PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 25602258-1 2015 BACKGROUND: NAD(P)H: quinone oxidoreductase 1 (NQO1), an obligate two-electron reductase, plays an important role in reducing reactive quinones to less reactive and less toxic hydroquinones. Quinones 136-144 NAD(P)H quinone dehydrogenase 1 Homo sapiens 48-52 25602258-1 2015 BACKGROUND: NAD(P)H: quinone oxidoreductase 1 (NQO1), an obligate two-electron reductase, plays an important role in reducing reactive quinones to less reactive and less toxic hydroquinones. Quinones 136-144 NAD(P)H quinone dehydrogenase 1 Homo sapiens 13-46 24074361-1 2013 NAD(P)H: quinone oxidoreductase (NQO1) and NRH:quinone oxidoreductase 2 (NQO2) catalyze the two-electron reduction of quinones and thereby prevent generation of toxic radicals. Quinones 118-126 NAD(P)H quinone dehydrogenase 1 Homo sapiens 33-37 24830960-4 2014 NQO1 catalyzes the two-electron reduction of quinones to hydroquinones, thereby preventing the formation of ROS. Quinones 45-53 NAD(P)H quinone dehydrogenase 1 Homo sapiens 0-4 24552538-1 2014 NAD(P)H: quinone oxidoreductase 1 (NQO1) is an enzyme capable of reducing a broad range of chemically reactive quinones and quinoneimines (QIs) and can be strongly upregulated by Nrf2/Keap1-mediated stress responses. Quinones 111-119 NAD(P)H quinone dehydrogenase 1 Homo sapiens 0-33 24552538-1 2014 NAD(P)H: quinone oxidoreductase 1 (NQO1) is an enzyme capable of reducing a broad range of chemically reactive quinones and quinoneimines (QIs) and can be strongly upregulated by Nrf2/Keap1-mediated stress responses. Quinones 111-119 NAD(P)H quinone dehydrogenase 1 Homo sapiens 35-39 24074361-3 2013 Based on similar structural features of quinones and QMs, it is logical to assume that NQO1 and/or NQO2 could also catalyze the two-electron reduction of QMs. Quinones 40-48 NAD(P)H quinone dehydrogenase 1 Homo sapiens 87-91 23937670-4 2013 In normal cells NQO1 is inducibly expressed, and its major role is to detoxify quinones via bioreduction; however, certain quinones become more toxic after reduction by NQO1, and these compounds have potential as selective anticancer agents. Quinones 79-87 NAD(P)H quinone dehydrogenase 1 Homo sapiens 16-20 23937670-4 2013 In normal cells NQO1 is inducibly expressed, and its major role is to detoxify quinones via bioreduction; however, certain quinones become more toxic after reduction by NQO1, and these compounds have potential as selective anticancer agents. Quinones 123-131 NAD(P)H quinone dehydrogenase 1 Homo sapiens 16-20 23937670-4 2013 In normal cells NQO1 is inducibly expressed, and its major role is to detoxify quinones via bioreduction; however, certain quinones become more toxic after reduction by NQO1, and these compounds have potential as selective anticancer agents. Quinones 123-131 NAD(P)H quinone dehydrogenase 1 Homo sapiens 169-173 23937670-7 2013 Here, we directly compare these quinones as substrates for NQO1 in vitro, and for their ability to kill cancer cells in culture in an NQO1-dependent manner. Quinones 32-40 NAD(P)H quinone dehydrogenase 1 Homo sapiens 59-63 23937670-7 2013 Here, we directly compare these quinones as substrates for NQO1 in vitro, and for their ability to kill cancer cells in culture in an NQO1-dependent manner. Quinones 32-40 NAD(P)H quinone dehydrogenase 1 Homo sapiens 134-138 23635904-1 2013 A series of heterocyclic quinones based on benzofuran, benzothiophene, indazole and benzisoxazole has been synthesized, and evaluated for their ability to function as substrates for recombinant human NAD(P)H:quinone oxidoreductase (NQO1), a two-electron reductase upregulated in tumor cells. Quinones 25-33 NAD(P)H quinone dehydrogenase 1 Homo sapiens 232-236 23635904-2 2013 Overall, the quinones are excellent substrates for NQO1, approaching the reduction rates observed for menadione. Quinones 13-21 NAD(P)H quinone dehydrogenase 1 Homo sapiens 51-55 22687461-6 2012 Further investigation revealed that there was an upregulation of NAD(P)H: quinone oxidoreductase 1 (NQO1), a detoxification enzyme for benzene-derived quinones, in W7.2 rfau cells. Quinones 151-159 NAD(P)H quinone dehydrogenase 1 Homo sapiens 65-98 22687461-6 2012 Further investigation revealed that there was an upregulation of NAD(P)H: quinone oxidoreductase 1 (NQO1), a detoxification enzyme for benzene-derived quinones, in W7.2 rfau cells. Quinones 151-159 NAD(P)H quinone dehydrogenase 1 Homo sapiens 100-104 22209713-0 2012 NAD(P)H:quinone oxidoreductase 1 (NQO1) in the sensitivity and resistance to antitumor quinones. Quinones 87-95 NAD(P)H quinone dehydrogenase 1 Homo sapiens 0-32 22736108-2 2012 NADPH:quinone oxidoreductase 1 (NQO1) and NRH:quinone oxidoreductase 2 (NQO2) are phase II cytosolic enzymes that catalyze metabolism of quinones, important in the detoxification of environmental carcinogens. Quinones 137-145 NAD(P)H quinone dehydrogenase 1 Homo sapiens 32-36 22793692-1 2012 NAD(P)H:quinone-oxidoreductase-1 (NQO1) is a cytosolic enzyme that catalyzes the reduction of various quinones using flavin adenine dinucleotide (FAD) as a cofactor. Quinones 102-110 NAD(P)H quinone dehydrogenase 1 Homo sapiens 0-32 22793692-1 2012 NAD(P)H:quinone-oxidoreductase-1 (NQO1) is a cytosolic enzyme that catalyzes the reduction of various quinones using flavin adenine dinucleotide (FAD) as a cofactor. Quinones 102-110 NAD(P)H quinone dehydrogenase 1 Homo sapiens 34-38 21947872-1 2012 NAD(P)H: quinone oxidoreductase 1 (NQO1) is a ubiquitous flavoenzyme that catalyzes two-electron reduction of various quinones by utilizing NAD(P)H as an electron donor. Quinones 118-126 NAD(P)H quinone dehydrogenase 1 Homo sapiens 0-33 21947872-1 2012 NAD(P)H: quinone oxidoreductase 1 (NQO1) is a ubiquitous flavoenzyme that catalyzes two-electron reduction of various quinones by utilizing NAD(P)H as an electron donor. Quinones 118-126 NAD(P)H quinone dehydrogenase 1 Homo sapiens 35-39 22586705-1 2012 Human NAD(P)H: quinone oxidoreductase 1 (NQO1) catalyzes the obligatory two-electron reduction of quinones. Quinones 98-106 NAD(P)H quinone dehydrogenase 1 Homo sapiens 6-39 22586705-1 2012 Human NAD(P)H: quinone oxidoreductase 1 (NQO1) catalyzes the obligatory two-electron reduction of quinones. Quinones 98-106 NAD(P)H quinone dehydrogenase 1 Homo sapiens 41-45 22209713-9 2012 Despite a large volume of preclinical data demonstrating that NQO1 is an important determinant of sensitivity to these antitumor quinones there is little information on whether the clinical response to these agents is influenced by the NQO1*2 polymorphism. Quinones 129-137 NAD(P)H quinone dehydrogenase 1 Homo sapiens 62-66 22209713-0 2012 NAD(P)H:quinone oxidoreductase 1 (NQO1) in the sensitivity and resistance to antitumor quinones. Quinones 87-95 NAD(P)H quinone dehydrogenase 1 Homo sapiens 34-38 22209713-3 2012 The two-electron reduction of quinones by NQO1 has been shown to be an efficient pathway to hydroquinone formation. Quinones 30-38 NAD(P)H quinone dehydrogenase 1 Homo sapiens 42-46 22209713-6 2012 Individuals homozygous for the NQO1*2 allele are NQO1 null and homozygous NQO1*2*2 cell lines have been shown to be more resistant to antitumor quinones when compared to isogenic cell lines overexpressing NQO1. Quinones 144-152 NAD(P)H quinone dehydrogenase 1 Homo sapiens 31-35 19941840-5 2010 NQO1 may also impact pathways in addition to metabolism of quinones due to protein-protein interactions or other mechanisms related to NQO1 activity. Quinones 59-67 NAD(P)H quinone dehydrogenase 1 Homo sapiens 0-4 22984577-1 2012 NAD(P)H:quinone oxidoreductase 1 (NQO1) is an FAD containing quinone reductase that catalyzes the 2-electron reduction of a broad range of quinones. Quinones 139-147 NAD(P)H quinone dehydrogenase 1 Homo sapiens 34-38 22984577-2 2012 The 2-electron reduction of quinones to hydroquinones by NQO1 is believed to be a detoxification process since this reaction bypasses the formation of the highly reactive semiquinone. Quinones 28-36 NAD(P)H quinone dehydrogenase 1 Homo sapiens 57-61 21843634-1 2011 NAD(P)H:quinone oxidoreductase (NQO1)-mediated detoxification of quinones plays a critical role in cancer prevention. Quinones 65-73 NAD(P)H quinone dehydrogenase 1 Homo sapiens 32-36 21733125-1 2011 NAD(P)H: quinone oxidoreductase1 (NQO1) is an important detoxification enzyme that can protect mammalian cells against toxic quinones and reduce the risk of tumorigenesis. Quinones 125-133 NAD(P)H quinone dehydrogenase 1 Homo sapiens 0-32 21733125-1 2011 NAD(P)H: quinone oxidoreductase1 (NQO1) is an important detoxification enzyme that can protect mammalian cells against toxic quinones and reduce the risk of tumorigenesis. Quinones 125-133 NAD(P)H quinone dehydrogenase 1 Homo sapiens 34-38 20970411-2 2011 NQO1 plays an important role in detoxification of benzene-derived quinones but plays a role in numerous other non-metabolic cellular functions. Quinones 66-74 NAD(P)H quinone dehydrogenase 1 Homo sapiens 0-4 21479364-1 2011 NAD(P)H:quinone oxidoreductase 1 (NQO1), is a cytosolic flavoenzyme that catalyzes the two-electron reduction of quinones into hydroquinones. Quinones 113-121 NAD(P)H quinone dehydrogenase 1 Homo sapiens 0-32 21479364-1 2011 NAD(P)H:quinone oxidoreductase 1 (NQO1), is a cytosolic flavoenzyme that catalyzes the two-electron reduction of quinones into hydroquinones. Quinones 113-121 NAD(P)H quinone dehydrogenase 1 Homo sapiens 34-38 20361926-1 2010 NAD(P)H:quinone acceptor oxidoreductase 1 (NQO1) is a widely-distributed FAD-dependent flavoprotein that promotes obligatory 2-electron reductions of quinones, quinoneimines, nitroaromatics, and azo dyes, at rates that are comparable with NADH or NADPH. Quinones 150-158 NAD(P)H