PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
1906734-6	1991	Dipyridamole, a phosphodiesterase (PDe) inhibitor, significantly potentiated the responses to SIN1 on control rings (EC50 = 57.1 +/- 1.8 nM), and on NTG-tolerant rings it reversed the responsiveness to SIN1 (EC50 = 88.9 +/- 9.2 nM), which suggests that nitrate tolerance may be partially due to an increase in PDe activity.	Nitrates	253-260	MAPK associated protein 1	Homo sapiens	94-98	
1906734-0	1991	Effect of nitrate tolerance and dipyridamole on the response to SIN1 in the human isolated saphenous vein.	Nitrates	10-17	MAPK associated protein 1	Homo sapiens	64-68	
6613236-8	1983	SIN 1 effectively dilates nonstenotic and especially stenotic epicardial coronary arteries, as it is already known for nitrates and calcium-channel blockers.	Nitrates	119-127	MAPK associated protein 1	Homo sapiens	0-5	
27593859-6	2016	RESULTS: SIN-1 treatment increased arginase activity in a time- and dose-dependent manner and reciprocally decreased nitrite/nitrate production that was prevented by peroxynitrite scavenger in HUVECs.	Nitrates	125-132	MAPK associated protein 1	Homo sapiens	9-14	
10350003-0	1999	The nitric oxide donor SIN-1 is free of tolerance and maintains its cyclic GMP stimulatory potency in nitrate-tolerant LLC-PK1 cells.	Nitrates	102-109	MAPK associated protein 1	Homo sapiens	23-28	
1790782-4	1991	At least one further site in the nitrate bioconversion cascade, possibly at the level of NO generation appears to be involved in tolerance development, which may also affect the non-nitrate vasodilator SIN-1.	Nitrates	33-40	MAPK associated protein 1	Homo sapiens	202-207	
1776339-1	1991	SIN 1, the bioactive metabolite of molsidomine, not only appears to lack the problem of inducing nitrate tolerance, but also exerts antiaggregatory and fibrinolytic properties.	Nitrates	97-104	MAPK associated protein 1	Homo sapiens	0-5	
2099413-0	1990	Inhibition of platelet activation by the nitrate Sin-1: studies with human aequorin-loaded platelets.	Nitrates	41-48	MAPK associated protein 1	Homo sapiens	49-54