PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 2649299-3 1989 Clonidine significantly lowered blood pressure, basal plasma norepinephrine levels, and epinephrine and renin activity but did not affect basal growth hormone concentrations. Clonidine 0-9 renin Homo sapiens 104-109 1822252-9 1991 In the patient with grossly elevated renin levels, blood pressure fell minimally (6%) after clonidine, but unlike others fell profoundly (37%) after captopril. Clonidine 92-101 renin Homo sapiens 37-42 2945415-9 1986 Endocrinologic and metabolic effects with transdermal clonidine are similar to those with the oral form: norepinephrine, renin, and aldosterone all tend to be reduced; and there are no significant changes in the lipid profile, uric acid, or electrolytes. Clonidine 54-63 renin Homo sapiens 121-126 3540504-7 1986 Plasma renin activity (PRA) was reduced by PRO (51%, P less than 0.01) and CLO (35%, P less than 0.05). Clonidine 75-78 renin Homo sapiens 7-12 3514447-5 1986 Absolute clonidine-induced reduction in plasma renin activity after diuretic treatment was three times greater than before treatment, although percent changes were similar. Clonidine 9-18 renin Homo sapiens 47-52 6400111-0 1983 Clonidine in unilateral renal artery stenosis and unilateral renal parenchymal disease--similar antihypertensive but different renin suppressive effects. Clonidine 0-9 renin Homo sapiens 127-132 2417048-1 1985 Central alpha-adrenoceptor agonists (methyldopa, clonidine, guanabenz) decrease sympathetic outflow and renin and vasopressin secretion as well as increase parasympathetic activity. Clonidine 49-58 renin Homo sapiens 104-109 6386275-3 1984 Both clonidine and guanfacine decreased plasma renin activity. Clonidine 5-14 renin Homo sapiens 47-52 6392861-0 1984 [Growth hormone secretion and plasma renin activity in children following administration of clonidine]. Clonidine 92-101 renin Homo sapiens 37-42 6392861-7 1984 Plasma renin activity prior to clonidine was 3.13 ng/ml/h, and 2.03 ng/ml/h 30 min after drugintake. Clonidine 31-40 renin Homo sapiens 7-12 3007707-3 1985 clonidine lowered blood pressure, increased sedation and raised levels of plasma renin activity and growth hormone. Clonidine 0-9 renin Homo sapiens 81-86 6375331-4 1984 Transdermal clonidine reduced plasma renin activity and urinary aldosterone excretion to the same extent as that reported for oral clonidine. Clonidine 12-21 renin Homo sapiens 37-42 6400111-2 1983 After clonidine blood pressure fell substantially in both groups, with the maximum fall in the fourth hour and effects persisting after 6 h. Levels of plasma renin activity were considerably higher in the renal artery stenosis patients and remained unchanged during the study; there was a progressive fall in levels in each of the patients with renal parenchymal disease. Clonidine 6-15 renin Homo sapiens 158-163 6314685-4 1983 Clonidine clearly reduced plasma ACTH, serum cortisol and renin activity. Clonidine 0-9 renin Homo sapiens 58-63 6822130-1 1983 Although the principal actions of clonidine are linked to its centrally mediated suppression of sympathetic activity, its inhibition of the renin axis also may contribute to its antihypertensive effects. Clonidine 34-43 renin Homo sapiens 140-145 6822130-2 1983 In patients with essential hypertension studied in a clinical research center, clonidine-induced decreases in diastolic blood pressure and in plasma renin activity (PRA) correlated closely after one day of treatment, but not thereafter. Clonidine 79-88 renin Homo sapiens 149-154 6822130-3 1983 Moreover, high-renin patients experienced significantly greater blood pressure decrements than low-renin patients during the first day of treatment, but subsequent blood pressure decreases were equal in the two groups, confirming that the sympathoinhibitory action of clonidine is probably independent of the renin-angiotensin system. Clonidine 268-277 renin Homo sapiens 15-20 6822130-7 1983 Thus, clonidine appears to have two separate actions on