PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 893492-8 1977 Urea formation from citrulline was confirmed in a continuous column reactor by the coimmobilized argininosuccinate synthetase, argininosuccinate lyase (EC 4.3.2.1), and arginase (EC 3.5.3.1). Urea 0-4 argininosuccinate lyase Homo sapiens 127-150 2834354-1 1988 Argininosuccinate lyase [EC 4.3.2.1] is an enzyme of the urea cycle in the liver of ureotelic animals. Urea 57-61 argininosuccinate lyase Homo sapiens 0-23 2834354-2 1988 The enzymes of the urea cycle, including argininosuccinate lyase, are regulated developmentally and in response to dietary and hormonal changes, in a coordinated manner. Urea 19-23 argininosuccinate lyase Homo sapiens 41-64 7329991-3 1981 Investigation of the urea-cycle enzyme in the leucocytes of patients with renal insufficiency, in the pre-dialytic and dialytic states, showed that in both groups the ornithine carbamoyl transferase and the argininosuccinate lyase activity was lower in both groups of patients than in normal persons. Urea 21-25 argininosuccinate lyase Homo sapiens 207-230 282632-1 1978 Argininosuccinic aciduria, an autosomal recessive disorder of the urea cycle in humans, is associated with a deficiency of argininosuccinate lyase (ASL; L-argininosuccinate arginine-lyase, EC 4.3.2.1). Urea 66-70 argininosuccinate lyase Homo sapiens 148-151 337792-2 1977 The urea cycle consist of five enzymatically controlled steps that are catalyzed by carbamyl phosphate synthetase, ornithine transcarbamylase, argininosuccinate synthetase, argininosuccinase, and arginase, respectively. Urea 4-8 argininosuccinate lyase Homo sapiens 173-190 21290785-0 1993 Argininosuccinate Lyase Deficiency CLINICAL CHARACTERISTICS: Deficiency of argininosuccinate lyase (ASL), the enzyme that cleaves argininosuccinic acid to produce arginine and fumarate in the fourth step of the urea cycle, is characterized by a severe neonatal onset form and a late onset form. Urea 211-215 argininosuccinate lyase Homo sapiens 100-103 885138-0 1977 Urea as a selective inhibitor of argininosuccinate lyase. Urea 0-4 argininosuccinate lyase Homo sapiens 33-56 885138-2 1977 It was demonstrated that argininosuccinate lyase was the only ornithine cycle enzyme inhibited by urea in a competitive manner. Urea 98-102 argininosuccinate lyase Homo sapiens 25-48 30901224-7 2019 Furthermore, dysregulation of CPS1, ASL, and ARG1, key enzymes involved in urea cycle, together with Annexin A6 and CES1, major proteins in regulating cholesterol homeostasis and fatty acid ester metabolism, was verified using immunohistochemical staining. Urea 75-79 argininosuccinate lyase Homo sapiens 36-39 32949613-9 2021 Co-mapped transcriptomics and proteomics data showed that co-exposure to phthalates and heavy metals leads to perturbations of the urea cycle due to differential expression levels of arginase-1 and -2, argininosuccinate synthase, carbamoyl-phosphate synthase, ornithine carbamoyltransferase, and argininosuccinate lyase. Urea 131-135 argininosuccinate lyase Homo sapiens 296-319 32410394-1 2020 BACKGROUND: The urea cycle plays a key role in preventing the accumulation of toxic nitrogenous waste products, including two essential enzymes: ornithine transcarbamylase (OTC) and argininosuccinate lyase (ASL). Urea 16-20 argininosuccinate lyase Homo sapiens 182-205 32410394-1 2020 BACKGROUND: The urea cycle plays a key role in preventing the accumulation of toxic nitrogenous waste products, including two essential enzymes: ornithine transcarbamylase (OTC) and argininosuccinate lyase (ASL). Urea 16-20 argininosuccinate lyase Homo sapiens 207-210 31037164-8 2018 Chromatography of amino acids in the urine showed increased basic amino acids evoking a deficit of the urea cycle due to deficit of the enzyme argininosuccinate lyase. Urea 103-107 argininosuccinate lyase