PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
12228253-7	2002	By contrast, the low affinity of SHBG for 2-hydroxyestradiol can be attributed to intra-molecular hydrogen bonding between the hydroxyls in the aromatic steroid ring A, which generates a steric clash with the amido group of Asn(82).	2-hydroxyestradiol	42-60	sex hormone binding globulin	Homo sapiens	33-37	
21793624-0	2011	The ability of hydroxylated estrogens (2-OH-E2 and 4-OH-E2) to increase of SHBG gene, protein expression and intracellular levels in MCF-7 cells line.	2-hydroxyestradiol	39-46	sex hormone binding globulin	Homo sapiens	75-79	
21793624-0	2011	The ability of hydroxylated estrogens (2-OH-E2 and 4-OH-E2) to increase of SHBG gene, protein expression and intracellular levels in MCF-7 cells line.	2-hydroxyestradiol	51-58	sex hormone binding globulin	Homo sapiens	75-79	
21793624-2	2011	This study was conducted to elucidate the effects of hydroxylated estrogen (E2) metabolites (2-OH-E2 and 4-OH-E2) on sex hormone binding globulin (SHBG) mRNA and protein expression as well as on intracellular and extracellular SHBG levels.	2-hydroxyestradiol	93-100	sex hormone binding globulin	Homo sapiens	117-145	
21793624-2	2011	This study was conducted to elucidate the effects of hydroxylated estrogen (E2) metabolites (2-OH-E2 and 4-OH-E2) on sex hormone binding globulin (SHBG) mRNA and protein expression as well as on intracellular and extracellular SHBG levels.	2-hydroxyestradiol	93-100	sex hormone binding globulin	Homo sapiens	147-151	
21793624-2	2011	This study was conducted to elucidate the effects of hydroxylated estrogen (E2) metabolites (2-OH-E2 and 4-OH-E2) on sex hormone binding globulin (SHBG) mRNA and protein expression as well as on intracellular and extracellular SHBG levels.	2-hydroxyestradiol	93-100	sex hormone binding globulin	Homo sapiens	227-231	
21793624-2	2011	This study was conducted to elucidate the effects of hydroxylated estrogen (E2) metabolites (2-OH-E2 and 4-OH-E2) on sex hormone binding globulin (SHBG) mRNA and protein expression as well as on intracellular and extracellular SHBG levels.	2-hydroxyestradiol	105-112	sex hormone binding globulin	Homo sapiens	117-145	
21793624-2	2011	This study was conducted to elucidate the effects of hydroxylated estrogen (E2) metabolites (2-OH-E2 and 4-OH-E2) on sex hormone binding globulin (SHBG) mRNA and protein expression as well as on intracellular and extracellular SHBG levels.	2-hydroxyestradiol	105-112	sex hormone binding globulin	Homo sapiens	147-151	
21793624-6	2011	Both metabolites increased SHBG mRNA expression, the rank order of potency being E2 > 4-OH-E2 > 2-OH-E2.	2-hydroxyestradiol	89-96	sex hormone binding globulin	Homo sapiens	27-31	
21793624-6	2011	Both metabolites increased SHBG mRNA expression, the rank order of potency being E2 > 4-OH-E2 > 2-OH-E2.	2-hydroxyestradiol	102-109	sex hormone binding globulin	Homo sapiens	27-31