PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
16985022-6	2006	Using experimentally derived rate constants for genetic variants of CYP1A1, CYP1B1, and COMT, we used the model to simulate the kinetic effect of enzyme polymorphisms on the pathway and identified those haplotypes generating the largest amounts of catechols and quinones.	Quinones	262-270	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	76-82	
14679015-1	2003	The Phase I enzyme cytochrome p450 1B1 (CYP1B1) has been postulated to play a key role in estrogen-induced mammary carcinogenesis by catalyzing the oxidative metabolism of 17beta-estradiol (E(2)) to catechol estrogens (2-OHE(2) and 4-OHE(2)) and highly reactive estrogen quinones (E(2)-2,3-Q and E(2)-3,4-Q).	Quinones	271-279	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	40-46	
32986415-3	2020	In this study hop extract and its bioactive compounds were investigated for its mechanism of action within the chemical estrogen carcinogenesis pathway, which is mainly mediated through the 4-hydroxylation pathway catalyzed by CYP1B1 that can form gentoxic quinones.	Quinones	257-265	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	227-233	
19250193-6	2009	Using rate constants of genetic variants of CYP1A1, CYP1B1, and COMT, the model further allowed examination of the kinetic impact of enzyme polymorphisms on the entire metabolic pathway, including the identification of those haplotypes producing the largest amounts of catechols and quinones.	Quinones	283-291	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	52-58	
17570247-11	2007	These experiments demonstrated that CYP1A1, CYP1B1, and CYP3A4 are able to oxidize catechol estrogens to their respective quinones, which can further react with GSH, protein, and DNA, the last resulting in depurinating adducts that can lead to mutagenesis.	Quinones	122-130	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	44-50	
17234793-5	2007	Because the reactive quinones were produced as part of the CYP1B1-mediated oxidation reaction, the adduct formation followed Michaelis-Menten kinetics.	Quinones	21-29	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	59-65	
12810639-1	2003	Cytochrome P450 1A1 (CYP1A1) and 1B1 (CYP1B1) catalyze the oxidative metabolism of 17 beta-estradiol (E2) to catechol estrogens (2-OHE2 and 4-OHE2) and estrogen quinones, which may lead to DNA damage.	Quinones	161-169	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	38-44	
19138946-4	2008	CYP1B1 favors quinone formation by catalyzing estrogen 4-hydroxylation, whereas NAD(P)H quinone oxidoreductase 1 (NQO1) catalyzes the protective reduction of quinones to catechols.	Quinones	158-166	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	0-6