PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
10887043-1	2000	Ofloxacin induces its antibacterial action mainly by inhibition of DNA gyrase which is equivalent to topoisomerase II in mammalian cells.	Ofloxacin	0-9	DNA topoisomerase II alpha	Homo sapiens	67-77	
23008691-1	2011	BACKGROUND AND THE PURPOSE OF THE STUDY: Ofloxacin is a quinolone synthetic antibiotic, which acts against resistant mutants of bacteria by inhibiting DNA gyrase.	Ofloxacin	41-50	DNA topoisomerase II alpha	Homo sapiens	151-161	
26812543-0	2016	RETRACTED: Ambient UV-B exposure reduces the binding of ofloxacin with bacterial DNA gyrase and induces DNA damage mediated apoptosis.	Ofloxacin	56-65	DNA topoisomerase II alpha	Homo sapiens	81-91	
10493278-1	1999	UNLABELLED: Ofloxacin is a synthetic fluoroquinolone antibacterial agent that inhibits the supercoiling activity of bacterial DNA gyrase, halting DNA replication.	Ofloxacin	12-21	DNA topoisomerase II alpha	Homo sapiens	126-136	
8013490-4	1994	In a supercoiling assay using the purified DNA gyrase and plasmid pBR322, high concentrations (> or = 250 micrograms/ml) of both ofloxacin and ciprofloxacin were needed for visible inhibition of enzyme activity suggesting mutations in the DNA gyrase gene as the significant mechanism of resistance in both strains.	Ofloxacin	132-141	DNA topoisomerase II alpha	Homo sapiens	43-53	
8013490-4	1994	In a supercoiling assay using the purified DNA gyrase and plasmid pBR322, high concentrations (> or = 250 micrograms/ml) of both ofloxacin and ciprofloxacin were needed for visible inhibition of enzyme activity suggesting mutations in the DNA gyrase gene as the significant mechanism of resistance in both strains.	Ofloxacin	132-141	DNA topoisomerase II alpha	Homo sapiens	242-252	
2842501-2	1988	Compound 1 was found to be a DNA gyrase inhibitor having potency similar to ofloxacin but less than ciprofloxacin.	Ofloxacin	76-85	DNA topoisomerase II alpha	Homo sapiens	29-39	
10838268-12	1998	Ofloxacin inhibits DNA topoisomerase (ATP-hydrolyzing), commonly referred to as DNA-gyrase.	Ofloxacin	0-9	DNA topoisomerase II alpha	Homo sapiens	80-90	
1723377-2	1991	Ofloxacin is a fluoroquinolone whose primary mechanism of action is inhibition of bacterial DNA gyrase.	Ofloxacin	0-9	DNA topoisomerase II alpha	Homo sapiens	92-102	
1850968-1	1991	A study was made of the correlation between the in vitro inhibitory effects of several quinolones, including four ofloxacin derivatives, on bacterial DNA gyrase from Escherichia coli KL-16 and on topoisomerase II from fetal calf thymus.	Ofloxacin	114-123	DNA topoisomerase II alpha	Homo sapiens	150-160	
1850968-5	1991	Among these derivatives, DR-3355, the S isomer of ofloxacin, showed the highest activity against DNA gyrase and low activity against topoisomerase II.	Ofloxacin	50-59	DNA topoisomerase II alpha	Homo sapiens	97-107	
3028965-2	1986	Ofloxacin was found to be characterized by potent bactericidal activity due to its strong inhibition of bacterial DNA gyrase.	Ofloxacin	0-9	DNA topoisomerase II alpha	Homo sapiens	114-124