quinone dehydrogenase 1 Homo sapiens 0-41 20361926-1 2010 NAD(P)H:quinone acceptor oxidoreductase 1 (NQO1) is a widely-distributed FAD-dependent flavoprotein that promotes obligatory 2-electron reductions of quinones, quinoneimines, nitroaromatics, and azo dyes, at rates that are comparable with NADH or NADPH. Quinones 150-158 NAD(P)H quinone dehydrogenase 1 Homo sapiens 43-47 20382756-9 2010 This study will help to guide future studies on characterizing the NQO1-mediated reduction and subsequent glucuronidation of other quinones. Quinones 131-139 NAD(P)H quinone dehydrogenase 1 Homo sapiens 67-71 22984577-1 2012 NAD(P)H:quinone oxidoreductase 1 (NQO1) is an FAD containing quinone reductase that catalyzes the 2-electron reduction of a broad range of quinones. Quinones 139-147 NAD(P)H quinone dehydrogenase 1 Homo sapiens 0-32 20226854-2 2010 NQO1 is mainly a cytosolic enzyme which catalyzes the metabolism of quinones and is present in almost all tissue types providing protection against different stresses including xenobiotics, oxidants, UV light, and ionizing radiation. Quinones 68-76 NAD(P)H quinone dehydrogenase 1 Homo sapiens 0-4 20204281-1 2010 NAD(P)H:quinone oxidoreductase 1 (NQO1) is a key enzyme involved in metabolism of quinones and may perform multiple functions within the cell. Quinones 82-90 NAD(P)H quinone dehydrogenase 1 Homo sapiens 0-32 20204281-1 2010 NAD(P)H:quinone oxidoreductase 1 (NQO1) is a key enzyme involved in metabolism of quinones and may perform multiple functions within the cell. Quinones 82-90 NAD(P)H quinone dehydrogenase 1 Homo sapiens 34-38 19362588-7 2009 On oxidation, polyphenols with B-ring catechol functionality form toxic alkylating quinones that are normally inactivated by cellular antioxidant defense and redox maintenance systems, including reduction by ascorbate and NAD(P)H:quinone oxidoreductase 1 (NQO1). Quinones 83-91 NAD(P)H quinone dehydrogenase 1 Homo sapiens 222-254 19628038-2 2009 NAD(P)H:quinone oxidoreductase 1 (NQO1) reduces these quinones back to catechols, and thus may protect against this mechanism. Quinones 54-62 NAD(P)H quinone dehydrogenase 1 Homo sapiens 0-32 19628038-2 2009 NAD(P)H:quinone oxidoreductase 1 (NQO1) reduces these quinones back to catechols, and thus may protect against this mechanism. Quinones 54-62 NAD(P)H quinone dehydrogenase 1 Homo sapiens 34-38 19362588-7 2009 On oxidation, polyphenols with B-ring catechol functionality form toxic alkylating quinones that are normally inactivated by cellular antioxidant defense and redox maintenance systems, including reduction by ascorbate and NAD(P)H:quinone oxidoreductase 1 (NQO1). Quinones 83-91 NAD(P)H quinone dehydrogenase 1 Homo sapiens 256-260 18374190-2 2008 The main function of QR1 is probably the detoxification of dietary quinones but it may also contribute to the reduction of vitamin K for its involvement in blood coagulation. Quinones 67-75 NAD(P)H quinone dehydrogenase 1 Homo sapiens 21-24 18996184-1 2009 The physiological function of NAD(P)H:quinone oxidoreductase (NQO1, DT-diaphorase) is to detoxify potentially reactive quinones by direct transfer of two electrons. Quinones 119-127 NAD(P)H quinone dehydrogenase 1 Homo sapiens 62-66 18996184-1 2009 The physiological function of NAD(P)H:quinone oxidoreductase (NQO1, DT-diaphorase) is to detoxify potentially reactive quinones by direct transfer of two electrons. Quinones 119-127 NAD(P)H quinone dehydrogenase 1 Homo sapiens 68-81 18996184-10 2009 Preliminary kinetic studies show that NQO2 is faster in reducing estrogen quinones than its homologue NQO1. Quinones 74-82 NAD(P)H quinone dehydrogenase 1 Homo sapiens 102-106 18254726-3 2008 Initially, QR2 was believed to function analogously to QR1 in protecting cells from highly reactive quinones. Quinones 100-108 NAD(P)H quinone dehydrogenase 1 Homo sapiens 55-58 18423374-7 2008 The results suggest possible detoxification pathways for quinones via NQO1 reduction followed by UGT glucuronidation. Quinones 57-65 NAD(P)H quinone dehydrogenase 1 Homo sapiens 70-74 18253865-2 2008 NAD(P)H:quinone oxidoreductase 1 (NQO1) catalyzes the two-electron reduction of quinones, preventing their participation in redox cycling and subsequent generation of reactive oxygen species. Quinones 80-88 NAD(P)H quinone dehydrogenase 1 Homo sapiens 0-32 18253865-2 2008 NAD(P)H:quinone oxidoreductase 1 (NQO1) catalyzes the two-electron reduction of quinones, preventing their participation in redox cycling and subsequent generation of reactive oxygen species. Quinones 80-88 NAD(P)H quinone dehydrogenase 1 Homo sapiens 34-38 18264564-0 2008 Natural and synthetic quinones and their reduction by the quinone reductase enzyme NQO1: from synthetic organic chemistry to compounds with anticancer potential. Quinones 22-30 NAD(P)H quinone dehydrogenase 1 Homo sapiens 83-87 18264564-1 2008 The quinone reductase enzyme NAD(P)H: quinone oxidoreductase 1 (NQO1) is a ubiquitous flavoenzyme that catalyzes the two-electron reduction of quinones. Quinones 143-151 NAD(P)H quinone dehydrogenase 1 Homo sapiens 29-62 18264564-1 2008 The quinone reductase enzyme NAD(P)H: quinone oxidoreductase 1 (NQO1) is a ubiquitous flavoenzyme that catalyzes the two-electron reduction of quinones. Quinones 143-151 NAD(P)H quinone dehydrogenase 1 Homo sapiens 64-68 18264564-2 2008 This Perspective briefly reviews the structure and mechanism, physiological role, and upregulation and induction of the enzyme, but focuses on the synthesis of new heterocyclic quinones and their metabolism by recombinant human NQO1. Quinones 177-185 NAD(P)H quinone dehydrogenase 1 Homo sapiens 228-232 19096102-1 2008 Two-electron reduction of quinones catalyzed by NAD(P)H:quinone oxidoreductase (NQO1) protects cells against oxidative stress and toxic quinones. Quinones 26-34 NAD(P)H quinone dehydrogenase 1 Homo sapiens 80-84 19096102-1 2008 Two-electron reduction of quinones catalyzed by NAD(P)H:quinone oxidoreductase (NQO1) protects cells against oxidative stress and toxic quinones. Quinones 136-144 NAD(P)H quinone dehydrogenase 1 Homo sapiens 80-84 19096102-2 2008 In fact, low level of NQO1 activity is often associated with increased risk of developing different types of tumours and with toxic effects linked to environmental quinones. Quinones 164-172 NAD(P)H quinone dehydrogenase 1 Homo sapiens 22-26 18374190-3 2008 In addition, the same reaction that QR1 uses in the detoxification of quinones, activates some compounds making them cytotoxic. Quinones 70-78 NAD(P)H quinone dehydrogenase 1 Homo sapiens 36-39 17546202-5 2007 A comparison of X-ray data of PETNR, mammalian NAD(P)H : quinone oxidoreductase (NQO1), and Enterobacter cloacae nitroreductase, which reduce quinones in a two-electron way, and their reactivity revealed that PETNR is much less reactive, and much less sensitive to the quinone substrate steric effects than NQO1. Quinones 142-150 NAD(P)H quinone dehydrogenase 1 Homo sapiens 81-85 17975886-2 2007 Drugs bioactivated to quinones have the potential to activate antioxidant/electrophile responsive element (ARE) transcription of genes for cytoprotective phase 2 enzymes such as NAD(P)H-dependent quinone oxidoreductase (NQO1) but can also cause cellular damage. Quinones 22-30 NAD(P)H quinone dehydrogenase 1 Homo sapiens 220-224 17971996-2 2007 The ability of these heterocyclic quinones to act as substrates for recombinant human NAD(P)H:quinone oxidoreductase (NQO1), a two-electron reductase upregulated in tumour cells, was determined. Quinones 34-42 NAD(P)H quinone dehydrogenase 1 Homo sapiens 118-122 17971996-3 2007 Overall, the quinones were excellent substrates for NQO1. Quinones 13-21 NAD(P)H quinone dehydrogenase 1 Homo sapiens 52-56 17893042-0 2007 Evidence from ESI-MS for NQO1-catalyzed reduction of estrogen ortho-quinones. Quinones 68-76 NAD(P)H quinone dehydrogenase 1 Homo sapiens 25-29 17893042-3 2007 In this investigation, we were successful in circumventing the problem of nonenzymatic reduction of estrogen quinone by NAD(P)H, which led to the above conclusion, and for the first time we show that NQO1 catalyzes the reduction of estrogen quinones. Quinones 241-249 NAD(P)H quinone dehydrogenase 1 Homo sapiens 200-204 17893042-11 2007 Thus, clear evidence for the catalytic reduction of estrogen ortho-quinones by NQO1 has been obtained; its mechanism and implications are discussed. Quinones 67-75 NAD(P)H quinone dehydrogenase 1 Homo sapiens 79-83 17546202-5 2007 A comparison of X-ray data of PETNR, mammalian NAD(P)H : quinone oxidoreductase (NQO1), and Enterobacter cloacae nitroreductase, which reduce quinones in a two-electron way, and their reactivity revealed that PETNR is much less reactive, and much less sensitive to the quinone substrate steric effects than NQO1. Quinones 142-150 NAD(P)H quinone dehydrogenase 1 Homo sapiens 307-311 16700548-1 2006 NAD(P)H quinone oxidoreductase 1 (NQO1) is a ubiquitous flavoenzyme that catalyzes two-electron reduction of quinones to hydroquinones utilizing NAD(P)H as an electron donor. Quinones 109-117 NAD(P)H quinone dehydrogenase 1 Homo sapiens 0-32 17009925-5 2007 These reductases often show broad and overlapping substrate specificities and some well-characterized members, e.g., carbonyl reductase (CBR1) or NADPH-quinone reductase (NQO1) have protective roles toward xenobiotic carbonyls and quinones because metabolic reduction leads to less toxic products, which can be further metabolized and excreted. Quinones 231-239 NAD(P)H quinone dehydrogenase 1 Homo sapiens 171-175 17396564-1 2007 Phytogenous flavonoid-containing agents (PFCA) are able to initiate electron flow bypassing the NAD-dependent region of respiratory chain, which is related with the activity of DT-diaphorase