PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 26341180-7 2015 Levels of IL-4, IL-5, IL-13 and TNF-alpha were also elevated with TDI-induction. Toluene 2,4-Diisocyanate 66-69 interleukin 4 Mus musculus 10-14 19332649-8 2009 In the model of chemical-induced asthma, TDI induced a ventilatory response [increased Penh after challenge; increased airway hyperreactivity (AHR)], inflammatory changes (bronchoalveolar lavage neutrophils), and immunological changes (increased CD19(+) lymphocytes, IL-4 and total serum IgE), whereas TDA did not show any of these responses. Toluene 2,4-Diisocyanate 41-44 interleukin 4 Mus musculus 267-271 22371401-9 2012 LF had some stimulatory effect on the ex vivo content of IL-4 in lymphocytes in the immune response to TDI. Toluene 2,4-Diisocyanate 103-106 interleukin 4 Mus musculus 57-61 21299354-7 2011 In contrast, using an identical exposure regimen, animals topically exposed to the known respiratory (Type 1) allergen toluene 2,4-diisocyanate (TDI) showed significant expression of IL-4 and IL-10 mRNA compared to IFN? Toluene 2,4-Diisocyanate 127-143 interleukin 4 Mus musculus 183-187 21299354-7 2011 In contrast, using an identical exposure regimen, animals topically exposed to the known respiratory (Type 1) allergen toluene 2,4-diisocyanate (TDI) showed significant expression of IL-4 and IL-10 mRNA compared to IFN? Toluene 2,4-Diisocyanate 145-148 interleukin 4 Mus musculus 183-187 18708131-6 2008 TDI induced marked increases in levels of cytokines (IL-4, IL-10, IL-13, and IFN-gamma) produced by restimulated LN cells. Toluene 2,4-Diisocyanate 0-3 interleukin 4 Mus musculus 53-57 17693426-4 2007 Dermal application of hexylmethane diisocyanate (HMDI), toluene diisocyanate (TDI), or methylene diisocyanate (MDI) significantly increased interleukin-4 (IL-4), IL-5, and IL-13 secretion in parotid lymph node cells. Toluene 2,4-Diisocyanate 56-76 interleukin 4 Mus musculus 140-153 18571882-6 2008 TMA and TDI induced marked increases in levels of antigen-specific serum IgE and of Th2 cytokines (IL-4, IL-5, IL-10, and IL-13) produced by ex vivo restimulated lymph node cells. Toluene 2,4-Diisocyanate 8-11 interleukin 4 Mus musculus 99-103 17693426-4 2007 Dermal application of hexylmethane diisocyanate (HMDI), toluene diisocyanate (TDI), or methylene diisocyanate (MDI) significantly increased interleukin-4 (IL-4), IL-5, and IL-13 secretion in parotid lymph node cells. Toluene 2,4-Diisocyanate 56-76 interleukin 4 Mus musculus 155-159 17693426-4 2007 Dermal application of hexylmethane diisocyanate (HMDI), toluene diisocyanate (TDI), or methylene diisocyanate (MDI) significantly increased interleukin-4 (IL-4), IL-5, and IL-13 secretion in parotid lymph node cells. Toluene 2,4-Diisocyanate 78-81 interleukin 4 Mus musculus 140-153 17693426-4 2007 Dermal application of hexylmethane diisocyanate (HMDI), toluene diisocyanate (TDI), or methylene diisocyanate (MDI) significantly increased interleukin-4 (IL-4), IL-5, and IL-13 secretion in parotid lymph node cells. Toluene 2,4-Diisocyanate 78-81 interleukin 4 Mus musculus 155-159 17257216-13 2007 CONCLUSION: the clear elevation of IL-4 and IgE could allow to conclude a possible Th2-like dominated allergic response in TDI-exposed BALB/c mouse model. Toluene 2,4-Diisocyanate 123-126 interleukin 4 Mus musculus 35-39 16963530-11 2007 IL-4 and IFN-gamma levels were increased in supernatants of concanavalin A-stimulated auricular lymph node cells from BALB/c mice completely treated with TDI. Toluene 2,4-Diisocyanate 154-157 interleukin 4 Mus musculus 0-4 17015710-6 2006 This study with the TDI-induced model of asthma revealed the following typical pathophysiological features: increased numbers of inflammatory cells of the airways, airway hyperresponsiveness, increased levels of Th2 cytokines (IL-4, IL-5, and IL-13), adhesion molecules (ICAM-1 and VCAM-1), chemokines (RANTES and eotaxin), TGF-beta1, and NF-kappaB in nuclear protein extracts. Toluene 2,4-Diisocyanate 20-23 interleukin 4 Mus musculus 227-231 17641053-6 2007 TDI exposure elevated IL-4, IL-5, IL-13, and IFN-gamma mRNA expression in the nasal mucosa, suggesting a mixed Th1/Th2 immune response. Toluene 2,4-Diisocyanate 0-3 interleukin 4 Mus musculus 22-26 17662138-10 2007 Toluene diisocyanate treated interleukin-4 deficient mothers were able to transfer asthma risk to offspring. Toluene 2,4-Diisocyanate 0-20 interleukin 4 Mus musculus 29-42 21783593-9 2005 Mice were treated with DNCB and TDI showed an increase in the percentage of CD4+IL-4+ cells compared with vehicle and irritant-treated mice. Toluene 2,4-Diisocyanate 32-35 interleukin 4 Mus musculus 80-84