PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 24196959-6 2013 All except the quinones were potentiated by POR overexpression. Quinones 15-23 cytochrome p450 oxidoreductase Homo sapiens 44-47 12440719-3 2002 A close parallelism was found between the reactivity of hydroxyanthraquinones and model quinones with single-electron transferring flavoenzymes ferredoxin: NADP+ reductase and NADPH:cytochrome P450 reductase, and their cytotoxicity. Quinones 69-77 cytochrome p450 oxidoreductase Homo sapiens 176-207 23546588-7 2013 Inhibition of CYPs shifts NPR"s electron flow more to quinones, which accelerates the redox cycle to enhance ROS production and quinone toxicity. Quinones 54-62 cytochrome p450 oxidoreductase Homo sapiens 26-29 17017857-2 2006 The cytotoxic effects of these quinones are mainly due to the following two factors: (i) inhibition of DNA topoisomerase-II and, (ii) formation of semiquinone radical that can transfer an electron to oxygen to produce super oxide, which is catalyzed by flavoenzymes such as NADPH-cytochrome-P-450 reductase. Quinones 31-39 cytochrome p450 oxidoreductase Homo sapiens 274-306 6584903-3 1984 The two-electron reduction of these quinones by NAD(P)H-quinone oxidoreductase (DT-diaphorase) was not mutagenic, whereas the one-electron reduction, catalyzed by NADPH-cytochrome P-450 reductase, was mutagenic, except for danthron, which was only slightly mutagenic. Quinones 36-44 cytochrome p450 oxidoreductase Homo sapiens 163-195 11506041-3 2001 The quinones were also reduced by microsomal NADPH-cytochrome P-450 reductase and the corresponding radicals species were also detected by ESR spectroscopy. Quinones 4-12 cytochrome p450 oxidoreductase Homo sapiens 45-77 9101243-2 1995 A semiquinone species was observed by direct ESR in aerobic conditions during: (a) NADPH-cytochrome P450 reductase-catalyzed reduction of the above quinones. Quinones 148-156 cytochrome p450 oxidoreductase Homo sapiens 83-114 1310854-1 1992 Bioreductive activation of quinones in mammalian liver has generally been attributed to NADPH-cytochrome P450 reductase. Quinones 27-35 cytochrome p450 oxidoreductase Homo sapiens 88-119 27558805-2 2016 In contrast, NADPH cytochrome P450 oxidoreductase (CYP450OR), catalyzes the 1-electron reduction of quinones and xenobiotics, resulting in enhanced superoxide formation. Quinones 100-108 cytochrome p450 oxidoreductase Homo sapiens 19-49 27558805-2 2016 In contrast, NADPH cytochrome P450 oxidoreductase (CYP450OR), catalyzes the 1-electron reduction of quinones and xenobiotics, resulting in enhanced superoxide formation. Quinones 100-108 cytochrome p450 oxidoreductase Homo sapiens 51-59