catalyzing two-electron reduction of quinones to hydroquinones and hydrogen peroxide in the presence of NADH and oxygen. Quinones 228-236 NAD(P)H quinone dehydrogenase 1 Homo sapiens 177-190 16978807-1 2006 NAD(P)H quinone oxidoreductase 1 (NQO1) can metabolize dopamine-derived quinones (DAQ) and absence of NQO1 due to the NQO1*2 polymorphism has been suggested to be a risk factor for Parkinson"s disease. Quinones 72-80 NAD(P)H quinone dehydrogenase 1 Homo sapiens 0-32 16978807-1 2006 NAD(P)H quinone oxidoreductase 1 (NQO1) can metabolize dopamine-derived quinones (DAQ) and absence of NQO1 due to the NQO1*2 polymorphism has been suggested to be a risk factor for Parkinson"s disease. Quinones 72-80 NAD(P)H quinone dehydrogenase 1 Homo sapiens 34-38 16314070-1 2006 NAD(P)H:quinone oxidoreductase (NQO1)-mediated detoxification of quinones is suggested to be involved in cancer prevention. Quinones 65-73 NAD(P)H quinone dehydrogenase 1 Homo sapiens 32-36 16818284-1 2006 NAD(P)H:quinone oxidoreductase (NQO1) detoxifies quinones. Quinones 49-57 NAD(P)H quinone dehydrogenase 1 Homo sapiens 32-36 16700548-1 2006 NAD(P)H quinone oxidoreductase 1 (NQO1) is a ubiquitous flavoenzyme that catalyzes two-electron reduction of quinones to hydroquinones utilizing NAD(P)H as an electron donor. Quinones 109-117 NAD(P)H quinone dehydrogenase 1 Homo sapiens 34-38 16003741-1 2005 NAD(P)H:quinone oxidoreductase (NQO1) functions as an important part of cellular antioxidant defense by detoxifying quinones, thus preventing the formation of reactive oxygen species (ROS). Quinones 116-124 NAD(P)H quinone dehydrogenase 1 Homo sapiens 32-36 16253210-2 2005 Because of its sequence homology with quinone reductase 1, it has been suspected to detoxify quinones. Quinones 93-101 NAD(P)H quinone dehydrogenase 1 Homo sapiens 38-57 16142378-5 2005 In addition, catechol estrogen quinones can be reduced back to catechol estrogens by NADPH quinone oxidoreductase 1 (NQO1) and/or are coupled with glutathione, preventing reaction with DNA. Quinones 31-39 NAD(P)H quinone dehydrogenase 1 Homo sapiens 85-115 16142378-5 2005 In addition, catechol estrogen quinones can be reduced back to catechol estrogens by NADPH quinone oxidoreductase 1 (NQO1) and/or are coupled with glutathione, preventing reaction with DNA. Quinones 31-39 NAD(P)H quinone dehydrogenase 1 Homo sapiens 117-121 15245776-1 2004 DT-diaphorase (DTD) is an obligate two-electron reductase which bioactivates chemotherapeutic quinones. Quinones 94-102 NAD(P)H quinone dehydrogenase 1 Homo sapiens 0-13 15665137-1 2005 Structure-based development of NAD(P)H:quinone oxidoreductase (NQO1)-directed antitumor quinones resulted in development of RH1 [2,5-diaziridinyl-3-(hydroxymethyl)-6-methyl-1,4-benzoquinone], a methyl-substituted diaziridinyl quinone. Quinones 88-96 NAD(P)H quinone dehydrogenase 1 Homo sapiens 63-67 15746574-2 2005 Previous studies have shown a significant statistical correlation between NQO1 enzymatic activity and the cytotoxicity of certain antitumor quinones. Quinones 140-148 NAD(P)H quinone dehydrogenase 1 Homo sapiens 74-78 15618957-1 2005 NAD(P)H:quinone oxidoreductase 1 (NQO1) is a detoxification enzyme that protects cells against oxidative stress and toxic quinones. Quinones 122-130 NAD(P)H quinone dehydrogenase 1 Homo sapiens 0-32 15618957-1 2005 NAD(P)H:quinone oxidoreductase 1 (NQO1) is a detoxification enzyme that protects cells against oxidative stress and toxic quinones. Quinones 122-130 NAD(P)H quinone dehydrogenase 1 Homo sapiens 34-38 15476858-3 2004 Firstly, the catalytic activity of NQO1 is directed towards the complete reduction and detoxication of highly reactive quinones. Quinones 119-127 NAD(P)H quinone dehydrogenase 1 Homo sapiens 35-39 15382274-1 2004 BACKGROUND: NAD(P)H:quinone oxidoreductase1 (NQO1) is a two-electron reductase that detoxifies quinones derived from the oxidation of phenolic metabolites of benzene. Quinones 95-103 NAD(P)H quinone dehydrogenase 1 Homo sapiens 12-43 15382274-1 2004 BACKGROUND: NAD(P)H:quinone oxidoreductase1 (NQO1) is a two-electron reductase that detoxifies quinones derived from the oxidation of phenolic metabolites of benzene. Quinones 95-103 NAD(P)H quinone dehydrogenase 1 Homo sapiens 45-49 15694256-2 2005 The quinone oxidoreductases, nicotinamide adenine dinucleotide (phosphate) (NAD[P]H): quinone oxidoreductase 1 (NQO1) and dihydronicotinamide riboside (NRH): quinone oxidoreductase 2 (NQO2) detoxify quinones and quinonoid compounds. Quinones 199-207 NAD(P)H quinone dehydrogenase 1 Homo sapiens 112-116 15554240-2 2004 NQO1 has long been viewed as a chemoprotective enzyme involved in cellular defense against the electrophilic and oxidizing metabolites of xenobiotic quinones. Quinones 149-157 NAD(P)H quinone dehydrogenase 1 Homo sapiens 0-4 15554240-8 2004 Polymorphisms in NQO1 which have profound influence on phenotype such as the NQO1*2 polymorphism may influence the chemoprotective actions of NQO1, and should be considered when NQO1-directed antitumor quinones are used for therapy in patients. Quinones 202-210 NAD(P)H quinone dehydrogenase 1 Homo sapiens 17-21 15554240-8 2004 Polymorphisms in NQO1 which have profound influence on phenotype such as the NQO1*2 polymorphism may influence the chemoprotective actions of NQO1, and should be considered when NQO1-directed antitumor quinones are used for therapy in patients. Quinones 202-210 NAD(P)H quinone dehydrogenase 1 Homo sapiens 77-81 15554240-8 2004 Polymorphisms in NQO1 which have profound influence on phenotype such as the NQO1*2 polymorphism may influence the chemoprotective actions of NQO1, and should be considered when NQO1-directed antitumor quinones are used for therapy in patients. Quinones 202-210 NAD(P)H quinone dehydrogenase 1 Homo sapiens 77-81 15554240-8 2004 Polymorphisms in NQO1 which have profound influence on phenotype such as the NQO1*2 polymorphism may influence the chemoprotective actions of NQO1, and should be considered when NQO1-directed antitumor quinones are used for therapy in patients. Quinones 202-210 NAD(P)H quinone dehydrogenase 1 Homo sapiens 77-81 15240547-1 2004 PURPOSE: NAD(P)H: quinone oxidoreductase (NQO(1)) catalyzes the two-electron reduction of quinones to hydroquinones. Quinones 91-99 NAD(P)H quinone dehydrogenase 1 Homo sapiens 43-49 15131056-8 2004 The toxicity of the NQO1-directed antitumor quinones RH1 and streptonigrin were markedly greater and the toxicity of menadione, which is detoxified by NQO1, was ameliorated in the NQ16 line. Quinones 44-52 NAD(P)H quinone dehydrogenase 1 Homo sapiens 20-24 15131056-11 2004 CONCLUSIONS: The MDA468/NQ16 isogenic cell line pair is a useful model system for evaluating the role of NQO1 in the bioactivation of antitumor quinones in both cell lines and xenografts. Quinones 144-152 NAD(P)H quinone dehydrogenase 1 Homo sapiens 105-109 15028260-9 2004 Quinones that are good substrates for hNQO1 are more toxic to the NQO1 containing or expressing cell lines (H460 and BE-NQ) than the NQO1 deficient cell lines (H596 and BE-WT). Quinones 0-8 NAD(P)H quinone dehydrogenase 1 Homo sapiens 38-43 15028260-9 2004 Quinones that are good substrates for hNQO1 are more toxic to the NQO1 containing or expressing cell lines (H460 and BE-NQ) than the NQO1 deficient cell lines (H596 and BE-WT). Quinones 0-8 NAD(P)H quinone dehydrogenase 1 Homo sapiens 39-43 15028260-9 2004 Quinones that are good substrates for hNQO1 are more toxic to the NQO1 containing or expressing cell lines (H460 and BE-NQ) than the NQO1 deficient cell lines (H596 and BE-WT). Quinones 0-8 NAD(P)H quinone dehydrogenase 1 Homo sapiens 66-70 14500388-1 2003 NADPH:quinone oxidoreductase (NQO(1)), a homodimeric, ubiquitous, flavoprotein, catalyzes the two-electron reduction of quinones to hydroquinones. Quinones 120-128 NAD(P)H quinone dehydrogenase 1 Homo sapiens 30-36 12859987-4 2003 The reactivity of quinones towards NQO1 did not depend on their E(1)7. Quinones 18-26 NAD(P)H quinone dehydrogenase 1 Homo sapiens 35-39 11809856-1 2002 NAD(P)H:quinone oxidoreductase (NQO1) and dihydronicotinamide riboside:quinone oxidoreductases (NQO2) are cytosolic flavoproteins that catalyze the two-electron reduction of quinones and quinoid compounds to hydroquinones, thereby promoting detoxification and preventing the formation of highly reactive oxygen species, which lead to DNA and cell damage. Quinones 174-182 NAD(P)H quinone dehydrogenase 1 Homo sapiens 32-36 12663042-3 2003 Two statistically correlated groups of quinones can be discerned: positive-correlated compounds, which are more active in cell lines expressing high baseline levels of BAD protein and NQO1 activity (e.g. the MCF-7 breast carcinoma), and negative-correlated compounds, which are more active in cell lines with undetectable levels of BAD and NQO1 activity (e.g. the HL-60 myeloid leukemia). Quinones 39-47 NAD(P)H quinone dehydrogenase 1 Homo sapiens 184-188 12663042-3 2003 Two statistically correlated groups of quinones can be discerned: positive-correlated compounds, which are more active in cell lines expressing high baseline levels of BAD protein and NQO1 activity (e.g. the MCF-7 breast carcinoma), and negative-correlated compounds, which are more active in cell lines with undetectable levels of BAD and NQO1 activity (e.g. the HL-60 myeloid leukemia). Quinones 39-47 NAD(P)H quinone dehydrogenase 1 Homo sapiens 340-344 12590933-5 2003 Ninety percent of H(2)O(2) generation by both the quinones can be prevented by dicumarol, an inhibitor of NAD(P)H quinone oxidoreductase (NQO1), at the submicromolar level, regardless of the quinone concentrations. Quinones 50-58 NAD(P)H quinone dehydrogenase 1 Homo sapiens 138-142 11882782-1 2002 NAD(P)H:quinone