PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
22572914-0	2012	Dietary nitrate ameliorates pulmonary hypertension: cytoprotective role for endothelial nitric oxide synthase and xanthine oxidoreductase.	Nitrates	8-15	nitric oxide synthase 3, endothelial cell	Mus musculus	76-109	
32368787-8	2020	We hypothesized that maternal dietary nitrate administration would increase NO bioavailability to reduce systolic blood pressure (SBP), improve vascular function and increase fetal growth in pregnant endothelial NO synthase knockout (eNOS-/- ) mice, which exhibit hypertension, endothelial dysfunction and FGR.	Nitrates	38-45	nitric oxide synthase 3, endothelial cell	Mus musculus	234-238	
27609225-0	2016	Enhanced XOR activity in eNOS-deficient mice: Effects on the nitrate-nitrite-NO pathway and ROS homeostasis.	Nitrates	61-68	nitric oxide synthase 3, endothelial cell	Mus musculus	25-29	
27609225-8	2016	Following an acute dose of nitrate, plasma nitrite increased more in eNOS-/- compared with wt, and this augmented response was abolished by the selective XOR inhibitor febuxostat.	Nitrates	27-34	nitric oxide synthase 3, endothelial cell	Mus musculus	69-73	
27609225-13	2016	A high dose of dietary nitrate reduced blood pressure in naive eNOS-/- mice, and again this effect was abolished by febuxostat.	Nitrates	23-30	nitric oxide synthase 3, endothelial cell	Mus musculus	63-67	
27609225-14	2016	In conclusion, eNOS deficiency is associated with an upregulation of XOR facilitating the nitrate-nitrite-NO pathway and decreasing the generation of ROS.	Nitrates	90-97	nitric oxide synthase 3, endothelial cell	Mus musculus	15-19	
26276822-2	2015	In mice, ART-induced vascular dysfunction is related to epigenetic alteration of the endothelial nitric oxide synthase (eNOS) gene, resulting in decreased vascular eNOS expression and nitrite/nitrate synthesis.	Nitrates	192-199	nitric oxide synthase 3, endothelial cell	Mus musculus	85-118	
26276822-2	2015	In mice, ART-induced vascular dysfunction is related to epigenetic alteration of the endothelial nitric oxide synthase (eNOS) gene, resulting in decreased vascular eNOS expression and nitrite/nitrate synthesis.	Nitrates	192-199	nitric oxide synthase 3, endothelial cell	Mus musculus	120-124	
24346018-2	2014	Subsets of circulating blood cells, including red blood cells (RBCs), carry a NOS3 and contribute to blood pressure regulation and RBC nitrite/nitrate formation.	Nitrates	143-150	nitric oxide synthase 3, endothelial cell	Mus musculus	78-82	
25158065-5	2014	Therefore, we hypothesized that nitrate tolerance induced by persistent GTN treatment results from NOS3 dysfunction and vascular toxicity.	Nitrates	32-39	nitric oxide synthase 3, endothelial cell	Mus musculus	99-103	
18685092-5	2008	Cardiac-specific eNOS overexpression resulted in significant increases in nitrite, nitrate, and nitrosothiols in the heart, plasma, and liver.	Nitrates	83-90	nitric oxide synthase 3, endothelial cell	Mus musculus	17-21	
18501719-6	2008	Mice deficient in endothelial nitric oxide synthase (eNOS-/-) demonstrated decreased blood and tissue nitrite, nitrate, and nitroso proteins, which were further reduced by low-nitrite (NOx) diet for 1 week.	Nitrates	111-118	nitric oxide synthase 3, endothelial cell	Mus musculus	18-51	
9854041-8	1998	Thus, our novel mouse model of chronic eNOS overexpression demonstrates that, in addition to the essential role of eNOS in blood pressure regulation, tonic NO release by eNOS in the endothelium induces the reduced vascular reactivity to NO-mediated vasodilators, providing several insights into the pathogenesis of nitrate tolerance.	Nitrates	315-322	nitric oxide synthase 3, endothelial cell	Mus musculus	39-43	
17606840-10	2007	The effects of eNOS-derived NO are reproduced by exogenous NO (NO donors), implying that nitrates can upregulate cardiac cyclooxygenase-2.	Nitrates	89-97	nitric oxide synthase 3, endothelial cell	Mus musculus	15-19	
16891913-0	2006	Ramipril treatment protects against nitrate-induced oxidative stress in eNOS-/- mice: An implication of the NADPH oxidase pathway.	Nitrates	36-43	nitric oxide synthase 3, endothelial cell	Mus musculus	72-79