PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 2092912-0 1990 [Efficient diagnosis of hypothalamo-hypophyseal nanism: 5 years" experience with the clonidine stimulation test in the diagnosis of growth hormone secretion]. Clonidine 85-94 growth hormone 1 Homo sapiens 132-146 2092912-1 1990 The clonidine stimulation test, using doses of 37.5--75 micrograms clonidine and assessment of growth hormone levels at times 0, 60 minutes, is a suitable, safe and relatively reliable screening test for ambulatory work. Clonidine 4-13 growth hormone 1 Homo sapiens 95-109 2084146-10 1990 Challenge with either L-dopa or clonidine produced a peak GH response of 2.3 ng/ml (normals = greater than 7 ng/ml). Clonidine 32-41 growth hormone 1 Homo sapiens 58-60 2204433-0 1990 Comparison of growth hormone response after clonidine and insulin hypoglycemia in affective illness. Clonidine 44-53 growth hormone 1 Homo sapiens 14-28 2204433-2 1990 In the present study, we examined the relationship between GH response after clonidine and insulin administration within the same subject to see if consistent response patterns were evident. Clonidine 77-86 growth hormone 1 Homo sapiens 59-61 2204433-3 1990 Though there was a significant reduction in the mean GH response after clonidine (p = 0.0002), similar differences were not observed after insulin (p = 0.10). Clonidine 71-80 growth hormone 1 Homo sapiens 53-55 2172136-1 1990 Comparative study of growth hormone (GH) secretion stimulated by clonidine and GH-releasing hormone. Clonidine 65-74 growth hormone 1 Homo sapiens 21-35 2172136-1 1990 Comparative study of growth hormone (GH) secretion stimulated by clonidine and GH-releasing hormone. Clonidine 65-74 growth hormone 1 Homo sapiens 37-39 2162745-0 1990 Down-regulation of alpha 2-adrenoceptors involved in growth hormone control in the hypothalamus of infant rats receiving short-term clonidine administration. Clonidine 132-141 growth hormone 1 Homo sapiens 53-67 2380338-0 1990 Acute clonidine administration potentiates spontaneous diurnal, but not nocturnal, growth hormone secretion in normal short children. Clonidine 6-15 growth hormone 1 Homo sapiens 83-97 19215376-3 1990 The GH-releasing effect of clonidine (0.15 mg infused iv over 10 min), an alpha(2)-adrenergic agonist, was significantly blunted by yohimbine (30 mg orally at -50 min), a relatively specific alpha(2)-adrenergic antagonist area under the response curve, mean+/-SEM: 672.6 +/- 143.0 versus 219.6 +/- 16.7 mug/l/h; P<0.05). Clonidine 27-36 growth hormone 1 Homo sapiens 4-6 2157699-1 1990 The growth hormone response to stimulation with oral clonidine and L-dopa was measured in 14 boys with major depressive disorder (MDD) and 15 normal boys. Clonidine 53-62 growth hormone 1 Homo sapiens 4-18 2318712-0 1990 Blunted growth hormone responses to clonidine in adolescent girls with early anorexia nervosa. Clonidine 36-45 growth hormone 1 Homo sapiens 8-22 2318712-5 1990 However, the GH response to the alpha-adrenergic agent clonidine was blunted (less than 10 ng/ml) in 11 of 14 girls with AN. Clonidine 55-64 growth hormone 1 Homo sapiens 13-15 2157699-2 1990 The six MDD boys who were prepubertal or in early puberty were significantly lower than the 10 normal subjects of this age in peak growth hormone response following clonidine administration (p = 0.029) and area under the curve for clonidine (p = 0.030) and L-dopa (p = 0.028). Clonidine 165-174 growth hormone 1 Homo sapiens 131-145 2333361-0 1990 Dose-response profiles of plasma growth hormone and vasopressin after clonidine challenge in man. Clonidine 70-79 growth hormone 1 Homo sapiens 33-47 2333361-1 1990 The objective of the study was to determine dose-response relationships of growth hormone, vasopressin, blood pressure, heart rate, and behavioral responses to clonidine. Clonidine 160-169 growth hormone 1 Homo sapiens 75-89 2100275-0 1990 Effect of chronic clonidine treatment on urinary growth hormone excretion and linear growth in children with short stature. Clonidine 18-27 growth hormone 1 Homo sapiens 49-63 2126361-0 1990 Growth hormone responses to growth hormone-releasing hormone, clonidine and insulin-induced hypoglycemia in normal weight bulimic women. Clonidine 62-71 growth hormone 1 Homo sapiens 0-14 2352756-1 1990 In eight children, after the termination of therapy for acute lymphoblastic leukaemia (ALL) the secretion of growth hormone (GH) was determined by the stimulation test with clonidine. Clonidine 173-182 growth hormone 1 Homo sapiens 109-123 2087535-0 1990 Growth hormone (GH) response to clonidine and growth hormone releasing factor (GRF) in normal controls. Clonidine 32-41 growth hormone 1 Homo sapiens 0-14 2087535-2 1990 Both clonidine and GRF caused significant increases in plasma GH levels over baseline. Clonidine 5-14 growth hormone 1 Homo sapiens 62-64 2087535-3 1990 The peak GH-responses to GRF and clonidine were similar (GRF = 8.7 +/- 6.7 ng/ml; clonidine = 6.5 +/- 5.9 ng/ml; Wilcoxon test: s = 361, z = -1.31, p = NS). Clonidine 33-42 growth hormone 1 Homo sapiens 9-11 2087535-4 1990 The GH responses to GRF and clonidine were significantly correlated (rs = 0.62, n = 20, p = 0.004). Clonidine 28-37 growth hormone 1 Homo sapiens 4-6 2087535-6 1990 There was a modest gender effect with clonidine (men greater than women; p less than 0.06) and a negative correlation between GH secretion and age with both GRF and clonidine. Clonidine 165-174 growth hormone 1 Homo sapiens 126-128 2087535-8 1990 These findings are consistent with animal studies suggesting that the GH response to clonidine is mediated by GRF. Clonidine 85-94 growth hormone 1 Homo sapiens 70-72 2195577-1 1990 Central alpha 2-adrenergic function is often inferred from the growth hormone (GH) response to clonidine, despite the drug"s known hypnotic effect and the accepted cholinergic mechanism for sleep-related GH secretion. Clonidine 95-104 growth hormone 1 Homo sapiens 63-77 2195577-1 1990 Central alpha 2-adrenergic function is often inferred from the growth hormone (GH) response to clonidine, despite the drug"s known hypnotic effect and the accepted cholinergic mechanism for sleep-related GH secretion. Clonidine 95-104 growth hormone 1 Homo sapiens 79-81 2195577-8 1990 We conclude that the GH response to clonidine may not be indicative of alpha 2-adrenergic function if sleep is permitted during the test. Clonidine 36-45 growth hormone 1 Homo sapiens 21-23 2087535-0 1990 Growth hormone (GH) response to clonidine and growth hormone releasing factor (GRF) in normal controls. Clonidine 32-41 growth hormone 1 Homo sapiens 16-18 2087535-1 1990 To investigate the relationship between the plasma growth hormone (GH) response to provocative challenge with the hypothalamic peptide growth hormone-releasing factor (GRF) and the alpha 2-adrenergic agonist clonidine, we administered GRF (1 microgram/kg), clonidine (2 micrograms/kg), and placebo to 21 healthy normal controls (13 men and eight women). Clonidine 208-217 growth hormone 1 Homo sapiens 51-65 6322574-2 1984 We found that clonidine is an effective and safe stimulator of GH release and provided a clearer distinction between GH-deficient and non-GH-deficient young persons than levodopa or arginine. Clonidine 14-23 growth hormone 1 Homo sapiens 63-65 6322574-0 1984 A comparison of clonidine and standard provocative agents of growth hormone. Clonidine 16-25 growth hormone 1 Homo sapiens 61-75 2510497-2 1989 Peak growth hormone levels (greater than or equal to 10 ng/mL) following oral clonidine administration were normal in individuals with normal height, constitutional growth delay, and neurosecretory dysfunction, as was the basal somatomedin C concentration; subjects with growth hormone deficiency had low peak growth hormone levels (less than 10 ng/mL) following oral clonidine administration as well as low basal somatomedin C values. Clonidine 78-87 growth hormone 1 Homo sapiens 5-19 2575439-3 1989 Systemic (IV) administration of the alpha 2 receptor agonist clonidine is known to stimulate secretion of PRL and growth hormone (GH) suggesting a stimulatory role of the central alpha 2 receptors in the regulation of the two hormones. Clonidine 61-70 growth hormone 1 Homo sapiens 114-128 2575439-3 1989 Systemic (IV) administration of the alpha 2 receptor agonist clonidine is known to stimulate secretion of PRL and growth hormone (GH) suggesting a stimulatory role of the central alpha 2 receptors in the regulation of the two hormones. Clonidine 61-70 growth hormone 1 Homo sapiens 130-132 2575439-5 1989 This conclusion is based on the following findings: 1) The minimum effective IV dose of clonidine or UK 14304 was four times larger for activation of PRL than GH secretion and had already manifest extracentral effects (elevation of arterial BP). Clonidine 88-97 growth hormone 1 Homo sapiens 159-161 34418530-0 2022 Diagnosing growth hormone deficiency - Can a combined arginine and clonidine stimulation test replace two separate tests? Clonidine 67-76 growth hormone 1 Homo sapiens 11-25 2568210-5 1989 The peak elevation in plasma growth hormone that was produced by clonidine on the day the placebo was given was inhibited an average of 87% by the 2 mg dose of MK-912 (p less than 0.01). Clonidine 65-74 growth hormone 1 Homo sapiens 29-43 2587519-0 1989 [The use of klofelin for studying somatotropin secretion in children]. Clonidine 12-20 growth hormone 1 Homo sapiens 34-46 2698383-0 1989 Oral clonidine: an effective growth hormone provocative test. Clonidine 5-14 growth hormone 1 Homo sapiens 29-43 2698383-4 1989 A significant rise (peak level greater than 7 ng/ml) of serum GH was found in 70, 80 and 85% of children after exercise, insulin and oral clonidine tests, respectively. Clonidine 138-147 growth hormone 1 Homo sapiens 62-64 2798598-0 1989 Growth hormone response to clonidine in untreated depressed patients. Clonidine 27-36 growth hormone 1 Homo sapiens 0-14 2798598-4 1989 Differences in the GH response to clonidine only occurred between male patients and controls. Clonidine 34-43 growth hormone 1 Homo sapiens 19-21 2742943-6 1989 The present results confirm prior observations of a blunted growth hormone response after clonidine and suggest that alterations in alpha 2-adrenergic receptor activity might also contribute to several neuroendocrine abnormalities in patients with melancholic depression. Clonidine 90-99 growth hormone 1 Homo sapiens 60-74 2568210-7 1989 However, a mean 59% inhibition of the clonidine-induced peak elevation of plasma growth hormone was observed (p less than 0.05). Clonidine 38-47 growth hormone 1 Homo sapiens 81-95 2597894-0 1989 Tricyclic wash-out and growth hormone response to clonidine. Clonidine 50-59 growth hormone 1 Homo sapiens 23-37 2597894-1 1989 We have observed a significantly higher growth hormone (GH) response to clonidine administration (150 micrograms i.v.) Clonidine 72-81 growth hormone 1 Homo sapiens 40-54 2597894-1 1989 We have observed a significantly higher growth hormone (GH) response to clonidine administration (150 micrograms i.v.) Clonidine 72-81 growth hormone 1 Homo sapiens 56-58 2597894-5 1989 The results suggest that studies on the GH response to clonidine in psychiatric patients need to take into account the confounding and long-lasting effects of tricyclics. Clonidine 55-64 growth hormone 1 Homo sapiens 40-42 2710869-0 1989 Clonidine-induced growth hormone secretion in elderly patients with senile dementia of the Alzheimer type and major depressive disorder. Clonidine 0-9 growth hormone 1 Homo sapiens 18-32 2567140-0 1989 [Determination of growth hormone: comparison between a physiologic stimulus (exercise) and pharmacologic stimuli (clonidine/guanfacine)]. Clonidine 114-123 growth hormone 1 Homo sapiens 18-32 2754022-0 1989 Relationship of plasma clonidine to growth hormone concentrations in children and adolescents. Clonidine 23-32 growth hormone 1 Homo sapiens 36-50 2754022-1 1989 The relationships of plasma clonidine to increases in growth hormone, blood pressure response and degree of sedation were studied in nine children with short stature after a 0.15 mg/m2 oral clonidine tolerance test. Clonidine 28-37 growth hormone 1 Homo sapiens 54-68 2754022-2 1989 A direct correlation was found between the peak plasma clonidine concentration and the increase in plasma growth hormone (P = 0.055). Clonidine 55-64 growth hormone 1 Homo sapiens 106-120 2469097-3 1989 Pretreatment growth hormone (GH) response to the clonidine challenge test (CCT) correlated significantly with clonidine treatment improvement in psychosis, anxiety, and negative symptom ratings. Clonidine 49-58 growth hormone 1 Homo sapiens 13-27 2469097-3 1989 Pretreatment growth hormone (GH) response to the clonidine challenge test (CCT) correlated significantly with clonidine treatment improvement in psychosis, anxiety, and negative symptom ratings. Clonidine 110-119 growth hormone 1 Homo sapiens 13-27 2918053-0 1989 Augmentation of growth hormone secretion in children with constitutional growth delay by short term clonidine administration: a pulse amplitude-modulated phenomenon. Clonidine 100-109 growth hormone 1 Homo sapiens 16-30 2710869-1 1989 This study was undertaken to assess the value of growth hormone (GH) response to clonidine as a tool in the differential diagnosis between depression and dementia. Clonidine 81-90 growth hormone 1 Homo sapiens 49-63 2710869-1 1989 This study was undertaken to assess the value of growth hormone (GH) response to clonidine as a tool in the differential diagnosis between depression and dementia. Clonidine 81-90 growth hormone 1 Homo sapiens 65-67 2492934-0 1989 Growth hormone response to diazepam, clonidine and glucagon in patients with epilepsy. Clonidine 37-46 growth hormone 1 Homo sapiens 0-14 2533520-9 1989 These results suggest that in obese subjects the impairment of GH release after clonidine is not mediated via receptors sensitivity to naloxone. Clonidine 80-89 growth hormone 1 Homo sapiens 63-65 2492166-5 1989 These findings with GH-RF extend findings from earlier reports that patients with panic disorder show blunted GH response to phobic stimulation and clonidine. Clonidine 148-157 growth hormone 1 Homo sapiens 20-22 2612023-0 1989 Impairment of modulating role of testosterone in growth hormone response to clonidine in essential hypertension. Clonidine 76-85 growth hormone 1 Homo sapiens 49-63 2732653-0 1989 Growth hormone release in normal children after oral clonidine 4 micrograms/kg. Clonidine 53-62 growth hormone 1 Homo sapiens 0-14 3243343-0 1988 Impaired growth hormone response to clonidine in obesity. Clonidine 36-45 growth hormone 1 Homo sapiens 9-23 2543999-0 1989 Effect of naloxone on the growth hormone response to clonidine in normal women during the mid-luteal phase. Clonidine 53-62 growth hormone 1 Homo sapiens 26-40 3141943-0 1988 Growth hormone (GH) responses to GH-releasing hormone in depression: correlation with GH release following clonidine. Clonidine 107-116 growth hormone 1 Homo sapiens 0-14 3208338-0 1988 [Personal experience with the clonidine test for acute growth hormone stimulation]. Clonidine 30-39 growth hormone 1 Homo sapiens 55-69 3138280-0 1988 Variable plasma growth hormone (GH)-releasing hormone and GH responses to clonidine, L-dopa, and insulin in normal men. Clonidine 74-83 growth hormone 1 Homo sapiens 32-34 3138280-0 1988 Variable plasma growth hormone (GH)-releasing hormone and GH responses to clonidine, L-dopa, and insulin in normal men. Clonidine 74-83 growth hormone 1 Homo sapiens 58-60 3138280-5 1988 Clonidine resulted in a significant increase in mean plasma GH levels (P less than 0.05) in the younger men, but not in the older men. Clonidine 0-9 growth hormone 1 Homo sapiens 60-62 3141943-0 1988 Growth hormone (GH) responses to GH-releasing hormone in depression: correlation with GH release following clonidine. Clonidine 107-116 growth hormone 1 Homo sapiens 16-18 3363023-0 1988 Growth hormone response to clonidine in panic disorder patients. Clonidine 27-36 growth hormone 1 Homo sapiens 0-14 3224252-0 1988 Blunted response of growth hormone to clonidine and apomorphine in endogenous depression. Clonidine 38-47 growth hormone 1 Homo sapiens 20-34 3224252-1 1988 We measured the growth hormone (GH) response to clonidine (an alpha-2-adrenergic agonist) and to apomorphine (a dopaminergic agonist) in 15 major endogenous and 15 minor depressive in-patients matched for gender and age. Clonidine 48-57 growth hormone 1 Homo sapiens 16-30 3139739-0 1988 Decreased growth hormone (GH) response to oral clonidine in endemic cretinism: effect of L-T3 therapy. Clonidine 47-56 growth hormone 1 Homo sapiens 10-24 2897907-1 1988 This article summarizes the existing neuroendocrine literature and reports the growth hormone response to stimulation with L-dopa and clonidine in male children and adolescents with attention deficit hyperactivity disorder. Clonidine 134-143 growth hormone 1 Homo sapiens 79-93 3380074-1 1988 This article summarizes the existing neuroendocrine literature and reports the growth hormone response to stimulation with L-dopa and clonidine in male children and adolescents with attention deficit hyperactivity disorder. Clonidine 134-143 growth hormone 1 Homo sapiens 79-93 3363023-1 1988 The growth hormone (GH) response to clonidine administration (2 micrograms/kg) was compared in three groups of subjects: seven panic disorder patients, seven depressed patients matched for age and sex, and seven normal controls. Clonidine 36-45 growth hormone 1 Homo sapiens 4-18 3060889-0 1988 Growth hormone, noradrenaline, blood pressure and cortisol responses to clonidine in healthy male volunteers: dose-response relations and reproducibility. Clonidine 72-81 growth hormone 1 Homo sapiens 0-14 3167367-0 1988 Growth hormone response to clonidine after recovery in patients with endogenous depression. Clonidine 27-36 growth hormone 1 Homo sapiens 0-14 3167367-1 1988 The growth hormone response to clonidine was measured in ten drug-free recovered patients, seven of whom had previously been tested when endogenously depressed, and compared with the response in ten individually matched controls. Clonidine 31-40 growth hormone 1 Homo sapiens 4-18 3286064-8 1988 However, in response to clonidine an increase in GH secretion in all hypertensive and normotensive cases with