oxidoreductase (NQO1) catalyzes the two- or four-electron reduction of numerous endogenous and environmental quinones (e.g., the vitamin E alpha-tocopherol quinone, menadione, benzene quinones). Quinones 125-133 NAD(P)H quinone dehydrogenase 1 Homo sapiens 32-36 12834817-1 2003 NAD(P)H: quinone oxidoreductase (NQO1), an obligate two-electron reductase of quinones, prevents their participation in redox cycling and subsequent generation of reactive oxygen species (ROS). Quinones 78-86 NAD(P)H quinone dehydrogenase 1 Homo sapiens 33-37 12590585-1 2003 NAD(P)H/quinone acceptor oxidoreductase type 1 (QR1) protects cells from cytotoxic and neoplastic effects of quinones though two-electron reduction. Quinones 109-117 NAD(P)H quinone dehydrogenase 1 Homo sapiens 0-46 12590585-1 2003 NAD(P)H/quinone acceptor oxidoreductase type 1 (QR1) protects cells from cytotoxic and neoplastic effects of quinones though two-electron reduction. Quinones 109-117 NAD(P)H quinone dehydrogenase 1 Homo sapiens 48-51 12590585-4 2003 The experimental and theoretical studies independently support a model in which quinones (with one to three fused aromatic rings) bind in the QR1 active site utilizing a pi-stacking interaction with the isoalloxazine ring of the FAD cofactor. Quinones 80-88 NAD(P)H quinone dehydrogenase 1 Homo sapiens 142-145 12052210-3 2002 Small molecular modifications can substantially reduce specificity for DT-diaphorase and under these circumstances the quinones become much less toxic in air but retain their potent cytotoxic effects under hypoxic conditions. Quinones 119-127 NAD(P)H quinone dehydrogenase 1 Homo sapiens 71-84 11701227-1 2001 NAD(P)H:quinone oxidoreductase 1 (NQO1) participates in the detoxification of many environmental quinones and related compounds. Quinones 97-105 NAD(P)H quinone dehydrogenase 1 Homo sapiens 0-32 11810042-9 2002 NQO1 results suggest that different quinones (possibly estrogenic quinone metabolites) might affect the histological development of breast tumors. Quinones 36-44 NAD(P)H quinone dehydrogenase 1 Homo sapiens 0-4 11701227-1 2001 NAD(P)H:quinone oxidoreductase 1 (NQO1) participates in the detoxification of many environmental quinones and related compounds. Quinones 97-105 NAD(P)H quinone dehydrogenase 1 Homo sapiens 34-38 11688992-2 2001 Phase II detoxification enzymes such as glutathione S-transferase M1 (GSTM1), NAD(P)H:quinone oxidoreductase 1 (NQO1) and dihydronicotinamide riboside (NRH):quinone oxidoreductase 2 (NQO2) are important as cellular defenses against catecholamine-derived quinones and the oxidative stress that arises as a consequence of their metabolism. Quinones 254-262 NAD(P)H quinone dehydrogenase 1 Homo sapiens 78-110 11688992-2 2001 Phase II detoxification enzymes such as glutathione S-transferase M1 (GSTM1), NAD(P)H:quinone oxidoreductase 1 (NQO1) and dihydronicotinamide riboside (NRH):quinone oxidoreductase 2 (NQO2) are important as cellular defenses against catecholamine-derived quinones and the oxidative stress that arises as a consequence of their metabolism. Quinones 254-262 NAD(P)H quinone dehydrogenase 1 Homo sapiens 112-116 11563930-4 2001 Metabolism of the quinones by NQO1 revealed that, in general, compounds with electron-withdrawing groups at the indole 3-position were among the best substrates, and that groups larger than methyl at N-1 are clearly tolerated. Quinones 18-26 NAD(P)H quinone dehydrogenase 1 Homo sapiens 30-34 11309386-1 2001 NAD(P)H:quinone oxidoreductase 1 (NQO1) is a flavoprotein that utilizes NAD(P)H as an electron donor, catalyzing the two-electron reduction and detoxification of quinones and their derivatives. Quinones 162-170 NAD(P)H quinone dehydrogenase 1 Homo sapiens 0-32 11377380-0 2001 Relationship between NAD(P)H:quinone oxidoreductase 1 (NQO1) levels in a series of stably transfected cell lines and susceptibility to antitumor quinones. Quinones 145-153 NAD(P)H quinone dehydrogenase 1 Homo sapiens 21-53 11377380-0 2001 Relationship between NAD(P)H:quinone oxidoreductase 1 (NQO1) levels in a series of stably transfected cell lines and susceptibility to antitumor quinones. Quinones 145-153 NAD(P)H quinone dehydrogenase 1 Homo sapiens 55-59 11377380-1 2001 To investigate the importance of NAD(P)H:quinone oxidoreductase 1 (or DT-diaphorase; NQO1) in the bioactivation of antitumor quinones, we established a series of stably transfected cell lines derived from BE human colon adenocarcinoma cells. Quinones 125-133 NAD(P)H quinone dehydrogenase 1 Homo sapiens 70-83 11377380-1 2001 To investigate the importance of NAD(P)H:quinone oxidoreductase 1 (or DT-diaphorase; NQO1) in the bioactivation of antitumor quinones, we established a series of stably transfected cell lines derived from BE human colon adenocarcinoma cells. Quinones 125-133 NAD(P)H quinone dehydrogenase 1 Homo sapiens 85-89 11587640-0 2001 Structure-based development of anticancer drugs: complexes of NAD(P)H:quinone oxidoreductase 1 with chemotherapeutic quinones. Quinones 117-125 NAD(P)H quinone dehydrogenase 1 Homo sapiens 62-94 11587640-1 2001 BACKGROUND: NAD(P)H:quinone acceptor oxidoreductase (QR1) protects animal cells from the deleterious and carcinogenic effects of quinones and other electrophiles. Quinones 129-137 NAD(P)H quinone dehydrogenase 1 Homo sapiens 53-56 11587640-3 2001 QR1"s ability to bioactivate quinones and its elevated expression in many human solid tumors makes this protein an excellent target for enzyme-directed drug development. Quinones 29-37 NAD(P)H quinone dehydrogenase 1 Homo sapiens 0-3 11377380-13 2001 These data provide evidence that NQO1 can bioactivate antitumor quinones in this system and suggest that a threshold level of NQO1 activity is required to initiate toxic events. Quinones 64-72 NAD(P)H quinone dehydrogenase 1 Homo sapiens 33-37 11309386-1 2001 NAD(P)H:quinone oxidoreductase 1 (NQO1) is a flavoprotein that utilizes NAD(P)H as an electron donor, catalyzing the two-electron reduction and detoxification of quinones and their derivatives. Quinones 162-170 NAD(P)H quinone dehydrogenase 1 Homo sapiens 34-38 11222389-10 2001 Thus, inheritance of NQO1 C609T confers an increased risk of de novo acute leukemia in adults, implicating quinones and related compounds that generate oxidative stress in producing acute leukemia. Quinones 107-115 NAD(P)H quinone dehydrogenase 1 Homo sapiens 21-25 11222389-1 2001 NAD(P)H:quinone oxidoreductase 1 (NQO1) is an enzyme that detoxifies quinones and reduces oxidative stress. Quinones 69-77 NAD(P)H quinone dehydrogenase 1 Homo sapiens 0-32 11222389-1 2001 NAD(P)H:quinone oxidoreductase 1 (NQO1) is an enzyme that detoxifies quinones and reduces oxidative stress. Quinones 69-77 NAD(P)H quinone dehydrogenase 1 Homo sapiens 34-38 11340659-1 2001 NAD(P)H:quinone oxidoreductase type 1 (QR1, NQO1, formerly DT-diaphorase; EC 1.6.99.2) is an FAD-containing enzyme that catalyzes the nicotinamide nucleotide-dependent reduction of quinones, quinoneimines, azo dyes, and nitro groups. Quinones 181-189 NAD(P)H quinone dehydrogenase 1 Homo sapiens 0-42 11340659-1 2001 NAD(P)H:quinone oxidoreductase type 1 (QR1, NQO1, formerly DT-diaphorase; EC 1.6.99.2) is an FAD-containing enzyme that catalyzes the nicotinamide nucleotide-dependent reduction of quinones, quinoneimines, azo dyes, and nitro groups. Quinones 181-189 NAD(P)H quinone dehydrogenase 1 Homo sapiens 44-48 11340659-1 2001 NAD(P)H:quinone oxidoreductase type 1 (QR1, NQO1, formerly DT-diaphorase; EC 1.6.99.2) is an FAD-containing enzyme that catalyzes the nicotinamide nucleotide-dependent reduction of quinones, quinoneimines, azo dyes, and nitro groups. Quinones 181-189 NAD(P)H quinone dehydrogenase 1 Homo sapiens 59-72 11340659-2 2001 Animal cells are protected by QR1 from the toxic and neoplastic effects of quinones and other electrophiles. Quinones 75-83 NAD(P)H quinone dehydrogenase 1 Homo sapiens 30-33 11023538-1 2000 NAD(P)H:quinone oxidoreductase (NQO1) is a polymorphic enzyme involved in the detoxification of potentially mutagenic and carcinogenic quinones. Quinones 135-143 NAD(P)H quinone dehydrogenase 1 Homo sapiens 32-36 11154736-1 2000 NAD(P)H:quinone oxidoreductase 1 (NQO1) is an obligate two-electron reductase that is involved in chemoprotection and can also bioactivate certain antitumor quinones. Quinones 157-165 NAD(P)H quinone dehydrogenase 1 Homo sapiens 0-32 11154736-1 2000 NAD(P)H:quinone oxidoreductase 1 (NQO1) is an obligate two-electron reductase that is involved in chemoprotection and can also bioactivate certain antitumor quinones. Quinones 157-165 NAD(P)H quinone dehydrogenase 1 Homo sapiens 34-38 11154737-2 2000 NQO1 is known to catalyse metabolic detoxification of quinones and protect cells from redox cycling, oxidative stress and neoplasia. Quinones 54-62 NAD(P)H quinone dehydrogenase 1 Homo sapiens 0-4 10644008-3 1999 The role of DT-diaphorase has been thoroughly investigated in situations when the enzyme is able to reduce exogenous and endogenous quinones, hence protecting the cells against these reactive intermediates. Quinones 132-140 NAD(P)H quinone dehydrogenase 1 Homo sapiens 12-25 11035252-2 2000 One defense against quinone toxicity is the enzyme NAD(P)H:quinone oxidoreductase type 1 (QR1), which metabolizes quinones by a two-electron reduction mechanism, thus averting production of radicals. Quinones 114-122 NAD(P)H quinone dehydrogenase 1 Homo sapiens 59-93 11035254-1 2000 NAD(P)H:quinone oxidoreductase (NQO1) and NRH:quinone oxidoreductase (NQO2) are flavoproteins that catalyze two-electron reduction and detoxification of quinones and its derivatives. Quinones 153-161 NAD(P)H quinone dehydrogenase 1 Homo sapiens 32-36 11035256-1 2000 DT-diaphorase, also referred