PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
25866245-3	2015	Here, we show that cytoplasmic PTEN is distributed along microtubules, tethered to vesicles via phosphatidylinositol 3-phosphate (PI(3)P), the signature lipid of endosomes.	phosphatidylinositol 3-phosphate	96-128	phosphatase and tensin homolog	Homo sapiens	31-35	
31932468-2	2020	PTEN inhibits the phosphatidylinositol 3-phosphate kinase (PI3K)/AKT pathway through its lipid phosphatase activity.	phosphatidylinositol 3-phosphate	18-50	phosphatase and tensin homolog	Homo sapiens	0-4	
25866245-3	2015	Here, we show that cytoplasmic PTEN is distributed along microtubules, tethered to vesicles via phosphatidylinositol 3-phosphate (PI(3)P), the signature lipid of endosomes.	phosphatidylinositol 3-phosphate	130-136	phosphatase and tensin homolog	Homo sapiens	31-35	
25866245-4	2015	We demonstrate that the non-catalytic C2 domain of PTEN specifically binds PI(3)P through the CBR3 loop.	phosphatidylinositol 3-phosphate	75-81	phosphatase and tensin homolog	Homo sapiens	51-55	
25866245-6	2015	This loss of function is rescued by fusion of the loop mutant PTEN to FYVE, the canonical PI(3)P binding domain, demonstrating the functional importance of targeting PTEN to endosomal membranes.	phosphatidylinositol 3-phosphate	90-96	phosphatase and tensin homolog	Homo sapiens	62-66	
25866245-6	2015	This loss of function is rescued by fusion of the loop mutant PTEN to FYVE, the canonical PI(3)P binding domain, demonstrating the functional importance of targeting PTEN to endosomal membranes.	phosphatidylinositol 3-phosphate	90-96	phosphatase and tensin homolog	Homo sapiens	166-170	
23453810-3	2013	We now identify MEK1 as an essential regulator of lipid/protein phosphatase PTEN, through which it controls phosphatidylinositol-3-phosphate accumulation and AKT signaling.	phosphatidylinositol 3-phosphate	108-140	phosphatase and tensin homolog	Homo sapiens	76-80	
23068606-0	2012	Essential roles of PIKfyve and PTEN on phagosomal phosphatidylinositol 3-phosphate dynamics.	phosphatidylinositol 3-phosphate	50-82	phosphatase and tensin homolog	Homo sapiens	31-35	
23068606-4	2012	Here we show that elimination of PtdIns(3)P from phagosomal membrane was significantly delayed in RAW264.7 macrophages lacking PTEN or PIKfyve.	phosphatidylinositol 3-phosphate	33-43	phosphatase and tensin homolog	Homo sapiens	127-131	
23068606-5	2012	In the PTEN-deficient cells treated with a PIKfyve inhibitor, degradation of PtdIns(3)P was almost lost, indicating that PTEN and PIKfyve are two major players in phagosomal PtdIns(3)P metabolism.	phosphatidylinositol 3-phosphate	77-87	phosphatase and tensin homolog	Homo sapiens	7-11	
23068606-5	2012	In the PTEN-deficient cells treated with a PIKfyve inhibitor, degradation of PtdIns(3)P was almost lost, indicating that PTEN and PIKfyve are two major players in phagosomal PtdIns(3)P metabolism.	phosphatidylinositol 3-phosphate	77-87	phosphatase and tensin homolog	Homo sapiens	121-125	
23068606-5	2012	In the PTEN-deficient cells treated with a PIKfyve inhibitor, degradation of PtdIns(3)P was almost lost, indicating that PTEN and PIKfyve are two major players in phagosomal PtdIns(3)P metabolism.	phosphatidylinositol 3-phosphate	174-184	phosphatase and tensin homolog	Homo sapiens	7-11	
23068606-5	2012	In the PTEN-deficient cells treated with a PIKfyve inhibitor, degradation of PtdIns(3)P was almost lost, indicating that PTEN and PIKfyve are two major players in phagosomal PtdIns(3)P metabolism.	phosphatidylinositol 3-phosphate	174-184	phosphatase and tensin homolog	Homo sapiens	121-125	
20610402-3	2010	Phosphatidylinositol 3-phosphate level is critically regulated by PI3K and PTEN (phosphatase and tensin homologue deleted chromosome ten).	phosphatidylinositol 3-phosphate	0-32	phosphatase and tensin homolog	Homo sapiens	75-79	
20610402-3	2010	Phosphatidylinositol 3-phosphate level is critically regulated by PI3K and PTEN (phosphatase and tensin homologue deleted chromosome ten).	phosphatidylinositol 3-phosphate	0-32	phosphatase and tensin homolog	Homo sapiens	81-136	
15313215-4	2004	PTEN is a major tumor suppressor of human cancer that acts by hydrolyzing membrane phosphatidylinositol (PtdIns)-3-phosphates, thus, preventing the activation of the survival signaling kinase Akt by PtdIns-3-kinase.	phosphatidylinositol 3-phosphate	105-125	phosphatase and tensin homolog	Homo sapiens	0-4	
12534371-3	2003	Surface-dilution analysis revealed the catalytic efficiency of PTEN for PtdIns(3,4,5) P (3) to be 200-fold greater than for either PtdIns(3,4) P (2) or PtdIns(3,5) P (2), and 1000-fold greater than for PtdIns3 P.	phosphatidylinositol 3-phosphate	202-211	phosphatase and tensin homolog	Homo sapiens	63-67