PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
22869602-8	2012	Mechanistic study indicated that andrographolide induced autophagic cell death by disruption of mitochondrial transmembrane potential and elevation of reactive oxygen species, which were correlated with mitochondrial permeability transition pore Inhibition of cyclophilin D (a component of MPTP) by cyclosporin A or abrogation of its expression by small interfering RNA significantly suppressed the cytotoxicity of andrographolide, suggesting that cyclophilin D may play an important role in mediating andrographolide-induced cytotoxicity.	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	290-294	peptidylprolyl isomerase D	Homo sapiens	260-273	
23583382-7	2013	Here, we suggest tumor suppressor, BTG2, as one of the regulators of necrosis in myocardium via inhibiting Akt/Erk, but activating GSK3beta and cyclophilin D, which resulted in mPTP opening in response to H2O2.	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	177-181	peptidylprolyl isomerase D	Homo sapiens	144-157