to as NQO1 or NAD(P)H: quinone acceptor oxidoreductase, is a flavoprotein that catalyzes the two-electron reduction of quinones and quinonoid compounds to hydroquinones, using either NADH or NADPH as the electron donor. Quinones 148-156 NAD(P)H quinone dehydrogenase 1 Homo sapiens 0-13 10706635-1 2000 NAD(P)H/quinone acceptor oxidoreductase (QR1, NQO1, formerly DT-diaphorase; EC ) protects animal cells from the deleterious and carcinogenic effects of quinones and other electrophiles. Quinones 152-160 NAD(P)H quinone dehydrogenase 1 Homo sapiens 41-44 10706635-1 2000 NAD(P)H/quinone acceptor oxidoreductase (QR1, NQO1, formerly DT-diaphorase; EC ) protects animal cells from the deleterious and carcinogenic effects of quinones and other electrophiles. Quinones 152-160 NAD(P)H quinone dehydrogenase 1 Homo sapiens 46-50 10706635-1 2000 NAD(P)H/quinone acceptor oxidoreductase (QR1, NQO1, formerly DT-diaphorase; EC ) protects animal cells from the deleterious and carcinogenic effects of quinones and other electrophiles. Quinones 152-160 NAD(P)H quinone dehydrogenase 1 Homo sapiens 61-74 10397748-1 1999 NAD(P)H:quinone oxidoreductase (NQO1) converts benzene-derived quinones to less toxic hydroquinones and has been implicated in benzene-associated hematotoxicity. Quinones 63-71 NAD(P)H quinone dehydrogenase 1 Homo sapiens 32-36 10463613-6 1999 We assayed, by PCR-RFLP, for a polymorphism in an enzyme that detoxifies quinones, NAD(P)H:quinone oxidoreductase (NQO1), in a series (n = 36) of infant leukemias with MLL rearrangements versus unselected cord blood controls (n = 100). Quinones 73-81 NAD(P)H quinone dehydrogenase 1 Homo sapiens 115-119 10748880-1 1999 AIMS: The two electron reduction of quinones to hydroquinones by NAD(P)H quinone oxidoreductase (NQO1) plays an important role in both activation and detoxification of quinone and similarly reactive compounds. Quinones 36-44 NAD(P)H quinone dehydrogenase 1 Homo sapiens 97-101 10393963-1 1999 NAD(P)H:quinone oxidoreductase 1 (NQO1) is a two-electron reductase that detoxifies quinones derived from the oxidation of phenolic metabolites of benzene. Quinones 84-92 NAD(P)H quinone dehydrogenase 1 Homo sapiens 0-32 10393963-1 1999 NAD(P)H:quinone oxidoreductase 1 (NQO1) is a two-electron reductase that detoxifies quinones derived from the oxidation of phenolic metabolites of benzene. Quinones 84-92 NAD(P)H quinone dehydrogenase 1 Homo sapiens 34-38 10714272-2 1999 NQO1 acts to protect against oxidative stress induced by a variety of metabolic situations, including metabolism of quinones and other xenobiotics, by: (i) functioning as a two electron donor to provide a shunt that competes with the formation of reactive oxygen species; (ii) maintaining reduced coenzyme Q; and (iii) regulating the stress activated kinase pathway. Quinones 116-124 NAD(P)H quinone dehydrogenase 1 Homo sapiens 0-4 10368308-8 1999 Alternatively, NQO1 activity may prevent the formation of adducts which result from polymerized products of the quinones. Quinones 112-120 NAD(P)H quinone dehydrogenase 1 Homo sapiens 15-19 9865924-0 1998 A new screening system for NAD(P)H:quinone oxidoreductase (NQO1)-directed antitumor quinones: identification of a new aziridinylbenzoquinone, RH1, as a NQO1-directed antitumor agent. Quinones 84-92 NAD(P)H quinone dehydrogenase 1 Homo sapiens 59-63 9865924-9 1998 In comparison to the parental cell line, RH1, MeDZQ, and mitomycin C were significantly more cytotoxic to BE-NQ7 cells (17-, 7-, and 3-fold, respectively), confirming that the presence of NQO1 is sufficient to increase cytotoxicity of these antitumor quinones. Quinones 251-259 NAD(P)H quinone dehydrogenase 1 Homo sapiens 188-192 9865924-0 1998 A new screening system for NAD(P)H:quinone oxidoreductase (NQO1)-directed antitumor quinones: identification of a new aziridinylbenzoquinone, RH1, as a NQO1-directed antitumor agent. Quinones 84-92 NAD(P)H quinone dehydrogenase 1 Homo sapiens 152-156 9748120-1 1998 NAD(P)H:quinone oxidoreductase (NQO1) is a flavoenzyme that catalyzes the two-electron reduction of quinones and related compounds. Quinones 100-108 NAD(P)H quinone dehydrogenase 1 Homo sapiens 32-36 9822546-4 1998 Metabolism of the quinones by NQO1 revealed that, in general, compounds with electron-withdrawing groups at the indole 3-position were among the best substrates, whereas those with amine groups at the 5-position were poor substrates. Quinones 18-26 NAD(P)H quinone dehydrogenase 1 Homo sapiens 30-34 9738013-1 1998 We have previously reported that antiestrogens stimulate quinone reductase (NAD(P)H:(quinone-acceptor) oxidoreductase (QR or NQO1); EC 1.6.99.2) enzymatic activity, an action that may provide protective effects against the toxicity and mutagenicity caused by quinones. Quinones 259-267 NAD(P)H quinone dehydrogenase 1 Homo sapiens 125-129 9748120-3 1998 NQO1 can bioactivate antitumor quinones such as mitomycin C, and new quinone-based drugs are currently being developed to target this enzyme in tumors such as NSCLC. Quinones 31-39 NAD(P)H quinone dehydrogenase 1 Homo sapiens 0-4 9579828-1 1998 DT-diaphorase, a homodimeric flavoenzyme, can provide for a defence mechanism against carcinogenesis mediated by dietary or environmental quinones as well as bioactivate quinone-containing chemotherapeutic drugs. Quinones 138-146 NAD(P)H quinone dehydrogenase 1 Homo sapiens 0-13 9731717-2 1998 NQO1 is involved in the reductive bioactivation of cytotoxic antitumour quinones such as mitomycin C, but also plays a protective role against the carcinogenicity and mutagenicity of quinones, their precursors and metabolites. Quinones 72-80 NAD(P)H quinone dehydrogenase 1 Homo sapiens 0-4 9731717-2 1998 NQO1 is involved in the reductive bioactivation of cytotoxic antitumour quinones such as mitomycin C, but also plays a protective role against the carcinogenicity and mutagenicity of quinones, their precursors and metabolites. Quinones 183-191 NAD(P)H quinone dehydrogenase 1 Homo sapiens 0-4 9050836-0 1997 Unexpected genetic and structural relationships of a long-forgotten flavoenzyme to NAD(P)H:quinone reductase (DT-diaphorase) A mammalian cytosolic FAD-dependent enzyme that catalyzes the reduction of quinones by N-ribosyl- and N-alkyldihydronicotinamides, but not by NADH, NADPH, or NMNH (reduced nicotinamide mononucleotide), was isolated from bovine kidney more than 30 years ago [S. Liao, J. T. Dulaney and H. G. Williams-Ashman (1962) J. Biol. Quinones 200-208 NAD(P)H quinone dehydrogenase 1 Homo sapiens 110-123 9343369-3 1997 These data indicate that the poor reactivity of nitrobenzimidazoles and other nitroaromatics in comparison to quinones could be determined by their binding in the adenosine-phosphate binding region of the NADPH-binding site, whereas quinones bind at the nicotinamide-binding pocket at the vicinity of FAD of DT-diaphorase. Quinones 110-118 NAD(P)H quinone dehydrogenase 1 Homo sapiens 308-321 27406966-7 1997 The results of the present experiments indicate that the relative stability of naphthohydroquinones cannot be judged on the basis of studies involving reduction of the quinone by DT-diaphorase and suggest that current concepts on the role of this enzyme in the detoxification of quinones may need revision. Quinones 91-99 NAD(P)H quinone dehydrogenase 1 Homo sapiens 179-192 9406243-1 1997 DT-diaphorase (EC 1.6.99.2) is a flavoprotein that catalyses two-electron reduction of quinones, quinone imines, and nitrogen oxides. Quinones 87-95 NAD(P)H quinone dehydrogenase 1 Homo sapiens 0-13 8999809-1 1997 DT-diaphorase (EC 1.6.99.2), also referred to as NAD(P)H:(quinone-acceptor) oxidoreductase, is involved in the reductive activation process of several cytotoxic antitumor quinones and nitrobenzenes. Quinones 171-179 NAD(P)H quinone dehydrogenase 1 Homo sapiens 0-13 9000600-1 1997 NAD(P)H:quinone oxidoreductase (NQO1, EC 1.6.99.2) is an obligate two-electron reductase that can either bioactivate or detoxify quinones and has been proposed to play an important role in chemoprevention. Quinones 129-137 NAD(P)H quinone dehydrogenase 1 Homo sapiens 32-36 9118890-4 1996 Peroxidases metabolize hydroquinone to the reactive 1,4-benzoquinone, whereas NQO1 reduces the quinones formed, resulting in detoxification. Quinones 95-103 NAD(P)H quinone dehydrogenase 1 Homo sapiens 78-82 8678904-5 1996 Since the activity of DT-diaphorase has been associated with sensitivity to quinones, we studied the cytotoxicity of mitomycin C under oxic conditions. Quinones 76-84 NAD(P)H quinone dehydrogenase 1 Homo sapiens 22-35 8863816-0 1996 Expression of human NAD(P)H: quinone oxidoreductase (DT-diaphorase) in Chinese hamster ovary cells: effect on the toxicity of antitumor quinones. Quinones 136-144 NAD(P)H quinone dehydrogenase 1 Homo sapiens 53-66 12226388-11 1996 As in the case with DT-diaphorase in animals, the main NAD(P)H-QR function in plant cells may be the reduction of quinones to quinols, which prevents the production of semiquinones and oxygen radicals. Quinones 114-122 NAD(P)H quinone dehydrogenase 1 Homo sapiens 20-33 8657209-1 1996 The influence of the quinone-reducing enzyme, DT diaphorase [NAD(P)H: (quinone acceptor) oxidoreductase], on the genotoxicity of quinones was examined in two cell lines, namely a human hepatoma cell line, HepG2 and a brown bullhead fibroblast cell line, BB. Quinones 129-137 NAD(P)H quinone dehydrogenase 1 Homo sapiens 46-59 8602872-1 1996 NAD(P)H:quinone oxidoreductase 1 (NQO1) is a flavoprotein that catalyzes two-electron reduction and detoxification of quinones. Quinones 118-126 NAD(P)H quinone dehydrogenase 1 Homo sapiens 0-32 8620484-1 1996 The two-electron bioreductive enzyme DT-diaphorase catalyzes the metabolism of quinones. Quinones 