PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
16537715-4	2006	Therefore, we assessed the human cytochrome P450-dependent oxidation of estrone using substrate concentrations that more closely approximate the maximum expected concentrations in breast tissue.	Estrone	72-79	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	33-48	
27966929-6	2017	We studied the structure of human estrogen metabolizing enzymes (CYP1A1, CYP1A2, CYP1B1, and CYP3A4) in complex with estrone using docking and investigated the susceptibility of estrone, equilin, and equilenin (which only differ in the unsaturation of ring B) to undergo 2- and 4-hydroxylation using several models of CYP enzymes (Compound I, methoxy, and phenoxy radical).	Estrone	117-124	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	65-68	
27966929-6	2017	We studied the structure of human estrogen metabolizing enzymes (CYP1A1, CYP1A2, CYP1B1, and CYP3A4) in complex with estrone using docking and investigated the susceptibility of estrone, equilin, and equilenin (which only differ in the unsaturation of ring B) to undergo 2- and 4-hydroxylation using several models of CYP enzymes (Compound I, methoxy, and phenoxy radical).	Estrone	178-185	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	65-68	
16537715-5	2006	The in vitro metabolism of estrone by recombinant human cytochrome P450 enzymes and human liver microsomes was studied.	Estrone	27-34	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	56-71	
12865317-14	2003	In conclusion, many human CYP isoforms are involved in the oxidative metabolism of 17beta-estradiol and estrone, with a varying degree of catalytic activity and distinct regioselectivity.	Estrone	104-111	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	26-29	
12865317-0	2003	Characterization of the oxidative metabolites of 17beta-estradiol and estrone formed by 15 selectively expressed human cytochrome p450 isoforms.	Estrone	70-77	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	119-134	
12865317-1	2003	We systematically characterized the oxidative metabolites of 17beta-estradiol and estrone formed by 15 human cytochrome P450 (CYP) isoforms.	Estrone	82-89	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	109-124	
12865317-1	2003	We systematically characterized the oxidative metabolites of 17beta-estradiol and estrone formed by 15 human cytochrome P450 (CYP) isoforms.	Estrone	82-89	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	126-129	
12548158-1	2003	Cytochrome P450 isoenzymes are known to contribute to estrone metabolism.	Estrone	54-61	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	0-15	
10640505-0	2000	Novel metabolic pathway of estrone and 17beta-estradiol catalyzed by cytochrome P-450.	Estrone	27-34	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	69-85	
10640505-2	2000	In the present study, we investigated whether estrone and 17beta-estadiol, each of which contains a p-alkylphenol moiety, are also oxidized into the corresponding quinols by cytochrome P-450.	Estrone	46-53	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	174-190