PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 15700025-1 2005 We have previously shown that acute intravenous injections of moxonidine and clonidine increase plasma atrial natriuretic peptide (ANP), a vasodilator, diuretic and natriuretic hormone. Clonidine 77-86 natriuretic peptide A Rattus norvegicus 103-129 15700025-1 2005 We have previously shown that acute intravenous injections of moxonidine and clonidine increase plasma atrial natriuretic peptide (ANP), a vasodilator, diuretic and natriuretic hormone. Clonidine 77-86 natriuretic peptide A Rattus norvegicus 131-134 1839909-2 1991 treatment with atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP) on the pressor response to i.c.v.-injected clonidine were investigated in conscious rats. Clonidine 127-136 natriuretic peptide A Rattus norvegicus 15-41 9152372-0 1997 The peripheral action of clonidine analog ST-91: involvement of atrial natriuretic factor. Clonidine 25-34 natriuretic peptide A Rattus norvegicus 64-89 9152372-2 1997 Our previous work has shown that diuresis and natriuresis caused by central administration of clonidine are mediated by an enhanced release of atrial natriuretic factor (ANF). Clonidine 94-103 natriuretic peptide A Rattus norvegicus 143-168 9152372-2 1997 Our previous work has shown that diuresis and natriuresis caused by central administration of clonidine are mediated by an enhanced release of atrial natriuretic factor (ANF). Clonidine 94-103 natriuretic peptide A Rattus norvegicus 170-173 9152372-3 1997 Because clonidine has been shown to have peripheral actions the objective of the present study was to determine whether ANF is also involved in these actions. Clonidine 8-17 natriuretic peptide A Rattus norvegicus 120-123 2525782-0 1989 Clonidine and morphine increase atrial natriuretic peptide secretion in anesthetized rats. Clonidine 0-9 natriuretic peptide A Rattus norvegicus 32-58 1836674-0 1991 [Effects of microinjection of clonidine into nucleus tractus solitarii on atrial natriuretic factor in rats]. Clonidine 30-39 natriuretic peptide A Rattus norvegicus 74-99 1836674-1 1991 In order to study whether atrial natriuretic factor (ANF) is involved in the depressor effect of clonidine, microinjection of the latter into nucleus tractus solitarii (NTS) was carried out in anesthetized stroke-prone spontaneously hypertensive rats (SHRsp) and normotensive Wistar-Kyoto (WKY) rats. Clonidine 97-106 natriuretic peptide A Rattus norvegicus 53-56 1836674-3 1991 A decrease of blood pressure and heart rate and a suppression of ANF release elicited by clonidine were significantly greater in SHRsp than in WKY rats. Clonidine 89-98 natriuretic peptide A Rattus norvegicus 65-68 1703600-0 1990 Blunted renal response to atrial natriuretic peptide in congestive heart failure rats is reversed by the alpha 2-adrenergic agonist clonidine. Clonidine 132-141 natriuretic peptide A Rattus norvegicus 26-52 2525782-2 1989 The central administration of a low dose of clonidine (10 ng/min) caused a significant increase in plasma ANP without changing arterial blood pressure or central venous pressure. Clonidine 44-53 natriuretic peptide A Rattus norvegicus 106-109 2525782-6 1989 Moreover, the effect of clonidine on plasma ANP was partially blocked by pretreatment with naloxone (5 micrograms/min). Clonidine 24-33 natriuretic peptide A Rattus norvegicus 44-47 2841088-0 1988 Is clonidine-induced diuresis mediated by atrial natriuretic factor? Clonidine 3-12 natriuretic peptide