PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
10801247-1	2000	BACKGROUND: Tangeretin is a flavonoid that stimulates the catalytic activity of cytochrome P450 3A4 (CYP3A4) and is found in high levels in tangerine juice.	tangeretin	12-22	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	101-107	
10801247-2	2000	METHODS: The effect of tangeretin on hydroxylation of midazolam, a CYP3A4 probe, was examined in vitro with human liver microsomes and recombinant CYP3A4.	tangeretin	23-33	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	67-73	
10801247-5	2000	In complementary deoxyribonucleic acid-expressed CYP3A4, a 52% stimulation of midazolam 1"-hydroxylation was reached at 50 micromol/L tangeretin with no effect on midazolam 4-hydroxylation.	tangeretin	134-144	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	49-55	
10801247-9	2000	CONCLUSION: Tangeretin is a potent regioselective stimulator of midazolam 1"-hydroxylation by human liver microsomes and complementary deoxyribonucleic acid-expressed CYP3A4.	tangeretin	12-22	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	167-173