the renin-aldosterone axis: an early antirenin action primarily in high-renin patients, and a longer-term suppressive effect on aldosterone. Clonidine 6-15 renin Homo sapiens 60-65 6822130-7 1983 Thus, clonidine appears to have two separate actions on the renin-aldosterone axis: an early antirenin action primarily in high-renin patients, and a longer-term suppressive effect on aldosterone. Clonidine 6-15 renin Homo sapiens 97-102 6822132-2 1983 Rapid administration of clonidine (200 micrograms) produced significant falls (p less than 0.01) in mean blood pressure, plasma levels of norepinephrine, plasma renin activity and aldosterone in both groups of patients. Clonidine 24-33 renin Homo sapiens 161-166 6338454-0 1983 [The effect of naloxone on plasma renin activity in patients with essential hypertension treated with clonidine]. Clonidine 102-111 renin Homo sapiens 34-39 7015796-0 1981 Prolonged clonidine treatment: catecholamines, renin activity and aldosterone following exercise in hypertensives. Clonidine 10-19 renin Homo sapiens 47-52 6125282-6 1982 Clonidine and alpha methyldopa share a similar pattern of peripheral effects, including reductions in preganglionic sympathetic nerve traffic, bradycardia, decreases in plasma renin activity, reductions in blood pressure in the supine position and adverse effects such as depression, sedation and bad dreams. Clonidine 0-9 renin Homo sapiens 176-181 7044649-1 1982 Beta-adrenoceptor blockade increases serum K, which may be related to renin inhibition, hypoaldosteronism, and exercise-induced skeletal muscle release of serum K. We report on the dynamic and biochemical response to clonidine (C) after single (S) 0.2-mg and repeated (R) 0.1-mg bid doses of C to six normal subjects at rest, 2 hr after dosing and immediately before dynamic physical activity (DPA) on a treadmill, and at peak activity and 2 hr after DPA. Clonidine 217-226 renin Homo sapiens 70-75 7037264-0 1982 Plasma clonidine in relation to blood pressure, catecholamines, and renin activity during long-term treatment of hypertension. Clonidine 7-16 renin Homo sapiens 68-73 7011348-0 1981 Changes in blood pressure, plasma catecholamines and plasma renin activity during and after treatment with tiamenidine and clonidine. Clonidine 123-132 renin Homo sapiens 60-65 6989768-0 1980 The effect of clonidine on renin and aldosterone of hypertensive patients. Clonidine 14-23 renin Homo sapiens 27-32 7004877-5 1980 In a second child with renin-induced hypertension since the firth month of life, treatment wiht hydralazine, clonidine and hydrochlorothiazide was in part effective, but failure to thrive was progressive. Clonidine 109-118 renin Homo sapiens 23-28 6768672-3 1980 In blood obtained while the patients were supine and then erect, plasma renin activity and norepinephrine levels were significantly lowered after clonidine therapy. Clonidine 146-155 renin Homo sapiens 72-77 6154836-2 1980 During treatment of hypertensive patients with clonidine, renal blood flow and glomerular filtration rate are well maintained, and renin secretion is reduced. Clonidine 47-56 renin Homo sapiens 131-136 6989768-6 1980 CONCLUSIONS: In our normal and low renin patients the antihypertensive action of clonidine is neither predicted by basal PRA and urinary aldosterone values nor explained by their changes. Clonidine 81-90 renin Homo sapiens 35-40 700917-0 1978 Effect of clonidine (Haemiton) on plasma renin level and angiotensin sensitivity in man. Clonidine 10-19 renin Homo sapiens 41-46 707522-0 1978 Role of renin and aldosterone suppression in the antihypertensive mechanism of clonidine. Clonidine 79-88 renin Homo sapiens 8-13 700917-1 1978 The effect of clonidine and of clonidine + spironolactone on renin activity and angiotensin sensitivity has been studied in 15 persons. Clonidine 31-40 renin Homo sapiens 61-66 746771-0 1978 [The effect of clonidine on the renin production system]. Clonidine 15-24 renin Homo sapiens 32-37 727216-0 1978 Renin stimulation during clonidine therapy