Homo sapiens 143-166 32042869-1 2019 Argininosuccinate lyase (ASL) plays an important role in the hepatic urea cycle, and can catalyze the reversible reaction of argininosuccinate to arginine and fumarate. Urea 69-73 argininosuccinate lyase Homo sapiens 0-23 32042869-1 2019 Argininosuccinate lyase (ASL) plays an important role in the hepatic urea cycle, and can catalyze the reversible reaction of argininosuccinate to arginine and fumarate. Urea 69-73 argininosuccinate lyase Homo sapiens 25-28 30613774-5 2019 In addition, their arginine concentrations reverse the urea cycle reaction catalyzed by argininosuccinate lyase, an effect not observed in vivo, and prevented by Plasmax in vitro. Urea 55-59 argininosuccinate lyase Homo sapiens 88-111 30176945-9 2018 In HLE cells, 148 downregulated metabolic genes in liver tumours also showed low gene/protein expression - notably in fatty acid beta-oxidation (e.g. ACAA1/2, ACADSB, HADH), urea cycle (e.g. CPS1, ARG1, ASL), molecule transport (e.g. SLC2A2, SLC7A1, SLC25A15/20), and amino acid metabolism (e.g. PHGDH, PSAT1, GOT1, GLUD1). Urea 174-178 argininosuccinate lyase Homo sapiens 203-206 26745957-2 2016 OBJECTIVES: We investigated the effect of cysteamine on mutant argininosuccinate lyase (ASL), the second most common defect in the urea cycle. Urea 131-135 argininosuccinate lyase Homo sapiens 63-86 20301396-1 1993 Severe deficiency or total absence of activity of any of the first four enzymes (CPS1, OTC, ASS, ASL) in the urea cycle or the cofactor producer (NAGS) results in the accumulation of ammonia and other precursor metabolites during the first few days of life. Urea 109-113 argininosuccinate lyase Homo sapiens 97-100 30158522-1 2018 Argininosuccinate lyase (ASL) belongs to the hepatic urea cycle detoxifying ammonia, and the citrulline-nitric oxide (NO) cycle producing NO. Urea 53-57 argininosuccinate lyase Homo sapiens 0-23 30158522-1 2018 Argininosuccinate lyase (ASL) belongs to the hepatic urea cycle detoxifying ammonia, and the citrulline-nitric oxide (NO) cycle producing NO. Urea 53-57 argininosuccinate lyase Homo sapiens 25-28 26745957-2 2016 OBJECTIVES: We investigated the effect of cysteamine on mutant argininosuccinate lyase (ASL), the second most common defect in the urea cycle. Urea 131-135 argininosuccinate lyase Homo sapiens 88-91 26731266-1 2016 delta-Crystallin is the major structural protein in avian eye lenses and is homologous to the urea cycle enzyme argininosuccinate lyase. Urea 94-98 argininosuccinate lyase Homo sapiens 112-135 25778938-1 2015 Loss of function of the urea cycle enzyme argininosuccinate lyase (ASL) is caused by mutations in the ASL gene leading to ASL deficiency (ASLD). Urea 24-28 argininosuccinate lyase Homo sapiens 42-65 25778938-1 2015 Loss of function of the urea cycle enzyme argininosuccinate lyase (ASL) is caused by mutations in the ASL gene leading to ASL deficiency (ASLD). Urea 24-28 argininosuccinate lyase Homo sapiens 67-70 25778938-1 2015 Loss of function of the urea cycle enzyme argininosuccinate lyase (ASL) is caused by mutations in the ASL gene leading to ASL deficiency (ASLD). Urea 24-28 argininosuccinate lyase Homo sapiens 102-105 19703900-1 2009 Deficiency of argininosuccinate lyase (ASL) causes argininosuccinic aciduria, an urea cycle defect that may present with a severe neonatal onset form or with a late onset phenotype. Urea 81-85 argininosuccinate lyase Homo sapiens 39-42 25634685-16 2015 Moreover, enzymes involved in the urea cycle were suppressed by high-fat diet, including carbamoyl phosphate synthase 1 (CPS1), ornithine transcarbamoylase (OTC), argininosuccinate synthase (ASS), argininosuccinate lyase (ASL), and arginase 1 (ARG 1). Urea 34-38 argininosuccinate lyase Homo sapiens 197-220 25634685-16 2015 Moreover, enzymes involved in the urea cycle were suppressed by high-fat