PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 6315964-1 1983 Catechol estrogens, such as 2-hydroxyestriol, 2-hydroxyestradiol, and 2-hydroxyestrone, inhibit human liver dihydropteridine reductase noncompetitively with Ki values ranging from 1.5 to 4.6 X 10(-6)M. Catechol estrogens lose approximately half of their inhibitory potency if the C-2 hydroxyl groups are methylated. 2-hydroxyestradiol 46-64 quinoid dihydropteridine reductase Homo sapiens 108-134