in "low renin" essential hypertension. Clonidine 25-34 renin Homo sapiens 0-5 727216-0 1978 Renin stimulation during clonidine therapy in "low renin" essential hypertension. Clonidine 25-34 renin Homo sapiens 51-57 727216-1 1978 Plasma renin activity (PRA) was measured during the administration of clonidine (0.1 mg twice daily) to 11 patients with essential hypertension. Clonidine 70-79 renin Homo sapiens 7-12 727216-4 1978 In contrast, in a small group of "normal renin" patients (n = 4), PRA did not change significantly but tended to decrease on clonidine therapy from 9.2 +/- 3.4 at control to 3.3 +/- 2.0 at one week, 3.4 +/- 0.6 at four weeks, and 4.7 +/- 1.7 ng Al/ml/hr at eight weeks. Clonidine 125-134 renin Homo sapiens 41-46 727216-7 1978 Previous studies have implicated alpha-adrenergic receptors as the site of clonidine actions on blood pressure and renin release. Clonidine 75-84 renin Homo sapiens 115-120 208038-0 1978 [The effect of clonidin (Haemiton) on plasma renin level and angiotensin sensitivity in man]. Clonidine 15-23 renin Homo sapiens 45-50 641212-0 1978 The effects of clonidine and propranolol, separately and in combination, on blood pressure and plasma renin activity in essential hypertension. Clonidine 15-24 renin Homo sapiens 102-107 928858-0 1977 [The effects of clonidine on the renin-angiotensin-aldosterone system in patients with hypertension]. Clonidine 16-25 renin Homo sapiens 33-38 71600-8 1977 Thus, sodium depletion stimulates total renin release, while propranolol and clonidine produce divergent responses of active renin and prorenin, the changes in prorenin depending on the changes induced in blood-pressure. Clonidine 77-86 renin Homo sapiens 125-130 872520-6 1977 Resting supine plasma renin activity before dosing was 0-95+/-0-16 pmol of angiotensin I h-1 ml-1 of plasma and rose significantly after clonidine to 3-50+/-0-39 pmol of angiotensin I h-1 ml-1 of plasma at 6 h. By 12 h plasma renin activity had returned to control values. Clonidine 137-146 renin Homo sapiens 22-27 343894-1 1977 Clonidine, propranolol, bethanidine and debrisoquine effectively decrease blood pressure by suppressing renin secretion or interfering with function of the sympathetic nervous system. Clonidine 0-9 renin Homo sapiens 104-109 1000443-0 1976 Effects of long-term administration of clonidine on plasma renin activity. Clonidine 39-48 renin Homo sapiens 59-64 401703-0 1977 Clonidine in primary hypertension: effects on blood pressure, plasma renin activity, plasma and urinary aldosterone. Clonidine 0-9 renin Homo sapiens 69-74 1000443-6 1976 Nonetheless, clonidine cannot generally be classified as a "renin-inhibiting" drug. Clonidine 13-22 renin Homo sapiens 60-65 1155220-0 1975 Plasma renin activity, blood pressure and sodium excretion during treatment with clonidine. Clonidine 81-90 renin Homo sapiens 7-12 998518-1 1976 In 18 hypertensive patients receiving a constant (100 mEq/day) sodium diet, treatment with clonidine (0.3 mg/day for 5 days) decreased blood pressure in 11 patients with high and normal renin levels and 7 with low renin levels. Clonidine 91-100 renin Homo sapiens 186-191 998518-1 1976 In 18 hypertensive patients receiving a constant (100 mEq/day) sodium diet, treatment with clonidine (0.3 mg/day for 5 days) decreased blood pressure in 11 patients with high and normal renin levels and 7 with low renin levels. Clonidine 91-100 renin Homo sapiens 214-219 998518-5 1976 Thus, two mechanisms of action of clonidine are possible, one related to acute inhibition of the renin-angiotensin system in patients with high and normal renin levels and another that is independent of renin mechanisms and occurs in all hypertensive patients. Clonidine 34-43 renin Homo sapiens 97-102 998518-5 1976 Thus, two mechanisms of action of clonidine are possible, one related to acute inhibition of the renin-angiotensin system in patients with high and normal renin levels and another that is independent of renin mechanisms and occurs in all hypertensive