normal body weight was demonstrated, whereas in all obese hypertensive and normotensive patients no significant GH rise was found. Clonidine 24-33 growth hormone 1 Homo sapiens 49-51 3286064-10 1988 A strong (r = 0.76) and significant (p less than 0.0005) correlation demonstrated between the maximal GH concentration during the nocturnal sleep and after clonidine suggests that the mechanism of GH inhibition in response to both these stimuli is similar and it probably is related to the inhibition of neurohormonal secretion of the growth hormone releasing factor (GRF). Clonidine 156-165 growth hormone 1 Homo sapiens 102-104 3286064-10 1988 A strong (r = 0.76) and significant (p less than 0.0005) correlation demonstrated between the maximal GH concentration during the nocturnal sleep and after clonidine suggests that the mechanism of GH inhibition in response to both these stimuli is similar and it probably is related to the inhibition of neurohormonal secretion of the growth hormone releasing factor (GRF). Clonidine 156-165 growth hormone 1 Homo sapiens 197-199 3286064-11 1988 However, the negative correlation between the fasting insulin concentration and GH response to clonidine shown in obese subjects only, points to a more complex mechanism of GH inhibition in obesity. Clonidine 95-104 growth hormone 1 Homo sapiens 80-82 3286064-11 1988 However, the negative correlation between the fasting insulin concentration and GH response to clonidine shown in obese subjects only, points to a more complex mechanism of GH inhibition in obesity. Clonidine 95-104 growth hormone 1 Homo sapiens 173-175 2856637-2 1988 This blunted growth hormone response to clonidine has led to the speculation that there is a central alpha-2 adrenergic receptor subsensitivity in depression. Clonidine 40-49 growth hormone 1 Homo sapiens 13-27 2856637-1 1988 A blunted growth hormone (GH) response to clonidine and other pharmacologic stimuli has been reported in patients with depression. Clonidine 42-51 growth hormone 1 Homo sapiens 10-24 2856637-1 1988 A blunted growth hormone (GH) response to clonidine and other pharmacologic stimuli has been reported in patients with depression. Clonidine 42-51 growth hormone 1 Homo sapiens 26-28 3060889-1 1988 The growth hormone (GH) response to clonidine (CLON) has been investigated to date mostly with CLON doses of 2.0 micrograms/kg or 150 micrograms intravenously (IV). Clonidine 36-45 growth hormone 1 Homo sapiens 4-18 3060889-1 1988 The growth hormone (GH) response to clonidine (CLON) has been investigated to date mostly with CLON doses of 2.0 micrograms/kg or 150 micrograms intravenously (IV). Clonidine 36-45 growth hormone 1 Homo sapiens 20-22 3060889-5 1988 CLON (1.5 and 2.0 micrograms/kg) induced a significant dose-dependent GH increase, but only the 2.0 micrograms/kg dose differentiated GH responders from nonresponders. Clonidine 0-4 growth hormone 1 Homo sapiens 70-72 2884230-0 1987 Effect of estrogen on the growth hormone response to the alpha-adrenergic agonist clonidine in women with menopausal flushing. Clonidine 82-91 growth hormone 1 Homo sapiens 26-40 2829258-2 1987 We studied the growth hormone (GH) response to clonidine (an alpha-adrenergic agonist) and apomorphine (a dopaminergic agonist) in seven inpatients meeting Research Diagnostic Criteria for mania. Clonidine 47-56 growth hormone 1 Homo sapiens 15-29 2829258-2 1987 We studied the growth hormone (GH) response to clonidine (an alpha-adrenergic agonist) and apomorphine (a dopaminergic agonist) in seven inpatients meeting Research Diagnostic Criteria for mania. Clonidine 47-56 growth hormone 1 Homo sapiens 31-33 2829258-6 1987 The three groups differed significantly in the GH peak response: after clonidine (mean +/- SD), 3.2 +/- 2.4 ng/ml in manics, 3.2 +/- 2.4 ng/ml in major depressives, and 13.2 +/- 8.7 ng/ml in minor depressives; after apomorphine, 10.5 +/- 7.4, 3.2 +/- 1.9, and 26.9 +/- 15.8, respectively. Clonidine 71-80 growth hormone 1 Homo sapiens 47-49 3309234-0 1987 Low-dose oral clonidine: effective growth hormone releasing agent in children but not in adolescents. Clonidine 14-23 growth hormone 1 Homo sapiens 35-49 3578588-0 1987 Growth hormone response to clonidine in depression. Clonidine 27-36 growth hormone 1 Homo sapiens 0-14 2951760-0 1987 Clonidine stimulation in anorexia nervosa: growth hormone, cortisol, and beta-endorphin responses. Clonidine 0-9 growth hormone 1 Homo sapiens 43-57 2951760-2 1987 Clonidine, an alpha 2-adrenoceptor agonist, has been shown to blunt growth hormone (GH) response and greatly lower plasma cortisol in PAD patients. Clonidine 0-9 growth hormone 1 Homo sapiens 68-82 2951760-2 1987 Clonidine, an alpha 2-adrenoceptor agonist, has been shown to blunt growth hormone (GH) response and greatly lower plasma cortisol in PAD patients. Clonidine 0-9 growth hormone 1 Homo sapiens 84-86 3095519-0 1986 Effect of prolonged clonidine administration on growth hormone concentrations and rate of linear growth in children with constitutional growth delay. Clonidine 20-29 growth hormone 1 Homo sapiens 48-62 3095519-4 1986 These and other studies suggest that prolonged stimulation of the hypothalamus by clonidine may ameliorate the impairment of growth hormone release seen in some children with constitutional growth delay. Clonidine 82-91 growth hormone 1 Homo sapiens 125-139 3717403-0 1986 The human growth hormone response to clonidine: relationship to clinical and neuroendocrine profile in depression. Clonidine 37-46 growth hormone 1 Homo sapiens 10-24 3741921-0 1986 Blunted growth hormone response to clonidine in panic disorder patients. Clonidine 35-44 growth hormone 1 Homo sapiens 8-22 3717403-1 1986 The authors found a significant negative correlation between human growth hormone (HGH) response to clonidine and urinary free cortisol level in 14 depressed patients. Clonidine 100-109 growth hormone 1 Homo sapiens 67-81 3786637-0 1986 Growth hormone and cortisol secretion after oral clonidine in healthy adults. Clonidine 49-58 growth hormone 1 Homo sapiens 0-14 3523192-0 1986 [Efficacy of the clonidine test in the evaluation of growth hormone secretion in childhood and comparison with the insulin test]. Clonidine 17-26 growth hormone 1 Homo sapiens 53-67 3082919-0 1986 Suppression of the growth hormone (GH) response to clonidine and GH-releasing hormone by exogenous GH. Clonidine 51-60 growth hormone 1 Homo sapiens 19-33 3028722-5 1986 The alpha 2-mediated growth hormone response to clonidine was increased after one week"s treatment with desipramine and then reduced during the second and third weeks of treatment. Clonidine 48-57 growth hormone 1 Homo sapiens 21-35 3028729-5 1986 The growth hormone response to clonidine tended to be blunted in depressed females and was significantly blunted in the subgroup of depressives who failed to suppress plasma cortisol concentrations in response to dexamethasone. Clonidine 31-40 growth hormone 1 Homo sapiens 4-18 3016788-3 1986 Clonidine"s ability to decrease blood pressure (BP) and plasma levels of the norepinephrine metabolite 3-methoxy-4-hydroxyphenylethyleneglycol (MHPG), and to increase sedation and plasma growth hormone (GH), were measured. Clonidine 0-9 growth hormone 1 Homo sapiens 187-201 3016788-3 1986 Clonidine"s ability to decrease blood pressure (BP) and plasma levels of the norepinephrine metabolite 3-methoxy-4-hydroxyphenylethyleneglycol (MHPG), and to increase sedation and plasma growth hormone (GH), were measured. Clonidine 0-9 growth hormone 1 Homo sapiens 203-205 3953517-0 1986 Growth hormone response after clonidine stimulation. Clonidine 30-39 growth hormone 1 Homo sapiens 0-14 3816411-3 1986 Growth hormone responses to clonidine were measured as indices partially reflecting alpha 2-adrenoceptor responsiveness. Clonidine 28-37 growth hormone 1 Homo sapiens 0-14 3080766-6 1986 The plasma level of growth hormone (GH) over 24 hours was elevated during fasting and administration of the alpha 2-adrenergic receptor agonist clonidine resulted in a subnormal GH response after restoration of original body weight. Clonidine 144-153 growth hormone 1 Homo sapiens 20-34 3080766-6 1986 The plasma level of growth hormone (GH) over 24 hours was elevated during fasting and administration of the alpha 2-adrenergic receptor agonist clonidine resulted in a subnormal GH response after restoration of original body weight. Clonidine 144-153 growth hormone 1 Homo sapiens 36-38 3080766-6 1986 The plasma level of growth hormone (GH) over 24 hours was elevated during fasting and administration of the alpha 2-adrenergic receptor agonist clonidine resulted in a subnormal GH response after restoration of original body weight. Clonidine 144-153 growth hormone 1 Homo sapiens 178-180 3786637-1 1986 The purpose of this study was to evaluate oral clonidine for testing growth hormone (GH) responsiveness in healthy adults. Clonidine 47-56 growth hormone 1 Homo sapiens 69-83 3786637-1 1986 The purpose of this study was to evaluate oral clonidine for testing growth hormone (GH) responsiveness in healthy adults. Clonidine 47-56 growth hormone 1 Homo sapiens 85-87 3786637-2 1986 Oral clonidine (0.15 mg) produced a satisfactory GH response (greater than 4 ng/ml from basal) in eight out of 10 subjects, which is similar to rates reported after an equivalent intravenous dose. Clonidine 5-14 growth hormone 1 Homo sapiens 49-51 3786637-6 1986 Results from this study indicate that oral clonidine is a reliable method for testing GH responsiveness in adult subjects. Clonidine 43-52 growth hormone 1 Homo sapiens 86-88 3982277-4 1985 Administration of the alpha 2-adrenoreceptor agonist clonidine (0.5 mg po) reliably increased GH levels (P less than 0.05). Clonidine 53-62 growth hormone 1 Homo sapiens 94-96 2934351-0 1985 Comparison of the effect of insulin hypoglycemia and clonidine on secretion of growth hormone, cortisol and beta-endorphin in children and adolescents. Clonidine 53-62 growth hormone 1 Homo sapiens 79-93 2989759-6 1985 In contrast, the GH response to clonidine was indistinguishable from normal after only 1 wk of intensified insulin treatment. Clonidine 32-41 growth hormone 1 Homo sapiens 17-19 3982277-7 1985 Clonidine administration significantly reduced total catecholamine, pancreatic polypeptide, and prolactin response to 2DG while opiate receptor blockade with naloxone (10 mg IV bolus followed by 2 mg/hr) did not affect catecholamine and pancreatic polypeptide response but did slightly attenuate the GH and PRL response to glucoprivation. Clonidine 0-9 growth hormone 1 Homo sapiens 300-302 3982277-5 1985 Elevated GH levels following clonidine administration abolished GH responses to subsequently infused 2DG (P less than 0.05). Clonidine 29-38 growth hormone 1 Homo sapiens 9-11 3982277-5 1985 Elevated GH levels following clonidine administration abolished GH responses to subsequently infused 2DG (P less than 0.05). Clonidine 29-38 growth hormone 1 Homo sapiens 64-66 6398251-0 1984 Plasma growth hormone response to oral clonidine as compared to insulin hypoglycemia in obese children and adolescents. Clonidine 39-48 growth hormone 1 Homo sapiens 7-21 3986086-0 1985 The plasma noradrenaline and growth hormone response to alpha-methyldopa and clonidine in hypertensive subjects. Clonidine 77-86 growth hormone 1 Homo sapiens 29-43 2986025-5 1985 Clonidine induced significant reductions of CRT and increases of GH in both groups; furthermore, a slight but significant reduction of PRL was registered in high IT group. Clonidine 0-9 growth hormone 1 Homo sapiens 65-67 3969992-2 1985 We evaluated the efficacy and side effects of a low dose of oral clonidine hydrochloride on growth hormone release in 24 healthy short children; ten received 100 micrograms (group A) and 14 received 50 micrograms (group B). Clonidine 65-88 growth hormone 1 Homo sapiens 92-106 6097932-3 1984 The peak increments in levels of plasma growth hormone (GH) and beta-endorphin induced by clonidine did not differ between heroin addicts and normal control subjects. Clonidine 90-99 growth hormone 1 Homo sapiens 40-54 6097932-4 1984 At no time interval could the clonidine-induced rise in GH levels in addicts be differentiated from that induced by placebo. Clonidine 30-39 growth hormone 1 Homo sapiens 56-58 3967801-4 1985 Group B diabetic subjects had a significantly higher mean +/- SD GH increase after clonidine than did group A patients (delta of 17.4 +/- 4.9 versus 5.7 +/- 6.0 ng/ml, P less than 0.01); the basal GH of both groups were similar (1.6 +/- 0.7 versus 2.3 +/- 1.4 ng/ml). Clonidine 83-92 growth hormone 1 Homo sapiens 65-67 6398251-1 1984 The response of plasma growth hormone (hGH) to a single oral dose of clonidine (0.15 mg/m2) was compared with that obtained with insulin hypoglycemia (ITT) induced by administration of double the usual dose (0.2 U/kg i.v.) Clonidine 69-78 growth hormone 1 Homo sapiens 23-37 6746865-0 1984 Cholinergic mediation of growth hormone secretion elicited by arginine, clonidine, and physical exercise in man. Clonidine 72-81 growth hormone 1 Homo sapiens 25-39 6508989-0 1984 Nicotine from cigarette smoking enhances clonidine-induced increase of serum growth hormone concentrations in men. Clonidine 41-50 growth hormone 1 Homo sapiens 77-91 6508989-1 1984 In order to determine whether nicotine exerts its stimulant effect on serum concentrations of growth hormone (GH) by interacting with an adrenergic pathway, we evaluated the effect of cigarette smoking on the response of GH to the administration of clonidine, a specific alpha-adrenoceptor agonist. Clonidine 249-258 growth hormone 1 Homo sapiens 221-223 6508989-2 1984 In six normal volunteers, clonidine significantly increased serum levels of GH. Clonidine 26-35 growth hormone 1 Homo sapiens 76-78 6513285-0 1984 [Stimulation of growth hormone by clonidine in children with growth retardation]. Clonidine 34-43 growth hormone 1 Homo sapiens 16-30 6392861-0 1984 [Growth hormone secretion and plasma renin activity in children following administration of clonidine]. Clonidine 92-101 growth hormone 1 Homo sapiens 1-15 6545412-0 1984 The GH response to clonidine in endogenous as compared with reactive depression. Clonidine 19-28 growth hormone 1 Homo sapiens 4-6 6545412-1 1984 The growth hormone (GH) response to clonidine was measured in 10 patients meeting standardized criteria for "endogenous" depression and in 10 patients individually matched for age and sex but meeting the corresponding criteria for "reactive" depression. Clonidine 36-45 growth hormone 1 Homo sapiens 4-18 6545412-1 1984 The growth hormone (GH) response to clonidine was measured in 10 patients meeting standardized criteria for "endogenous" depression and in 10 patients individually matched for age and sex but meeting the corresponding criteria for "reactive" depression. Clonidine 36-45 growth hormone 1 Homo sapiens 20-22 6545412-2 1984 In a paired comparison of patients with reactive and endogenous depression (matched for age and sex), the GH response to clonidine was less in the endogenous member of the pair in 8 out of 10 cases. Clonidine 121-130 growth hormone 1 Homo sapiens 106-108 6492890-0 1984 Effect of aging on human plasma growth hormone response to clonidine. Clonidine 59-68 growth hormone 1 Homo sapiens 32-46 6492890-1 1984 The effect of the oral administration of 0.150 mg/m2 clonidine on the plasma level of human growth hormone (hGH) was studied in 53 adults (25 males and 28 females) aged from 28 to 68 years, of which 15 were healthy volunteers and 38 were hypertensive. Clonidine 53-62 growth hormone 1 Homo sapiens 92-106 6432895-3 1984 In the normal children brisk and clear-cut GH rises were detected in plasma after hpGRF-40 (peak GH levels at 15-30 min) or clonidine (peak GH levels 60-90 min). Clonidine 124-133 growth hormone 1 Homo sapiens 43-45 6743929-0 1984 A comparison of the growth hormone responses to clonidine and apomorphine in the same patients with endogenous depression. Clonidine 48-57 growth hormone 1 Homo sapiens 20-34 6743929-1 1984 The growth hormone responses to clonidine (1.3 micrograms/kgm) and apomorphine (0.005 mg/kgm) have been measured in 8 drug free patients with endogenous depression. Clonidine 32-41 growth hormone 1 Homo sapiens 4-18 6743929-2 1984 In these patients the growth hormone responses to clonidine were significantly smaller than to apomorphine. Clonidine 50-59 growth hormone 1 Homo sapiens 22-36 6743929-3 1984 As these doses of clonidine and apomorphine have previously been reported to cause similar growth hormone responses in normal subjects, these findings support the hypothesis of a defect in the adrenergic but not the dopaminergic regulation of growth hormone in patients with endogenous depression. Clonidine 18-27 growth hormone 1 Homo sapiens 91-105 6743929-3 1984 As these doses of clonidine and apomorphine have previously been reported to cause similar growth hormone responses in normal subjects, these findings support the hypothesis of a defect in the adrenergic but not the dopaminergic regulation of growth hormone in patients with endogenous depression. Clonidine 18-27 growth hormone 1 Homo sapiens 243-257 6087965-4 1984 By contrast, the growth hormone response to clonidine tended to be increased after one week of desipramine, reduced after three weeks of treatment, and further reduced after discontinuation. Clonidine 44-53 growth hormone 1 Homo sapiens 17-31 6501804-0 1984 The effects of oral clonidine on the growth hormone level in acromegalic patients. Clonidine 20-29 growth hormone 1 Homo sapiens 37-51 6501804-1 1984 The effects of the noradrenergic agent clonidine on GH secretion of the adenohypophysis were studied in 10 healthy volunteers and 11 acromegalic patients. Clonidine 39-48 growth hormone 1 Homo sapiens 52-54 6501804-2 1984 Orally administered clonidine led to a considerable serum human growth hormone (GH) level increase in the healthy individuals. Clonidine 20-29 growth hormone 1 Homo sapiens 64-78 6501804-2 1984 Orally administered clonidine led to a considerable serum human growth hormone (GH) level increase in the healthy individuals. Clonidine 20-29 growth hormone 1 Homo sapiens 80-82 6501804-3 1984 In the acromegalic patients the clonidine resulted in a slight, but not significant GH increase. Clonidine 32-41 growth hormone 1 Homo sapiens 84-86 6326924-3 1984 