PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 23324999-4 2013 Among these are, the cAMP response element binding (CREB) protein, extracellular signal-regulated kinase (ERK), both CREB and ERK-part of the mitogen-activated kinase pathway-were upregulated by lithium, downregulated by MPTP, and maintained in mice fed with lithium chloride (LiCl) supplemented diet and treated with MPTP. 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine 318-322 cAMP responsive element binding protein 1 Mus musculus 21-50 23324999-4 2013 Among these are, the cAMP response element binding (CREB) protein, extracellular signal-regulated kinase (ERK), both CREB and ERK-part of the mitogen-activated kinase pathway-were upregulated by lithium, downregulated by MPTP, and maintained in mice fed with lithium chloride (LiCl) supplemented diet and treated with MPTP. 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine 221-225 cAMP responsive element binding protein 1 Mus musculus 21-50 28456375-3 2017 When we examined the cAMP/CREB signaling in the hippocampus, decreased levels of cAMP and phosphorylated CREB were observed in the dentate gyrus (DG) of MPTP-treated mice. 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine 153-157 cAMP responsive element binding protein 1 Mus musculus 26-30 28456375-3 2017 When we examined the cAMP/CREB signaling in the hippocampus, decreased levels of cAMP and phosphorylated CREB were observed in the dentate gyrus (DG) of MPTP-treated mice. 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine 153-157 cAMP responsive element binding protein 1 Mus musculus 105-109 28456375-4 2017 Administration of rolipram improved the memory deficits with concomitant recovery of cAMP and phosphorylated CREB levels, suggesting that reduced cAMP/CREB signaling in the DG leads to cognitive impairment in MPTP-treated mice. 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine 209-213 cAMP responsive element binding protein 1 Mus musculus 151-155 28005447-6 2017 These results suggest that GP-EX ameliorates habit learning memory deficits by activating dopaminergic neurons and spatial memory deficits by modulating NMDA receptor-ERK1/2-CREB system in MPTP-lesioned mice treated with L-DOPA. 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine 189-193 cAMP responsive element binding protein 1 Mus musculus 174-178 27790091-10 2016 Protein kinase A (PKA) and Ca2+/cAMP-response element binding protein (CREB) phosphorylation were reduced in v-DG of MPTP-mice, which were reversed by D1-like receptor (D1R) agonist SKF38393, but not D2R agonist quinpirole. 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine 117-121 cAMP responsive element binding protein 1 Mus musculus 27-69 27790091-10 2016 Protein kinase A (PKA) and Ca2+/cAMP-response element binding protein (CREB) phosphorylation were reduced in v-DG of MPTP-mice, which were reversed by D1-like receptor (D1R) agonist SKF38393, but not D2R agonist quinpirole. 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine 117-121 cAMP responsive element binding protein 1 Mus musculus 71-75 26515688-4 2016 Furthermore, within the dopaminergic neurons of the substantia nigra in MPTP-treated mice, JNK2/3 phosphorylates threonine 69 (Thr69) of Activating transcription factor-2 (ATF2), a transcription factor of the ATF/CREB family, whereas the phosphorylation of Thr71 is constitutive and remains unchanged. 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine 72-76 cAMP responsive element binding protein 1 Mus musculus 213-217 30204307-9 2019 Levels of PKA and CREB phosphorylation in PVN were increased at 4-hour post-MPTP, which were blocked by quinpirole, but not WIN552,12. 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine 76-80 cAMP responsive element binding protein 1 Mus musculus 18-22 8595201-3 1995 In MPTP-treated mice, in which dopaminergic neurones are degenerated and which show Parkinsonism-like behaviour, however, CREB phosphorylation is not induced by cocaine exposure and c-fos expression is significantly depressed in comparison with controls. 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine 3-7 cAMP responsive element binding protein 1 Mus musculus 122-126 34119603-6 2021 Forced expression of VP16-CREB, a constitutively active mutant, rescued Nurr1 expression and showed prominent neuroprotection in MPTP-intoxicated mice. 