patients. Clonidine 34-43 renin Homo sapiens 155-160 998518-5 1976 Thus, two mechanisms of action of clonidine are possible, one related to acute inhibition of the renin-angiotensin system in patients with high and normal renin levels and another that is independent of renin mechanisms and occurs in all hypertensive patients. Clonidine 34-43 renin Homo sapiens 155-160 998518-11 1976 Thus, the antirenin effect of clonidine enhances its antihypertensive action not only by acutely ablating renin-angiotensin pressor mechanisms, but also by inhibiting aldosterone production and thereby minimizing longer-term reactive volume retention during treatment. Clonidine 30-39 renin Homo sapiens 14-19 998518-0 1976 Renin and aldosterone suppression in the antihypertensive action of clonidine. Clonidine 68-77 renin Homo sapiens 0-5 1263403-0 1976 [The effect of clonidine on renin-release (author"s transl)]. Clonidine 15-24 renin Homo sapiens 28-33 1263403-1 1976 In patients with primary hypertension, intravenous administration of 150 mug Clonidin caused a decrease in arterial pressure, renin activity, RPF, GFR and electrolyte excretion. Clonidine 77-85 renin Homo sapiens 126-131 802649-10 1975 With reserpine and clonidine, heart rate and plasma renin activity were significantly decreased, whereas plasma aldosterone did not change significantly. Clonidine 19-28 renin Homo sapiens 52-57 22147655-5 2012 Beta-blockers, alpha-methyldopa, clonidine, and nonsteroidal anti-inflammatory drugs suppress renin, raising the ARR with potential for false positives. Clonidine 33-42 renin Homo sapiens 94-99 4595556-0 1974 [Letter: Effect of injectable clonidine on renin secretion in essential arterial hypertension]. Clonidine 30-39 renin Homo sapiens 43-48 238481-1 1975 In various kinds of hypertension clonidine induced a decrease in urinary catecholamines, plasma renin activity and urinary aldosterone, concommitant with a fall in blood pressure and pulse rate in both short term and chronic studies. Clonidine 33-42 renin Homo sapiens 96-101 238481-5 1975 --During clonidine the increase in catecholamines and renin after insulin induced hypoglycemia was largely abolished. Clonidine 9-18 renin Homo sapiens 54-59 4522166-0 1973 The effect of clonidine on plasma renin activity in human hypertension. Clonidine 14-23 renin Homo sapiens 34-39 11727145-4 2001 RESULTS: Heart rate, arterial blood pressures, and plasma renin activity were lower during and after pneumoperitoneum in patients with clonidine. Clonidine 135-144 renin Homo sapiens 58-63 11727145-7 2001 CONCLUSIONS: Clonidine enabled stable hemodynamics and prevented activation of RAAS seen as unchanged plasma renin activity. Clonidine 13-22 renin Homo sapiens 109-114 9777817-9 1998 RESULTS: Clonidine and diltiazem had consistent response rates regardless of renin profile (76%, 67%, and 80% for low, medium, and high renin, respectively, for clonidine and 83%, 82%, and 83%, respectively, for diltiazem for patients with baseline DBP of 95-99 mm Hg). Clonidine 9-18 renin Homo sapiens 136-141 21991736-11 2011 Significant decrease in plasma renin activity was seen in clonidine group (P = 0.001). Clonidine 58-67 renin Homo sapiens 31-36 20833658-7 2010 RESULTS: Good clonidine responders had better natriuresis and diuresis as well as a significant decrease in abdominal circumference, plasma renin, aldosterone and norepinephrine levels. Clonidine 14-23 renin Homo sapiens 140-145 15834464-10 2005 More clinical trials are needed for the centrally acting antihypertensives (clonidine, rilmenidine) in obese hypertensive patients, as they inhibit the sympathetic nervous and renin--angiotensin systems, which are overactive in this population. Clonidine 76-85 renin Homo sapiens 176-181 12014310-8 2002 In these patients, after 8 days, clonidine decreases sympathetic activity, increases glomerular filtration rate and after 18 days, decreases plasma renin and aldosterone concentrations allowing a better action of spironolactone. Clonidine 33-42 renin Homo sapiens 148-153