PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
30936093-4	2019	Structural and mutational analyses identified conserved residues within the CCD of ATG16L1 that mediate direct binding to phosphoinositides, including phosphatidylinositol 3-phosphate (PI3P).	phosphatidylinositol 3-phosphate	151-183	autophagy related 16 like 1	Homo sapiens	83-90	
31448519-3	2019	Cells lacking ATG7 or ATG16L1 exhibit increased levels of phosphatidylinositol-3-phosphate (PI(3)P), a key determinant of early endosome maturation.	phosphatidylinositol 3-phosphate	58-90	autophagy related 16 like 1	Homo sapiens	22-29	
31448519-3	2019	Cells lacking ATG7 or ATG16L1 exhibit increased levels of phosphatidylinositol-3-phosphate (PI(3)P), a key determinant of early endosome maturation.	phosphatidylinositol 3-phosphate	92-98	autophagy related 16 like 1	Homo sapiens	22-29	
29940791-3	2018	Newly formed phosphatidylinositol 3-phosphate (PtdIns3P) on the membranes destined to become phagophores recruits WIPI2, which, in turn, binds ATG16L1 to define the sites of autophagosome formation.	phosphatidylinositol 3-phosphate	47-55	autophagy related 16 like 1	Homo sapiens	143-150	
30811270-7	2019	Furthermore, the ALPS motif and VPS34 catalytic activity are required for downstream recruitment of WD-repeat domain phosphoinositide-interacting protein (WIPI)2, a protein that binds phosphatidylinositol 3-phosphate and its product phosphatidylinositol 3, 5-bisphosphate, and a WIPI-binding protein, ATG2A, but do not affect membrane association of ATG3 and ATG16L1, enzymes contributing directly to LC3 lipidation.	phosphatidylinositol 3-phosphate	184-216	autophagy related 16 like 1	Homo sapiens	359-366	
29634932-2	2018	These membranes are specified by phosphatidylinositol 3-phosphate (PI3P), which recruits WIPI2, which, in turn, recruits ATG16L1 to specify the sites of LC3-conjugation.	phosphatidylinositol 3-phosphate	33-65	autophagy related 16 like 1	Homo sapiens	121-128	
30646805-1	2019	WIPI2 contributes to autophagy by recruiting the ATG12-ATG5-ATG16L1 complex to PtdIns3P-rich membranes, which enables the growth and elongation of phagophores.	phosphatidylinositol 3-phosphate	79-87	autophagy related 16 like 1	Homo sapiens	60-67	
29940791-3	2018	Newly formed phosphatidylinositol 3-phosphate (PtdIns3P) on the membranes destined to become phagophores recruits WIPI2, which, in turn, binds ATG16L1 to define the sites of autophagosome formation.	phosphatidylinositol 3-phosphate	13-45	autophagy related 16 like 1	Homo sapiens	143-150	
25629784-0	2015	WIPI2B links PtdIns3P to LC3 lipidation through binding ATG16L1.	phosphatidylinositol 3-phosphate	13-21	autophagy related 16 like 1	Homo sapiens	56-63	
25629784-4	2015	Our model of WIPI2 function provides an explanation for the PtdIns3P-dependent recruitment of the ATG12-ATG5-ATG16L1 complex during initiation of autophagy.	phosphatidylinositol 3-phosphate	60-68	autophagy related 16 like 1	Homo sapiens	109-116	
24954904-4	2014	By identifying interacting partners of WIPIs, WD-repeat PtdIns(3)P effector proteins, we found that Atg16L1 directly binds WIPI2b.	phosphatidylinositol 3-phosphate	56-66	autophagy related 16 like 1	Homo sapiens	100-107	
24954904-5	2014	Mutation experiments and ectopic localization of WIPI2b to plasma membrane show that WIPI2b is a PtdIns(3)P effector upstream of Atg16L1 and is required for LC3 conjugation and starvation-induced autophagy through recruitment of the Atg12-5-16L1 complex.	phosphatidylinositol 3-phosphate	97-107	autophagy related 16 like 1	Homo sapiens	129-136	
23558782-3	2013	The association between these two proteins allows the formation of the autophagy-specific PtdIns3K complex, which activity favors the generation of phosphatidylinositol-3-phosphate (PtdIns3P) and the subsequent association of the autophagy-related (ATG) proteins, including ATG16L1, with the phagophore membranes.	phosphatidylinositol 3-phosphate	148-180	autophagy related 16 like 1	Homo sapiens	274-281	
23558782-3	2013	The association between these two proteins allows the formation of the autophagy-specific PtdIns3K complex, which activity favors the generation of phosphatidylinositol-3-phosphate (PtdIns3P) and the subsequent association of the autophagy-related (ATG) proteins, including ATG16L1, with the phagophore membranes.	phosphatidylinositol 3-phosphate	182-190	autophagy related 16 like 1	Homo sapiens	274-281