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine 129-133 cAMP responsive element binding protein 1 Mus musculus 26-30 34119603-7 2021 Collectively, our results demonstrate that Nurr1 downregulation in the MPTP-induced PD mouse model is caused by CREB inactivation, which may provide a new target for neuroprotective therapy in PD. 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine 71-75 cAMP responsive element binding protein 1 Mus musculus 112-116 35501151-4 2022 An MPTP mouse model was used to further elucidate the mechanism underlying CREB dephosphorylation. 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine 3-7 cAMP responsive element binding protein 1 Mus musculus 75-79 35501151-9 2022 Disrupting CREB/HDAC1 interaction via either overexpression of GAL4 M1, a CREB mutant, or administration of trichostatin A, a pan-HDAC inhibitor, restored the expression levels of phospho-CREB (Ser133) and NURR1, and protected nigral dopaminergic neurons in the MPTP-treated mice brain. 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine 262-266 cAMP responsive element binding protein 1 Mus musculus 11-15 35501151-9 2022 Disrupting CREB/HDAC1 interaction via either overexpression of GAL4 M1, a CREB mutant, or administration of trichostatin A, a pan-HDAC inhibitor, restored the expression levels of phospho-CREB (Ser133) and NURR1, and protected nigral dopaminergic neurons in the MPTP-treated mice brain. 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine 262-266 cAMP responsive element binding protein 1 Mus musculus 74-78 35501151-9 2022 Disrupting CREB/HDAC1 interaction via either overexpression of GAL4 M1, a CREB mutant, or administration of trichostatin A, a pan-HDAC inhibitor, restored the expression levels of phospho-CREB (Ser133) and NURR1, and protected nigral dopaminergic neurons in the MPTP-treated mice brain. 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine 262-266 cAMP responsive element binding protein 1 Mus musculus 188-192 35501151-15 2022 Disrupting CREB/HDAC1 interaction restored CREB activity and protected nigral dopaminergic neurons in the MPTP mouse brains. 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine 106-110 cAMP responsive element binding protein 1 Mus musculus 11-15 33911050-8 2021 Moreover, PAP inhibited nuclear factor-kappaB (NF-kappaB) and enhanced cAMP-response element binding protein (CREB) activity in the SN of MPTP/LPS mice. 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine 138-142 cAMP responsive element binding protein 1 Mus musculus 110-114 31717815-1 2019 Previously, we found that 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced Parkinson"s disease (PD) model mice (PD mice) showed facilitation of hippocampal memory extinction via reduced cyclic adenosine monophosphate (cAMP)/cAMP-dependent response element-binding protein (CREB) signaling, which may cause cognitive impairment in PD. 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine 26-70 cAMP responsive element binding protein 1 Mus musculus 284-288 31717815-1 2019 Previously, we found that 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced Parkinson"s disease (PD) model mice (PD mice) showed facilitation of hippocampal memory extinction via reduced cyclic adenosine monophosphate (cAMP)/cAMP-dependent response element-binding protein (CREB) signaling, which may cause cognitive impairment in PD. 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine 72-76 cAMP responsive element binding protein 1 Mus musculus 284-288 29960099-10 2018 These results suggest that Trx-1 ameliorates learning and memory deficits in MPTP-induced PD model in mice via modulating the D1R and the NMDAR-ERK1/2-CREB pathway. 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine 77-81 cAMP responsive element binding protein 1 Mus musculus 151-155 28321769-11 2018 We found that PACA induced the phosphorylation of Akt, ERK, and CREB against MPTP-mediated alterations. 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine 77-81 cAMP responsive element binding protein 1 Mus musculus 64-68 29019056-5 2018 Further, enrichment analyses of the RNA-sequencing data revealed that in the MPTP-treated mice physical exercise predominantly modulated signaling cascades that are regulated by the top upstream regulators L-DOPA, RICTOR, CREB1, or bicuculline/dalfampridine, associated with movement disorders, mitochondrial dysfunction, and epilepsy-related processes. 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine 77-81 cAMP responsive element binding protein 1 Mus musculus 222-227