Postsynaptic alpha-2 adrenergic receptor function was assessed by measuring the growth hormone response to clonidine before and during treatment. Clonidine 107-116 growth hormone 1 Homo sapiens 80-94 6398141-0 1984 Growth hormone response to clonidine is impaired in patients with central sympathetic degeneration. Clonidine 27-36 growth hormone 1 Homo sapiens 0-14 6585418-0 1984 Growth hormone response to clonidine in children ages 4-17: Tourette"s syndrome vs. children with short stature. Clonidine 27-36 growth hormone 1 Homo sapiens 0-14 6319449-0 1984 Partial blockade by naloxone of clonidine-induced increase in plasma growth hormone in hypertensive patients. Clonidine 32-41 growth hormone 1 Homo sapiens 69-83 6320477-4 1984 However, 3 of the asthmatic subjects demonstrated marked hyper-responsiveness of the plasma GH levels after clonidine. Clonidine 108-117 growth hormone 1 Homo sapiens 92-94 6386488-1 1984 The time courses of the changes in plasma growth hormone and noradrenaline concentrations in response to 15 min infusions of clonidine 0.2 mgs and guanfacine 2 mgs, were studied in six normal volunteers, in a double-blind, randomised, cross-over study. Clonidine 125-134 growth hormone 1 Homo sapiens 42-56 6398141-7 1984 Clonidine-induced growth hormone release may be a potentially useful neuroendocrine marker indicating derangement of certain components of the central alpha-adrenergic system in man. Clonidine 0-9 growth hormone 1 Homo sapiens 18-32 6473616-0 1984 The dependence of the clonidine growth hormone test on alcohol drinking habits and the menstrual cycle. Clonidine 22-31 growth hormone 1 Homo sapiens 32-46 6527749-1 1984 Clonidine, a central alpha-adrenergic agent and prophylactic antimigraine drug is known to stimulate human growth hormone (HGH) release and to suppress cortisol secretion. Clonidine 0-9 growth hormone 1 Homo sapiens 107-121 6093177-1 1984 The growth hormone response to clonidine may be impaired in some patients with endogenous depression. Clonidine 31-40 growth hormone 1 Homo sapiens 4-18 6473616-1 1984 The dependence of the growth hormone (GH) response to clonidine (CLON) on alcohol drinking habits and on the menstrual cycle was investigated. Clonidine 65-69 growth hormone 1 Homo sapiens 22-36 6688812-0 1983 Cholinergic receptor control mechanisms for L-dopa, apomorphine, and clonidine-induced growth hormone secretion in man. Clonidine 69-78 growth hormone 1 Homo sapiens 87-101 6325258-10 1983 In s-EH, clonidine caused a significant lowering of both blood pressure and PNE with a simultaneously marked increment of GH; on the other hand, in b-EH blood pressure and PNE did not change significantly in spite of the distinct rise of GH. Clonidine 9-18 growth hormone 1 Homo sapiens 122-124 6325258-10 1983 In s-EH, clonidine caused a significant lowering of both blood pressure and PNE with a simultaneously marked increment of GH; on the other hand, in b-EH blood pressure and PNE did not change significantly in spite of the distinct rise of GH. Clonidine 9-18 growth hormone 1 Homo sapiens 238-240 6305451-4 1983 Postsynaptic alpha-2 adrenergic receptor sensitivity was assessed by determining the growth hormone (GH) response to clonidine before and during treatment. Clonidine 117-126 growth hormone 1 Homo sapiens 85-99 6684063-0 1983 Clonidine (Haemiton) as a reliable stimulus of growth hormone secretion in patients with short stature. Clonidine 0-9 growth hormone 1 Homo sapiens 47-61 6886930-0 1983 Low oral dose of clonidine: an effective test of growth hormone reserve. Clonidine 17-26 growth hormone 1 Homo sapiens 49-63 6137940-0 1983 Clonidine-induced growth hormone secretion in chronic schizophrenia. Clonidine 0-9 growth hormone 1 Homo sapiens 18-32 6841564-0 1983 Effect of the benzodiazepine derivative, diazepam, on the clonidine-stimulated human growth hormone secretion. Clonidine 58-67 growth hormone 1 Homo sapiens 85-99 6827430-0 1983 Clonidine: an effective growth hormone-releasing agent. Clonidine 0-9 growth hormone 1 Homo sapiens 24-38 7160519-0 1982 [Effect of long-term administration of clonidine on growth hormone secretion in hypertensive diabetics]. Clonidine 39-48 growth hormone 1 Homo sapiens 52-66 6839074-0 1983 Growth hormone response to clonidine in obsessive-compulsive patients. Clonidine 27-36 growth hormone 1 Homo sapiens 0-14 6839074-1 1983 We have observed a lesser growth hormone response to intravenous clonidine administration in nine obsessive-compulsive disorder patients meeting research diagnostic criteria than in nine matched controls. Clonidine 65-74 growth hormone 1 Homo sapiens 26-40 6839074-3 1983 As blunted growth hormone responses to clonidine are also characteristic of affective disorder patients, these results support other observations of a psychobiologic affinity between these two groups and are also compatible with an association between increased presynaptic noradrenergic activity and decreased post-synaptic receptor responsiveness. Clonidine 39-48 growth hormone 1 Homo sapiens 11-25 7160519-3 1982 In chronic administration, the effects of clonidine on GH secretion are not well documented. Clonidine 42-51 growth hormone 1 Homo sapiens 55-57 7160519-6 1982 Blood glucose and GH values recorded before the intake and after stopping the drug, in the basal state, after meals, after measured muscular exercise and during the first stage of sleep could be superimposed when on and off clonidine. Clonidine 224-233 growth hormone 1 Homo sapiens 18-20 7160519-7 1982 The effects of prolonged administration of clonidine on GH secretion thus differ markedly from the effects of acute administration as in non diabetic subjects. Clonidine 43-52 growth hormone 1 Homo sapiens 56-58 6283576-0 1982 Growth hormone response to clonidine as a probe of noradrenergic receptor responsiveness in affective disorder patients and controls. Clonidine 27-36 growth hormone 1 Homo sapiens 0-14 7040621-0 1982 Oral clonidine-an effective growth hormone-releasing agent in prepubertal subjects. Clonidine 5-14 growth hormone 1 Homo sapiens 28-42 7040621-2 1982 The peak serum growth hormone values after insulin and clonidine were significantly higher than after metoclopramide administration. Clonidine 55-64 growth hormone 1 Homo sapiens 15-29 7040621-5 1982 Clonidine appears to be a reliable, sensitive, and safe out-patient stimulation test of growth hormone reserve in prepubertal children, whereas metoclopramide seems not to be a suitable growth hormone-releasing agent in this age group. Clonidine 0-9 growth hormone 1 Homo sapiens 88-102 6293637-3 1982 The growth hormone (GH) response to clonidine was initially impaired, but increased significantly after one week of treatment. Clonidine 36-45 growth hormone 1 Homo sapiens 4-18 6959166-1 1982 The effect of 4 to 6 weeks of treatment with the antidepressants, desmethylimipramine and amitriptyline, on the growth hormone response to clonidine was studied in 12 depressed patients. Clonidine 139-148 growth hormone 1 Homo sapiens 112-126 6959167-0 1982 Growth hormone response to clonidine unchanged by chronic clorgyline treatment. Clonidine 27-36 growth hormone 1 Homo sapiens 0-14 6959167-1 1982 The growth hormone (GH) response to the alpha 2-adrenergic agonist, clonidine, was determined before and after chronic clorgyline treatment in 10 psychiatric patients. Clonidine 68-77 growth hormone 1 Homo sapiens 4-18 6959167-1 1982 The growth hormone (GH) response to the alpha 2-adrenergic agonist, clonidine, was determined before and after chronic clorgyline treatment in 10 psychiatric patients. Clonidine 68-77 growth hormone 1 Homo sapiens 20-22 6279050-4 1982 The ability of clonidine to increase growth hormone (GH) secretion was also assessed. Clonidine 15-24 growth hormone 1 Homo sapiens 53-55 6279050-6 1982 However, the GH response to clonidine was blunted in the depressed patients. Clonidine 28-37 growth hormone 1 Homo sapiens 13-15 6279050-4 1982 The ability of clonidine to increase growth hormone (GH) secretion was also assessed. Clonidine 15-24 growth hormone 1 Homo sapiens 37-51 6283576-4 1982 A modest negative correlation was found between the plasma MHPG values and the magnitude of the GH responses to clonidine, although baseline plasma MHPG levels were not significantly different between patients and controls. Clonidine 112-121 growth hormone 1 Homo sapiens 96-98 6283576-5 1982 The diminished GH response to clonidine observed suggests that many depressed patients may have decreased alpha-adrenoreceptor responsiveness. Clonidine 30-39 growth hormone 1 Homo sapiens 15-17 7030224-0 1981 Comparison of the intravenous insulin and oral clonidine tolerance tests for growth hormone secretion. Clonidine 47-56 growth hormone 1 Homo sapiens 77-91 6756089-8 1982 The response to acute doses of clonidine on sedation, growth hormone release, blood pressure, and plasma MHPG levels may be predictive of eventual therapeutic response. Clonidine 31-40 growth hormone 1 Homo sapiens 54-68 7308974-0 1981 Effect of clonidine on growth hormone and glucagon secretion. Clonidine 10-19 growth hormone 1 Homo sapiens 23-37 7219880-0 1981 Effects of the interaction between methysergide and clonidine on growth hormone and prolactin secretion in normal man. Clonidine 52-61 growth hormone 1 Homo sapiens 65-79 7283286-0 1981 [Oral clonidine test for growth hormone release (author"s transl)]. Clonidine 6-15 growth hormone 1 Homo sapiens 25-39 7283286-3 1981 Authors findings confirm that clonidine is a potent stimulus for growth hormone release, without relevant side effects. Clonidine 30-39 growth hormone 1 Homo sapiens 65-79 7283286-4 1981 In two children with short stature without endocrinological disturb, there was a partial failure to increase GH in response to clonidine. Clonidine 127-136 growth hormone 1 Homo sapiens 109-111 6268238-1 1981 To test the hypothesis the desipramine alters alpha adrenoceptor function in depressed patients, the effects of clonidine upon growth hormone sedation and blood pressure have been measured in depressed patients before and after treatment with desipramine. Clonidine 112-121 growth hormone 1 Homo sapiens 127-141 6268238-3 1981 Growth hormone responses to clonidine were enhanced in five of the six patients but this effect was not statistically significant. Clonidine 28-37 growth hormone 1 Homo sapiens 0-14 7333861-0 1981 Oral clonidine: an effective provocative test of growth hormone release. Clonidine 5-14 growth hormone 1 Homo sapiens 49-63 7272645-1 1981 The growth hormone response to clonidine was significantly less in 10 drug-free patients with endogenous depression than in 10 normal subjects who were individually matched with the patients for age and sex. Clonidine 31-40 growth hormone 1 Homo sapiens 4-18 7333861-1 1981 The authors tested the efficiency of clonidine as a stimulant for growth hormone (GH) release in a group of 31 undersized children aged from four to fourteen years. Clonidine 37-46 growth hormone 1 Homo sapiens 66-80 6251501-0 1980 Effect of clonidine on growth hormone release in psychiatric patients and controls. Clonidine 10-19 growth hormone 1 Homo sapiens 23-37 7244057-0 1981 Enhanced growth hormone response to clonidine after repeated electroconvulsive shock in a primate species. Clonidine 36-45 growth hormone 1 Homo sapiens 9-23 6251501-1 1980 The stimulation of human growth hormone (HGH) release by clonidine (0.15 mg i.v.) Clonidine 57-66 growth hormone 1 Homo sapiens 25-39 212772-0 1978 Clonidine-induced increase in serum growth hormone: possible role of epinephrine-mediated synapses. Clonidine 0-9 growth hormone 1 Homo sapiens 36-50 7357832-2 1980 In an attempt to test the hypothesis of a derangement in central catecholaminergic function in hypertensive patients, the serum growth hormone and prolactin responses to the alpha-adrenergic agonist clonidine (0.15 mg infused intravenously) and to L-dopa administration (500 mg orally) were evaluated in 15 hypertensive and 15 normotensive subjects matched for sex, age and body weight. Clonidine 199-208 growth hormone 1 Homo sapiens 128-142 7357832-4 1980 Whereas L-dopa elicited a growth hormone response of similar magnitude in both groups, clonidine infusion induced a significant increase in serum growth hormone in normotensive, but not in hypertensive, subjects. Clonidine 87-96 growth hormone 1 Homo sapiens 146-160 119798-0 1979 Suppression of clonidine-induced release of growth hormone by thyrotropin releasing hormone in humans. Clonidine 15-24 growth hormone 1 Homo sapiens 44-58 119798-1 1979 A single oral dose of clonidine (0.15 mg), a selective alpha-adrenergic stimulating agent, was able to increase plasma growth hormone (GH) levels (above 5 ng/ml) in 6 out of 7 normal men tested. Clonidine 22-31 growth hormone 1 Homo sapiens 119-133 119798-1 1979 A single oral dose of clonidine (0.15 mg), a selective alpha-adrenergic stimulating agent, was able to increase plasma growth hormone (GH) levels (above 5 ng/ml) in 6 out of 7 normal men tested. Clonidine 22-31 growth hormone 1 Homo sapiens 135-137 119798-3 1979 When oral clonidine administration was associated to a slow thyrotropin releasing hormone (TRH) infusion (1 mg dissolved in 400 ml of 0.9% saline solution, at a constant rate during 150 min) the plasma GH response was significantly inhibited when compared with that observed after clonidine alone. Clonidine 10-19 growth hormone 1 Homo sapiens 202-204 119798-3 1979 When oral clonidine administration was associated to a slow thyrotropin releasing hormone (TRH) infusion (1 mg dissolved in 400 ml of 0.9% saline solution, at a constant rate during 150 min) the plasma GH response was significantly inhibited when compared with that observed after clonidine alone. Clonidine 281-290 growth hormone 1 Homo sapiens 202-204 30678423-5 2019 Serum insulin-like growth factor-1 (IGF-1) and IGF-binding protein-3 were undetectable and the peak GH concentration by clonidine stimulation test was extremely low (0.18 ng/mL). Clonidine 120-129 growth hormone 1 Homo sapiens 100-102 32034477-3 2020 Our aim was to assess the efficacy of clonidine growth hormone test (CGH test) to distinguish MSA-C from ILOCA in the early stage of the disease. Clonidine 38-47 growth hormone 1 Homo sapiens 48-62 1184719-1 1975 Clonidine (0.15 mg iv), a selective noradrenergic receptor agonist, increased serum growth hormone (GH) levels (greater than 6 ng/ml) on 8 out of 12 administrations to 6 normal men. Clonidine 0-9 growth hormone 1 Homo sapiens 84-98 1184719-1 1975 Clonidine (0.15 mg iv), a selective noradrenergic receptor agonist, increased serum growth hormone (GH) levels (greater than 6 ng/ml) on 8 out of 12 administrations to 6 normal men. Clonidine 0-9 growth hormone 1 Homo sapiens 100-102 29688887-11 2018 Three subjects developed hematuria after GH stimulation testing (clonidine/arginine). Clonidine 65-74 growth hormone 1 Homo sapiens 41-43 29956027-1 2018 BACKGROUND: 123I-MIBG myocardial scintigraphy and clonidine growth hormone test (CGH test) may help to distinguish multiple system atrophy (MSA) from Parkinson"s disease (PD). Clonidine 50-59 growth hormone 1 Homo sapiens 60-74 27166774-0 2016 Clonidine-stimulated growth hormone concentrations (cut-off values) measured by immunochemiluminescent assay (ICMA) in children and adolescents with short stature. Clonidine 0-9 growth hormone 1 Homo sapiens 21-35 26874268-0 2016 GH response to intravenous clonidine challenge correlates with history of childhood trauma in personality disorder. Clonidine 27-36 growth hormone 1 Homo sapiens 0-2 26874268-4 2016 In this study, we sought to test the hypothesis that childhood trauma is associated with blunted growth hormone response to the alpha-2 adrenergic autoreceptor agonist clonidine. Clonidine 168-177 growth hormone 1 Homo sapiens 97-111 26874268-8 2016 RESULTS: Contrary to our a priori hypothesis, childhood trauma was associated with enhanced GH response to clonidine. Clonidine 107-116 growth hormone 1 Homo sapiens 92-94 26874268-11 2016 DISCUSSION: Childhood trauma is positively correlated with GH response to clonidine challenge in adults with personality disorder. Clonidine 74-83 growth hormone 1 Homo sapiens 59-61 27166774-1 2016 OBJECTIVES: To establish cut-off values for growth hormone concentrations using clonidine as a secretagogue and an immunochemiluminescent assay as the method of measurement and to analyze the response time as well as the influence of gender, nutritional status and pubertal stage. Clonidine 80-89 growth hormone 1 Homo sapiens 44-58 27166774-10 2016 The receiver operating characteristic curve demonstrated that growth hormone concentrations >= 3.0 ng/mL defined responsiveness to clonidine. Clonidine 134-143 growth hormone 1 Homo sapiens 62-76 27166774-12 2016 CONCLUSION: Clonidine-stimulated growth hormone concentrations >=3 ng/mL, as measured by immunochemiluminescent assay, suggest responsiveness to the stimulus regardless of gender, body mass index standard deviation score or pubertal stage. Clonidine 12-21 growth hormone 1 Homo sapiens 33-47 26361394-0 2015 Modified Clonidine Testing for Growth Hormone Stimulation Reveals alpha2-Adrenoreceptor Sub Sensitivity in Children with Idiopathic Growth Hormone Deficiency. Clonidine 9-18 growth hormone 1 Homo sapiens 31-45 26630691-1 2016 BACKGROUND: The growth hormone (GH) stimulation protocols for clonidine and arginine tests are non-standardized and can be lengthy. Clonidine 62-71 growth hormone 1 Homo sapiens 16-30 26630691-1 2016 BACKGROUND: The growth hormone (GH) stimulation protocols for clonidine and arginine tests are non-standardized and can be lengthy. Clonidine 62-71 growth hormone 1 Homo sapiens 32-34 26630691-3 2016 METHODS: We retrospectively studied all children who had GH stimulation with clonidine and arginine to test for GH deficiency (GHD). Clonidine 77-86 growth hormone 1 Homo sapiens 57-59 25311879-6 2016 Clonidine-stimulated growth hormone (GH) was measured in patients with height <=-3 SD. Clonidine 0-9 growth hormone 1 Homo sapiens 21-35 25311879-6 2016 Clonidine-stimulated growth hormone (GH) was measured in patients with height <=-3 SD. Clonidine 0-9 growth hormone 1 Homo sapiens 37-39 26485273-0 2015 Correction: Modified Clonidine Testing for Growth Hormone Stimulation Reveals alpha2-Adrenoreceptor Sub Sensitivity in Children with Idiopathic Growth Hormone