PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 6129126-6 1982 Clonidine decreased plasma renin activity, but the other agonists increased it. Clonidine 0-9 renin Canis lupus familiaris 27-32 6129946-1 1983 The location and nature of the receptors in the brain on which clonidine acts to decrease renin secretion have been investigated in dogs. Clonidine 63-72 renin Canis lupus familiaris 90-95 6129126-7 1982 In dogs treated with 6-hydroxydopamine, the decrease in blood pressure and ACTH and renin secretion produced by clonidine was not altered but the growth hormone response was reduced. Clonidine 112-121 renin Canis lupus familiaris 84-89 6120802-0 1981 Inhibition of renin secretion by clonidine after alpha-adrenoceptor blockade in anesthetized dogs. Clonidine 33-42 renin Canis lupus familiaris 14-19 6120802-1 1981 Dogs anaesthetised with pentobarbital were used to study the effects of the alpha-adrenoceptor antagonists phentolamine and piperoxan on the clonidine-induced suppression of plasma renin activity (PRA). Clonidine 141-150 renin Canis lupus familiaris 181-186 6120802-10 1981 These results demonstrate that the renin-lowering action of clonidine in the dog is not inhibited by two classical alpha-adrenoceptor antagonists. Clonidine 60-69 renin Canis lupus familiaris 35-40 6991409-0 1980 Suppression of stimulated plasma renin by clonidine in the dog. Clonidine 42-51 renin Canis lupus familiaris 33-38 6248808-0 1980 Sites at which clonidine acts to affect blood pressure and the secretion of renin, growth hormone and ACTH. Clonidine 15-24 renin Canis lupus familiaris 76-81 6248808-1 1980 To further define the sites in the brain at which clonidine acts to lower blood pressure, inhibit renin secretion, inhibit ACTH secretion, and stimulate growth hormone secretion, small doses of this drug were infused into the vertebral arteries, into the carotid arteries and intravenously in pentobarbital-anesthetized dogs. Clonidine 50-59 renin Canis lupus familiaris 98-103 6248808-6 1980 Intracarotid and intravertebral clonidine decreased plasma renin activity whereas in this dose intravenous clonidine did not. Clonidine 32-41 renin Canis lupus familiaris 59-64 6248808-10 1980 The data confirm the observation that clonidine acts on the brain to inhibit renin secretion, and establish that the renin-inhibiting site is different from the blood pressure-lowering site. Clonidine 38-47 renin Canis lupus familiaris 77-82 6991409-1 1980 The mechanism by which clonidine suppresses plasma renin activity (PRA) was investigated in dogs anesthetized with pentobarbital. Clonidine 23-32 renin Canis lupus familiaris 51-56 6991409-7 1980 These results indicate that clonidine reduces stimulated renin by a central mechanism that is dependent upon the integrity of the sympathetic innervation of the kidney. Clonidine 28-37 renin Canis lupus familiaris 57-62 6991409-8 1980 Other stimuli for renin release may override the inhibitory effect of central clonidine. Clonidine 78-87 renin Canis lupus familiaris 18-23 1120965-0 1975 Studies concerning the mechanism of suppression of renin secretion by clonidine. Clonidine 70-79 renin Canis lupus familiaris 51-56 206850-1 1978 To determine whether the inhibitory effect of clonidine (CLON) on renin secretion is due in part to a direct action on the kidneys or due entirely to an action on the brain, the drug was administered intravenously in a dose of 30 microgram/kg to dogs in which the spinal cord had been transected in the cervical region. Clonidine 46-55 renin Canis lupus familiaris 66-71 206850-1 1978 To determine whether the inhibitory effect of clonidine (CLON) on renin secretion is due in part to a direct action on the kidneys or due entirely to an action on the brain, the drug was administered intravenously in a dose of 30 microgram/kg to dogs in which the spinal cord had been transected in the cervical region. Clonidine 57-61 renin Canis lupus familiaris 66-71 475475-0 1979 Effect of intravenous or intracisternal clonidine and propranolol on plasma renin. Clonidine 40-49 renin Canis lupus familiaris 76-81 620441-0 1978 Mechanism of suppression of renin secretion by clonidine in the dog. Clonidine 47-56 renin Canis lupus familiaris 28-33 620441-1 1978 The mechanism by which clonidine suppresses renin secretion was investigated in pentobarbital-anesthetized dogs in which renal perfusion pressure was controlled by means of an aortic clamp. Clonidine 23-32 renin Canis lupus familiaris 44-49 620441-2 1978 Clonidine (30 microgram/kg, iv) lowered mean arterial pressure (MAP) from 124 +/- 8 to 104 +/- 4 mm Hg (P less than 0.01) and reduced plasma renin activity (PRA) to 32 +/- 4 percent of the control value (P less than 0.01) after 60 minutes. Clonidine 0-9 renin Canis lupus familiaris 141-146 620441-8 1978 Taken together, these data support the hypothesis that the inhibition of renin secretion by clonidine results from a centrally mediated decrease in sympathetic neural activity. Clonidine 92-101 renin Canis lupus familiaris 73-78 191299-4 1977 The centrally active alpha-adrenergic agonist clonidine decreases renin secretion, lowers blood pressure, inhibits ACTH and vasopressin secretion, and increases growth hormone secretion in dogs. Clonidine 46-55 renin Canis lupus familiaris 66-71 1071584-0 1976 Effects of carotid occlusion and clonidine on renin secretion in anaesthetized dogs. Clonidine 33-42 renin Canis lupus familiaris 46-51 1071584-5 1976 Administration of clonidine decreased plasma renin activity, arterial pressure and heart rate and blocked the renin secretory and blood pressure responses to carotid occlusion. Clonidine 18-27 renin Canis lupus familiaris 45-50 1071584-5 1976 Administration of clonidine decreased plasma renin activity, arterial pressure and heart rate and blocked the renin secretory and blood pressure responses to carotid occlusion. Clonidine 18-27 renin Canis lupus familiaris 110-115 1071584-7 1976 These results support the hypothesis that the suppression of renin secretion by clonidine is a consequence of the decrease in sympathetic activity produced by this drug. Clonidine 80-89 renin Canis lupus familiaris 61-66 1120965-1 1975 Two series of experiments were performed in anesthetized dogs to test the hypothesis that the suppression of renin secretion by clonidine results from a centrally mediated decrease in the activity in the renal sympathetic nerves. Clonidine 128-137 renin Canis lupus familiaris 109-114 1120965-3 1975 In these animals, clonidine produced hypotension and bradycardia and suppressed plasma renin activity to 39 percent of the control value. Clonidine 18-27 renin Canis lupus familiaris 87-92 1120965-7 1975 Intravenous clonidine produced a transient hypertension followed by hypotension, decreased heart rate and suppressed plasma renin activity to 49 percent of the control value. Clonidine 12-21 renin Canis lupus familiaris 124-129 1120965-8 1975 Renal denervation reduced renin secretion and prevented the suppression of renin secretion produced by intravenous clonidine. Clonidine 115-124 renin Canis lupus familiaris 75-80 1120965-9 1975 Thus, these data are consistent with the hypothesis that the suppression of renin secretion by clonidine results from a centrally mediated decrease in renal sympathetic neural tone. Clonidine 95-104 renin Canis lupus familiaris 76-81