A Rattus norvegicus 42-67 2841088-5 1988 Plasma IR-ANF rose from 30.7 +/- 8.8 to 113.3 +/- 32.3 pg/ml plasma 5 min after the 0.5 micrograms clonidine dose (P less than 0.05), and urinary cGMP excretion was augmented from 8.49 +/- 4.29 to 27.7 +/- 5.0 pmol/min 1 h after 0.5 micrograms clonidine (P less than 0.05). Clonidine 99-108 natriuretic peptide A Rattus norvegicus 10-13 2841088-6 1988 Pretreatment with peripherally administered anti-ANF serum abolished the diuretic effect of intracerebroventricularly administered clonidine; urine output decreased from 1.49 +/- 0.41 to 0.42 +/- 0.21 ml/h. Clonidine 131-140 natriuretic peptide A Rattus norvegicus 49-52 2841088-10 1988 These data suggest that ANF may be involved in the mechanism of diuresis of centrally applied clonidine, which appears to enhance ANF release through its central stimulation of opiate and alpha 2-adrenergic receptors. Clonidine 94-103 natriuretic peptide A Rattus norvegicus 24-27 2841088-10 1988 These data suggest that ANF may be involved in the mechanism of diuresis of centrally applied clonidine, which appears to enhance ANF release through its central stimulation of opiate and alpha 2-adrenergic receptors. Clonidine 94-103 natriuretic peptide A Rattus norvegicus 130-133 2856643-0 1988 Clonidine stimulates atrial natriuretic factor (ANF) release in water-deprived rats. Clonidine 0-9 natriuretic peptide A Rattus norvegicus 21-46 2856643-0 1988 Clonidine stimulates atrial natriuretic factor (ANF) release in water-deprived rats. Clonidine 0-9 natriuretic peptide A Rattus norvegicus 48-51 2856643-2 1988 In normally-hydrated rats clonidine produced a marked elevation of plasma IR-ANF from 40.5 +/- 4.6 pg/ml to 1064 +/- 22 pg/ml (mean +/- SEM) and sodium excretion from 73.3 +/- 6.8 microEq to 723.4 +/- 62.3 microEq. Clonidine 26-35 natriuretic peptide A Rattus norvegicus 77-80 2856643-3 1988 Clonidine evoked an increase in plasma IR-ANF from 16.6 +/- 5.9 pg/ml to 229.5 +/- 60 pg/ml (mean +/- SEM) after 24 hr water deprivation and from 13.6 +/- 7.4 pg/ml to 104.8 +/- 21 pg/ml (mean +/- SEM) after 48 hr water deprivation. Clonidine 0-9 natriuretic peptide A Rattus norvegicus 42-45 3035429-1 1987 Effects of alpha 2-adrenergic receptors and calcium channel blockade on basal and clonidine-stimulated immunoreactive atrial natriuretic factor (IR-ANF) in conscious Sprague-Dawley rats were evaluated. Clonidine 82-91 natriuretic peptide A Rattus norvegicus 118-143 3035429-1 1987 Effects of alpha 2-adrenergic receptors and calcium channel blockade on basal and clonidine-stimulated immunoreactive atrial natriuretic factor (IR-ANF) in conscious Sprague-Dawley rats were evaluated. Clonidine 82-91 natriuretic peptide A Rattus norvegicus 148-151 3035429-7 1987 Clonidine injection in a dose of 50 micrograms caused a marked increase of plasma IR-ANF from 34.0 +/- 7.0 pg/ml (mean +/- S.E.M.) Clonidine 0-9 natriuretic peptide A Rattus norvegicus 85-88 3035429-9 1987 Clonidine-stimulated ANF secretion was partially inhibited by yohimbine from 457.1 +/- 66.3 pg/ml (mean +/- S.E.M.) Clonidine 0-9 natriuretic peptide A Rattus norvegicus 21-24 2856643-9 1988 In conclusion, clonidine stimulates ANF release both in normally-hydrated and water-deprived rats. Clonidine 15-24 natriuretic peptide A Rattus norvegicus 36-39 2856643-10 1988 The diuretic effect of clonidine appears to be related to ANF release but not to inhibition of vasopressin. Clonidine 23-32 natriuretic peptide A Rattus norvegicus 58-61