PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
15531296-9	2004	Western blotting showed that the synthesis of intracellular p53 and bax protein was gradually up-regulated in the virus-loading period of 72 h. Naloxone had an apparent additive rather than antagonistic effect on the morphine-associated enhancement of bax expression.	Naloxone	144-152	tumor protein p53	Homo sapiens	60-63	
19397953-4	2009	RESULTS: We show that p53 and damage-specific DNA binding protein 2 (ddb2) genes are up-regulated by morphine in a naloxone-sensitive manner.	Naloxone	115-123	tumor protein p53	Homo sapiens	22-25	
19397953-5	2009	Furthermore, the results indicate that DNA damage, quantified by apurinic-apyrimidinic site counting assay and phosphorylation of Ser-15 in P53 protein, is induced in CD3+ T cells by morphine in a naloxone-sensitive manner.	Naloxone	197-205	tumor protein p53	Homo sapiens	140-143	
12702572-14	2003	Our results suggest that morphine, alone or in combination with Nx, may reduce the growth of certain tumors, apparently in part through activation of p53.	Naloxone	64-66	tumor protein p53	Homo sapiens	150-153	
12927789-5	2003	Pretreatment of the cells with 10nM morphine caused a transient, naloxone-reversible suppression of the appearance of activated p53 and the generation of DNA laddering.	Naloxone	65-73	tumor protein p53	Homo sapiens	128-131