PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 16179486-1 2006 Urea transport in the kidney is mediated by a family of transporter proteins, including renal urea transporters (UT-A) and erythrocyte urea transporters (UT-B). Urea 0-4 solute carrier family 14 member 1 (Kidd blood group) Rattus norvegicus 154-158 15798087-0 2005 Regulated expression of renal and intestinal UT-B urea transporter in response to varying urea load. Urea 50-54 solute carrier family 14 member 1 (Kidd blood group) Rattus norvegicus 45-49 15798087-3 2005 In this study, we examined the expression of the UT-B urea transporter in rats fed a low-protein diet (LPD), a high-protein diet (HPD), and a 20% urea-supplemented diet. Urea 54-58 solute carrier family 14 member 1 (Kidd blood group) Rattus norvegicus 49-53 15798087-4 2005 In the kidney, UT-B protein abundance increased in the outer medulla of both LPD-fed rats and 20% urea-fed rats, without changes in the inner medulla of either group compared with controls. Urea 98-102 solute carrier family 14 member 1 (Kidd blood group) Rattus norvegicus 15-19 15798087-8 2005 In rat colon, UT-B protein abundance was mildly, but significantly, decreased in LPD-fed and 20% urea-fed rats. Urea 97-101 solute carrier family 14 member 1 (Kidd blood group) Rattus norvegicus 14-18 15798087-10 2005 These findings indicate that UT-B expression is regulated in response to different loads of urea, with a pattern that suggests involvement of tissue-specific regulatory mechanism in kidney and colon. Urea 92-96 solute carrier family 14 member 1 (Kidd blood group) Rattus norvegicus 29-33 15068976-9 2004 UT-B may participate in the regulation of epithelial cell volume and osmolality, in the dissipation of urea gradients, and in possible net urea transport across uroepithelia. Urea 103-107 solute carrier family 14 member 1 (Kidd blood group) Rattus norvegicus 0-4 15251864-7 2005 Additionally, both UT-A2 and UT-B protein abundances in the outer medulla increased during urea-induced osmotic diuresis but not in NaCl or glucose diuresis. Urea 91-95 solute carrier family 14 member 1 (Kidd blood group) Rattus norvegicus 29-33 15251864-8 2005 We conclude that during osmotic diuresis, UT-A1 abundance increases when the percentage of urea in total urinary solute is low and UT-A2 and UT-B abundances increase when the urea concentration in the medullary interstitium is high. Urea 175-179 solute carrier family 14 member 1 (Kidd blood group) Rattus norvegicus 141-145 15068976-9 2004 UT-B may participate in the regulation of epithelial cell volume and osmolality, in the dissipation of urea gradients, and in possible net urea transport across uroepithelia. Urea 139-143 solute carrier family 14 member 1 (Kidd blood group) Rattus norvegicus 0-4 11704564-3 2001 A reduced urea content in the inner medulla of senescent rats, fed ad libitum or food-restricted, was suggested by the marked decrease in expression of UT-A1 and UT-B1 urea transporters. Urea 10-14 solute carrier family 14 member 1 (Kidd blood group) Rattus norvegicus 162-167 13679141-11 2003 The distribution of UT-A and UT-B in the inner ear suggests that the cells that surround the inner ear fluids may be involved in urea transport and thus play an important role in fluid homeostasis in the inner ear. Urea 129-133 solute carrier family 14 member 1 (Kidd blood group) Rattus norvegicus 29-33 12167610-9 2002 This study showed that urea must enter endothelial cells, probably by UT-B, to inhibit L-Arg transport. Urea 23-27 solute carrier family 14 member 1 (Kidd blood group) Rattus norvegicus 70-74 12167610-10 2002 In view of the wide distribution of UT-B in rat vasculature, elevated blood urea nitrogen may lead to endothelial L-Arg deficiency in vivo. Urea 76-80 solute carrier family 14 member 1 (Kidd blood group) Rattus norvegicus 36-40 11832436-1 2002 Urea transport in the kidney is mediated by a family of transporter proteins that includes renal urea transporters (UT-A) and erythrocyte urea transporters (UT-B). Urea 0-4 solute carrier family 14 member 1 (Kidd blood group) Rattus norvegicus 157-161 9623675-9 1998 UT3 mRNA expression by astrocytes is markedly upregulated in quinolinic acid-induced gliosis, possibly as a result of increased urea levels during gliosis induced polyamine formation. Urea 128-132 solute carrier family 14 member 1 (Kidd blood group) Rattus norvegicus 0-3 10972682-1 2000 BACKGROUND: The facilitated urea transporters (UT), UT-A1, UT-A2, and UT-B1, are involved in intrarenal recycling of urea, an essential feature of the urinary concentrating mechanism, which is impaired in chronic renal failure (CRF). Urea 28-32 solute carrier family 14 member 1 (Kidd blood group) Rattus norvegicus 70-75 10215321-1 1999 Urea transport in the kidney is important for the production of concentrated urine and is mediated by a family of transporter proteins, identified from erythropoietic tissue (UT-B) and from kidney (UT-A). Urea 0-4 solute carrier family 14 member 1 (Kidd blood group) Rattus norvegicus 175-179 10073615-5 1999 The facilitated urea transporter (UT-B) in erythrocytes permits these cells to lose urea rapidly as they traverse the ascending vasa recta, thereby preventing loss of urea from the medulla and decreasing urine-concentrating ability by decreasing the efficiency