PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
20570945-0	2010	CYP2D6 mediates 4-hydroxylation of clonidine in vitro: implication for pregnancy-induced changes in clonidine clearance.	Clonidine	35-44	cytochrome P450 family 2 subfamily D member 6	Homo sapiens	0-6	
23355638-5	2013	For verification, the disposition of CYP1A2-metabolized drug theophylline (THEO) and CYP2D6-metabolized drugs paroxetine (PAR), dextromethorphan (DEX), and clonidine (CLO) during pregnancy was predicted.	Clonidine	167-170	cytochrome P450 family 2 subfamily D member 6	Homo sapiens	85-91	
20570945-0	2010	CYP2D6 mediates 4-hydroxylation of clonidine in vitro: implication for pregnancy-induced changes in clonidine clearance.	Clonidine	100-109	cytochrome P450 family 2 subfamily D member 6	Homo sapiens	0-6	
20570945-5	2010	Selective inhibition studies in human liver microsomes confirmed that these isoforms are jointly responsible for 4-hydroxylation of clonidine in vitro, and CYP2D6 accounted for approximately two-thirds of the activity.	Clonidine	132-141	cytochrome P450 family 2 subfamily D member 6	Homo sapiens	156-162	
20570945-6	2010	The major role of CYP2D6 in clonidine metabolism might explain the increase in its nonrenal clearance during pregnancy.	Clonidine	28-37	cytochrome P450 family 2 subfamily D member 6	Homo sapiens	18-24	
28520366-6	2012	They also state that for individuals who have more than two functional gene copies of CYP2D6, i.e., individuals with so-called ultrarapid metabolizer status, physicians should either be alert to reduced efficacy with the standard dose of atomoxetine, or they should prescribe an alternative drug, such as methylphenidate or clonidine (Table 1) (2).	Clonidine	324-333	cytochrome P450 family 2 subfamily D member 6	Homo sapiens	86-92	
31585114-0	2019	Effects of 24 CYP2D6 variants found in Chinese population on the metabolism of clonidine in vitro.	Clonidine	79-88	cytochrome P450 family 2 subfamily D member 6	Homo sapiens	14-20	
31585114-5	2019	Our goal is to research the effect of CYP2D6 genetic polymorphism on the metabolism of clonidine and evaluate the functions of 22 CYP2D6 allelic variants in vitro, which were discovered in Chinese Han population recently.	Clonidine	87-96	cytochrome P450 family 2 subfamily D member 6	Homo sapiens	38-44	
31585114-8	2019	Metabolite 4-OH clonidine was accurately detected via ultra-performance liquid-chromatography tandem mass spectrometry to evaluate the effect of CYP2D6 genetic polymorphism on the clonidine.	Clonidine	16-25	cytochrome P450 family 2 subfamily D member 6	Homo sapiens	145-151	
31585114-8	2019	Metabolite 4-OH clonidine was accurately detected via ultra-performance liquid-chromatography tandem mass spectrometry to evaluate the effect of CYP2D6 genetic polymorphism on the clonidine.	Clonidine	180-189	cytochrome P450 family 2 subfamily D member 6	Homo sapiens	145-151	
31585114-13	2019	CONCLUSION: We comprehensively evaluated the effect of 22 novel CYP2D6 variants on the metabolism of clonidine for the first time and hoped corresponding data provide a reference for metabolism of clonidine for further studies in vivo, and extend our understanding of the clinical drug toxicity or ineffectiveness by CYP2D6 genetic polymorphism.	Clonidine	101-110	cytochrome P450 family 2 subfamily D member 6	Homo sapiens	64-70	
31585114-13	2019	CONCLUSION: We comprehensively evaluated the effect of 22 novel CYP2D6 variants on the metabolism of clonidine for the first time and hoped corresponding data provide a reference for metabolism of clonidine for further studies in vivo, and extend our understanding of the clinical drug toxicity or ineffectiveness by CYP2D6 genetic polymorphism.	Clonidine	101-110	cytochrome P450 family 2 subfamily D member 6	Homo sapiens	317-323	
31585114-13	2019	CONCLUSION: We comprehensively evaluated the effect of 22 novel CYP2D6 variants on the metabolism of clonidine for the first time and hoped corresponding data provide a reference for metabolism of clonidine for further studies in vivo, and extend our understanding of the clinical drug toxicity or ineffectiveness by CYP2D6 genetic polymorphism.	Clonidine	197-206	cytochrome P450 family 2 subfamily D member 6	Homo sapiens	64-70	
31585114-13	2019	CONCLUSION: We comprehensively evaluated the effect of 22 novel CYP2D6 variants on the metabolism of clonidine for the first time and hoped corresponding data provide a reference for metabolism of clonidine for further studies in vivo, and extend our understanding of the clinical drug toxicity or ineffectiveness by CYP2D6 genetic polymorphism.	Clonidine	197-206	cytochrome P450 family 2 subfamily D member 6	Homo sapiens	317-323