PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
25637482-4	2015	We found a strong immune response in the gut of mice treated with MPTP, as demonstrated by the prominent presence of macrophages derived from CD115(+) CD11b(+) Ly6C(Hi) monocytes, known as M1 monocytes, and increased production of IL-1beta and IL-6.	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	66-70	interleukin 1 beta	Mus musculus	231-239	
24995576-5	2014	The administration of MPTP (30 mg/kg for four successive days) significantly induced motor impairments as determined by behavioral studies (narrow beam test, catalepsy and akinesia), lowered dopamine levels and up-regulated the expressions of the inflammatory and apoptotic markers (tumor necrosis factor-alpha, interleukin-1beta, interleukin-6, inducible nitric oxide synthase, glial fibrillary acidic protein, cyclooxygenase-2 and Bax).	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	22-26	interleukin 1 beta	Mus musculus	312-329	
23764428-3	2014	We observed that resveratrol treatment significantly reduced glial activation, decreasing the levels of IL-1beta, IL-6 and TNF-alpha, as well as their respective receptors in the SNpc of MPTP-treated mice, as demonstrated by Western blotting, RT-PCR and quantitative PCR analysis.	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	187-191	interleukin 1 beta	Mus musculus	104-112	
24576689-7	2014	Treatment with baicalein decreased the upregulation of cytokines (tumor necrosis factor-alpha and interleukin-1beta) in the substantia nigra and striatum in the mice injected with MPTP.	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	180-184	interleukin 1 beta	Mus musculus	98-115	
23391521-7	2013	Additionally, there was significant upregulation of tumor necrosis factor-alpha (TNF-alpha) and interleukin-1 beta (IL-1beta) expression in the striata of MPTP injected mice compared to saline controls.	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	155-159	interleukin 1 beta	Mus musculus	96-114	
20938211-5	2011	In MPTP-treated animals we observed a significant increase in IL-1beta, TNF-alpha and IL-6 mRNA expression levels both in the SN and CP in comparison with untreated mice.	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	3-7	interleukin 1 beta	Mus musculus	62-70	
21970803-4	2011	MPTP treatment enhanced the release of interleukin (IL)-1beta, IL-6, tumor necrosis factor (TNF)-alpha, IL-4 and IL-10 (P < 0.05).	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	0-4	interleukin 1 beta	Mus musculus	39-61	
20333481-10	2010	The levels of proinflammatory cytokines (interleukin-1 beta, interleukin-6, and tumor necrosis factor-alpha) in the SN were also decreased and induced by MPTP.	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	154-158	interleukin 1 beta	Mus musculus	41-59	
19570816-7	2009	In addition, exendin-4 also suppressed MPTP-induced expression of pro-inflammatory molecules and tumor necrosis factor alpha and interleukin-1 beta.	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	39-43	interleukin 1 beta	Mus musculus	129-147	
19631617-0	2009	Elevated interleukin-1beta induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine aggravating dopaminergic neurodegeneration in old male mice.	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	38-82	interleukin 1 beta	Mus musculus	9-26	
19631617-7	2009	In conclusion, the present study demonstrated that elevated IL-1beta gene expression at early period of time may be in part responsible for the DA neuron susceptibility to MPTP in old male mice.	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	172-176	interleukin 1 beta	Mus musculus	60-68	
19384567-7	2009	Ghrelin prevents MPTP-induced microglial activation in the SNpc and striatum, the expression of pro-inflammatory molecules tumor necrosis factor alpha (TNF-alpha) and interleukin-1beta (IL-1beta), and the activation of inducible nitric oxide synthase.	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	17-21	interleukin 1 beta	Mus musculus	186-194	
19286483-6	2009	MPTP caused a common inflammatory reaction characterized by microglial activation, infiltration of T cells into the substantia nigra and striatum and increased expression of mRNA encoding pro-inflammatory cytokines (IL-1 beta, TNFalpha, INF gamma) and trophic factors (TGFbeta, GDNF).	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	0-4	interleukin 1 beta	Mus musculus	216-225	
15910760-7	2005	The results showed that after MPTP treatment, striatal DA content was dramatically decreased, IL-1beta levels increased on day 3, while IL-6 levels increased on day 14.	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	30-34	interleukin 1 beta	Mus musculus	94-102	
17234424-4	2007	Compared with WT mice, TNF-alpha KO mice treated with MPTP showed reduced FITC-LA leakage, decreased numbers of activated microglia, and reduced proinflammatory cytokines (TNF-alpha and interleukin 1beta) associated with significant MPTP-induced DA neuron loss.	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	54-58	interleukin 1 beta	Mus musculus	186-203	
15910760-12	2005	These results have clearly demonstrated our hypotheses, that MPTP can induce increase of plasma IL-1beta and IL-6 levels in mice, and this effect is shaped by behavioral lateralization.	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	61-65	interleukin 1 beta	Mus musculus	96-104	