Deficiency. Clonidine 21-30 growth hormone 1 Homo sapiens 43-57 26297663-8 2015 Growth hormone stimulation tests showed a low response to clonidine and insulin. Clonidine 58-67 growth hormone 1 Homo sapiens 0-14 25538882-10 2014 The peak GH response to clonidine provocation test did not differ before (n = 42) versus after 9 years (n = 32) of age. Clonidine 24-33 growth hormone 1 Homo sapiens 9-11 24927347-5 2014 Serum levels of basal and clonidine stimulated GH were measured using radioimmunoassay while IGF-1 and IGFBP-3 were measured by ELISA. Clonidine 26-35 growth hormone 1 Homo sapiens 47-49 23888314-0 2013 Clonidine and glucagon stimulation for testing growth hormone secretion in children and adolescents: can we make it with fewer samples? Clonidine 0-9 growth hormone 1 Homo sapiens 47-61 23795255-6 2013 CONCLUSION: We conclude that the combined clonidine+insulin test is a feasible, reliable, convenient, time saving, and safe tool for evaluation of the growth hormone (GH) axes than the clonidine test or ITT. Clonidine 42-51 growth hormone 1 Homo sapiens 151-165 24015042-7 2013 BMI SDS correlated negatively with ln peak GH level induced by clonidine but not by dopamine. Clonidine 63-72 growth hormone 1 Homo sapiens 43-45 24015042-8 2013 In stepwise multivariate regression analysis, BMI SDS was the only significant predictor of ln peak GH level in the combination of tests and the clonidine test, but not in the dopamine test. Clonidine 145-154 growth hormone 1 Homo sapiens 100-102 23322583-5 2013 Growth hormone (GH): Insulin like growth factor-1 (IGF-1) axis was evaluated by GH stimulation test by insulin tolerance and clonidine stimulation test, among other hormonal assays. Clonidine 125-134 growth hormone 1 Homo sapiens 0-14 23795255-6 2013 CONCLUSION: We conclude that the combined clonidine+insulin test is a feasible, reliable, convenient, time saving, and safe tool for evaluation of the growth hormone (GH) axes than the clonidine test or ITT. Clonidine 42-51 growth hormone 1 Homo sapiens 167-169 23087879-5 2012 Therefore a growth hormone stimulation test with Clonidine was performed which confirmed complete GH deficiency (at 0 min=0.16 mug/l, 60 min=0.27 mug/l, 120 min=4.73 mug/l). Clonidine 49-58 growth hormone 1 Homo sapiens 12-26 24023592-0 2013 Growth hormone response to clonidine administration for evaluation of autonomic dysfunction in multiple sclerosis patients. Clonidine 27-36 growth hormone 1 Homo sapiens 0-14 24023592-1 2013 UNLABELLED: OBJECTIVES: Our objective was to assess the dynamic serum growth hormone (GH) response to clonidine administration in multiple sclerosis patients, looking for a possible biomarker of degenerative process and to correlative with disability. Clonidine 103-112 growth hormone 1 Homo sapiens 71-85 24023592-1 2013 UNLABELLED: OBJECTIVES: Our objective was to assess the dynamic serum growth hormone (GH) response to clonidine administration in multiple sclerosis patients, looking for a possible biomarker of degenerative process and to correlative with disability. Clonidine 103-112 growth hormone 1 Homo sapiens 87-89 24023592-5 2013 CONCLUSION: Despite the small number of subjects enrolled in this pilot study, there is a tendency of blunted GH response in patients with more severe physical disability (stated by an increased value of EDSS), suggesting that GH response to clonidine could assess central autonomic dysfunction in MS patients. Clonidine 242-251 growth hormone 1 Homo sapiens 110-112 24023592-5 2013 CONCLUSION: Despite the small number of subjects enrolled in this pilot study, there is a tendency of blunted GH response in patients with more severe physical disability (stated by an increased value of EDSS), suggesting that GH response to clonidine could assess central autonomic dysfunction in MS patients. Clonidine 242-251 growth hormone 1 Homo sapiens 227-229 23565409-11 2012 He was biochemically euthyroid and GH stimulation testing with clonidine (0.15 mg/m(2)) showed low GH levels at 30", 60", and 90" were 1.7, 1.6, and 1.1ng/ml, respectively. Clonidine 63-72 growth hormone 1 Homo sapiens 35-37 23565409-11 2012 He was biochemically euthyroid and GH stimulation testing with clonidine (0.15 mg/m(2)) showed low GH levels at 30", 60", and 90" were 1.7, 1.6, and 1.1ng/ml, respectively. Clonidine 63-72 growth hormone 1 Homo sapiens 99-101 21797890-5 2012 The postsynaptic DRD2 function was measured by the growth hormone (GH) response to apomorphine (APO) and the postsynaptic alpha2-adrenoceptor function by GH response to clonidine (CLON). Clonidine 169-178 growth hormone 1 Homo sapiens 154-156 21521260-0 2011 Effect of body mass index on the growth hormone response to clonidine stimulation testing in children with short stature. Clonidine 60-69 growth hormone 1 Homo sapiens 33-47 22517235-3 2012 Afterwards, it has been reported that clonidine stimulated growth hormone (GH) release in many species including man. Clonidine 38-47 growth hormone 1 Homo sapiens 59-73 22517235-3 2012 Afterwards, it has been reported that clonidine stimulated growth hormone (GH) release in many species including man. Clonidine 38-47 growth hormone 1 Homo sapiens 75-77 21521260-3 2011 The aim of this study was to investigate the effect of BMI on the GH response to clonidine in a large number of children with short stature. Clonidine 81-90 growth hormone 1 Homo sapiens 66-68 21521260-4 2011 DESIGN: We conducted a retrospective study on the GH response to clonidine in a single centre. Clonidine 65-74 growth hormone 1 Homo sapiens 50-52 21521260-7 2011 In univariate regression analysis, the peak GH after clonidine was negatively correlated with BMI-standard deviation score (BMI-SDS) and positively correlated with height velocity-SDS and IGF-I-SDS. Clonidine 53-62 growth hormone 1 Homo sapiens 44-46 21521260-12 2011 CONCLUSIONS: BMI affects the GH response to clonidine in children with short stature and should be considered when interpreting the results to the stimulation test. Clonidine 44-53 growth hormone 1 Homo sapiens 29-31 21349805-0 2011 Ghrelin and growth hormone serum levels during the clonidine test in children with short stature and variable growth hormone status. Clonidine 51-60 growth hormone 1 Homo sapiens 12-26 21349805-2 2011 The aim of the present study was 1) to investigate the effect of a substance promoting GH secretion (clonidine) on ghrelin levels in children with short stature with growth hormone deficiency (GHD) and normal growth hormone (NGH), and 2) to assess possible correlations between GH and ghrelin values during the clonidine test. Clonidine 101-110 growth hormone 1 Homo sapiens 87-89 21349805-2 2011 The aim of the present study was 1) to investigate the effect of a substance promoting GH secretion (clonidine) on ghrelin levels in children with short stature with growth hormone deficiency (GHD) and normal growth hormone (NGH), and 2) to assess possible correlations between GH and ghrelin values during the clonidine test. Clonidine 101-110 growth hormone 1 Homo sapiens 166-180 21349805-2 2011 The aim of the present study was 1) to investigate the effect of a substance promoting GH secretion (clonidine) on ghrelin levels in children with short stature with growth hormone deficiency (GHD) and normal growth hormone (NGH), and 2) to assess possible correlations between GH and ghrelin values during the clonidine test. Clonidine 101-110 growth hormone 1 Homo sapiens 193-195 20001614-4 2009 Growth hormone (GH) response to provocation with clonidine and glucagon was defective in half of the short T children (peak GH < 7 ng/dL). Clonidine 49-58 growth hormone 1 Homo sapiens 0-14 20368793-0 2010 Respiratory Depression in Young Prader Willi Syndrome Patients following Clonidine Provocation for Growth Hormone Secretion Testing. Clonidine 73-82 growth hormone 1 Homo sapiens 99-113 20368793-16 2010 Clonidine doses to assess GH secretion often exceed doses used for sedation and result in significant respiratory depression in some children with PWS. Clonidine 0-9 growth hormone 1 Homo sapiens 26-28 20585360-6 2010 Growth hormone provocative tests revealed a reduced peak growth hormone response in both insulin and clonidine tests. Clonidine 101-110 growth hormone 1 Homo sapiens 0-14 20585360-6 2010 Growth hormone provocative tests revealed a reduced peak growth hormone response in both insulin and clonidine tests. Clonidine 101-110 growth hormone 1 Homo sapiens 57-71 20405138-9 2010 However, when the clonidine and arginine were applied combined, the contrast of the maximal average GH concentration in serum in two groups was markedly increased (5.02 +/- 1.12 vs. 10.75 +/- 1.11; P < 0.05) with a sensitivity and specificity of 73.91 and 92.31%, and the specificity was notably increased in the combined GH stimulation test. Clonidine 18-27 growth hormone 1 Homo sapiens 100-102 20405138-9 2010 However, when the clonidine and arginine were applied combined, the contrast of the maximal average GH concentration in serum in two groups was markedly increased (5.02 +/- 1.12 vs. 10.75 +/- 1.11; P < 0.05) with a sensitivity and specificity of 73.91 and 92.31%, and the specificity was notably increased in the combined GH stimulation test. Clonidine 18-27 growth hormone 1 Homo sapiens 322-324 20405138-10 2010 Compared to the arginine GH stimulation test, the clonidine GH stimulation displayed a higher sensitivity and specificity; combined GH stimulation test of clonidine plus arginine could significantly enhance the specificity in differential diagnosis of MSA-p from PD. Clonidine 50-59 growth hormone 1 Homo sapiens 60-62 20405138-10 2010 Compared to the arginine GH stimulation test, the clonidine GH stimulation displayed a higher sensitivity and specificity; combined GH stimulation test of clonidine plus arginine could significantly enhance the specificity in differential diagnosis of MSA-p from PD. Clonidine 50-59 growth hormone 1 Homo sapiens 60-62 19028836-0 2010 Noradrenergic function in pathological gambling: blunted growth hormone response to clonidine. Clonidine 84-93 growth hormone 1 Homo sapiens 57-71 19028836-3 2010 The net effects of clonidine are a decrease in neurotransmission by depressing locus coeruleus activity and stimulation of GH secretion through activation of post-synaptic alpha2-adrenergic receptors in the hypothalamus. Clonidine 19-28 growth hormone 1 Homo sapiens 123-125 19028836-6 2010 The area under the curve for GH response to clonidine was significantly lower (separate variance t with 44.3 df = 2.626, P = 0.012, d = 0.58) in the PG group (199.6) than in the control group (426.3). Clonidine 44-53 growth hormone 1 Homo sapiens 29-31 19028836-7 2010 PG had significantly blunted GH responses compared with controls at 120 and 150 min post-clonidine. Clonidine 89-98 growth hormone 1 Homo sapiens 29-31 20529608-8 2010 Deficiency of growth hormone was diagnosed because maximal serum levels of growth hormone in stimulating tests with clonidine and insulin did not exceed 10.7 muIU/ml. Clonidine 116-125 growth hormone 1 Homo sapiens 14-28 19570739-3 2009 Children in the GHD-1 subgroup (n=33) had low GH values (<10 microg/L) after clonidine and levo-dopa while those in the GHD-2 subgroup (n=32) had normal GH values after pharmacologic provocation but low 24-hour GH secretory rates compared to 187 Normal Statured (NS) children. Clonidine 80-89 growth hormone 1 Homo sapiens 16-18 19570739-3 2009 Children in the GHD-1 subgroup (n=33) had low GH values (<10 microg/L) after clonidine and levo-dopa while those in the GHD-2 subgroup (n=32) had normal GH values after pharmacologic provocation but low 24-hour GH secretory rates compared to 187 Normal Statured (NS) children. Clonidine 80-89 growth hormone 1 Homo sapiens 46-48 19570739-3 2009 Children in the GHD-1 subgroup (n=33) had low GH values (<10 microg/L) after clonidine and levo-dopa while those in the GHD-2 subgroup (n=32) had normal GH values after pharmacologic provocation but low 24-hour GH secretory rates compared to 187 Normal Statured (NS) children. Clonidine 80-89 growth hormone 1 Homo sapiens 46-48 20001614-4 2009 Growth hormone (GH) response to provocation with clonidine and glucagon was defective in half of the short T children (peak GH < 7 ng/dL). Clonidine 49-58 growth hormone 1 Homo sapiens 16-18 19337171-8 2008 Peak growth hormone (GH) responses to clonidine and glucagon tests were 7.6 ng/ml and 6.2 ng/ml, respectively. Clonidine 38-47 growth hormone 1 Homo sapiens 5-19 19337171-8 2008 Peak growth hormone (GH) responses to clonidine and glucagon tests were 7.6 ng/ml and 6.2 ng/ml, respectively. Clonidine 38-47 growth hormone 1 Homo sapiens 21-23 18540253-1 2008 AIM: To determine the usefulness of priming with gonadal steroids prior to growth hormone (GH) stimulation with clonidine in the evaluation of the GH status of short peripubertal children. Clonidine 112-121 growth hormone 1 Homo sapiens 147-149 18540253-11 2008 CONCLUSIONS: Priming with gonadal steroids significantly improves GH secretion following GH stimulation with clonidine and diminishes the possibility of a false diagnosis of GH deficiency. Clonidine 109-118 growth hormone 1 Homo sapiens 66-68 18540253-11 2008 CONCLUSIONS: Priming with gonadal steroids significantly improves GH secretion following GH stimulation with clonidine and diminishes the possibility of a false diagnosis of GH deficiency. Clonidine 109-118 growth hormone 1 Homo sapiens 89-91 16201978-2 2005 The purpose of this study was to investigate the cause of GH deficiency in infertile men with spermatogenetic maturation arrest using the clonidine loading test (GH stimulation test). Clonidine 138-147 growth hormone 1 Homo sapiens 58-60 17100548-5 2006 RESULTS: The mean GH peak in the test with clonidine was significantly higher than that in both other tests (p<0.01). Clonidine 43-52 growth hormone 1 Homo sapiens 18-20 17100548-6 2006 The rate of decreased GH secretion was 48.7 % in the test with clonidine, 80.5 % in the test with insulin and 81.5 % in the test with glucagon. Clonidine 63-72 growth hormone 1 Homo sapiens 22-24 16404729-2 2006 In normal subjects, intravenous infusion of the selective alpha2-adrenoceptor agonist clonidine reduces BP and plasma noradrenaline (NA) levels by means of central alpha2-adrenoceptor action, as well as inducing growth hormone (GH) release. Clonidine 86-95 growth hormone 1 Homo sapiens 212-226 16404729-2 2006 In normal subjects, intravenous infusion of the selective alpha2-adrenoceptor agonist clonidine reduces BP and plasma noradrenaline (NA) levels by means of central alpha2-adrenoceptor action, as well as inducing growth hormone (GH) release. Clonidine 86-95 growth hormone 1 Homo sapiens 228-230 16404729-3 2006 Clonidine-induced GH release is impaired in MSA but spared in PAF. Clonidine 0-9 growth hormone 1 Homo sapiens 18-20 16607922-3 2006 We describe the effects of transdermal estradiol (E2-t) priming on GH response after clonidine stimulation in prepubertal children with familial short stature (group 1, n = 12) or constitutional growth delay (group 2, n = 22). Clonidine 85-94 growth hormone 1 Homo sapiens 67-69 17889730-0 2007 Oral hydration during growth hormone stimulation with clonidine. Clonidine 54-63 growth hormone 1 Homo sapiens 22-36 17213788-1 2006 AIM: The aim of this study was to evaluate the positive predictive value of two growth hormone stimulation tests (insulin-induced hypoglycemia and clonidine) for stature below percentile 10 in patients treated for acute lymphoblastic leukemia in childhood. Clonidine 147-156 growth hormone 1 Homo sapiens 80-94 16989290-5 2006 We assessed both hypothalamic-pituitary-adrenocortical axis (HPA) responses to the Trier Social Stress Test and growth hormone (GH) responses to clonidine, a centrally active alpha-2 adrenoreceptor agonist, in 15 persons with major depression without anxiety, 15 with an anxiety disorder without depression, 18 comorbid for anxiety and depression, and 48 individually matched control subjects. Clonidine 145-154 growth hormone 1 Homo sapiens 112-126 16989290-5 2006 We assessed both hypothalamic-pituitary-adrenocortical axis (HPA) responses to the Trier Social Stress Test and growth hormone (GH) responses to clonidine, a centrally active alpha-2 adrenoreceptor agonist, in 15 persons with major depression without anxiety, 15 with an anxiety disorder without depression, 18 comorbid for anxiety and depression, and 48 individually matched control subjects. Clonidine 145-154 growth hormone 1 Homo sapiens 128-130 15219643-0 2004 Growth hormone response to clonidine predicts aggression in Alzheimer"s disease. Clonidine 27-36 growth hormone 1 Homo sapiens 0-14 15219643-7 2004 CONCLUSIONS: Certain types of physically aggressive behaviors are associated with a blunted GH response to clonidine challenge. Clonidine 107-116 growth hormone 1 Homo sapiens 92-94 15358444-1 2005 BACKGROUND: Patients with panic disorder have blunted growth hormone (GH) responses to clonidine, suggesting subsensitivity of post-synaptic alpha(2)-adrenoreceptors, presumably in response to excessive central noradrenergic outflow. Clonidine 87-96 growth hormone 1 Homo sapiens 54-68 15358444-1 2005 BACKGROUND: Patients with panic disorder have blunted growth hormone (GH) responses to clonidine, suggesting subsensitivity of post-synaptic alpha(2)-adrenoreceptors, presumably in response to excessive central noradrenergic outflow. Clonidine 87-96 growth hormone 1 Homo sapiens 70-72 15219643-4 2004 Growth Hormone (GH) response to clonidine challenge (5 microg/kg) was used as an index of central alpha(2)-adrenergic function. Clonidine 32-41 growth hormone 1 Homo sapiens 0-14 15219643-4 2004 Growth Hormone (GH) response to clonidine challenge (5 microg/kg) was used as an index of central alpha(2)-adrenergic function. Clonidine 32-41 growth hormone 1 Homo sapiens 16-18 14711552-0 2004 Increased growth hormone response to clonidine in nonobese normoinsulinemic patients with polycystic ovary syndrome. Clonidine 37-46 growth hormone 1 Homo sapiens 10-24 14735587-1 2004 We report a case of a girl with clinical features of Peters" Plus Syndrome (PPS) (association of anterior eye chamber defects; peculiar facies; cleft lip/palate; brachymelia; developmental delay; growth retardation) and documented growth hormone deficiency (height -3.5 SDS at chronological age 5 years 8 months; low