PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
23975095-0	2013	Clonidine suppresses the induction of long-term potentiation by inhibiting HCN channels at the Schaffer collateral-CA1 synapse in anesthetized adult rats.	Clonidine	0-9	carbonic anhydrase 1	Rattus norvegicus	115-118	
27291858-2	2016	Based on the available evidence, the aim of our study was to investigate consequences of the activation and deactivation of CA1 alpha2 adrenergic receptors (by clonidine and yohimbine, respectively) on the impairment of memory retention induced by total sleep deprivation (TSD) and the reversal of circadian rhythm (RCR) in a rat model.	Clonidine	160-169	carbonic anhydrase 1	Rattus norvegicus	124-127	
25641668-0	2015	Clonidine ameliorates cognitive impairment induced by chronic cerebral hypoperfusion via up-regulation of the GABABR1 and GAD67 in hippocampal CA1 in rats.	Clonidine	0-9	carbonic anhydrase 1	Rattus norvegicus	143-146	
25641668-11	2015	These findings demonstrated that clonidine could ameliorate cognitive deficits and neuronal impairment induced by chronic cerebral hypoperfusion via up-regulation of GABABR1 and GAD67 in hippocampal CA1.	Clonidine	33-42	carbonic anhydrase 1	Rattus norvegicus	199-202	
23975095-10	2013	In conclusion, clonidine can suppress the induction of LTP at the Schaffer collateral-CA1 synapse, and the possible mechanism is that activation of presynaptic alpha2-adrenoceptors reduces the Glu release by inhibiting HCN channels.	Clonidine	15-24	carbonic anhydrase 1	Rattus norvegicus	86-89	
8887976-10	1996	Clonidine (0.1 microM), a partial alpha 2-agonist, decrease glutamate/hypoxia-mediated calcium changes in CA1 (p = 0.01), but 1 microM clonidine, which stimulates alpha 1-receptors, did not.	Clonidine	0-9	carbonic anhydrase 1	Rattus norvegicus	106-109	
20064624-5	2010	Interestingly, pre-test intra-CA1 microinjection of alpha1-adrenergic agonist, phenylephrine (1 and 2 microg/rat) or alpha2-adrenergic agonist, clonidine improved post-training scopolamine (2 microg/rat)-induced retrieval impairment.	Clonidine	144-153	carbonic anhydrase 1	Rattus norvegicus	30-33	
9421826-0	1997	Alprazolam, diazepam, yohimbine, clonidine: in vivo CA1 hippocampal norepinephrine and serotonin release profiles under chloral hydrate anesthesia.	Clonidine	33-42	carbonic anhydrase 1	Rattus norvegicus	52-55	
2292030-2	1990	Neonatal depletion of noradrenaline by daily subcutaneous injections of clonidine results in supersensitivity to noradrenaline in adult hippocampal CA1 cells as shown in our previous microiontophoretic study.	Clonidine	72-81	carbonic anhydrase 1	Rattus norvegicus	148-151	
2574070-4	1989	However, there was a significantly stronger depression of glutamate-evoked activity of CA1 pyramidal neurons by noradrenaline in the clonidine-treated rats.	Clonidine	133-142	carbonic anhydrase 1	Rattus norvegicus	87-90	
33489031-3	2020	In the present research, we wanted to investigate the effect of stimulation and blockage of CA1 alpha2 adrenergic receptors by clonidine (an agonist of alpha2 adrenergic receptor) and yohimbine (an antagonist of alpha2 adrenergic receptor), respectively, on memory retention impairment induced by REM SD (RSD) in rats.	Clonidine	127-136	carbonic anhydrase 1	Rattus norvegicus	92-95	
33489031-5	2020	Clonidine and yohimbine were injected intra-CA1.	Clonidine	0-9	carbonic anhydrase 1	Rattus norvegicus	44-47