diet, including carbamoyl phosphate synthase 1 (CPS1), ornithine transcarbamoylase (OTC), argininosuccinate synthase (ASS), argininosuccinate lyase (ASL), and arginase 1 (ARG 1). Urea 34-38 argininosuccinate lyase Homo sapiens 222-225 21963434-1 2012 Argininosuccinate lyase (ASL) catalyzes the conversion of argininosuccinate into arginine and fumarate, a key step in the biosynthesis of urea and arginine. Urea 138-142 argininosuccinate lyase Homo sapiens 0-23 24166829-1 2014 Argininosuccinate lyase deficiency (ASLD) is caused by a defect of the urea cycle enzyme argininosuccinate lyase (ASL) encoded by the ASL gene. Urea 71-75 argininosuccinate lyase Homo sapiens 89-112 24166829-1 2014 Argininosuccinate lyase deficiency (ASLD) is caused by a defect of the urea cycle enzyme argininosuccinate lyase (ASL) encoded by the ASL gene. Urea 71-75 argininosuccinate lyase Homo sapiens 36-39 24166829-1 2014 Argininosuccinate lyase deficiency (ASLD) is caused by a defect of the urea cycle enzyme argininosuccinate lyase (ASL) encoded by the ASL gene. Urea 71-75 argininosuccinate lyase Homo sapiens 114-117 22531684-1 2012 Argininosuccinate lyase (ASL) is an important enzyme in the hepatic urea cycle, and catalyzes the reversible reaction of argininosuccinate to arginine and fumarate. Urea 68-72 argininosuccinate lyase Homo sapiens 0-23 22531684-1 2012 Argininosuccinate lyase (ASL) is an important enzyme in the hepatic urea cycle, and catalyzes the reversible reaction of argininosuccinate to arginine and fumarate. Urea 68-72 argininosuccinate lyase Homo sapiens 25-28 20167786-5 2010 Acetylation activated enoyl-coenzyme A hydratase/3-hydroxyacyl-coenzyme A dehydrogenase in fatty acid oxidation and malate dehydrogenase in the TCA cycle, inhibited argininosuccinate lyase in the urea cycle, and destabilized phosphoenolpyruvate carboxykinase in gluconeogenesis. Urea 196-200 argininosuccinate lyase Homo sapiens 165-188 15320872-1 2004 Delta crystallin, a taxon-specific crystallin present in avian eye lenses, is homologous to the urea cycle enzyme ASL (argininosuccinate lyase). Urea 96-100 argininosuccinate lyase Homo sapiens 114-117 18666241-2 2009 There are five key enzymes in the urea cycle: carbamoyl-phosphate synthetase 1 (CPS1), ornithine transcarbamylase (OTC), argininosuccinate synthetase (ASS1), argininosuccinate lyase (ASL), and arginase 1 (ARG1). Urea 34-38 argininosuccinate lyase Homo sapiens 158-181 18666241-2 2009 There are five key enzymes in the urea cycle: carbamoyl-phosphate synthetase 1 (CPS1), ornithine transcarbamylase (OTC), argininosuccinate synthetase (ASS1), argininosuccinate lyase (ASL), and arginase 1 (ARG1). Urea 34-38 argininosuccinate lyase Homo sapiens 183-186 19217439-2 2009 Citrulline, which is formed as a by-product of the NOS reaction, can be recycled to arginine by the 2 enzymes acting in the urea cycle: argininosuccinate synthetase (ASS) and argininosuccinate lyase (ASL). Urea 124-128 argininosuccinate lyase Homo sapiens 175-198 19217439-2 2009 Citrulline, which is formed as a by-product of the NOS reaction, can be recycled to arginine by the 2 enzymes acting in the urea cycle: argininosuccinate synthetase (ASS) and argininosuccinate lyase (ASL). Urea 124-128 argininosuccinate lyase Homo sapiens 200-203 16808909-2 2006 We tested whether argininosuccinate lyase deficiency (ASL), a genetic disorder of the urea cycle with hepatomegaly and biochemical hepatitis, causes increased CDT results and whether this depends on the analytical method. Urea 86-90 argininosuccinate lyase Homo sapiens 54-57 15320872-1 2004 Delta crystallin, a taxon-specific crystallin present in avian eye lenses, is homologous to the urea cycle enzyme ASL (argininosuccinate lyase). Urea 96-100 argininosuccinate lyase Homo sapiens 119-142 11698398-2 2002 ASL is part of the urea and arginine-citrulline cycles and