PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
26541818-0	2016	The natural dual cyclooxygenase and 5-lipoxygenase inhibitor flavocoxid is protective in EAE through effects on Th1/Th17 differentiation and macrophage/microglia activation.	flavocoxid	61-71	arachidonate 5-lipoxygenase	Homo sapiens	36-50	
24561313-0	2014	Flavocoxid, dual inhibitor of cyclooxygenase-2 and 5-lipoxygenase, exhibits neuroprotection in rat model of ischaemic stroke.	flavocoxid	0-10	arachidonate 5-lipoxygenase	Homo sapiens	51-65	
22471974-0	2012	Effects of flavocoxid, a dual inhibitor of COX and 5-lipoxygenase enzymes, on benign prostatic hyperplasia.	flavocoxid	11-21	arachidonate 5-lipoxygenase	Homo sapiens	51-65	
20972845-1	2010	OBJECTIVE: twice-daily flavocoxid, a cyclooxygenase and 5-lipoxygenase inhibitor with potent antioxidant activity of botanical origin, was evaluated for 12 weeks in a randomized, double-blind, active-comparator study against naproxen in 220 subjects with moderate-severe osteoarthritis (OA) of the knee.	flavocoxid	23-33	arachidonate 5-lipoxygenase	Homo sapiens	56-70	
20845002-1	2010	INTRODUCTION: Flavocoxid is a novel flavonoid-based "dual inhibitor" of the 5-lipoxygenase (5-LOX) enzyme and the cyclooxygenase (COX) enzymes.	flavocoxid	14-24	arachidonate 5-lipoxygenase	Homo sapiens	76-90	
20845002-1	2010	INTRODUCTION: Flavocoxid is a novel flavonoid-based "dual inhibitor" of the 5-lipoxygenase (5-LOX) enzyme and the cyclooxygenase (COX) enzymes.	flavocoxid	14-24	arachidonate 5-lipoxygenase	Homo sapiens	92-97	
20845002-9	2010	CONCLUSION: Flavocoxid, a first-in-class flavonoid-based therapeutic that inhibits COX-1 and COX-2 as well as 5-LOX, was as effective as naproxen in managing the signs and symptoms of OA of the knee.	flavocoxid	12-22	arachidonate 5-lipoxygenase	Homo sapiens	110-115	
20977452-0	2010	Flavocoxid, a dual inhibitor of cyclooxygenase-2 and 5-lipoxygenase, reduces pancreatic damage in an experimental model of acute pancreatitis.	flavocoxid	0-10	arachidonate 5-lipoxygenase	Homo sapiens	53-67	
34906776-3	2022	Flavocoxid is a mixed extract containing baicalin and catechin showing antioxidant effects and anti-inflammatory activity mainly due to a dual inhibition of inducible cyclooxygenase (COX-2), 5-lipoxygenase (5-LOX) and NLRP3 pathway.	flavocoxid	0-10	arachidonate 5-lipoxygenase	Homo sapiens	191-205	
34906776-3	2022	Flavocoxid is a mixed extract containing baicalin and catechin showing antioxidant effects and anti-inflammatory activity mainly due to a dual inhibition of inducible cyclooxygenase (COX-2), 5-lipoxygenase (5-LOX) and NLRP3 pathway.	flavocoxid	0-10	arachidonate 5-lipoxygenase	Homo sapiens	207-212	
34906776-6	2022	Flavocoxid increased Nrf2, prompted a marked reduction in malondialdehyde levels and reduced the expression of COX-2 and 5-LOX together with PGE2, and LTB4 levels.	flavocoxid	0-10	arachidonate 5-lipoxygenase	Homo sapiens	121-126