PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 7613528-9 1995 Liquid hybridization and Northern blotting assays revealed drug-specific regulation of the angiotensinogen mRNA level in the adrenal gland, with cilazapril producing the most marked stimulation of adrenal angiotensinogen gene expression. Cilazapril 145-155 angiotensinogen Rattus norvegicus 91-106 7613528-9 1995 Liquid hybridization and Northern blotting assays revealed drug-specific regulation of the angiotensinogen mRNA level in the adrenal gland, with cilazapril producing the most marked stimulation of adrenal angiotensinogen gene expression. Cilazapril 145-155 angiotensinogen Rattus norvegicus 205-220 7613528-10 1995 Both lisinopril and cilazapril suppressed hypothalamic angiotensinogen mRNA. Cilazapril 20-30 angiotensinogen Rattus norvegicus 55-70 7614507-2 1995 Angiotensin II may contribute to lung vascular remodeling in pulmonary hypertensive disease, since cilazapril, an inhibitor of ACE, reduces pulmonary vascular medical thickening in chronically hypoxic rats with established pulmonary hypertension. Cilazapril 99-109 angiotensinogen Rattus norvegicus 0-14 2965632-12 1988 Superimposed administration of either angiotensin II or angiotensin III during cilazapril infusion completely reversed the blood pressure and bilateral renal responses of cilazapril in both hypertensive and normotensive rats. Cilazapril 79-89 angiotensinogen Rattus norvegicus 38-52 2965632-12 1988 Superimposed administration of either angiotensin II or angiotensin III during cilazapril infusion completely reversed the blood pressure and bilateral renal responses of cilazapril in both hypertensive and normotensive rats. Cilazapril 171-181 angiotensinogen Rattus norvegicus 38-52 2965632-14 1988 These results indicate that cilazapril reduces arterial pressure and enhances renal excretion mainly via inhibition of angiotensin II and angiotensin III formation. Cilazapril 28-38 angiotensinogen Rattus norvegicus 119-133 10446934-12 1999 Human and rat renin and angiotensinogen genes were downregulated in dTGR and were increased by losartan and cilazapril treatments, whereas no changes in the expression of rat ACE and AT1A receptor genes were observed. Cilazapril 108-118 angiotensinogen Rattus norvegicus 24-39 9314843-6 1997 Both cilazapril (angiotensin II-converting enzyme inhibitor) and E4177 (angiotensin II type 1 [AT1] receptor antagonist) significantly suppressed the phosphorylation of Tyk2 and partially inhibited the phosphorylation of JAK2, but neither affected JAK1. Cilazapril 5-15 angiotensinogen Rattus norvegicus 17-31 2532469-7 1989 Further studies are required to determine whether this effect of cilazapril was due to the decrease of arterial blood pressure or to an effect of cilazapril on growth factors such as angiotensin II. Cilazapril 146-156 angiotensinogen Rattus norvegicus 183-197 2977443-1 1988 Previous studies have shown that atrial natriuretic factor (ANF) inhibits renin secretion whereas cilazapril blocks angiotensin II generation via converting enzyme inhibition. Cilazapril 98-108 angiotensinogen Rattus norvegicus 116-130 2468061-3 1988 Cilazapril is a new long-lasting inhibitor of angiotensin-converting enzyme which suppresses the peripheral vasoconstrictor effect of angiotensin I by inhibiting its transformation in angiotensin II. Cilazapril 0-10 angiotensinogen Rattus norvegicus 184-198