PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 23824185-3 2013 Deletion of KCS1, which blocks synthesis of inositol pyrophosphates on the 5-hydroxyl of the inositol ring, causes inositol auxotrophy and decreased intracellular inositol and phosphatidylinositol. inositol pyrophosphates 44-67 inositol polyphosphate kinase KCS1 Saccharomyces cerevisiae S288C 12-16 25423617-3 2015 Yeast strains lacking the inositol hexakisphosphate (IP6) kinase Kcs1, which is required for the synthesis of inositol pyrophosphates, display increased sensitivity to translation inhibitors and decreased protein synthesis. inositol pyrophosphates 110-133 inositol polyphosphate kinase KCS1 Saccharomyces cerevisiae S288C 65-69 34436165-4 2021 In this yeast, a specific class of inositol pyrophosphates (IPPs), named IP7, made by the IP6K family member Kcs1 regulate polyP synthesis by associating with the SPX domains of the vacuolar transporter chaperone (VTC) complex. inositol pyrophosphates 35-58 inositol polyphosphate kinase KCS1 Saccharomyces cerevisiae S288C 109-113 29939992-8 2018 Overexpression of KCS1, which promotes formation of inositol pyrophosphates, is sufficient to drive pseudohyphal filamentation on medium with normal nitrogen levels. inositol pyrophosphates 52-75 inositol polyphosphate kinase KCS1 Saccharomyces cerevisiae S288C 18-22 23824185-10 2013 We conclude that INO1 transcription is fine-tuned by the synthesis of inositol pyrophosphates, and we propose a model in which modulation of Kcs1 controls INO1 transcription by regulating synthesis of inositol pyrophosphates. inositol pyrophosphates 201-224 inositol polyphosphate kinase KCS1 Saccharomyces cerevisiae S288C 141-145 23824185-9 2013 The Kcs1-catalyzed production of inositol pyrophosphates from inositol pentakisphosphate but not inositol hexakisphosphate is indispensable for optimal INO1 transcription. inositol pyrophosphates 33-56 inositol polyphosphate kinase KCS1 Saccharomyces cerevisiae S288C 4-8 23824185-10 2013 We conclude that INO1 transcription is fine-tuned by the synthesis of inositol pyrophosphates, and we propose a model in which modulation of Kcs1 controls INO1 transcription by regulating synthesis of inositol pyrophosphates. inositol pyrophosphates 70-93 inositol polyphosphate kinase KCS1 Saccharomyces cerevisiae S288C 141-145 18694931-5 2008 Interestingly, telomere shortening in elo3Delta cells was almost completely prevented by deletion of IPK2 or KCS1, which are involved in the generation of inositol phosphates (IP4, IP5, and inositol pyrophosphates). inositol pyrophosphates 190-213 inositol polyphosphate kinase KCS1 Saccharomyces cerevisiae S288C 109-113 23179856-8 2013 Our data provide genetic, metabolic, and biochemical evidence that synthesis of inositol pyrophosphates through activation of Plc1 and Kcs1 plays an important role in the signaling response required for cell cycle progression after mating pheromone arrest. inositol pyrophosphates 80-103 inositol polyphosphate kinase KCS1 Saccharomyces cerevisiae S288C 135-139