PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 27166183-4 2016 In this study, we utilized a CHK1 inhibitor, LY2603618, to decrease Mcl-1 and enhance ABT-199 efficacy. LY2603618 45-54 MCL1 apoptosis regulator, BCL2 family member Homo sapiens 68-73 27166183-6 2016 LY2603618 treatment resulted in decrease of Mcl-1, which coincided with the initiation of apoptosis. LY2603618 0-9 MCL1 apoptosis regulator, BCL2 family member Homo sapiens 44-49 27166183-7 2016 Overexpression of Mcl-1 in AML cells significantly attenuated apoptosis induced by LY2603618, confirming the critical role of Mcl-1 in apoptosis induced by the agent. LY2603618 83-92 MCL1 apoptosis regulator, BCL2 family member Homo sapiens 18-23