of countercurrent exchange, as occurs in Jk null individuals (who lack Kidd antigen). Urea 16-20 solute carrier family 14 member 1 (Kidd blood group) Rattus norvegicus 34-38 10073615-5 1999 The facilitated urea transporter (UT-B) in erythrocytes permits these cells to lose urea rapidly as they traverse the ascending vasa recta, thereby preventing loss of urea from the medulla and decreasing urine-concentrating ability by decreasing the efficiency of countercurrent exchange, as occurs in Jk null individuals (who lack Kidd antigen). Urea 84-88 solute carrier family 14 member 1 (Kidd blood group) Rattus norvegicus 34-38 9623675-10 1998 We propose that UT3 in astrocytes represents a mechanism to control urea formed in the brain by equilibrating it throughout the astrocyte network and guiding it to blood vessels and the CSF for disposal. Urea 68-72 solute carrier family 14 member 1 (Kidd blood group) Rattus norvegicus 16-19 9545259-9 1998 In UT3-expressing oocytes, the time course of oocyte volume in response to different urea gradients (induced osmosis) gave sigmaurea approximately 0.3 for the UT3 pathway, in agreement with sigmaurea determined by the increase in uptake of [14C]urea during osmotic gradient-induced oocyte swelling (solvent drag). Urea 128-132 solute carrier family 14 member 1 (Kidd blood group) Rattus norvegicus 159-162 9545259-6 1998 Relative single channel urea permeabilities (purea) were 1.0 (UT2), 0.44 (UT3), and 0.0 (AQP1). Urea 24-28 solute carrier family 14 member 1 (Kidd blood group) Rattus norvegicus 74-77 9545259-7 1998 UT3-mediated water and urea transport were weakly temperature-dependent (activation energy <4 kcal/mol), inhibited > 75% by the urea transport inhibitor 1,3-dimethylthiourea, but not inhibited by the water transport inhibitor HgCl2. Urea 23-27 solute carrier family 14 member 1 (Kidd blood group) Rattus norvegicus 0-3 9545259-7 1998 UT3-mediated water and urea transport were weakly temperature-dependent (activation energy <4 kcal/mol), inhibited > 75% by the urea transport inhibitor 1,3-dimethylthiourea, but not inhibited by the water transport inhibitor HgCl2. Urea 134-138 solute carrier family 14 member 1 (Kidd blood group) Rattus norvegicus 0-3 9545259-11 1998 These results indicate that UT3 functions as a urea/water channel utilizing a common aqueous pathway. Urea 47-51 solute carrier family 14 member 1 (Kidd blood group) Rattus norvegicus 28-31 9545259-12 1998 The water transporting function and low urea reflection coefficient of UT3 in vasa recta may be important for the formation of a concentrated urine by countercurrent exchange in the kidney. Urea 40-44 solute carrier family 14 member 1 (Kidd blood group) Rattus norvegicus 71-74 25613743-2 2015 The urea analog dimethylthiourea (DMTU) was recently found to inhibit the UT isoforms UT-A1 (expressed in kidney tubule epithelium) and UT-B (expressed in kidney vasa recta endothelium) with IC50 of 2-3 mM, and was shown to have diuretic action when administered to rats. Urea 4-8 solute carrier family 14 member 1 (Kidd blood group) Rattus norvegicus 136-140 25993324-0 2015 Salt-sparing diuretic action of a water-soluble urea analog inhibitor of urea transporters UT-A and UT-B in rats. Urea 48-52 solute carrier family 14 member 1 (Kidd blood group) Rattus norvegicus 100-104 26879937-1 2016 BACKGROUND: Previous work found that urea accumulation in urothelial cells caused by urea transporter B knockout led to DNA damage and apoptosis that contributed to the carcinogenesis. Urea 37-41 solute carrier family 14 member 1 (Kidd blood group) Rattus norvegicus 85-103 21127847-0 2011 UT-B1 mediates transepithelial urea flux in the rat gastrointestinal tract. Urea 31-35 solute carrier family 14 member 1 (Kidd blood group) Rattus norvegicus 0-5 23486518-4 2013 The half-maximal inhibitory concentration of PU-14 on rat UT-B-mediated urea transport was ~0.8 mumol/l, and it did not affect urea transport in mouse erythrocytes lacking UT-B but inhibited UT-A-type urea transporters, with 36% inhibition at 4 mumol/l. Urea 72-76 solute carrier family 14 member 1 (Kidd blood group) Rattus norvegicus 58-62 21127847-8 2011 We therefore concluded that UT-B1 mediates the transepithelial movement of urea that occurs in specific distal regions of the rat gastrointestinal tract. Urea 75-79 solute carrier family 14 member 1 (Kidd blood group) Rattus norvegicus 28-33 19034881-2 2008 Two groups of urea transporters (UT-A and UT-B) have been identified in mammals, and both are involved in intrarenal recycling of urea. Urea 14-18 solute carrier family 14 member 1 (Kidd blood group) Rattus norvegicus 42-46 16849692-6 2007 These findings are consistent with the notion that urea and creatinine are continuously reabsorbed from the urine across the urothelium, urea in part via UT-B, and that urine is thus altered in its passage through the urinary tract. Urea 51-55 solute carrier family 14 member 1 (Kidd blood group) Rattus norvegicus 154-158 16849692-6 2007 These findings are consistent with the notion that urea and creatinine are continuously reabsorbed from the urine across the urothelium, urea in part via UT-B, and that urine is thus altered in its passage through the urinary tract. Urea 137-141 solute carrier family 14 member 1 (Kidd blood group) Rattus norvegicus 154-158