PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
27535021-5	2016	Moreover, BBH-mediated induction and activation of HO-1 were reduced by genetic silencing of Nrf2 using small interfering RNA (siRNA).	alpha-hexachlorocyclohexane	10-13	nuclear factor, erythroid derived 2, like 2	Mus musculus	93-97	
27535021-1	2016	Preclinical Research The aim of the present study was to evaluate the effects of berberine hydrochloride (BBH), an isoquinoline alkaloid that can be isolated from a variety of herbs, on hydrogen peroxide (H2 O2 )-induced oxidative stress in C2C12 myoblasts and to investigate the molecular mechanisms involved in this process, especially the expression of the Nrf2/HO-1 pathway.	alpha-hexachlorocyclohexane	106-109	nuclear factor, erythroid derived 2, like 2	Mus musculus	360-364	
27535021-6	2016	In addition, the effects of BBH against H2 O2 -induced ROS accumulation and growth inhibition were abrogated in C2C12 cells transfected with Nrf2 siRNA.	alpha-hexachlorocyclohexane	28-31	nuclear factor, erythroid derived 2, like 2	Mus musculus	141-145	
27535021-7	2016	Therefore, the present study demonstrated that BBH could protect C2C12 cells against oxidative stress-induced injury and this effect involved activation of the Nrf2/HO-1 pathway.	alpha-hexachlorocyclohexane	47-50	nuclear factor, erythroid derived 2, like 2	Mus musculus	160-164