79-87 NAD(P)H quinone dehydrogenase 1 Homo sapiens 37-50 8653808-1 1996 DT-diaphorase (DTD) activity has been related to bioactivation and cytotoxicity of antitumor quinones. Quinones 93-101 NAD(P)H quinone dehydrogenase 1 Homo sapiens 0-13 8602872-1 1996 NAD(P)H:quinone oxidoreductase 1 (NQO1) is a flavoprotein that catalyzes two-electron reduction and detoxification of quinones. Quinones 118-126 NAD(P)H quinone dehydrogenase 1 Homo sapiens 34-38 8987252-2 1996 Peroxidase-mediated activation of phenolic metabolites of benzene generates reactive quinones which can be detoxified by NAD(P)H:quinone acceptor oxidoreductase (NQO1). Quinones 85-93 NAD(P)H quinone dehydrogenase 1 Homo sapiens 162-166 7639539-1 1995 NAD(P)H: quinone-acceptor oxidoreductase (EC 1.6.99.2), also referred to as DT-diaphorase, is a flavoprotein that catalyzes the two-electron reduction of quinones and quinonoid compounds to hydroquinones, using either NADH or NADPH as the electron donor. Quinones 154-162 NAD(P)H quinone dehydrogenase 1 Homo sapiens 76-89 8536688-10 1995 It is proposed that NAD(P)H-QR by scavenging unreduced quinones and making them prone to conjugation may act in plant tissues as a functional equivalent of DT-diaphorase. Quinones 55-63 NAD(P)H quinone dehydrogenase 1 Homo sapiens 156-169 7565631-0 1995 Nicotinamide adenine dinucleotide (phosphate): quinone oxidoreductase (DT-diaphorase) as a target for bioreductive antitumor quinones: quinone cytotoxicity and selectivity in human lung and breast cancer cell lines. Quinones 125-133 NAD(P)H quinone dehydrogenase 1 Homo sapiens 71-84 8033096-1 1994 NAD(P)H:quinone acceptor oxidoreductase (NQO1, EC 1.6.99.2) is an enzyme that is believed to play a central role in the bioreductive activation of several compounds, particularly quinones. Quinones 179-187 NAD(P)H quinone dehydrogenase 1 Homo sapiens 41-45 7531691-1 1995 NAD(P)H:quinone oxidoreductase (EC 1.6.99.2) (DT-diaphorase) is an FAD-containing enzyme that catalyzes the 2-electron reduction of quinones to hydroquinones using either NADH or NADPH as the electron donor. Quinones 132-140 NAD(P)H quinone dehydrogenase 1 Homo sapiens 46-59 7531691-11 1995 The enzyme reconstituted with oxidized 5-deaza-FAD has significant catalytic activity, confirming that DT-diaphorase is an obligatory 2-electron transfer enzyme and plays a role in the detoxification of quinones and quinoid compounds by reducing them to the relatively stable hydroquinones. Quinones 203-211 NAD(P)H quinone dehydrogenase 1 Homo sapiens 103-116 8004128-1 1994 NAD(P)H:Quinone oxidoreductase1 (NQO1) is a flavoprotein which promotes obligatory two-electron reduction of quinones, preventing their participation in redox cycling, oxidative stress and neoplasia. Quinones 109-117 NAD(P)H quinone dehydrogenase 1 Homo sapiens 0-31 8004128-1 1994 NAD(P)H:Quinone oxidoreductase1 (NQO1) is a flavoprotein which promotes obligatory two-electron reduction of quinones, preventing their participation in redox cycling, oxidative stress and neoplasia. Quinones 109-117 NAD(P)H quinone dehydrogenase 1 Homo sapiens 33-37 8375015-1 1993 NAD(P)H:Quinone Oxidoreductase1 (NQO1) also known as DT-diaphorase is a flavoprotein that catalyzes the two-electron reduction of quinones, quinone imines and azo-dyes and thereby protects cells against mutagenicity and carcinogenicity resulting from free radicals and toxic oxygen metabolites generated by the one-electron reductions catalyzed by cytochromes P450 and other enzymes. Quinones 130-138 NAD(P)H quinone dehydrogenase 1 Homo sapiens 0-31 8375023-0 1993 DT-diaphorase in activation and detoxification of quinones. Quinones 50-58 NAD(P)H quinone dehydrogenase 1 Homo sapiens 0-13 7620214-7 1994 The complex interplay of the levels of oxygen and of DT-diaphorase governs the effectiveness of these agents and other quinones such as mitomycin C. Quinones 119-127 NAD(P)H quinone dehydrogenase 1 Homo sapiens 53-66 7620217-0 1994 Bioactivation of quinones by DT-diaphorase, molecular, biochemical, and chemical studies. Quinones 17-25 NAD(P)H quinone dehydrogenase 1 Homo sapiens 29-42 7620221-1 1994 NAD(P)H:quinone oxidoreductase1 (DT-diaphorase or NQO1) is a flavoprotein that promotes obligatory two-electron reduction of quinones, preventing their participation in redox cycling, oxidative stress, and neoplasia. Quinones 125-133 NAD(P)H quinone dehydrogenase 1 Homo sapiens 0-31 7620221-1 1994 NAD(P)H:quinone oxidoreductase1 (DT-diaphorase or NQO1) is a flavoprotein that promotes obligatory two-electron reduction of quinones, preventing their participation in redox cycling, oxidative stress, and neoplasia. Quinones 125-133 NAD(P)H quinone dehydrogenase 1 Homo sapiens 33-46 7620221-1 1994 NAD(P)H:quinone oxidoreductase1 (DT-diaphorase or NQO1) is a flavoprotein that promotes obligatory two-electron reduction of quinones, preventing their participation in redox cycling, oxidative stress, and neoplasia. Quinones 125-133 NAD(P)H quinone dehydrogenase 1 Homo sapiens 50-54 8375015-1 1993 NAD(P)H:Quinone Oxidoreductase1 (NQO1) also known as DT-diaphorase is a flavoprotein that catalyzes the two-electron reduction of quinones, quinone imines and azo-dyes and thereby protects cells against mutagenicity and carcinogenicity resulting from free radicals and toxic oxygen metabolites generated by the one-electron reductions catalyzed by cytochromes P450 and other enzymes. Quinones 130-138 NAD(P)H quinone dehydrogenase 1 Homo sapiens 33-37 8375015-1 1993 NAD(P)H:Quinone Oxidoreductase1 (NQO1) also known as DT-diaphorase is a flavoprotein that catalyzes the two-electron reduction of quinones, quinone imines and azo-dyes and thereby protects cells against mutagenicity and carcinogenicity resulting from free radicals and toxic oxygen metabolites generated by the one-electron reductions catalyzed by cytochromes P450 and other enzymes. Quinones 130-138 NAD(P)H quinone dehydrogenase 1 Homo sapiens 53-66 1510692-2 1992 Sensitivity has been compared with the intra-cellular levels of DT-diaphorase, an enzyme thought to be important in the reductive activation of these quinones. Quinones 150-158 NAD(P)H quinone dehydrogenase 1 Homo sapiens 64-77 1324793-1 1992 The enzyme DT-diaphorase (DTD; NAD(P)H:quinone oxidoreductase, EC 1.6.99.2), is an obligate two electron reductase which catalyzes reduction of a broad range of substrates, including quinones. Quinones 183-191 NAD(P)H quinone dehydrogenase 1 Homo sapiens 11-24 1714284-2 1991 NAD(P)H: (quinone-acceptor) oxidoreductase (quinone reductase, DT-diaphorase, EC 1.6.99.2) is an obligate 2-electron donating enzyme that can reduce a variety of quinones resulting either in bioactivation or bioprotection. Quinones 162-170 NAD(P)H quinone dehydrogenase 1 Homo sapiens 63-76 1777518-1 1991 The interaction of quinones (menadione and duroquinone) with DT-diaphorase and mitochondrial electron transport chain translocators at low (120 mosM) and high (400 mosM) values of the medium tonicity in the quinone concentration range of 6-90 microM was studied. Quinones 19-27 NAD(P)H quinone dehydrogenase 1 Homo sapiens 61-74 1651729-1 1991 NAD(P)H:quinone oxidoreductase (NQO1) is a flavoprotein which catalyzes the two-electron reduction of quinones and azo-dyes and thus prevents the formation of free radicals and toxic oxygen metabolites that may be generated by the one-electron reductions catalyzed by cytochrome P450 reductase. Quinones 102-110 NAD(P)H quinone dehydrogenase 1 Homo sapiens 32-36 1737339-1 1992 NAD(P)H:quinone oxidoreductase (DT-diaphorase; DTD) is an obligate two-electron reductase which may play a role in the bioactivation of antitumor quinones such as mitomycin C (MMC). Quinones 146-154 NAD(P)H quinone dehydrogenase 1 Homo sapiens 32-45 2113030-0 1990 Activation and deactivation of quinones catalyzed by DT-diaphorase. Quinones 31-39 NAD(P)H quinone dehydrogenase 1 Homo sapiens 53-66 1899380-1 1991 NAD(P)H: quinone oxidoreductase (NQO1) is believed to be protective against cancer and toxicity caused by exposure to quinones and their metabolic precursors. Quinones 118-126 NAD(P)H quinone dehydrogenase 1 Homo sapiens 33-37 1899380-6 1991 263, 13572-13578] and provided preliminary evidence that this enzyme may correspond to diaphorase 4, an enzymatic activity present in various tissues that catalyzes the reduction of a variety of quinones by both NADH and NADPH [Edwards et al. Quinones 195-203 NAD(P)H quinone dehydrogenase 1 Homo sapiens 87-99 2307529-1 1990 NAD(P)H:(quinone-acceptor)oxidoreductase (QAO), previously known as DT-diaphorase, catalyzes the reduction of quinones to hydroquinones. Quinones 110-118 NAD(P)H quinone dehydrogenase 1 Homo sapiens 68-81 34833955-1 2021 NAD(P)H:quinone acceptor oxidoreductase-1 (NQO1) is a ubiquitous flavin adenine dinucleotide-dependent flavoprotein that promotes obligatory two-electron reductions of quinones, quinonimines, nitroaromatics, and azo dyes. Quinones 168-176 NAD(P)H quinone dehydrogenase 1 Homo sapiens 0-41 34833955-1 2021 NAD(P)H:quinone acceptor oxidoreductase-1 (NQO1) is a ubiquitous flavin adenine dinucleotide-dependent flavoprotein that promotes obligatory two-electron reductions of quinones, quinonimines, nitroaromatics, and azo dyes. Quinones 168-176 NAD(P)H quinone dehydrogenase 1 Homo sapiens 43-47 34356648-2 2021 Based on the findings of clinical trials, it is safe to conclude that genetic predisposition and environmental factors are the main factors responsible for the formation of colorectal cancer.The NQO1 gene plays an important role in reducing endogenous and exogenous quinones as well as quinone compounds to hydroquinones. Quinones 266-274 NAD(P)H quinone dehydrogenase 1 Homo sapiens 195-199 34252539-3 2021 NAD(P)H: quinone oxidoreductase 1 (NQO1) is a ubiquitous flavoenzyme that catalyzes the reduction and detoxification of quinones and other organic compounds. Quinones 120-128 NAD(P)H quinone dehydrogenase 1 Homo sapiens 0-33 34252539-3 2021 NAD(P)H: quinone oxidoreductase 1 (NQO1) is a ubiquitous flavoenzyme that catalyzes the reduction and detoxification of quinones and other organic compounds. Quinones 120-128 NAD(P)H quinone dehydrogenase 1 Homo sapiens 35-39 2843525-2 1988 NAD(P)H:menadione oxidoreductase (NMOR1) is a flavoprotein that catalyzes the two-electron reduction of various redox dyes and quinones. Quinones 127-135 NAD(P)H quinone dehydrogenase 1 Homo sapiens 34-39 2539822-8 1989 DT-diaphorase activity and intracellular glutathione were found to protect the cells from the toxicity of both quinones. Quinones 111-119 NAD(P)H quinone dehydrogenase 1 Homo sapiens 0-13 2425252-4 1986 The presence of dicumarol, a specific inhibitor of the two-electron reduction of quinones by DT-diaphorase, afforded some protection against cytotoxicity. Quinones 81-89 NAD(P)H quinone dehydrogenase 1 Homo sapiens 93-106 4060194-3 1985 In fibroblasts, effects on both DNA and membrane integrity were potentiated by the presence of dicoumarol, a specific inhibitor of the 2-electron reduction of quinones by DT-diaphorase, whereas in hepatocytes only the cell membrane damage was sensitive to dicoumarol. Quinones 159-167 NAD(P)H quinone dehydrogenase 1 Homo sapiens 171-184 6584903-3 1984 The two-electron reduction of these quinones by NAD(P)H-quinone oxidoreductase (DT-diaphorase) was not mutagenic, whereas the one-electron reduction, catalyzed by NADPH-cytochrome P-450 reductase, was mutagenic, except for danthron, which was only slightly mutagenic. Quinones 36-44 NAD(P)H quinone dehydrogenase 1 Homo sapiens 80-93 33774477-3 2021 Exogenous substrates for NQO1 include many xenobiotic quinones. Quinones 54-62 NAD(P)H quinone dehydrogenase 1 Homo sapiens 25-29 6313461-7 1983 Finally, cytosolic DT diaphorase, which carries out a two-electron reduction of quinones to more stable hydroquinones, may compete with the one-electron systems and participate in the detoxification of quinones by supplying hydroquinones for conjugation reactions. Quinones 80-88 NAD(P)H quinone dehydrogenase 1 Homo sapiens 19-32 6313461-7 1983 Finally, cytosolic DT diaphorase, which carries out a two-electron reduction of quinones to more stable hydroquinones, may compete with the one-electron systems and participate in the detoxification of quinones by supplying hydroquinones for conjugation reactions. Quinones 109-117 NAD(P)H quinone dehydrogenase 1 Homo sapiens 19-32 6181068-3 1982 The two-electron reduction of quinones to diols, mediated by DT-diaphorase (NAD(P)H: (quinone-acceptor) oxidoreductase), may therefore represent a detoxifying pathway which protects the cell from the formation of these reactive intermediates. Quinones 30-38 NAD(P)H quinone dehydrogenase 1 Homo sapiens 61-74 32007910-9 2020 Our results suggest that NRF2/KEAP1 mutational status might serve as a predictive biomarker for response to NQO1-bioactivatable quinones in patients. Quinones 128-136 NAD(P)H quinone dehydrogenase 1 Homo sapiens 108-112 31775023-5 2020 A recent study suggested that the cytosolic enzyme NAD(P)H: quinone acceptor oxidoreductase (NQO1) is the major enzyme involved in the activation of idebenone, and the beneficial effects of idebenone are dependent on the expression of NQO1. Quinones 60-67 NAD(P)H quinone dehydrogenase 1 Homo sapiens 93-97 31775023-5 2020 A recent study suggested that the cytosolic enzyme NAD(P)H: quinone acceptor oxidoreductase (NQO1) is the major enzyme involved in the activation of idebenone, and the beneficial effects of idebenone are dependent on the expression of NQO1. Quinones 60-67 NAD(P)H quinone dehydrogenase 1 Homo sapiens 235-239 33313330-1 2020 NAD(P)H: quinone oxidoreductase 1 (NQO1) is an endogenous cellular defence mechanism against several carcinogenic quinones derived from cigarette smoke. Quinones 114-122 NAD(P)H quinone dehydrogenase 1 Homo sapiens 0-33 33313330-1 2020 NAD(P)H: quinone oxidoreductase 1 (NQO1) is an endogenous cellular defence mechanism against several carcinogenic quinones derived from cigarette smoke. Quinones 114-122 NAD(P)H quinone dehydrogenase 1 Homo sapiens 35-39 31935063-4 2020 After internalization into NQO1-positive vesicles, cytosolic NQO1 enzyme triggers self-immolative cleavage of quinone linkages and fluorogenic release of conjugated photosensitizers, leading to NIR fluorescence emission turn-on and activated PDT. Quinones 110-117 NAD(P)H quinone dehydrogenase 1 Homo sapiens 27-31 31935063-4 2020 After internalization into NQO1-positive vesicles, cytosolic NQO1 enzyme triggers self-immolative cleavage of quinone linkages and fluorogenic release of conjugated photosensitizers, leading to NIR fluorescence emission turn-on and activated PDT. Quinones 110-117 NAD(P)H quinone dehydrogenase 1 Homo sapiens 61-65 31533349-7 2019 Inhibitor of NQO1, dicoumarol, and inhibitors of cytochromes P-450 alpha-naphthoflavone, isoniazid and miconazole statistically significantly (p < 0.02) decreased the toxicity of ArN O, and potentiated the cytotoxicity of quinones. Quinones 222-230 NAD(P)H quinone dehydrogenase 1 Homo sapiens 13-17 31589435-3 2019 We demonstrate that the chemical modification of protein with QPN, a ligand that could be reduced by tumor cell-specific NAD(P)H dehydrogenase [quinone] 1 (NQO1), is reversible in the presence of NQO1. Quinones 144-151 NAD(P)H quinone dehydrogenase 1 Homo sapiens 156-160 31589435-3 2019 We demonstrate that the chemical modification of protein with QPN, a ligand that could be reduced by tumor cell-specific NAD(P)H dehydrogenase [quinone] 1 (NQO1), is reversible in the presence of NQO1. Quinones 144-151 NAD(P)H quinone dehydrogenase 1 Homo sapiens 196-200 31608921-4 2019 Herein, based on a dye generated in situ strategy, a dual-enzyme-responsive probe, CNN, was rationally designed and synthesized by installing p-nitrobenzene and trimethyl-locked quinone propionic acid groups, which are specific for NTR and hNQO1, respectively, into a single fluorophore. Quinones 178-200 NAD(P)H quinone dehydrogenase 1 Homo sapiens 240-245 31480790-0 2019 Cancer Cell Sensitivity to Redox-Cycling Quinones is Influenced by NAD(P)H: Quinone Oxidoreductase 1 Polymorphism. Quinones 41-49 NAD(P)H quinone dehydrogenase 1 Homo sapiens 67-100 29934320-1 2018 NAD(P)H:quinone oxidoreductase 1 (NQO1) protects cells against oxidative stress and toxic quinones. Quinones 90-98 NAD(P)H quinone dehydrogenase 1 Homo sapiens 0-32 30518535-1 2019 NAD(P)H quinone oxidoreductase 1 (NQO1) catalyses the two electron reduction of quinones and a wide range of other organic compounds. Quinones 80-88 NAD(P)H quinone dehydrogenase 1 Homo sapiens 0-32 30518535-1 2019 NAD(P)H quinone oxidoreductase 1 (NQO1) catalyses the two electron reduction of quinones and a wide range of other organic compounds. Quinones 80-88 NAD(P)H quinone dehydrogenase 1 Homo sapiens 34-38 31091472-1 2019 NAD(P)H quinone oxidoreductase 1 (NQO1) is a multi-functional protein that catalyses the reduction of quinones (and other molecules), thus playing roles in xenobiotic detoxification and redox balance, and also has roles in stabilising apoptosis regulators such as p53. Quinones 102-110 NAD(P)H quinone dehydrogenase 1 Homo sapiens 0-32 31091472-1 2019 NAD(P)H quinone oxidoreductase 1 (NQO1) is a multi-functional protein that catalyses the reduction of quinones (and other molecules), thus playing roles in xenobiotic detoxification and redox balance, and also has roles in stabilising apoptosis regulators such as p53. Quinones 102-110 NAD(P)H quinone dehydrogenase 1 Homo sapiens 34-38 29712428-1 2018 NAD(P)H:quinone oxidoreductase 1 (NQO1) is a two-electron reductase responsible for detoxification of quinones and also bioactivation of certain quinones. Quinones 102-110 NAD(P)H quinone dehydrogenase 1 Homo sapiens 0-32 29712428-1 2018 NAD(P)H:quinone oxidoreductase 1 (NQO1) is a two-electron reductase responsible for detoxification of quinones and also bioactivation of certain quinones. Quinones 102-110 NAD(P)H quinone dehydrogenase 1 Homo sapiens 34-38 29712428-1 2018 NAD(P)H:quinone oxidoreductase 1 (NQO1) is a two-electron reductase responsible for detoxification of quinones and also bioactivation of certain quinones. Quinones 145-153 NAD(P)H quinone dehydrogenase 1 Homo sapiens 0-32 29712428-1 2018 NAD(P)H:quinone oxidoreductase 1 (NQO1) is a two-electron reductase responsible for detoxification of quinones and also bioactivation of certain quinones. Quinones 145-153 NAD(P)H quinone dehydrogenase 1 Homo sapiens 34-38 32055310-5 2019 This strategy is demonstrated using a PA probe designed for a tumor biomarker, human NAD(P)H: quinone oxidoreductase isozyme 1 (hNQO1), which affords high contrast and excellent sensitivity for PA detection and imaging of hNQO1 in living cells and animals. Quinones 94-101 NAD(P)H quinone dehydrogenase 1 Homo sapiens 128-133 32055310-5 2019 This strategy is demonstrated using a PA probe designed for a tumor biomarker, human NAD(P)H: quinone oxidoreductase isozyme 1 (hNQO1), which affords high contrast and excellent sensitivity for PA detection and imaging of hNQO1 in living cells and animals. Quinones 94-101 NAD(P)H quinone dehydrogenase 1 Homo sapiens 222-227 31360690-1 2019 Background: NAD(P)H:quinone oxidoreductase-1 (NQO1) is a widely-distributed flavin adenine dinucleotide-dependent flavoprotein that promotes obligatory 2-electron reductions of quinones, quinoneimines, nitroaromatics, and azo dyes. Quinones 177-185 NAD(P)H quinone dehydrogenase 1 Homo sapiens 12-44 31360690-1 