growth factors; bone age delay; growth velocity 4.4 cm/year (<3rd centile); and peak growth hormone levels of 1.7 and 4.7 ng/ml by clonidine and insulin provocative testing, respectively). Clonidine 451-460 growth hormone 1 Homo sapiens 231-245 14604605-0 2004 Blunted growth hormone response to clonidine in post-traumatic stress disorder. Clonidine 35-44 growth hormone 1 Homo sapiens 8-22 14604605-2 2004 Assessment of noradrenergic receptor function can be undertaken by measuring the growth hormone (GH) response to the alpha2-agonist clonidine. Clonidine 132-141 growth hormone 1 Homo sapiens 81-95 14604605-2 2004 Assessment of noradrenergic receptor function can be undertaken by measuring the growth hormone (GH) response to the alpha2-agonist clonidine. Clonidine 132-141 growth hormone 1 Homo sapiens 97-99 14604605-3 2004 The aim of this study was to examine whether subjects with combat-related PTSD (with or without co-morbid depression) have a blunted growth hormone response to clonidine, compared to a combat-exposed control group. Clonidine 160-169 growth hormone 1 Homo sapiens 133-147 14604605-6 2004 The growth hormone response to clonidine was significantly blunted in the non-depressed PTSD group compared to both the depressed PTSD group and the control group as measured by peak growth hormone, delta growth hormone and AUC growth hormone. Clonidine 31-40 growth hormone 1 Homo sapiens 4-18 14604605-6 2004 The growth hormone response to clonidine was significantly blunted in the non-depressed PTSD group compared to both the depressed PTSD group and the control group as measured by peak growth hormone, delta growth hormone and AUC growth hormone. Clonidine 31-40 growth hormone 1 Homo sapiens 183-197 14604605-6 2004 The growth hormone response to clonidine was significantly blunted in the non-depressed PTSD group compared to both the depressed PTSD group and the control group as measured by peak growth hormone, delta growth hormone and AUC growth hormone. Clonidine 31-40 growth hormone 1 Homo sapiens 183-197 14604605-6 2004 The growth hormone response to clonidine was significantly blunted in the non-depressed PTSD group compared to both the depressed PTSD group and the control group as measured by peak growth hormone, delta growth hormone and AUC growth hormone. Clonidine 31-40 growth hormone 1 Homo sapiens 183-197 14604605-7 2004 Subjects with PTSD and no co-morbid depressive illness show a blunted growth hormone response to clonidine. Clonidine 97-106 growth hormone 1 Homo sapiens 70-84 14711552-1 2004 OBJECTIVE: To assess growth hormone (GH) levels in response to acute clonidine stimulation in nonobese patients with polycystic ovary syndrome (PCOS) in comparison to patients with idiopathic hirsutism (IH) and normal women without hirsutism. Clonidine 69-78 growth hormone 1 Homo sapiens 21-35 14711552-1 2004 OBJECTIVE: To assess growth hormone (GH) levels in response to acute clonidine stimulation in nonobese patients with polycystic ovary syndrome (PCOS) in comparison to patients with idiopathic hirsutism (IH) and normal women without hirsutism. Clonidine 69-78 growth hormone 1 Homo sapiens 37-39 14711552-9 2004 CONCLUSION(S): The greater GH response to clonidine in nonobese normoinsulinemic PCOS patients observed in this study suggests a dysregulation in GH secretion in these patients. Clonidine 42-51 growth hormone 1 Homo sapiens 27-29 14711552-9 2004 CONCLUSION(S): The greater GH response to clonidine in nonobese normoinsulinemic PCOS patients observed in this study suggests a dysregulation in GH secretion in these patients. Clonidine 42-51 growth hormone 1 Homo sapiens 146-148 12202963-7 2002 RESULTS: In CFS patients versus controls, clonidine enhanced both growth hormone ( P = 0.028) and cortisol release ( P = 0.021) and increased speed in the initial stage of a planning task ( P = 0.023). Clonidine 42-51 growth hormone 1 Homo sapiens 66-80 12242540-0 2002 Stimulation of growth-hormone release with clonidine does not distinguish individual cases of idiopathic Parkinson"s disease from those with striatonigral degeneration. Clonidine 43-52 growth hormone 1 Homo sapiens 15-29 12242540-5 2002 Clonidine induced a greater total serum growth-hormone production in PD than in SND (p = 0.01). Clonidine 0-9 growth hormone 1 Homo sapiens 40-54 14712170-11 2003 Regarding the individual correlational analyses, the persistence scale of the TPQ was significantly positively correlated with the growth hormone response to clonidine (r=.30, P<.008). Clonidine 158-167 growth hormone 1 Homo sapiens 131-145 14642012-0 2003 Growth hormone response to growth hormone-releasing hormone and clonidine in young monkeys: correlation with behavioral characteristics. Clonidine 64-73 growth hormone 1 Homo sapiens 0-14 14642012-14 2003 Results showed a population distribution of GH response to GHRH and clonidine ranging from 120 ng/mL/90 minutes to 3,000 ng/mL/90 minutes. Clonidine 68-77 growth hormone 1 Homo sapiens 44-46 12465063-8 2002 Serum growth hormone concentrations after clonidine significantly increased in PD (mean increase +/- SEM, 4.19 +/- 0.92 ng/ml; P < 0.0001), but remained unchanged in both MSA-p (0.83 +/- 0.61 ng/ml) and MSA-c (1.45 +/- 0.58 ng/ml). Clonidine 42-51 growth hormone 1 Homo sapiens 6-20 12465063-9 2002 The growth hormone responses to clonidine in MSA-p were significantly different from those in PD (P < 0.05). Clonidine 32-41 growth hormone 1 Homo sapiens 4-18 12383174-0 2002 Growth-hormone release to clonidine and the clinical response to levodopa in parkinsonism. Clonidine 26-35 growth hormone 1 Homo sapiens 0-14 11487765-1 2001 We have observed 4 cases of hypoglycemia associated with clonidine stimulation of growth hormone secretion; only one patient had growth hormone deficiency. Clonidine 57-66 growth hormone 1 Homo sapiens 82-96 11967661-0 2002 Is clonidine-growth hormone stimulation a good test to differentiate multiple system atrophy from idiopathic Parkinson"s disease? Clonidine 3-12 growth hormone 1 Homo sapiens 13-27 11795657-0 2001 Growth hormone stimulation testing with oral clonidine: 90 minutes is the preferred duration for the assessment of growth hormone reserve. Clonidine 45-54 growth hormone 1 Homo sapiens 0-14 11795657-0 2001 Growth hormone stimulation testing with oral clonidine: 90 minutes is the preferred duration for the assessment of growth hormone reserve. Clonidine 45-54 growth hormone 1 Homo sapiens 115-129 11795657-1 2001 Provocative growth hormone (GH) testing using oral clonidine, a central alpha2-adrenergic agonist, is routinely performed by many pediatric endocrinologists worldwide. Clonidine 51-60 growth hormone 1 Homo sapiens 12-26 11474477-12 2001 Although short stature is a feature of this genetic disorder, defective growth hormone (GH) secretion in response to provocation with clonidine and glucagon was found in 4 of the 8 patients. Clonidine 134-143 growth hormone 1 Homo sapiens 72-86 11474477-12 2001 Although short stature is a feature of this genetic disorder, defective growth hormone (GH) secretion in response to provocation with clonidine and glucagon was found in 4 of the 8 patients. Clonidine 134-143 growth hormone 1 Homo sapiens 88-90 11487211-2 2001 We studied GH release in response to clonidine in 7 IPD patients, 6 MSA patients, 4 patients affected by idiopathic late-onset cerebellar ataxia (ILOCA) and 8 healthy controls. Clonidine 37-46 growth hormone 1 Homo sapiens 11-13 11419677-5 2001 Growth hormone (GH) response to clonidine provocation was evaluated and circulating free thyroxine (FT4) and insulin-like growth factor-I (IGF-I) concentrations measured. Clonidine 32-41 growth hormone 1 Homo sapiens 0-14 11472079-0 2001 Age- and gender-related growth hormone responses to intravenous clonidine in healthy adults. Clonidine 64-73 growth hormone 1 Homo sapiens 24-38 11472079-1 2001 The alpha(2)-adrenoceptor agonist clonidine stimulates growth hormone (GH) release in both animals and humans. Clonidine 34-43 growth hormone 1 Homo sapiens 55-69 11490178-2 2001 The purpose of this study was to assess the growth hormone (GH) response to clonidine, an alpha-2-adrenergic agonist, in majorly depressed inpatients with a history of highly lethal suicide attempt compared to depressed patients with a history of low lethal suicide attempt and nonattempters. Clonidine 76-85 growth hormone 1 Homo sapiens 44-58 11490178-2 2001 The purpose of this study was to assess the growth hormone (GH) response to clonidine, an alpha-2-adrenergic agonist, in majorly depressed inpatients with a history of highly lethal suicide attempt compared to depressed patients with a history of low lethal suicide attempt and nonattempters. Clonidine 76-85 growth hormone 1 Homo sapiens 60-62 11490178-6 2001 Moreover, GH peak responses to clonidine were not related to the degree of lethality of the attempt. Clonidine 31-40 growth hormone 1 Homo sapiens 10-12 11084218-3 2000 Norepinephrine (NE) function was evaluated by growth hormone (GH) responses to acute stimulation with clonidine (clon); serotonin (5-HT) function by prolactin (PRL) and cortisol (CORT) responses to acute stimulation with D-fenfluramine (D-fen) and dopamine (DA) function by GH and PRL responses to acute administration of bromocriptine (brom). Clonidine 102-111 growth hormone 1 Homo sapiens 62-64 11041314-1 2000 RATIONALE: In depression, the growth hormone (GH) response to clonidine and L-tryptophan (L-TRP) is reduced, suggesting reduced alpha2-adrenergic and serotonin (5-HT)1A receptor function. Clonidine 62-71 growth hormone 1 Homo sapiens 30-44 11151417-0 2000 Is clonidine growth hormone stimulation a good test to differentiate multiple system atrophy from idiopathic Parkinson"s disease? Clonidine 3-12 growth hormone 1 Homo sapiens 13-27 11151417-5 2000 GH levels remained stable after clonidine infusion in all 7 MSA patients but increased in only 12 of the 19 IPD patients, while remaining stable in the other 7. Clonidine 32-41 growth hormone 1 Homo sapiens 0-2 11151417-7 2000 We conclude that the GH response to clonidine infusion has a very high sensitivity (100% in our series and in previous studies) for the diagnosis of MSA. Clonidine 36-45 growth hormone 1 Homo sapiens 21-23 11041314-1 2000 RATIONALE: In depression, the growth hormone (GH) response to clonidine and L-tryptophan (L-TRP) is reduced, suggesting reduced alpha2-adrenergic and serotonin (5-HT)1A receptor function. Clonidine 62-71 growth hormone 1 Homo sapiens 46-48 10963795-0 2000 Growth hormone response to clonidine in adversely reared young adult primates: relationship to serial cerebrospinal fluid corticotropin-releasing factor concentrations. Clonidine 27-36 growth hormone 1 Homo sapiens 0-14 10963795-1 2000 A reduction of the growth hormone (GH) response to the alpha(2) adrenergic agonist clonidine is a neuroendocrine abnormality observed with reasonable consistency among human patients with mood and anxiety disorders. Clonidine 83-92 growth hormone 1 Homo sapiens 19-33 10963795-1 2000 A reduction of the growth hormone (GH) response to the alpha(2) adrenergic agonist clonidine is a neuroendocrine abnormality observed with reasonable consistency among human patients with mood and anxiety disorders. Clonidine 83-92 growth hormone 1 Homo sapiens 35-37 10963795-3 2000 As CRF has been demonstrated to inhibit GH release, the authors hypothesized that within VFD-reared subjects, animals with relatively high CRF concentrations would exhibit relatively diminished GH responses to clonidine. Clonidine 210-219 growth hormone 1 Homo sapiens 194-196 10963795-4 2000 The current study examined the relationship between the GH response to clonidine in VFD-reared adult primates in relation to a range of both juvenile and follow-up CSF CRF concentrations. Clonidine 71-80 growth hormone 1 Homo sapiens 56-58 10963795-8 2000 The mean of the serial CSF CRF concentrations exhibited a significant inverse relationship towards the GH response to clonidine in young adulthood, with relatively high CSF CRF associated with relatively attenuated GH responses to clonidine. Clonidine 118-127 growth hormone 1 Homo sapiens 103-105 10963795-8 2000 The mean of the serial CSF CRF concentrations exhibited a significant inverse relationship towards the GH response to clonidine in young adulthood, with relatively high CSF CRF associated with relatively attenuated GH responses to clonidine. Clonidine 231-240 growth hormone 1 Homo sapiens 215-217 10963795-9 2000 These data raise the possibility that a reduced GH response to clonidine may inversely reflect trait-like increases of central nervous system (CNS) CRF activity. Clonidine 63-72 growth hormone 1 Homo sapiens 48-50 10870038-0 2000 Combined clonidine-short-ACTH test for the simultaneous assessment of growth hormone reserve and hypothalamic-pituitary-adrenal axis integrity in children. Clonidine 9-18 growth hormone 1 Homo sapiens 70-84 10869054-4 2000 The response to growth hormone-clonidine testing, a neuropharmacological assessment of central adrenoceptor function, was also assessed in 14 PSP and 10 MSA subjects, and compared with 10 controls. Clonidine 31-40 growth hormone 1 Homo sapiens 16-30 10869054-9 2000 After clonidine administration, growth hormone rose in PSP subjects (median increase 4.3; interquartile range 1.8-7.8 mU/l) and controls, unlike MSA subjects (0.9; 0.3-2.4 mU/l; P < 0.005, Mann-Whitney U-test). Clonidine 6-15 growth hormone 1 Homo sapiens 32-46 10870038-16 2000 CONCLUSIONS: Our results suggest that the combined clonidine-short-ACTH test is a reliable and safe tool for the simultaneous assessment of growth hormone reserve and hypothalamic-pituitary-adrenal axis integrity in children. Clonidine 51-60 growth hormone 1 Homo sapiens 140-154 10632417-0 2000 Growth hormone response to clonidine in anovulatory infertile women resistant to clomiphene citrate stimulation. Clonidine 27-36 growth hormone 1 Homo sapiens 0-14 10777003-0 2000 Seizures following clonidine test for growth hormone reserve: unusual presentation of benign partial epilepsy. Clonidine 19-28 growth hormone 1 Homo sapiens 38-52 10661676-1 2000 Postsynaptic alpha-2-receptor function, as assessed by growth hormone (GH) response to clonidine (CLON), has been shown to be downregulated in patients investigated in acute but also in late withdrawal after heavy alcohol intake. Clonidine 87-96 growth hormone 1 Homo sapiens 55-69 10667001-2 1999 We studied the growth hormone (GH) response to provocation by clonidine and glucagon, measured the circulating concentrations of insulin, insulin-like growth factor-I (IGF-I), IGF-binding protein-3 (IGFBP3), and ferritin, and evaluated the spontaneous nocturnal (12 h) GH secretion in prepubertal patients with thalassaemia and age-matched children with constitutional short stature (CSS) (height SDS < -2, but normal GH response to provocation). Clonidine 62-71 growth hormone 1 Homo sapiens 15-29 9826209-1 1998 We present the characteristic features of 14 children with the recessive form of Robinow syndrome and the growth hormone (GH) response to provocation with clonidine and the serum insulin-like growth factor-I (IGF-I) concentration in 12 of these children. Clonidine 155-164 growth hormone 1 Homo sapiens 106-120 10533850-0 1999 Growth hormone response to the insulin tolerance and clonidine tests in type 1 diabetes. Clonidine 53-62 growth hormone 1 Homo sapiens 0-14 10410422-4 1999 Growth hormone (GH) secretion was evaluated by using clonidine and insulin stimulation to evaluate the presence of classic and partial deficits of GH. Clonidine 53-62 growth hormone 1 Homo sapiens 0-14 10410422-4 1999 Growth hormone (GH) secretion was evaluated by using clonidine and insulin stimulation to evaluate the presence of classic and partial deficits of GH. Clonidine 53-62 growth hormone 1 Homo sapiens 16-18 10193871-3 1999 Furthermore, in these patients GH secretion is impaired in response to all traditional pharmacological stimuli acting at the hypothalamus (insulin-induced hypoglycaemia, arginine, galanin, L-dopa, clonidine, acute glucocorticoid administration) and to direct somatotrope stimulation by exogenous growth hormone releasing hormone (GHRH). Clonidine 197-206 growth hormone 1 Homo sapiens 31-33 10528814-1 1999 The possible relationship between postsynaptic alpha2-adrenoceptor function, as assessed by the growth hormone (GH) response to clonidine (CLON) and aspects of mental well-being by self-report of mood using the Swedish Mood Adjective Check List, was investigated in alcohol-dependent patients in the early withdrawal period. Clonidine 128-137 growth hormone 1 Homo sapiens 96-110 10528814-1 1999 The possible relationship between postsynaptic alpha2-adrenoceptor function, as assessed by the growth hormone (GH) response to clonidine (CLON) and aspects of mental well-being by self-report of mood using the Swedish Mood Adjective Check List, was investigated in alcohol-dependent patients in the early withdrawal period. Clonidine 128-137 growth hormone 1 Homo sapiens 112-114 9826209-1 1998 We present the characteristic features of 14 children with the recessive form of Robinow syndrome and the growth hormone (GH) response to provocation with clonidine and the serum insulin-like growth factor-I (IGF-I) concentration in 12 of these children. Clonidine 155-164 growth hormone 1 Homo sapiens 122-124 10773931-3 1998 In children with NS, the peak serum GH response to clonidine (5.4 +/- 2.7 ug/L) and glucagon (7.4 +/- 3.4 ug/L) were significantly lower than those for children with CSS (14.8 +/- 3.4 and 12.8 +/- 2.8 ug/L respectively). Clonidine 51-60 growth hormone 1 Homo sapiens 36-38 9583205-4 1998 Growth hormone stimulation tests were done with L-dopa and clonidine before or during acidosis therapy and after the correction of metabolic acidosis. Clonidine 59-68 growth hormone 1 Homo sapiens 0-14 9595891-6 1998 OUTCOME MEASURES: The primary measure was the growth hormone response to the clonidine challenge. Clonidine 77-86 growth hormone 1 Homo sapiens 46-60 9595891-8 1998 RESULTS: The pre-treatment growth hormone response to clonidine was significantly more blunted in patients than in controls (p = 0.02). Clonidine 54-63 growth hormone 1 Homo sapiens 27-41 9595891-10 1998 In the patients, a decreased growth hormone response to clonidine at baseline was correlated with response to treatment. Clonidine 56-65 