33662500-8	2021	KRG treatment prevented MPTP-induced behavioral impairment, dopaminergic neuronal death, activation of microglia and astrocytes in the nigrostriatal pathway, disruption of tight junction and the increase in alpha-synuclein, interleukin-1beta and tumor necrosis factor-alpha expression in the colon.	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	24-28	interleukin 1 beta	Mus musculus	224-241	
12926538-5	2003	The IL1beta mRNA expression rapidly increased and peaked at 6 h. The first increase of mRNA for TNFalpha and IFNgamma was noticed at 6-24 h and the second at the 7th day after MPTP intoxication.	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	176-180	interleukin 1 beta	Mus musculus	4-11	
10208603-0	1999	Transgenic mice expressing a dominant negative mutant interleukin-1beta converting enzyme show resistance to MPTP neurotoxicity.	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	109-113	interleukin 1 beta	Mus musculus	54-71	
9696057-0	1998	Effects of repeated systemic administration of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) to mice on interleukin-1beta and nerve growth factor in the striatum.	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	47-91	interleukin 1 beta	Mus musculus	110-127	
9696057-0	1998	Effects of repeated systemic administration of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) to mice on interleukin-1beta and nerve growth factor in the striatum.	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	93-97	interleukin 1 beta	Mus musculus	110-127	
15589033-8	2005	The results showed that MPTP treatment induced dramatic loss of DA in striatum, simultaneously, IL-6 levels decreased in the striatum and increased in hippocampus and hypothalamus, while IL-1beta levels decreased in the striatum, cerebral cortex and hippocampus.	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	24-28	interleukin 1 beta	Mus musculus	187-195	
15589033-11	2005	Behavioral lateralization also influenced IL-6 hippocampal levels under basal conditions and IL-1beta cortical levels after MPTP.	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	124-128	interleukin 1 beta	Mus musculus	93-101	
16219171-1	2004	The work is to explore the relationship between the levels of cytokines (IL-1beta and IL-6) in C57BL/6J mice treated with MPTP and brain lateralization.	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	122-126	interleukin 1 beta	Mus musculus	73-81	
12626429-8	2003	VIP prevents MPTP-induced activation of microglia in SNpc and striatum and the expression of the cytotoxic mediators, iNOS, interleukin 1beta, and numor necrosis factor alpha.	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	13-17	interleukin 1 beta	Mus musculus	124-141	
33911050-6	2021	In addition, MPTP/LPS enhanced interleukin-1beta (IL-1beta) expression and processing via nod-like receptor protein 3 (NLRP3) inflammasome activation in the SN region of mice.	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	13-17	interleukin 1 beta	Mus musculus	31-48	
30644041-7	2019	Expression of pro-inflammatory cytokine genes, TNF-alpha, Interleukin-12 (IL-12) and Interleukin-1beta (IL-1beta) were found to be upregulated in MPTP-intoxicated mice, whereas TCAE treatment restored their levels.	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	146-150	interleukin 1 beta	Mus musculus	85-102	
31656063-4	2019	In 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated mice, oral administration of KMS99220 attenuated microglial activation and decreased the levels of inducible nitric oxide synthase and interleukin 1 beta (IL-1b) in the nigrostriatal system.	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	3-47	interleukin 1 beta	Mus musculus	211-216	
30728466-12	2019	Furthermore, the olfactory bulbs in MPTP/P-treated mice showed significantly increased levels of interleukin-1beta (IL-1beta), caspase-1, glial fibrillary acidic protein (GFAP), Toll receptor 4 (TLR4), phosphorylation of p65, as well as activated molecules of NOD-like receptor protein 3 (NLRP3) that were associated with neuroinflammation.	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	36-40	interleukin 1 beta	Mus musculus	97-114	
31732967-7	2020	Furthermore, the increments of pro-inflammatory cytokines (TNF-alpha, IL-1beta and IL-6) and TUNEL-positive apoptotic cells in MPTP-treated mice were ameliorated by miR-29c.	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	127-131	interleukin 1 beta	Mus musculus	70-78	
31697983-7	2020	Furthermore, ACT001 abolished MPTP-induced alpha-synuclein overexpression, astrocyte activation and interleukin-1beta (IL-1beta) production in the substantia nigra and striatum of the mouse brain.	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	30-34	interleukin 1 beta	Mus musculus	100-117	
29786072-5	2019	Furthermore, NLRP3 deficiency abolishes MPTP-induced microglial recruitment, interleukin-1beta production and caspase-1 activation in the SN of mouse brain.	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	40-44	interleukin 1 beta	Mus musculus	77-94	
29421335-5	2018	After subcutaneous injection of MPTP (25 mg/kg) every 4 days for 40-days, immune responses became unbalanced, with increased IL-1beta concentrations.	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	32-36	interleukin 1 beta	Mus musculus	125-133