PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
24196959-6	2013	All except the quinones were potentiated by POR overexpression.	Quinones	15-23	cytochrome p450 oxidoreductase	Homo sapiens	44-47	
12440719-3	2002	A close parallelism was found between the reactivity of hydroxyanthraquinones and model quinones with single-electron transferring flavoenzymes ferredoxin: NADP+ reductase and NADPH:cytochrome P450 reductase, and their cytotoxicity.	Quinones	69-77	cytochrome p450 oxidoreductase	Homo sapiens	176-207	
23546588-7	2013	Inhibition of CYPs shifts NPR"s electron flow more to quinones, which accelerates the redox cycle to enhance ROS production and quinone toxicity.	Quinones	54-62	cytochrome p450 oxidoreductase	Homo sapiens	26-29	
17017857-2	2006	The cytotoxic effects of these quinones are mainly due to the following two factors: (i) inhibition of DNA topoisomerase-II and, (ii) formation of semiquinone radical that can transfer an electron to oxygen to produce super oxide, which is catalyzed by flavoenzymes such as NADPH-cytochrome-P-450 reductase.	Quinones	31-39	cytochrome p450 oxidoreductase	Homo sapiens	274-306	
6584903-3	1984	The two-electron reduction of these quinones by NAD(P)H-quinone oxidoreductase (DT-diaphorase) was not mutagenic, whereas the one-electron reduction, catalyzed by NADPH-cytochrome P-450 reductase, was mutagenic, except for danthron, which was only slightly mutagenic.	Quinones	36-44	cytochrome p450 oxidoreductase	Homo sapiens	163-195	
11506041-3	2001	The quinones were also reduced by microsomal NADPH-cytochrome P-450 reductase and the corresponding radicals species were also detected by ESR spectroscopy.	Quinones	4-12	cytochrome p450 oxidoreductase	Homo sapiens	45-77	
9101243-2	1995	A semiquinone species was observed by direct ESR in aerobic conditions during: (a) NADPH-cytochrome P450 reductase-catalyzed reduction of the above quinones.	Quinones	148-156	cytochrome p450 oxidoreductase	Homo sapiens	83-114	
1310854-1	1992	Bioreductive activation of quinones in mammalian liver has generally been attributed to NADPH-cytochrome P450 reductase.	Quinones	27-35	cytochrome p450 oxidoreductase	Homo sapiens	88-119	
27558805-2	2016	In contrast, NADPH cytochrome P450 oxidoreductase (CYP450OR), catalyzes the 1-electron reduction of quinones and xenobiotics, resulting in enhanced superoxide formation.	Quinones	100-108	cytochrome p450 oxidoreductase	Homo sapiens	19-49	
27558805-2	2016	In contrast, NADPH cytochrome P450 oxidoreductase (CYP450OR), catalyzes the 1-electron reduction of quinones and xenobiotics, resulting in enhanced superoxide formation.	Quinones	100-108	cytochrome p450 oxidoreductase	Homo sapiens	51-59