2019 Background: NAD(P)H:quinone oxidoreductase-1 (NQO1) is a widely-distributed flavin adenine dinucleotide-dependent flavoprotein that promotes obligatory 2-electron reductions of quinones, quinoneimines, nitroaromatics, and azo dyes. Quinones 177-185 NAD(P)H quinone dehydrogenase 1 Homo sapiens 46-50 29934320-1 2018 NAD(P)H:quinone oxidoreductase 1 (NQO1) protects cells against oxidative stress and toxic quinones. Quinones 90-98 NAD(P)H quinone dehydrogenase 1 Homo sapiens 34-38 32264042-1 2017 DT-diaphorase, which catalyzes the reduction of various biological substances like quinones, is overexpressed in some malignant tumors. Quinones 83-91 NAD(P)H quinone dehydrogenase 1 Homo sapiens 0-13 29298345-1 2018 NQO1 is a FAD containing NAD(P)H-dependent oxidoreductase that catalyzes the reduction of quinones and related substrates. Quinones 90-98 NAD(P)H quinone dehydrogenase 1 Homo sapiens 0-4 28643389-2 2018 Molecular docking results indicated that some favourable interactions of key amino acid residues at the binding site of NQO1 with these quinones would be responsible for an improvement of the NQO1 activity of these compounds. Quinones 136-144 NAD(P)H quinone dehydrogenase 1 Homo sapiens 192-196 28578385-1 2017 NQO1 is a FAD-binding protein that can form homodimers and reduce quinones to hydroquinones, and a growing body of evidence currently suggests that NQO1 is dramatically elevated in solid cancers. Quinones 66-74 NAD(P)H quinone dehydrogenase 1 Homo sapiens 0-4 28578385-1 2017 NQO1 is a FAD-binding protein that can form homodimers and reduce quinones to hydroquinones, and a growing body of evidence currently suggests that NQO1 is dramatically elevated in solid cancers. Quinones 66-74 NAD(P)H quinone dehydrogenase 1 Homo sapiens 148-152 28643389-1 2018 A combination of three-dimensional quantitative structure-activity relationship (3D-QSAR), and molecular modelling methods were used to understand the potent inhibitory NAD(P)H:quinone oxidoreductase 1 (NQO1) activity of a set of 52 heterocyclic quinones. Quinones 246-254 NAD(P)H quinone dehydrogenase 1 Homo sapiens 169-201 28643389-1 2018 A combination of three-dimensional quantitative structure-activity relationship (3D-QSAR), and molecular modelling methods were used to understand the potent inhibitory NAD(P)H:quinone oxidoreductase 1 (NQO1) activity of a set of 52 heterocyclic quinones. Quinones 246-254 NAD(P)H quinone dehydrogenase 1 Homo sapiens 203-207 28643389-2 2018 Molecular docking results indicated that some favourable interactions of key amino acid residues at the binding site of NQO1 with these quinones would be responsible for an improvement of the NQO1 activity of these compounds. Quinones 136-144 NAD(P)H quinone dehydrogenase 1 Homo sapiens 120-124 28164770-5 2018 NQO1 is a cytosolic homodimeric flavoprotein that catalyses the two-electron reduction of quinones and related molecules aimed at increasing their solubility and excretion. Quinones 90-98 NAD(P)H quinone dehydrogenase 1 Homo sapiens 0-4 28883796-4 2017 Established roles of NQO1 include its ability to prevent certain quinones from one electron redox cycling but its role in quinone detoxification is dependent on the redox stability of the hydroquinone generated by two-electron reduction. Quinones 65-73 NAD(P)H quinone dehydrogenase 1 Homo sapiens 21-25 28639725-1 2017 NAD(P)H: Quinone oxidoreductase (NQO1) functions as an important part of cellular antioxidant defense by detoxifying quinones, thus preventing the formation of reactive oxygen species. Quinones 117-125 NAD(P)H quinone dehydrogenase 1 Homo sapiens 33-37 27986568-0 2017 Distinct responses of compartmentalized glutathione redox potentials to pharmacologic quinones targeting NQO1. Quinones 86-94 NAD(P)H quinone dehydrogenase 1 Homo sapiens 105-109 26721407-1 2016 NAD(P)H: quinone oxidoreductase 1 (NQO1) is an antioxidant and detoxifying enzyme involved in the two-electron reduction of a wide variety of quinones. Quinones 142-150 NAD(P)H quinone dehydrogenase 1 Homo sapiens 0-33 27617882-9 2017 This perspective explores the varied biological targets of quinones including GSH, NADPH, protein sulfhydryls [heat shock proteins, P450s, cyclooxygenase-2 (COX-2), glutathione S-transferase (GST), NAD(P)H:quinone oxidoreductase 1, (NQO1), kelch-like ECH-associated protein 1 (Keap1), IkappaB kinase (IKK), and arylhydrocarbon receptor (AhR)], and DNA. Quinones 59-67 NAD(P)H quinone dehydrogenase 1 Homo sapiens 198-230 26856346-1 2016 The NADPH dehydrogenase quinone oxido-reductase 1 (NQO1) enzyme is an antioxidant and metabolic enzyme that performs two electron reduction of quinones and other chemicals. Quinones 143-151 NAD(P)H quinone dehydrogenase 1 Homo sapiens 4-49 26856346-1 2016 The NADPH dehydrogenase quinone oxido-reductase 1 (NQO1) enzyme is an antioxidant and metabolic enzyme that performs two electron reduction of quinones and other chemicals. Quinones 143-151 NAD(P)H quinone dehydrogenase 1 Homo sapiens 51-55 27048660-9 2016 Unlike other NQO1-dependent cytotoxic quinones, such as streptonigrin, menadione, mitomycin, and 17-allylamino-17-demethoxygeldanamycin, beta-lap was the only agent that could cause Hsp90 cleavage. Quinones 38-46 NAD(P)H quinone dehydrogenase 1 Homo sapiens 13-17 26687450-0 2016 Overexpression of NAD(P)H:quinone oxidoreductase 1 (NQO1) and genomic gain of the NQO1 locus modulates breast cancer cell sensitivity to quinones. Quinones 137-145 NAD(P)H quinone dehydrogenase 1 Homo sapiens 52-56 26687450-0 2016 Overexpression of NAD(P)H:quinone oxidoreductase 1 (NQO1) and genomic gain of the NQO1 locus modulates breast cancer cell sensitivity to quinones. Quinones 137-145 NAD(P)H quinone dehydrogenase 1 Homo sapiens 82-86 26687450-5 2016 Finally, the importance of NQO1 overexpression in the putative acquisition of either drug resistance or an increased sensitivity to quinones by cancer cells was investigated by immunoblotting and cytotoxicity assays. Quinones 132-140 NAD(P)H quinone dehydrogenase 1 Homo sapiens 27-31 27913299-2 2017 NQO1 reduces quinones to hydroquinones using NADH as an electron donor and consequently increases the intracellular NAD+/NADH ratio. Quinones 13-21 NAD(P)H quinone dehydrogenase 1 Homo sapiens 0-4 27617882-9 2017 This perspective explores the varied biological targets of quinones including GSH, NADPH, protein sulfhydryls [heat shock proteins, P450s, cyclooxygenase-2 (COX-2), glutathione S-transferase (GST), NAD(P)H:quinone oxidoreductase 1, (NQO1), kelch-like ECH-associated protein 1 (Keap1), IkappaB kinase (IKK), and arylhydrocarbon receptor (AhR)], and DNA. Quinones 59-67 NAD(P)H quinone dehydrogenase 1 Homo sapiens 233-237 27558805-1 2016 NQO1 (NAD(P)H-quinone oxidoreductase 1) reduces quinones and xenobiotics to less-reactive compounds via 2-electron reduction, one feature responsible for the role of NQO1 in antioxidant defense in several tissues. Quinones 48-56 NAD(P)H quinone dehydrogenase 1 Homo sapiens 0-4 27558805-1 2016 NQO1 (NAD(P)H-quinone oxidoreductase 1) reduces quinones and xenobiotics to less-reactive compounds via 2-electron reduction, one feature responsible for the role of NQO1 in antioxidant defense in several tissues. Quinones 48-56 NAD(P)H quinone dehydrogenase 1 Homo sapiens 6-38 27558805-1 2016 NQO1 (NAD(P)H-quinone oxidoreductase 1) reduces quinones and xenobiotics to less-reactive compounds via 2-electron reduction, one feature responsible for the role of NQO1 in antioxidant defense in several tissues. Quinones 48-56 NAD(P)H quinone dehydrogenase 1 Homo sapiens 166-170 26721407-1 2016 NAD(P)H: quinone oxidoreductase 1 (NQO1) is an antioxidant and detoxifying enzyme involved in the two-electron reduction of a wide variety of quinones. Quinones 142-150 NAD(P)H quinone dehydrogenase 1 Homo sapiens 35-39 26257249-1 2015 PURPOSE: NAD(P)H dehydrogenase, encoded by NAD(P)H quinone oxidoreductase 1 (NQO1), is an enzyme that catalyzes the reduction of quinones, including vitamin K. Quinones 129-137 NAD(P)H quinone dehydrogenase 1 Homo sapiens 43-75 26424559-2 2015 The NQO1- mediated two-electron reduction of quinones can be either chemoprotection/detoxification or a chemotherapeutic response, depending on the target quinones. Quinones 45-53 NAD(P)H quinone dehydrogenase 1 Homo sapiens 4-8 26424559-2 2015 The NQO1- mediated two-electron reduction of quinones can be either chemoprotection/detoxification or a chemotherapeutic response, depending on the target quinones. Quinones 155-163 NAD(P)H quinone dehydrogenase 1 Homo sapiens 4-8 26424559-3 2015 When toxic quinones are reduced by NQO1, they are conjugated with glutathione or glucuronic acid and excreted from the cells. Quinones 11-19 NAD(P)H quinone dehydrogenase 1 Homo sapiens 35-39 26444384-6 2015 NQO1 is a 2-electron reductase responsible for the detoxification of quinones. Quinones 69-77 NAD(P)H quinone dehydrogenase 1 Homo sapiens 0-4 26257249-1 2015 PURPOSE: NAD(P)H dehydrogenase, encoded by NAD(P)H quinone oxidoreductase 1 (NQO1), is an enzyme that catalyzes the reduction of quinones, including vitamin K. Quinones 129-137 NAD(P)H quinone dehydrogenase 1 Homo sapiens 77-81 25677663-5 2015 Cytotoxicity studies and determination of superoxide (O2(-)) production in the presence and absence of the NOQ1 inhibitor dicoumarol confirmed that the ortho-quinones exerted their antitumor activity through NQO1-mediated ROS production by redox cycling. Quinones 158-166 NAD(P)H quinone dehydrogenase 1 Homo sapiens 208-212 25885439-1 2015 BACKGROUND: NAD(P)H: quinone oxidoreductase (NQO1) is a flavoprotein that catalyzes two-electron reduction and detoxification of quinones and its derivatives. Quinones 130-138 NAD(P)H quinone dehydrogenase 1 Homo sapiens 46-50