growth hormone 1 Homo sapiens 29-43 9595891-18 1998 DISCUSSION: Treatment with either desipramine or ECT modified noradrenergic functioning in patients with depression, as assessed by growth hormone response to the clonidine challenge. Clonidine 163-172 growth hormone 1 Homo sapiens 132-146 9591744-5 1998 The GH response to provocation by clonidine and glucagon was defective (peak GH < 7 microg/L) in 12 of the 30 thalassemic children. Clonidine 34-43 growth hormone 1 Homo sapiens 4-6 9773098-2 1998 The first part of the article will focus on the interest to pharmacology of elucidating pathophysiological mechanisms underlying autonomic involvement at the central level (growth hormone response to clonidine acute challenge), presynaptic level (plasma catecholamine levels after yohimbine administration) and on post-synaptic receptors (binding studies, pressor responses to noradrenaline). Clonidine 200-209 growth hormone 1 Homo sapiens 173-187 9370898-7 1997 Growth hormone response to clonidine stimulation and insulin-like growth factor-1 concentrations were both within reference values and there was no difference between treatment periods. Clonidine 27-36 growth hormone 1 Homo sapiens 0-14 9361679-3 1997 Nine of 21 children with SCD had a defective GH response to both clonidine and glucagon provocation (peak < 10 micrograms/L); these children differed from the 12 others in having slower linear growth velocity (GV and GVSDS), lower circulating concentrations of IGF-I and IGFBP-3, and either partial or complete empty sellae in computed tomographic scans of the hypothalamic-pituitary area. Clonidine 65-74 growth hormone 1 Homo sapiens 45-47 9350902-3 1997 Recovery of poor growth hormone response to clonidine stimulation was associated with benign intracranial hypertension accompanied by headaches and vomiting. Clonidine 44-53 growth hormone 1 Homo sapiens 17-31 9217760-0 1997 Distinction of idiopathic Parkinson"s disease from multiple-system atrophy by stimulation of growth-hormone release with clonidine. Clonidine 121-130 growth hormone 1 Homo sapiens 93-107 9255200-4 1997 Growth hormone reserve was assessed by at least two stimulation tests (clonidine, L-dopa, growth hormone-releasing hormone). Clonidine 71-80 growth hormone 1 Homo sapiens 0-14 9255200-10 1997 The GH response to clonidine was significantly less than that found with the other stimuli. Clonidine 19-28 growth hormone 1 Homo sapiens 4-6 9255200-16 1997 The growth rate in conjunction with the GH response to clonidine provides a sensitive measure of GHD associated with chemotherapy. Clonidine 55-64 growth hormone 1 Homo sapiens 40-42 9241113-13 1997 In the subset of HIV-positive patients with abnormal peak growth hormone levels after clonidine stimulation, growth hormone response correlated positively with CD4+ count (r = .657, p = .0056) and beta carotene concentration (R = .596, p = .0192). Clonidine 86-95 growth hormone 1 Homo sapiens 109-123 9133220-0 1996 [Sensitivity of the clonidine and guanfacine tests (alpha-2-adrenergic agonists) as pharmacologic stimulants of growth hormone. Clonidine 20-29 growth hormone 1 Homo sapiens 112-126 9109183-1 1997 Growth hormone response to clonidine stimulation. Clonidine 27-36 growth hormone 1 Homo sapiens 0-14 9109183-4 1997 GH responses to clonidine stimulation were blunted in patients suggesting that post-synaptic alpha-2-adrenoceptors are subsensitive, possibly due to higher than normal noradrenergic secretion. Clonidine 16-25 growth hormone 1 Homo sapiens 0-2 9203090-0 1997 Effect of sleep deprivation on the growth hormone response to the alpha-3 adrenergic receptor agonist, clonidine, in normal subjects. Clonidine 103-112 growth hormone 1 Homo sapiens 35-49 9203090-1 1997 One night"s sleep deprivation (SD) increased the growth hormone (GH) response to clonidine (20 ug/kg i.v.) Clonidine 81-90 growth hormone 1 Homo sapiens 49-63 9203090-1 1997 One night"s sleep deprivation (SD) increased the growth hormone (GH) response to clonidine (20 ug/kg i.v.) Clonidine 81-90 growth hormone 1 Homo sapiens 65-67 9230631-0 1997 A view on noradrenergic, hypothalamic-pituitary-adrenal axis and extrahypothalamic corticotrophin-releasing factor function in anxiety and affective disorders: the reduced growth hormone response to clonidine. Clonidine 199-208 growth hormone 1 Homo sapiens 172-186 9159285-9 1997 Concentrations of GH increased in saline-pretreated ewes following injections of clonidine or GHRH (P < .01). Clonidine 81-90 growth hormone 1 Homo sapiens 18-20 9159285-10 1997 Treatment of ewes with MB, however, limited the ability of clonidine-induced mechanisms to increase concentrations of GH, but did not affect pituitary responsiveness to GHRH (P < .01). Clonidine 59-68 growth hormone 1 Homo sapiens 118-120 9100596-3 1997 We performed a GH provocative test, using oral clonidine, in 108 patients who had previously been treated with GH during childhood (73 men and 35 women). Clonidine 47-56 growth hormone 1 Homo sapiens 15-17 9133220-13 1996 CONCLUSIONS: The alpha-2-adrenergic agonists, clonidine and guanfacine, appear to be reliable agents for testing of the growth hormone reserve of the pituitary gland. Clonidine 46-55 growth hormone 1 Homo sapiens 120-134 9004111-6 1996 The delta serum GH during clonidine administration was 3.0 +/- 3.2 ng ml-1 in DS and 17.3 +/- 5.6 ng ml-1 in controls. Clonidine 26-35 growth hormone 1 Homo sapiens 16-18 9004111-11 1996 These results indicate that levodopa and clonidine (drugs stimulating hypothalamic GHRH release and secondary pituitary GH release in normal individuals) do not stimulate GH release in DS. Clonidine 41-50 growth hormone 1 Homo sapiens 83-85 8936959-1 1996 Seventy-seven prepubertal short children with heights below the third centile for age and gender were divided into three groups according to their peak GH response to clonidine and insulin provocation. Clonidine 167-176 growth hormone 1 Homo sapiens 152-154 8936961-3 1996 In addition, we evaluated growth hormone (GH) responses to oral clonidine and measured the circulating insulin-like growth factor-I concentration in thalassemic children on long-term transfusion and controls. Clonidine 64-73 growth hormone 1 Homo sapiens 26-40 8936961-3 1996 In addition, we evaluated growth hormone (GH) responses to oral clonidine and measured the circulating insulin-like growth factor-I concentration in thalassemic children on long-term transfusion and controls. Clonidine 64-73 growth hormone 1 Homo sapiens 42-44 8936961-10 1996 GH responses to clonidine provocation were subnormal in thalassemic children after long-term blood transfusion compared to controls. Clonidine 16-25 growth hormone 1 Homo sapiens 0-2 8887137-16 1996 The clonidine test may identify patients who may benefit from this combination, during the GH/hMG cycle and possibly also during the succeeding cycle. Clonidine 4-13 growth hormone 1 Homo sapiens 91-93 8905472-0 1996 The effects of clonidine on blood pressure, catecholamine and growth hormone release in hypogonadal men is preserved and not influenced by testosterone replacement therapy. Clonidine 15-24 growth hormone 1 Homo sapiens 62-76 8723134-6 1996 Findings in patients with panic disorder at baseline related to heart rate, blood pressure, baseline norepinephrine and its metabolites, and platelet adrenergic receptors have been mixed, while the most consistent findings have been blunted growth hormone response to clonidine and increased 3-methoxy-4-hydroxy-phenylethylene-glucol (MHPG) and anxiety following stimulation of the noradrenergic system with yohimbine. Clonidine 268-277 growth hormone 1 Homo sapiens 241-255 8762731-0 1996 Growth hormone responses to growth hormone-releasing hormone and clonidine in patients with type I diabetes and in normal controls: effect of age, body mass index and sex. Clonidine 65-74 growth hormone 1 Homo sapiens 0-14 8615503-6 1996 Clonidine and tizanidine 12 mg had also similar effects on the secretion of growth hormone. Clonidine 0-9 growth hormone 1 Homo sapiens 76-90 8852865-0 1996 Growth hormone response to clonidine and the cortisol response to dexamethasone in depressive patients. Clonidine 27-36 growth hormone 1 Homo sapiens 0-14 8561324-8 1996 The main reason for improved nitrogen economy may be clonidine-induced growth hormone (GH) release. Clonidine 53-62 growth hormone 1 Homo sapiens 71-85 8561324-8 1996 The main reason for improved nitrogen economy may be clonidine-induced growth hormone (GH) release. Clonidine 53-62 growth hormone 1 Homo sapiens 87-89 8606442-0 1995 Nocturnal growth hormone (GH) secretion and GH response to clonidine provocation in children before and after long-term prednisone therapy. Clonidine 59-68 growth hormone 1 Homo sapiens 44-46 8820618-8 1996 Basal concentrations of GH and peak GH response to clonidine were significantly elevated and IGF-I concentrations were significantly depressed in the malnourished groups v. the other two groups. Clonidine 51-60 growth hormone 1 Homo sapiens 36-38 8606442-10 1995 Growth parameters (HtSDS and GVSDS) during LTPT correlated significantly with the peak GH response to clonidine (r=0.69 and 0.78, respectively) as well as to the growth parameters before therapy (r > 0.9). Clonidine 102-111 growth hormone 1 Homo sapiens 87-89 8950617-6 1996 The most widely established criterion is the peak serum GH concentration achieved during a provocative test, usually the insulin tolerance test (ITT), or following other pharmacological stimuli (e.g. glucagon, arginine, clonidine or GH-releasing factor) but, alternatively, a more physiological stimulus (such as sleep, fasting or exercise) has been used. Clonidine 220-229 growth hormone 1 Homo sapiens 56-58 8938679-0 1996 Growth hormone responses to growth hormone-releasing hormone and clonidine before and after erythropoietin therapy in CAPD patients. Clonidine 65-74 growth hormone 1 Homo sapiens 0-14 8938679-2 1996 The aim of the present work was to evaluate the growth hormone (GH) responses to GH-releasing hormone (GHRH) and clonidine stimulation, as well as the baseline concentrations of insulin-like growth factor I(IGF-I), before and after the correction of anemia with rhEPO in a group of uremic patients undergoing continuous ambulatory peritoneal dialysis (CAPD). Clonidine 113-122 growth hormone 1 Homo sapiens 48-62 8938679-2 1996 The aim of the present work was to evaluate the growth hormone (GH) responses to GH-releasing hormone (GHRH) and clonidine stimulation, as well as the baseline concentrations of insulin-like growth factor I(IGF-I), before and after the correction of anemia with rhEPO in a group of uremic patients undergoing continuous ambulatory peritoneal dialysis (CAPD). Clonidine 113-122 growth hormone 1 Homo sapiens 64-66 8938679-15 1996 In control subjects, clonidine administration was followed by a GH release that reached a maximum at 90 min (7.67 +/- 2.24 micrograms/l). Clonidine 21-30 growth hormone 1 Homo sapiens 64-66 8606442-5 1995 GH response to clonidine as well as integrated and mean nocturnal GH secretion were significantly after LTPT. Clonidine 15-24 growth hormone 1 Homo sapiens 0-2 8606442-6 1995 GH response to clonidine as well as integrated and mean nocturnal GH secretion were significantly depressed after LTPT v. before treatment. Clonidine 15-24 growth hormone 1 Homo sapiens 0-2 7495927-0 1995 Growth hormone response to growth hormone-releasing hormone and clonidine in depression. Clonidine 64-73 growth hormone 1 Homo sapiens 0-14 7495927-1 1995 Growth hormone (GH) responses to the alpha 2-adrenoceptor agonist clonidine and to GH-releasing hormone (GHRH) were measured in 12 patients fulfilling DSM-III-R criteria for major depressive disorder and in 12 age- and sex-matched controls. Clonidine 66-75 growth hormone 1 Homo sapiens 0-14 7495927-1 1995 Growth hormone (GH) responses to the alpha 2-adrenoceptor agonist clonidine and to GH-releasing hormone (GHRH) were measured in 12 patients fulfilling DSM-III-R criteria for major depressive disorder and in 12 age- and sex-matched controls. Clonidine 66-75 growth hormone 1 Homo sapiens 16-18 7495927-2 1995 GH responses to clonidine correlated significantly with the GH responses to GHRH in the depressed patients as well as in the controls. Clonidine 16-25 growth hormone 1 Homo sapiens 0-2 7495927-2 1995 GH responses to clonidine correlated significantly with the GH responses to GHRH in the depressed patients as well as in the controls. Clonidine 16-25 growth hormone 1 Homo sapiens 60-62 7578668-0 1995 Growth hormone response to clonidine in nondepressed patients with a history of suicide attempts. Clonidine 27-36 growth hormone 1 Homo sapiens 0-14 7563274-0 1995 Defective clonidine-induced growth hormone secretion and normal thyroid and adrenal functions in prepubertal children with chronic renal insufficiency (CRF). Clonidine 10-19 growth hormone 1 Homo sapiens 28-42 7561639-0 1995 Inverse control of growth hormone and prolactin secretion in clonidine-stimulated dairy cattle. Clonidine 61-70 growth hormone 1 Homo sapiens 19-33 7561639-1 1995 Clonidine is a specific alpha-2-adrenoreceptor agonist that stimulates growth hormone (GH) release in animals and humans. Clonidine 0-9 growth hormone 1 Homo sapiens 71-85 7561639-1 1995 Clonidine is a specific alpha-2-adrenoreceptor agonist that stimulates growth hormone (GH) release in animals and humans. Clonidine 0-9 growth hormone 1 Homo sapiens 87-89 7603406-3 1995 Growth hormone (GH) reserve was assessed by two different provocative stimuli (Clonidine and L-Dopa). Clonidine 79-88 growth hormone 1 Homo sapiens 0-14 7603406-3 1995 Growth hormone (GH) reserve was assessed by two different provocative stimuli (Clonidine and L-Dopa). Clonidine 79-88 growth hormone 1 Homo sapiens 16-18 7563274-1 1995 We evaluated clonidine-induced growth hormone (GH) secretion, insulin-like factor-I (IGF-I), free thyroxine (FT4), and thyroid stimulating hormone (TSH) concentrations, basal (8-h) as well as adrenocorticotrophic hormone (ACTH) provoked cortisol secretion in 14 prepubertal children suffering from chronic renal failure (CRF) with impaired statural growth [growth velocity (GV) = 3.7 +/- 0.3 cm/year] and compared these values with those of 10 normal age matched children with normal variant short stature (NVSS) (GV = 4.6 +/- 0.4 cm/year). Clonidine 13-22 growth hormone 1 Homo sapiens 31-45 7563274-4 1995 The peak GH response to clonidine was significantly lower in children with CRF (8.4 +/- 1.7 micrograms/l) v. (19.6 +/- 2.3 micrograms/l) for the control group (P < 0.01). Clonidine 24-33 growth hormone 1 Homo sapiens 9-11 7647083-10 1995 Only clonidine 300 micrograms produced a significant elevation in GH release. Clonidine 5-14 growth hormone 1 Homo sapiens 66-68 8525861-3 1995 In the present study, in a first part, we assessed the growth hormone (GH) response to clonidine, a selective alpha 2-adrenergic agonist, and to apomorphine, a dopaminergic agonist, in 22 DSM-III-R major depressive male inpatients with a history of suicide attempts compared to 22 age-matched major depressive inpatients without history of suicidal behavior. Clonidine 87-96 growth hormone 1 Homo sapiens 55-69 8525861-3 1995 In the present study, in a first part, we assessed the growth hormone (GH) response to clonidine, a selective alpha 2-adrenergic agonist, and to apomorphine, a dopaminergic agonist, in 22 DSM-III-R major depressive male inpatients with a history of suicide attempts compared to 22 age-matched major depressive inpatients without history of suicidal behavior. Clonidine 87-96 growth hormone 1 Homo sapiens 71-73 24283632-0 1995 Central defects of autonomic function in secondary progressive multiple sclerosis: observations based on cardiovascular and growth hormone responses to clonidine. Clonidine 152-161 growth hormone 1 Homo sapiens 124-138 24283632-10 1995 The impaired growth hormone response to clonidine occurred in a greater number of patients and may indicate lesions in the hypothalamus. Clonidine 40-49 growth hormone 1 Homo sapiens 13-27 24283632-11 1995 These observations in MS patients, without overt clinical evidence of autonomic failure, indicate that the haemodynamic and growth hormone responses to clonidine may be an early indicator of autonomic dysfunction involving central autonomic centres and pathways. Clonidine 152-161 growth hormone 1 Homo sapiens 124-138 7972568-3 1994 In the present study, we assessed the growth hormone response to clonidine, a selective alpha 2-adrenergic agonist, in 15 DSM-III-R major depressive inpatients with a history of suicide attempts, compared with 15 age- and gender-matched major depressive inpatients without a history of suicidal behavior. Clonidine 65-74 growth hormone 1 Homo sapiens 38-52 7671940-1 1995 UNLABELLED: Growth hormone (GH) secretion was determined by evaluating circadian GH profiles for 24 h and GH responses to clonidine stimulation test and insulin-stimulated hypoglycaemia (ITT), in nine prepubertal children with beta-thalassaemia major (TM) and 17 with non-GH deficient short stature (NGHDSS). Clonidine 122-131 growth hormone 1 Homo sapiens 12-26 7568369-0 1995 Growth-hormone response to clonidine in panic disorder patients in comparison to patients with major depression and healthy controls. Clonidine 27-36 growth hormone 1 Homo sapiens 0-14 7568369-1 1995 Growth-hormone (GH) responses to the alpha 2-adrenoceptor agonist clonidine were measured in 9 panic disorder patients, in 9 patients fulfilling DSM-III-R criteria for major depressive episode, and in 9 age- and sex-matched controls. Clonidine 66-75 growth hormone 1 Homo sapiens 0-14 7568369-1 1995 Growth-hormone (GH) responses to the alpha 2-adrenoceptor agonist clonidine were measured in 9 panic disorder patients, in 9 patients fulfilling DSM-III-R criteria for major depressive episode, and in 9 age- and sex-matched controls. Clonidine 66-75 growth hormone 1 Homo sapiens 16-18 7568369-2 1995 GH responses to clonidine were not significantly different between the groups. Clonidine 16-25 growth hormone 1 Homo sapiens 0-2 7568369-3 1995 The data do not agree with the assumption that blunted GH responses to clonidine represent a general feature of panic disorder or major depression. Clonidine 71-80 growth hormone 1 Homo sapiens 55-57 7535224-3 1995 In this study, we investigated the relationship between P300 