PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 31855101-2 2020 The pathway for the transformation of the prodrug nabumetone, 4-(6-methoxynaphthalen-2-yl)butan-2-on, to the active metabolite 6-methoxy-2-naphthylacetic acid (6-MNA), a potent cyclooxygenase-2 inhibitor, has not yet been clarified in humans.2. 6-methoxy-2-naphthylacetic acid 127-158 prostaglandin-endoperoxide synthase 2 Homo sapiens 177-193 7996488-9 1994 IC50 values (microM) for inhibition of PGHS-1 and PGHS-2 were: indomethacin, 0.70 +/- 0.20 vs 0.36 +/- 0.10 (P < .05); S-indobufen, 0.64 +/- 0.22 vs. 14.9 +/- 8 (P < .05), R-indobufen, 38 +/- 18 vs. 230 +/- 68 (P < .01), 6-methoxy-2-naphthyl acetic acid (the active metabolite of nabumetone), 278 +/- 96 vs. 187 +/- 96. 6-methoxy-2-naphthylacetic acid 230-262 prostaglandin-endoperoxide synthase 2 Homo sapiens 50-56 31855101-2 2020 The pathway for the transformation of the prodrug nabumetone, 4-(6-methoxynaphthalen-2-yl)butan-2-on, to the active metabolite 6-methoxy-2-naphthylacetic acid (6-MNA), a potent cyclooxygenase-2 inhibitor, has not yet been clarified in humans.2. 6-methoxy-2-naphthylacetic acid 160-165 prostaglandin-endoperoxide synthase 2 Homo sapiens 177-193