PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
22371401-9	2012	LF had some stimulatory effect on the ex vivo content of IL-4 in lymphocytes in the immune response to TDI.	Toluene 2,4-Diisocyanate	103-106	interleukin 4	Mus musculus	57-61	
26341180-7	2015	Levels of IL-4, IL-5, IL-13 and TNF-alpha were also elevated with TDI-induction.	Toluene 2,4-Diisocyanate	66-69	interleukin 4	Mus musculus	10-14	
21299354-7	2011	In contrast, using an identical exposure regimen, animals topically exposed to the known respiratory (Type 1) allergen toluene 2,4-diisocyanate (TDI) showed significant expression of IL-4 and IL-10 mRNA compared to IFN?	Toluene 2,4-Diisocyanate	127-143	interleukin 4	Mus musculus	183-187	
21299354-7	2011	In contrast, using an identical exposure regimen, animals topically exposed to the known respiratory (Type 1) allergen toluene 2,4-diisocyanate (TDI) showed significant expression of IL-4 and IL-10 mRNA compared to IFN?	Toluene 2,4-Diisocyanate	145-148	interleukin 4	Mus musculus	183-187	
18571882-6	2008	TMA and TDI induced marked increases in levels of antigen-specific serum IgE and of Th2 cytokines (IL-4, IL-5, IL-10, and IL-13) produced by ex vivo restimulated lymph node cells.	Toluene 2,4-Diisocyanate	8-11	interleukin 4	Mus musculus	99-103	
18708131-6	2008	TDI induced marked increases in levels of cytokines (IL-4, IL-10, IL-13, and IFN-gamma) produced by restimulated LN cells.	Toluene 2,4-Diisocyanate	0-3	interleukin 4	Mus musculus	53-57	
19332649-8	2009	In the model of chemical-induced asthma, TDI induced a ventilatory response [increased Penh after challenge; increased airway hyperreactivity (AHR)], inflammatory changes (bronchoalveolar lavage neutrophils), and immunological changes (increased CD19(+) lymphocytes, IL-4 and total serum IgE), whereas TDA did not show any of these responses.	Toluene 2,4-Diisocyanate	41-44	interleukin 4	Mus musculus	267-271	
17693426-4	2007	Dermal application of hexylmethane diisocyanate (HMDI), toluene diisocyanate (TDI), or methylene diisocyanate (MDI) significantly increased interleukin-4 (IL-4), IL-5, and IL-13 secretion in parotid lymph node cells.	Toluene 2,4-Diisocyanate	56-76	interleukin 4	Mus musculus	140-153	
17693426-4	2007	Dermal application of hexylmethane diisocyanate (HMDI), toluene diisocyanate (TDI), or methylene diisocyanate (MDI) significantly increased interleukin-4 (IL-4), IL-5, and IL-13 secretion in parotid lymph node cells.	Toluene 2,4-Diisocyanate	56-76	interleukin 4	Mus musculus	155-159	
17693426-4	2007	Dermal application of hexylmethane diisocyanate (HMDI), toluene diisocyanate (TDI), or methylene diisocyanate (MDI) significantly increased interleukin-4 (IL-4), IL-5, and IL-13 secretion in parotid lymph node cells.	Toluene 2,4-Diisocyanate	78-81	interleukin 4	Mus musculus	140-153	
17693426-4	2007	Dermal application of hexylmethane diisocyanate (HMDI), toluene diisocyanate (TDI), or methylene diisocyanate (MDI) significantly increased interleukin-4 (IL-4), IL-5, and IL-13 secretion in parotid lymph node cells.	Toluene 2,4-Diisocyanate	78-81	interleukin 4	Mus musculus	155-159	
17641053-6	2007	TDI exposure elevated IL-4, IL-5, IL-13, and IFN-gamma mRNA expression in the nasal mucosa, suggesting a mixed Th1/Th2 immune response.	Toluene 2,4-Diisocyanate	0-3	interleukin 4	Mus musculus	22-26	
17662138-10	2007	Toluene diisocyanate treated interleukin-4 deficient mothers were able to transfer asthma risk to offspring.	Toluene 2,4-Diisocyanate	0-20	interleukin 4	Mus musculus	29-42	
17257216-13	2007	CONCLUSION: the clear elevation of IL-4 and IgE could allow to conclude a possible Th2-like dominated allergic response in TDI-exposed BALB/c mouse model.	Toluene 2,4-Diisocyanate	123-126	interleukin 4	Mus musculus	35-39	
16963530-11	2007	IL-4 and IFN-gamma levels were increased in supernatants of concanavalin A-stimulated auricular lymph node cells from BALB/c mice completely treated with TDI.	Toluene 2,4-Diisocyanate	154-157	interleukin 4	Mus musculus	0-4	
21783593-9	2005	Mice were treated with DNCB and TDI showed an increase in the percentage of CD4+IL-4+ cells compared with vehicle and irritant-treated mice.	Toluene 2,4-Diisocyanate	32-35	interleukin 4	Mus musculus	80-84	
17015710-6	2006	This study with the TDI-induced model of asthma revealed the following typical pathophysiological features: increased numbers of inflammatory cells of the airways, airway hyperresponsiveness, increased levels of Th2 cytokines (IL-4, IL-5, and IL-13), adhesion molecules (ICAM-1 and VCAM-1), chemokines (RANTES and eotaxin), TGF-beta1, and NF-kappaB in nuclear protein extracts.	Toluene 2,4-Diisocyanate	20-23	interleukin 4	Mus musculus	227-231