amplitude and catecholaminergic neurotransmission as assessed by the growth hormone (GH) response to clonidine and apomorphine challenges in 20 major depressive patients. Clonidine 162-171 growth hormone 1 Homo sapiens 130-144 7535224-3 1995 In this study, we investigated the relationship between P300 amplitude and catecholaminergic neurotransmission as assessed by the growth hormone (GH) response to clonidine and apomorphine challenges in 20 major depressive patients. Clonidine 162-171 growth hormone 1 Homo sapiens 146-148 7938032-2 1994 Clonidine and BRO (10(-6) M) inhibited basal and GHRH (10(-10) M)-stimulated GH release. Clonidine 0-9 growth hormone 1 Homo sapiens 49-51 7870845-1 1994 Growth hormone (GH) and prolactin (PRL) responses to the acute administration of clonidine (150 micrograms) and apomorphine (0.5 mg) were investigated in parallel in 20 drug-free subchronic and chronic schizophrenic patients and in nine control subjects. Clonidine 81-90 growth hormone 1 Homo sapiens 0-14 7870845-5 1994 A greater than normal GH response to clonidine stimulation was observed in paranoid patients. Clonidine 37-46 growth hormone 1 Homo sapiens 22-24 7942005-8 1994 The peak GH responses to insulin and clonidine hydrochloride were 5.8 and 8.2 ng/mL, respectively. Clonidine 37-60 growth hormone 1 Homo sapiens 9-11 7993663-3 1994 Two patients with propionic acidemia had decreased growth hormone secretion in response to provocative stimuli (intravenous L-arginine and oral levodopa or clonidine); the remaining subjects had sufficient growth hormone secretion. Clonidine 156-165 growth hormone 1 Homo sapiens 51-65 8069405-2 1994 After clonidine, there was a decrease in blood pressure and plasma noradrenaline (NA) and adrenaline (Ad) levels, with an increase in growth hormone (GH) levels, in both NT and HT. Clonidine 6-15 growth hormone 1 Homo sapiens 134-148 8069405-2 1994 After clonidine, there was a decrease in blood pressure and plasma noradrenaline (NA) and adrenaline (Ad) levels, with an increase in growth hormone (GH) levels, in both NT and HT. Clonidine 6-15 growth hormone 1 Homo sapiens 150-152 7929726-5 1994 A significant (P < 0.05) decrease in the secretion of growth hormone 60-90 min after clonidine ingestion was observed in the low responders as compared to five controls with previous normal response to ovarian stimulation. Clonidine 88-97 growth hormone 1 Homo sapiens 57-71 7788012-0 1995 Growth hormone response to growth hormone-releasing hormone (GHRH), insulin, clonidine and arginine after GHRH pretreatment in obese children: evidence of somatostatin increase? Clonidine 77-86 growth hormone 1 Homo sapiens 0-14 7626468-7 1995 Moreover, to investigate the specificity of this mechanism, GHRH-induced GH release was tested after inducing hypercortisolism and enhancing alpha 2-adrenergic or muscarinic cholinergic tone, by giving clonidine (CLO) or pyridostigmine (PD), respectively. Clonidine 202-211 growth hormone 1 Homo sapiens 60-62 7694915-0 1995 Persistence of blunted human growth hormone response to clonidine in fluoxetine-treated patients with panic disorder. Clonidine 56-65 growth hormone 1 Homo sapiens 29-43 7694915-1 1995 OBJECTIVE: The authors determined the effects of antipanic treatment with fluoxetine on human growth hormone (GH) response to the alpha 2 agonist clonidine. Clonidine 146-155 growth hormone 1 Homo sapiens 94-108 7694915-1 1995 OBJECTIVE: The authors determined the effects of antipanic treatment with fluoxetine on human growth hormone (GH) response to the alpha 2 agonist clonidine. Clonidine 146-155 growth hormone 1 Homo sapiens 110-112 7694915-6 1995 RESULTS: The patients with panic disorder (N = 13 for the first challenge and N = 9 for the second) had significantly lower human GH responses to clonidine than the healthy subjects (N = 14 during the first challenge and N = 9 for the second) during both challenges, despite clinical improvement in eight of the nine patients at the time of the second challenge. Clonidine 146-155 growth hormone 1 Homo sapiens 130-132 7694915-7 1995 CONCLUSIONS: Blunted secretion of human GH in response to clonidine in patients with panic disorder persists despite clinical recovery. Clonidine 58-67 growth hormone 1 Homo sapiens 40-42 7619663-5 1995 Clonidine decreased blood pressure, heart rate, oral body temperature, salivary excretion, plasma noradrenaline, 3,4-dihydroxyphenylglycol (DHPG) concentrations, increased plasma growth hormone but did not modify plasma insulin and C-peptide concentrations. Clonidine 0-9 growth hormone 1 Homo sapiens 179-193 7619663-6 1995 Treatments tended to modify only the effect of clonidine on growth hormone (P = 0.07). Clonidine 47-56 growth hormone 1 Homo sapiens 60-74 7584524-1 1995 It is well established that the central alpha 2-adrenergic agonist clonidine can enhance growth hormone (GH) secretion in humans. Clonidine 67-76 growth hormone 1 Homo sapiens 89-103 7584524-1 1995 It is well established that the central alpha 2-adrenergic agonist clonidine can enhance growth hormone (GH) secretion in humans. Clonidine 67-76 growth hormone 1 Homo sapiens 105-107 7584524-6 1995 Serum GH levels increased significantly in response to GHRH, clonidine, and moxonidine. Clonidine 61-70 growth hormone 1 Homo sapiens 6-8 7584524-7 1995 However, the increase was less pronounced in response to clonidine and moxonidine as compared to GHRH (mean +/- SEM): after clonidine, GH increased from 0.2 +/- 0.1 to 5.4 +/- 1.5 ng/ml, p < 0.05; moxonidine increased GH levels from 0.1 +/- 0.04 to 4.8 +/- 1.9 ng/ml (p < 0.05); GHRH caused an increase from 0.01 +/- 0.05 to 14.8 +/- 2.5 ng/ml (p < 0.05). Clonidine 57-66 growth hormone 1 Homo sapiens 135-137 7584524-7 1995 However, the increase was less pronounced in response to clonidine and moxonidine as compared to GHRH (mean +/- SEM): after clonidine, GH increased from 0.2 +/- 0.1 to 5.4 +/- 1.5 ng/ml, p < 0.05; moxonidine increased GH levels from 0.1 +/- 0.04 to 4.8 +/- 1.9 ng/ml (p < 0.05); GHRH caused an increase from 0.01 +/- 0.05 to 14.8 +/- 2.5 ng/ml (p < 0.05). Clonidine 124-133 growth hormone 1 Homo sapiens 97-99 7584524-7 1995 However, the increase was less pronounced in response to clonidine and moxonidine as compared to GHRH (mean +/- SEM): after clonidine, GH increased from 0.2 +/- 0.1 to 5.4 +/- 1.5 ng/ml, p < 0.05; moxonidine increased GH levels from 0.1 +/- 0.04 to 4.8 +/- 1.9 ng/ml (p < 0.05); GHRH caused an increase from 0.01 +/- 0.05 to 14.8 +/- 2.5 ng/ml (p < 0.05). Clonidine 124-133 growth hormone 1 Homo sapiens 135-137 7566518-4 1995 Indeed, whereas the influence of tricyclic antidepressants on the GH response to apomorphine is presently unknown, several reports have suggested that tricyclics may impair the GH response to clonidine for periods longer than 3 weeks following their discontinuation. Clonidine 192-201 growth hormone 1 Homo sapiens 177-179 7892755-7 1994 After clonidine, there was a fall in blood pressure in NS and MSA patients but not in MS and PAF patients; a rise in growth hormone (GH) in NS and PAF patients but not in MS and MSA patients; and an up-regulation in PBMCs beta-adrenoceptors in NS but not in MS, MSA and PAF patients. Clonidine 6-15 growth hormone 1 Homo sapiens 117-131 7892755-7 1994 After clonidine, there was a fall in blood pressure in NS and MSA patients but not in MS and PAF patients; a rise in growth hormone (GH) in NS and PAF patients but not in MS and MSA patients; and an up-regulation in PBMCs beta-adrenoceptors in NS but not in MS, MSA and PAF patients. Clonidine 6-15 growth hormone 1 Homo sapiens 133-135 7946243-5 1994 Whereas 16 pregnancies were achieved in the 26 Clonidine-negative patients (61.5%) either in the GH/hMG cycle (11) or in the succeeding one (5), no benefit was detected in 8 Clonidine-positive patients from the GH/hMG combination. Clonidine 47-56 growth hormone 1 Homo sapiens 97-99 8080904-0 1994 Growth hormone response to growth hormone releasing hormone and to clonidine stimulation in peripubertal patients with major depressive disorder. Clonidine 67-76 growth hormone 1 Homo sapiens 0-14 7519979-0 1994 Effect of the combined administration of galanin and clonidine on serum growth hormone levels in normal subjects and in patients under chronic glucocorticoid treatment. Clonidine 53-62 growth hormone 1 Homo sapiens 72-86 7519979-1 1994 Aim of our study was to investigate the effect of clonidine and galanin (alone or in combination) on growth hormone (GH) secretion in normal subjects and in adult patients with increased somatostatin tone due to chronic daily immunosuppressive glucocorticoid treatment. Clonidine 50-59 growth hormone 1 Homo sapiens 101-115 7519979-1 1994 Aim of our study was to investigate the effect of clonidine and galanin (alone or in combination) on growth hormone (GH) secretion in normal subjects and in adult patients with increased somatostatin tone due to chronic daily immunosuppressive glucocorticoid treatment. Clonidine 50-59 growth hormone 1 Homo sapiens 117-119 7972568-4 1994 Mean (+/- SD) growth hormone peak responses to clonidine were significantly lower in the group of suicide attempters than in the control group: 2.93 +/- 3.01 ng/ml vs. 8.28 +/- 8.15 ng/ml. Clonidine 47-56 growth hormone 1 Homo sapiens 14-28 7972568-5 1994 Therefore, these results suggest that a blunted growth hormone response to clonidine could be a biological correlate of suicidal behavior. Clonidine 75-84 growth hormone 1 Homo sapiens 48-62 7832833-3 1994 Numerous other neuroendocrine disturbances have also been described, including blunted clonidine-induced growth hormone release and blunted fenfluramine-induced prolactin release. Clonidine 87-96 growth hormone 1 Homo sapiens 105-119 9160547-1 1994 Blunted growth hormone responses to clonidine have been reported in most studies of humans with panic disorder but have been an inconsistent finding in the study of other anxiety syndromes. Clonidine 36-45 growth hormone 1 Homo sapiens 8-22 8193484-4 1994 In the other four subjects, growth hormone production was measured by growth hormone pharmacological stimulation tests (clonidine, arginine): three of four patients had insufficient growth hormone responses (peak growth hormone < 10 micrograms/l); all three had delayed puberty; their growth hormone responses increased after "priming" with testosterone, reaching values > 10 micrograms/l in two of them and allowing diagnosis of "true" growth hormone deficiency in the third. Clonidine 120-129 growth hormone 1 Homo sapiens 28-42 8296892-0 1994 Effects of gender and diagnosis on growth hormone response to clonidine for major depression: a large-scale multicenter study. Clonidine 62-71 growth hormone 1 Homo sapiens 35-49 8296892-1 1994 OBJECTIVE: The authors" goal was to establish, in a large multicenter sample of patients classified according to gender and menopausal status, if the growth hormone (GH) response to clonidine discriminated patients with episodes of major depression from patients with episodes of minor depression. Clonidine 182-191 growth hormone 1 Homo sapiens 150-164 8296892-1 1994 OBJECTIVE: The authors" goal was to establish, in a large multicenter sample of patients classified according to gender and menopausal status, if the growth hormone (GH) response to clonidine discriminated patients with episodes of major depression from patients with episodes of minor depression. Clonidine 182-191 growth hormone 1 Homo sapiens 166-168 8296892-2 1994 METHOD: The GH response to intravenous clonidine administration (150 micrograms) was compared in 71 male and 140 female patients with major depressive episodes and 47 male and 53 female patients with minor depressive episodes. Clonidine 39-48 growth hormone 1 Homo sapiens 12-14 8296892-4 1994 RESULTS: Differences in the GH response to clonidine between diagnostic groups occurred only between male patients. Clonidine 43-52 growth hormone 1 Homo sapiens 28-30 8296892-6 1994 The GH responses to clonidine of premenopausal women differed significantly from those of postmenopausal women in each diagnostic group. Clonidine 20-29 growth hormone 1 Homo sapiens 4-6 8296892-7 1994 CONCLUSIONS: These results confirm that gender and menopausal status are of the utmost importance in the interpretation of the clonidine GH test. Clonidine 127-136 growth hormone 1 Homo sapiens 137-139 8027274-0 1994 Growth hormone co-treatment for ovulation induction may enhance conception in the co-treatment and succeeding cycles, in clonidine negative but not clonidine positive patients. Clonidine 121-130 growth hormone 1 Homo sapiens 0-14 8027274-4 1994 In 24 clonidine negative patients 14 pregnancies were achieved (58.3%) either in the GH/HMG/HCG cycle or in the succeeding one. Clonidine 6-15 growth hormone 1 Homo sapiens 85-87 8027274-7 1994 The beneficial, synergistic effect of GH co-treatment was detected in clonidine negative but not in clonidine positive infertile patients. Clonidine 70-79 growth hormone 1 Homo sapiens 38-40 8027274-7 1994 The beneficial, synergistic effect of GH co-treatment was detected in clonidine negative but not in clonidine positive infertile patients. Clonidine 100-109 growth hormone 1 Homo sapiens 38-40 7887119-0 1994 Effects of intravenous clonidine on the secretion of growth hormone in the perioperative period. Clonidine 23-32 growth hormone 1 Homo sapiens 53-67 9160587-0 1994 Growth hormone response to clonidine and L-dopa in normal volunteers. Clonidine 27-36 growth hormone 1 Homo sapiens 0-14 8144867-0 1993 Growth hormone response to oral clonidine test in normal and short children. Clonidine 32-41 growth hormone 1 Homo sapiens 0-14 8047638-0 1994 Blunted growth hormone response to clonidine in Gilles de la Tourette syndrome. Clonidine 35-44 growth hormone 1 Homo sapiens 8-22 9210208-7 1994 Both in Study-A and in Study B, 8 of 11 subjects had a stable GH response to clonidine across both study days when defined dichotomously (blunted < 4 ng/ml; otherwise, not blunted). Clonidine 77-86 growth hormone 1 Homo sapiens 62-64 8144867-1 1993 We evaluated the growth hormone (GH) response to an acute clonidine test (0.15 mg/m2 po) in 30 normal prepubertal children (stature between the 3rd and 97th centile), in 29 short children (stature < 3rd centile for age) with height velocity (HV) > 10th centile and in 20 short children with HV < 10th centile. Clonidine 58-67 growth hormone 1 Homo sapiens 17-31 8291522-4 1993 One of 12 patients had discordance between insulin growth factor I levels and growth hormone responses to insulin and clonidine suggestive of end organ resistance to growth hormone. Clonidine 118-127 growth hormone 1 Homo sapiens 78-92 7901854-4 1993 Relative to saline-injected controls, activation of alpha 2-adrenergic receptors with clonidine (2 micrograms/kg body wt iv) before feeding rapidly increased serum growth hormone concentrations, but clonidine had no effect when administered after feeding. Clonidine 86-95 growth hormone 1 Homo sapiens 164-178 8291522-4 1993 One of 12 patients had discordance between insulin growth factor I levels and growth hormone responses to insulin and clonidine suggestive of end organ resistance to growth hormone. Clonidine 118-127 growth hormone 1 Homo sapiens 166-180 8292687-0 1993 Growth hormone response to intravenous clonidine in social phobia: comparison to patients with panic disorder and healthy volunteers. Clonidine 39-48 growth hormone 1 Homo sapiens 0-14 8292687-1 1993 The growth hormone (GH) response to intravenous administration of clonidine hydrochloride (2 micrograms/kg) was assessed in 16 patients with DSM-III-R social phobia, 13 patients with DSM-III-R panic disorder, and 31 healthy controls. Clonidine 66-89 growth hormone 1 Homo sapiens 4-18 8210606-0 1993 Growth hormone response after administration of L-dopa, clonidine, and growth hormone releasing hormone in children with Down syndrome. Clonidine 56-65 growth hormone 1 Homo sapiens 0-14 8299303-0 1993 Hypoglycemia due to sedation following clonidine test for growth hormone reserve. Clonidine 39-48 growth hormone 1 Homo sapiens 58-72 8299303-2 1993 We report hypoglycemic convulsions in a child with congenital hypopituitarism after the administration of clonidine to assess growth hormone reserve. Clonidine 106-115 growth hormone 1 Homo sapiens 126-140 8246373-2 1993 Endogenous growth hormone (GH) levels were measured after stimulation with L-dopa and clonidine in growth retarded children whose height (ht) was greater than or equal to 2 standard deviations (SD) below the mean for age. Clonidine 86-95 growth hormone 1 Homo sapiens 11-25 8224263-2 1993 DESIGN: Comparison of GH secretion in response to clonidine (Catapressan; Boehringer Ingelheim, Reims, France) and growth hormone-releasing factor (GH-RF). Clonidine 50-59 growth hormone 1 Homo sapiens 22-24 8224263-12 1993 CONCLUSIONS: These results raise concern about using the GH secretory response to a single clonidine administration as a predictive test of the therapeutic benefit that could be obtained by co-stimulating the somatotropic axis during a treatment with gonadotropins in poor responder patients, especially when their FSH basal levels are elevated. Clonidine 91-100 growth hormone 1 Homo sapiens 57-59 7823001-6 1993 Peak plasma GH level after oral clonidine provocation, insulin induced hypoglycemia, and I.V. Clonidine 32-41 growth hormone 1 Homo sapiens 12-14 8284031-12 1993 The delta GH was -2.5 +/- 3.1 after placebo, +3.7 +/- 4.5 after clonidine, +17.0 +/- 3.3 after GHRH and -13.4 +/- 4.5 following dexamethasone administration. Clonidine 64-73 growth hormone 1 Homo sapiens 10-12 8416019-0 1993 Growth hormone response to clonidine in neuroleptic-free patients with multidagnostically defined schizophrenia. Clonidine 27-36 growth hormone 1 Homo sapiens 0-14 8210606-1 1993 We studied the response of growth hormone secretion after the administration of L-dopa, clonidine, and growth hormone releasing hormone in eight growth-retarded children with Down syndrome aged 1 to 6.5 years. Clonidine 88-97 growth hormone 1 Homo sapiens 27-41 8210606-7 1993 In comparison with peak growth hormone levels reported in normal children, our cohort had significantly lower growth hormone levels only after clonidine administration. Clonidine 143-152 growth hormone 1 Homo sapiens 110-124 8232833-5 1993 GH secretion after clonidine stimulation was not