catalyzes the reversible breakdown of argininosuccinate to arginine and fumarate. Urea 19-23 argininosuccinate lyase Homo sapiens 0-3 11747432-1 2001 Argininosuccinate lyase (ASL) catalyzes the reversible breakdown of argininosuccinate to arginine and fumarate, a reaction involved in the biosynthesis of arginine in all species and in the production of urea in ureotelic species. Urea 204-208 argininosuccinate lyase Homo sapiens 0-23 11747432-1 2001 Argininosuccinate lyase (ASL) catalyzes the reversible breakdown of argininosuccinate to arginine and fumarate, a reaction involved in the biosynthesis of arginine in all species and in the production of urea in ureotelic species. Urea 204-208 argininosuccinate lyase Homo sapiens 25-28 11092456-1 2000 Argininosuccinate lyase (ASL) catalyzes the reversible hydrolysis of argininosuccinate to arginine and fumarate, a reaction important for the detoxification of ammonia via the urea cycle and for arginine biosynthesis. Urea 176-180 argininosuccinate lyase Homo sapiens 0-23 10709858-3 2000 In this context, it is notable that cell types that do not have a complete urea cycle often possess the urea cycle enzymes argininosuccinate synthase and argininosuccinate lyase; together, these enzymes confer the ability to regenerate arginine from the NOS product, L-citrulline. Urea 75-79 argininosuccinate lyase Homo sapiens 154-177 10709858-3 2000 In this context, it is notable that cell types that do not have a complete urea cycle often possess the urea cycle enzymes argininosuccinate synthase and argininosuccinate lyase; together, these enzymes confer the ability to regenerate arginine from the NOS product, L-citrulline. Urea 104-108 argininosuccinate lyase Homo sapiens 154-177 10091655-1 1999 Delta-crystallin, the major soluble protein component of the avian and reptilian eye lens, is homologous to the urea cycle enzyme argininosuccinate lyase (ASL). Urea 112-116 argininosuccinate lyase Homo sapiens 130-153 10091655-1 1999 Delta-crystallin, the major soluble protein component of the avian and reptilian eye lens, is homologous to the urea cycle enzyme argininosuccinate lyase (ASL). Urea 112-116 argininosuccinate lyase Homo sapiens 155-158 8867809-1 1996 Argininosuccinate synthetase and argininosuccinate lyase are soluble cytoplasmic enzymes of the urea cycle. Urea 96-100 argininosuccinate lyase Homo sapiens 33-56 2259230-1 1990 Argininosuccinate synthetase (ASS) is a ATP-dependent and rate-limiting enzyme of the urea cycle which catalyzes L-citrulline to L-arginine in combination with argininosuccinate lyase (ASL). Urea 86-90 argininosuccinate lyase Homo sapiens 160-183 7511585-4 1994 Regeneration of arginine from citrulline is accomplished by two urea cycle enzymes: arginino-succinate synthetase (AS) and argininosuccinate lyase (AL). Urea 64-68 argininosuccinate lyase Homo sapiens 123-146 2235124-1 1990 Circulating arginine available for synthesis of protein is produced in the kidney of the adult mammal by the action of the last two enzymes of the urea cycle, argininosuccinate synthase and argininosuccinate lyase. Urea 147-151 argininosuccinate lyase Homo sapiens 190-213 34861885-6 2021 RESULTS: We show that the mRNA and protein expression of urea cycle enzymes ASS1 and ASL are reduced in ccRCC tumors when compared to the normal kidney. Urea 57-61 argininosuccinate lyase Homo sapiens 85-88 34861885-10 2021 CONCLUSIONS: ccRCC tumors downregulate the components of the urea cycle including the enzymes argininosuccinate synthase 1 (ASS1) and argininosuccinate lyase (ASL). Urea 61-65 argininosuccinate lyase Homo sapiens 134-157 34861885-10 2021 CONCLUSIONS: ccRCC tumors downregulate the components of the urea cycle including the enzymes argininosuccinate synthase 1 (ASS1) and argininosuccinate lyase (ASL). Urea 61-65 argininosuccinate lyase Homo sapiens 159-162