-iminoethyl)lysine (l-NIL) and aminoguanidine, prevented the effect of LPS on nitrite+nitrate levels and on IGF-I gene expression in hepatocyte cultures. Nitrates 160-167 nitric oxide synthase 2 Homo sapiens 26-47 17003285-6 2006 In addition, two specific inducible NO synthase (iNOS) inhibitors, l-N6-(1-iminoethyl)lysine (l-NIL) and aminoguanidine, prevented the effect of LPS on nitrite+nitrate levels and on IGF-I gene expression in hepatocyte cultures. Nitrates 160-167 nitric oxide synthase 2 Homo sapiens 49-53 17003285-8 2006 However, in cocultures, the iNOS inhibitor l-NIL prevented the effect of LPS on nitrite+nitrate levels, but only attenuated the LPS-induced decrease in IGF-I gene expression. Nitrates 88-95 nitric oxide synthase 2 Homo sapiens 28-32 15199233-1 2004 Nitrite and nitrate are widely used reporters of endogenous nitric oxide (NO) and nitric oxide synthase (NOS) activity, which are crucial for a broad spectrum of physiological and pathophysiological pathways. Nitrates 12-19 nitric oxide synthase 2 Homo sapiens 82-103 15199238-1 2004 Measurement of the nitric oxide (NO) metabolites nitrite and nitrate in biological matrices is a reliable method to assess NO synthase (NOS) activity. Nitrates 61-68 nitric oxide synthase 2 Homo sapiens 123-134 14657339-8 2003 Scavenging free NO from the iNOS milieu by the MPO/H2O2 system subsequently restores the full capacity of iNOS to convert L-arginine to product (NO), as judged by the increase in the rates of citrulline and nitrite/nitrate production. Nitrates 215-222 nitric oxide synthase 2 Homo sapiens 28-32 14657339-8 2003 Scavenging free NO from the iNOS milieu by the MPO/H2O2 system subsequently restores the full capacity of iNOS to convert L-arginine to product (NO), as judged by the increase in the rates of citrulline and nitrite/nitrate production. Nitrates 215-222 nitric oxide synthase 2 Homo sapiens 106-110 12390892-1 2002 Recently, we have found that the nitrate/nitrite concentrations in preovulatory follicles significantly decrease after hCG injection and that inducible nitric oxide synthase (iNOS) plays a main role in the decrease of the intrafollicular nitric oxide (NO) concentration. Nitrates 33-40 nitric oxide synthase 2 Homo sapiens 175-179 12059056-5 2002 In addition, iNOS expression in circulating monocytes was assessed by Western blotting, immunocytochemistry and measurement of the NO metabolites nitrite and nitrate in plasma. Nitrates 158-165 nitric oxide synthase 2 Homo sapiens 13-17 12052727-1 2002 Nitrites and nitrates are widely used reporters of endogenous activity of nitric oxide synthases (NOS), an important group of enzymes producing the gaseous signal molecule nitric oxide (NO). Nitrates 13-21 nitric oxide synthase 2 Homo sapiens 74-96 12115884-6 2002 Induction of iNOS was confirmed by measurement of nitrate/nitrite production and by immunodetection. Nitrates 50-57 nitric oxide synthase 2 Homo sapiens 13-17 9673545-5 1998 We examined mRNA expression of inducible NO synthase (iNOS) in circulating PMNs from those patients pre- and postoperatively using the reverse transcriptase polymerase chain reaction (RT-PCR) method and measured their serum nitrate (NO2-) + nitrate (NO3-) concentration, peripheral blood white cell (WBC) count, and serum C-reactive protein (CRP) level. Nitrates 241-248 nitric oxide synthase 2 Homo sapiens 31-52 11479842-7 2001 The low levels of LMVEC iNOS expression are associated with a 4-fold lower nitrite and nitrate production. Nitrates 87-94 nitric oxide synthase 2 Homo sapiens 24-28 9811394-9 1998 There are a few studies assessing NO generation in hypertensive children via plasma nitrite and nitrate, the NO end products, which suggest normal or increased production as opposed to a reduction, perhaps as a compensatory phenomenon. Nitrates 96-103 nitric oxide synthase 2 Homo sapiens 34-36 9811394-10 1998 In the treatment of hypertension, nitroprusside and nitrates exert their actions via NO donation. Nitrates 52-60 nitric oxide synthase 2 Homo sapiens 85-87 9759949-8 1998 RESULTS: In all of seven specimens from children with increased levels of nitrate/nitrite in the urine, we detected antibodies to iNOS, whereas in five of six control specimens--that is, from children with normal nitrate/nitrite levels--we could not detect any iNOS. Nitrates 74-81 nitric oxide synthase 2 Homo sapiens 130-134 9673545-5 1998 We examined mRNA expression of inducible NO synthase (iNOS) in circulating PMNs from those patients pre- and postoperatively using the reverse transcriptase polymerase chain reaction (RT-PCR) method and measured their serum nitrate (NO2-) + nitrate (NO3-) concentration, peripheral blood white cell (WBC) count, and serum C-reactive protein (CRP) level. Nitrates 241-248 nitric oxide synthase 2 Homo sapiens 54-58 9655731-2 1998 It is produced by nitric oxide synthase (NOS) and is rapidly metabolized to nitrite and nitrate (NO2/NO3). Nitrates 88-95 nitric oxide synthase 2 Homo sapiens 18-39 9316879-3 1997 We found that chronic proteasome inhibition using MG-341 significantly attenuated the peptidoglycan/polysaccharide (PG/PS)-induced up-regulation of iNOS in the colon and spleen and the consequent increase in plasma levels of nitrate and nitrite. Nitrates 225-232 nitric oxide synthase 2 Homo sapiens 148-152 35392923-8 2022 The functionality of the NOS2-2 protein was analyzed by transient transfection of expression clones in human DLD1 cells and nitrate measurement in the supernatant of these cells. Nitrates 124-131 nitric oxide synthase 2 Homo sapiens 25-31 8627326-0 1996 Ex vivo measurement of brain tissue nitrite and nitrate accurately reflects nitric oxide synthase activity in vivo. Nitrates 48-55 nitric oxide synthase 2 Homo sapiens 76-97 8627326-1 1996 The ex vivo tissue concentration of nitrite and nitrate (NOx) was found to correlate closely with the activity of nitric oxide synthase (NOS; EC 1.14.13.39) in various brain regions. Nitrates 48-55 nitric oxide synthase 2 Homo sapiens 114-135 35391922-2 2022 At least two major pathways produce NO: (1) the L-arginine-NO-oxidative pathway in which NO synthase (NOS) enzymes convert L-arginine to NO; (2) the nitrate-nitrite-NO reductive pathway in which NO is produced from the serial reduction of nitrate and nitrite. Nitrates 239-246 nitric oxide synthase 2 Homo sapiens 89-100