PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 24552538-1 2014 NAD(P)H: quinone oxidoreductase 1 (NQO1) is an enzyme capable of reducing a broad range of chemically reactive quinones and quinoneimines (QIs) and can be strongly upregulated by Nrf2/Keap1-mediated stress responses. Quinones 111-119 kelch like ECH associated protein 1 Homo sapiens 184-189 32007910-9 2020 Our results suggest that NRF2/KEAP1 mutational status might serve as a predictive biomarker for response to NQO1-bioactivatable quinones in patients. Quinones 128-136 kelch like ECH associated protein 1 Homo sapiens 30-35 27617882-9 2017 This perspective explores the varied biological targets of quinones including GSH, NADPH, protein sulfhydryls [heat shock proteins, P450s, cyclooxygenase-2 (COX-2), glutathione S-transferase (GST), NAD(P)H:quinone oxidoreductase 1, (NQO1), kelch-like ECH-associated protein 1 (Keap1), IkappaB kinase (IKK), and arylhydrocarbon receptor (AhR)], and DNA. Quinones 59-67 kelch like ECH associated protein 1 Homo sapiens 240-275 27617882-9 2017 This perspective explores the varied biological targets of quinones including GSH, NADPH, protein sulfhydryls [heat shock proteins, P450s, cyclooxygenase-2 (COX-2), glutathione S-transferase (GST), NAD(P)H:quinone oxidoreductase 1, (NQO1), kelch-like ECH-associated protein 1 (Keap1), IkappaB kinase (IKK), and arylhydrocarbon receptor (AhR)], and DNA. Quinones 59-67 kelch like ECH associated protein 1 Homo sapiens 277-282 20846517-11 2011 Thus, based on theoretical and experimental evidence, the oxidation of para- and ortho-hydroquinones to their corresponding electrophilic quinones is a requisite step for the activation of the Keap1/Nrf2/ARE pathway. Quinones 92-100 kelch like ECH associated protein 1 Homo sapiens 193-198