altered. Clonidine 19-28 growth hormone 1 Homo sapiens 0-2 8354769-3 1993 Growth hormone secretion after clonidine stimulation was blunted on depressive and hypomanic days. Clonidine 31-40 growth hormone 1 Homo sapiens 0-14 8170565-4 1993 After clonidine there was a decrease in plasma levels of noradrenaline (NA) and adrenaline (Ad) in PD, MSA, and NC, and an increase in growth hormone (GH) in PD, PAF, and NC. Clonidine 6-15 growth hormone 1 Homo sapiens 135-149 8427240-4 1993 Endocrine studies of these patients documented low growth-hormone levels after clonidine and insulin stimulation and blunted growth-hormone response to growth hormone releasing hormone. Clonidine 79-88 growth hormone 1 Homo sapiens 51-65 8422091-0 1993 Blunted growth hormone responses to growth hormone-releasing factor and to clonidine in panic disorder. Clonidine 75-84 growth hormone 1 Homo sapiens 8-22 8422091-1 1993 Blunted growth hormone (GH) responses to growth hormone-releasing factor (GH-RF) and clonidine have been reported in patients with panic disorder. Clonidine 85-94 growth hormone 1 Homo sapiens 8-22 8422091-1 1993 Blunted growth hormone (GH) responses to growth hormone-releasing factor (GH-RF) and clonidine have been reported in patients with panic disorder. Clonidine 85-94 growth hormone 1 Homo sapiens 24-26 8422091-3 1993 Compared to the normal subjects, the patients with panic disorder had significantly blunted GH responses after both GH-RF and clonidine. Clonidine 126-135 growth hormone 1 Homo sapiens 92-94 8380310-0 1993 Effects of estrogen on growth hormone following clonidine stimulation. Clonidine 48-57 growth hormone 1 Homo sapiens 23-37 8380310-1 1993 OBJECTIVE: To test the usefulness of estrogen priming to enhance the growth hormone (GH) response following stimulation with clonidine hydrochloride in short children. Clonidine 125-148 growth hormone 1 Homo sapiens 69-83 8380310-1 1993 OBJECTIVE: To test the usefulness of estrogen priming to enhance the growth hormone (GH) response following stimulation with clonidine hydrochloride in short children. Clonidine 125-148 growth hormone 1 Homo sapiens 85-87 8345071-3 1993 Pituitary growth hormone reserve was evaluated by clonidine stimulation and insulin tolerance tests before commencement of treatment. Clonidine 50-59 growth hormone 1 Homo sapiens 10-24 8307113-0 1993 Effects of thyroid hormone status on the growth hormone responses to clonidine. Clonidine 69-78 growth hormone 1 Homo sapiens 41-55 8307113-3 1993 The growth hormone responses to clonidine administration (4 micrograms/kg) have been therefore studied in a group of female patients with thyroid disease (seven hyperthyroid and five hypothyroid) before and after the achievement of the euthyroid state. Clonidine 32-41 growth hormone 1 Homo sapiens 4-18 8419612-2 1993 Orally administered clonidine, an alpha 2-adrenergic agonist, is a potent acute stimulator of growth hormone releasing hormone-mediated pituitary GH release. Clonidine 20-29 growth hormone 1 Homo sapiens 94-108 8419612-2 1993 Orally administered clonidine, an alpha 2-adrenergic agonist, is a potent acute stimulator of growth hormone releasing hormone-mediated pituitary GH release. Clonidine 20-29 growth hormone 1 Homo sapiens 146-148 8419612-7 1993 Diminution in clonidine-stimulated peak GH levels was not observed after long-term oral clonidine therapy. Clonidine 14-23 growth hormone 1 Homo sapiens 40-42 8419612-9 1993 Subsequent acceleration in growth velocity during GH therapy suggests that a proposed increase in clonidine-induced endogenous GH secretion does not result in an effective growth-promoting stimulus. Clonidine 98-107 growth hormone 1 Homo sapiens 127-129 1305718-1 1992 Growth hormone concentration has been assayed in 105 children (45 girls and 60 boys) during starvation and following its stimulation with clonidine and insulin and during the sleep. Clonidine 138-147 growth hormone 1 Homo sapiens 0-14 1334889-0 1992 [Altered responses of heart rate, renal sodium handling and plasma growth hormone to clonidine in type II diabetic patients]. Clonidine 85-94 growth hormone 1 Homo sapiens 67-81 1488479-0 1992 Growth hormone response to clonidine in male patients with panic disorder untreated by antidepressants. Clonidine 27-36 growth hormone 1 Homo sapiens 0-14 1306774-0 1992 [Reaction of serum growth hormone in patients with endemic cretinism to arginine and clonidine in continuous excitement tests]. Clonidine 85-94 growth hormone 1 Homo sapiens 19-33 1306774-1 1992 Reaction of serum growth hormone in cretins whose pituitary and thyroid function have returned to normal in IDD-control by using iodized salt to arginine and clonidine in continuous excitement tests ws observed. Clonidine 158-167 growth hormone 1 Homo sapiens 18-32 1306774-2 1992 The result is that during the phase of clonidine excitement, serum growth hormone in cretins was obviously lower than that in normal controls and the reaction peak value, maximum increase value and reaction time all markedly lower than those of the normal controls. Clonidine 39-48 growth hormone 1 Homo sapiens 67-81 1488479-1 1992 We report a non-significantly higher growth hormone (GH) response to intravenous clonidine administration (150 micrograms) in 10 male patients with panic disorder who had never received antidepressant therapy than in 10 matched controls. Clonidine 81-90 growth hormone 1 Homo sapiens 37-51 1488479-1 1992 We report a non-significantly higher growth hormone (GH) response to intravenous clonidine administration (150 micrograms) in 10 male patients with panic disorder who had never received antidepressant therapy than in 10 matched controls. Clonidine 81-90 growth hormone 1 Homo sapiens 53-55 1333719-3 1992 A blunted growth hormone response to clonidine and a significant clonidine-induced decrease in plasma MHPG was also observed in this subgroup of panic disorder patients. Clonidine 37-46 growth hormone 1 Homo sapiens 10-24 1391293-3 1992 The data replicated the previously reported finding of blunted growth hormone (GH) responses to clonidine in patients with panic disorder. Clonidine 96-105 growth hormone 1 Homo sapiens 63-77 1353191-0 1992 Growth hormone response to clonidine in central and peripheral primary autonomic failure. Clonidine 27-36 growth hormone 1 Homo sapiens 0-14 1353191-3 1992 We have investigated the growth hormone (GH) releasing effects of clonidine in patients with PAF and MSA to see whether this hormonal response could serve as a neuroendocrine marker to distinguish between the groups. Clonidine 66-75 growth hormone 1 Homo sapiens 25-39 1353191-8 1992 Clonidine, therefore, stimulates growth hormone release in PAF but not MSA and may serve as a neuroendocrine marker in differentiating patients with MSA and a central autonomic defect from those with PAF with a peripheral defect. Clonidine 0-9 growth hormone 1 Homo sapiens 33-47 1610485-0 1992 Evidence for hypothalamo-growth hormone dysfunction in panic disorder: profile of growth hormone (GH) responses to clonidine, yohimbine, caffeine, glucose, GRF and TRH in panic disorder patients versus healthy volunteers. Clonidine 115-124 growth hormone 1 Homo sapiens 98-100 1398465-5 1992 The GH responses to clonidine were also blunted (p less than 0.05) in steroid-treated patients (GH peak 5.8 +/- 2.8 micrograms/L) with respect to normal subjects (GH peak 17.6 +/- 2.3 micrograms/L). Clonidine 20-29 growth hormone 1 Homo sapiens 4-6 1398465-5 1992 The GH responses to clonidine were also blunted (p less than 0.05) in steroid-treated patients (GH peak 5.8 +/- 2.8 micrograms/L) with respect to normal subjects (GH peak 17.6 +/- 2.3 micrograms/L). Clonidine 20-29 growth hormone 1 Homo sapiens 96-98 1398465-5 1992 The GH responses to clonidine were also blunted (p less than 0.05) in steroid-treated patients (GH peak 5.8 +/- 2.8 micrograms/L) with respect to normal subjects (GH peak 17.6 +/- 2.3 micrograms/L). Clonidine 20-29 growth hormone 1 Homo sapiens 96-98 1599607-0 1992 The growth hormone response to clonidine in acute and remitted depressed male patients. Clonidine 31-40 growth hormone 1 Homo sapiens 4-18 1599607-1 1992 The growth hormone (GH) response to clonidine was evaluated in 28 acutely depressed male patients, 17 remitted depressed patients, and 26 normal control subjects. Clonidine 36-45 growth hormone 1 Homo sapiens 4-18 1317592-4 1992 The level of GH secretion induced by clonidine was significantly reduced after ECT, but the hypotensive responses to clonidine remained unchanged. Clonidine 37-46 growth hormone 1 Homo sapiens 13-15 1323363-3 1992 After clonidine there was a decrease in plasma levels of noradrenaline and adrenaline, and an increase in growth hormone. Clonidine 6-15 growth hormone 1 Homo sapiens 106-120 1323363-4 1992 There was up-regulation of beta-adrenergic receptors on peripheral blood mononuclear cells 30 and 60 min after clonidine which was related to the fall in blood pressure, noradrenaline and adrenaline levels and to the increase in growth hormone levels. Clonidine 111-120 growth hormone 1 Homo sapiens 229-243 1398465-0 1992 Comparative effect of clonidine and growth hormone (GH)-releasing hormone on GH secretion in adult patients on chronic glucocorticoid therapy. Clonidine 22-31 growth hormone 1 Homo sapiens 77-79 1605491-0 1992 Growth hormone response to clonidine and cortisol secretion pattern predict changes in peripheral blood lymphocyte subsets in major depressive patients. Clonidine 27-36 growth hormone 1 Homo sapiens 0-14 1533556-4 1992 GH was evaluated by levodopa (125 mg up to 15 kg, and 250 mg between 15-30 kg), clonidine (0.15 mg m-2) stimulation tests and hGH secretory patterns by the integrated 24 h. GH concentration (IC-GH) using a constant withdrawal pump with continuous blood collection every 30 min. Clonidine 80-89 growth hormone 1 Homo sapiens 0-2 1533556-8 1992 Of the 12 children, peak serum GH after levodopa was found to be below 10 ng ml-1 in five children; and peak serum GH after clonidine was found to be below 10 ng ml-1 in six. Clonidine 124-133 growth hormone 1 Homo sapiens 115-117 1533556-9 1992 One child had a clonidine peak increase in serum GH concentration exactly 10 ng ml-1, but had a 12 h IC-GH of 1.5 ng ml-1 (N greater than 3.2). Clonidine 16-25 growth hormone 1 Homo sapiens 49-51 1533556-10 1992 Two children with peak GH after clonidine above 10 ng ml-1 had a 24 h IC-GH of 0.7 and 1.3 ng ml-1. Clonidine 32-41 growth hormone 1 Homo sapiens 23-25 1610485-2 1992 Previously we demonstrated that panic disorder patients have blunted growth hormone (GH) responses to clonidine, an alpha 2-adrenergic agonist. Clonidine 102-111 growth hormone 1 Homo sapiens 69-83 1610485-2 1992 Previously we demonstrated that panic disorder patients have blunted growth hormone (GH) responses to clonidine, an alpha 2-adrenergic agonist. Clonidine 102-111 growth hormone 1 Homo sapiens 85-87 1610485-5 1992 Although stress-mediated increases in GH are thought to be a common correlate of stress in humans, our findings indicate that panic disorder patients have significantly blunted GH responses to clonidine, yohimbine, growth-hormone releasing factor, and caffeine compared to normal control subjects. Clonidine 193-202 growth hormone 1 Homo sapiens 177-179 1938795-1 1991 The ratio of growth hormone response to clonidine and L-dopa challenge was compared in 74 boys: 15 with purported physical abuse, 7 with purported sexual abuse, 13 normal controls, and 39 psychiatric controls. Clonidine 40-49 growth hormone 1 Homo sapiens 13-27 1361819-5 1992 Insulin-induced hypoglycemia (0.1 U/kg iv in bolus) and clonidine (0.15 mg/m2 po) were used as indirect stimuli for GH release. Clonidine 56-65 growth hormone 1 Homo sapiens 116-118 1806268-1 1991 The authors give an account of their five-year experience with the clonidine test of growth hormone (GH) secretion. Clonidine 67-76 growth hormone 1 Homo sapiens 85-99 1806268-1 1991 The authors give an account of their five-year experience with the clonidine test of growth hormone (GH) secretion. Clonidine 67-76 growth hormone 1 Homo sapiens 101-103 1665918-0 1991 Growth hormone responses to intravenous clonidine challenge correlate with behavioral irritability in psychiatric patients and healthy volunteers. Clonidine 40-49 growth hormone 1 Homo sapiens 0-14 1665918-1 1991 To explore the relationship between central noradrenergic receptor responsivity and indices of impulsive aggression, growth hormone responses to infusions with the alpha 2-adrenergic receptor agonist clonidine (GH[CLON]) and responses on the Buss-Durkee Hostility Inventory (BDHI) were examined in healthy male volunteers and male patients with major affective or personality disorder. Clonidine 200-209 growth hormone 1 Homo sapiens 117-131 1831841-3 1991 Before treatment, peak serum growth hormone concentrations were less than 10 micrograms/L after levodopa and clonidine stimulation tests in five patients, after clonidine in three patients, and after levodopa in three patients. Clonidine 109-118 growth hormone 1 Homo sapiens 29-43 1938795-2 1991 Sexually abused boys demonstrate a statistically significant elevated ratio of growth hormone response to clonidine versus response to L-dopa. Clonidine 106-115 growth hormone 1 Homo sapiens 79-93 1905509-0 1991 Synergistic effect of growth hormone and gonadotropins in achieving conception in "clonidine-negative" patients with unexplained infertility. Clonidine 83-92 growth hormone 1 Homo sapiens 22-36 1677361-5 1991 The administration of both clonidine and pyridostigmine significantly (P less than 0.01) enhanced the GH responses to GHRH compared to those elicited by this challenge when given after placebo. Clonidine 27-36 growth hormone 1 Homo sapiens 102-104 1677361-7 1991 When atropine and clonidine were given together, the inhibitory effect of the former was overcame and mean GHRH-elicited GH peak response was significantly (P less than 0.05) higher than that in the control study. Clonidine 18-27 growth hormone 1 Homo sapiens 107-109 1677361-9 1991 These data confirm our previous postulate suggesting that the stimulatory effect of clonidine on GH release is mainly exerted by inhibiting the hypothalamic SRIF release. Clonidine 84-93 growth hormone 1 Homo sapiens 97-99 1652141-0 1991 Growth hormone and other hormonal responses to clonidine in melancholic and nonmelancholic depressed subjects and controls. Clonidine 47-56 growth hormone 1 Homo sapiens 0-14 1876628-8 1991 Improvement in OCD symptoms after clonidine significantly correlated with GH response to clonidine, suggesting specific noradrenergic mediation. Clonidine 34-43 growth hormone 1 Homo sapiens 74-76 1876628-8 1991 Improvement in OCD symptoms after clonidine significantly correlated with GH response to clonidine, suggesting specific noradrenergic mediation. Clonidine 89-98 growth hormone 1 Homo sapiens 74-76 1849217-4 1991 However, the response of GH to clonidine injection was blunted in obese patients. Clonidine 31-40 growth hormone 1 Homo sapiens 25-27 2058608-10 1991 Paired clonidine-provoked growth hormone levels and an integrated concentration of 24-hour growth hormone levels and serum levels of insulinlike growth hormone I measured in a control group of normally growing children were also analyzed and showed no seasonal variation. Clonidine 7-16 growth hormone 1 Homo sapiens 26-40 1800346-0 1991 Growth hormone response to clonidine in obese children. Clonidine 27-36 growth hormone 1 Homo sapiens 0-14 1800346-4 1991 The positive responses (peak level of serum GH greater than 7 ng/ml) were seen in 10% with exercise, in 10% with clonidine and in none with IIH test. Clonidine 113-122 growth hormone 1 Homo sapiens 44-46 1800346-5 1991 These observations suggest that GH response to oral clonidine is subnormal in obese children. Clonidine 52-61 growth hormone 1 Homo sapiens 32-34 1989571-0 1991 Blunted growth hormone response to clonidine in patients with generalized anxiety disorder. Clonidine 35-44 growth hormone 1 Homo sapiens 8-22 1989571-5 1991 Clonidine produced significantly smaller growth hormone responses in patients than in healthy controls. Clonidine 0-9 growth hormone 1 Homo sapiens 41-55 1989571-8 1991 The blunting of the growth hormone response to clonidine in all three disorders could be due to the presence of generalized anxiety symptoms. Clonidine 47-56 growth hormone 1 Homo sapiens 20-34 1989571-9 1991 Subsensitivity of postsynaptic alpha 2-adrenoreceptors may be present in all three disorders; however, there are alternative interpretations of growth hormone blunting in response to clonidine. Clonidine 183-192 growth hormone 1 Homo sapiens 144-158 1905509-2 1991 The study included patients with long-standing (2-11 years) unexplained infertility with a negative or reduced GH response to clonidine (up to 150 micrograms of clonidine orally). Clonidine 126-135 growth hormone 1 Homo sapiens 111-113 1806474-7 1991 Peak GH after clonidine was 22.4 +/- 8.9 and 22.8 +/- 8.1, respectively. Clonidine 14-23 growth hormone 1 Homo sapiens 5-7 1823078-0 1991 Acute effects of clonidine and growth-hormone-releasing hormone on growth hormone secretion in patients with hyperthyroidism. Clonidine 17-26 growth hormone 1 Homo sapiens 67-81 1977761-2 1990 In 10 normal subjects we compared the pattern of clonidine-induced GH release to that elicited by GH-releasing hormone (GHRH) given at a time of presumably similar responsiveness of the somatotrope. Clonidine 49-58 growth hormone 1 Homo sapiens 67-69 2279968-0 1990 Growth hormone response to L-dopa and clonidine in autistic children. Clonidine 38-47 growth hormone 1 Homo sapiens 0-14 2279968-8 1990 In the autistic subjects, the L-Dopa-stimulated growth hormone peak was delayed and the clonidine growth hormone peak was premature. Clonidine 88-97 growth hormone 1 Homo sapiens 98-112 2279968-9 1990 A statistical difference with the control subjects was found when consideration was given to both the premature response of growth hormone to clonidine and the delayed response to L-Dopa (p = .01, Fisher"s Exact Test). Clonidine 142-151 growth hormone 1 Homo sapiens 124-138 1977761-9 1990 The close relationship between pre-GHRH plasma GH values and GHRH-elicited GH peaks, not observed for clonidine, was lost after pretreatment with this drug. Clonidine 102-111 growth hormone 1 Homo sapiens 47-49