PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
11741520-8	2001	This result suggests that in human liver microsomes CYP1A2 and CYP3A4 play an important role in 2-hydroxy estradiol formation.	2-hydroxyestradiol	96-115	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	63-69	
16112414-4	2005	A major metabolite of estradiol, 2-hydroxyestradiol, is mainly catalyzed by CYP1A2 and CYP3A4 in liver, and by CYP1A1 in extrahepatic tissues.	2-hydroxyestradiol	33-51	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	87-93	
12865317-7	2003	CYP3A4 had strong activity for the formation of 2-hydroxyestradiol, followed by 4-hydroxyestradiol and an unknown polar metabolite, and small amounts of 16alpha- and 16beta-hydroxyestrogens were also formed.	2-hydroxyestradiol	48-66	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	0-6	
15050414-5	2004	Estradiol (E2) is usually metabolized by CYP1A1/1A2 and CYP3A4 to the 2-hydroxy estradiol (2-OHE2) and 4-hydroxy estradiol (4-OHE2) in human liver.	2-hydroxyestradiol	70-89	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	56-62	
15050414-5	2004	Estradiol (E2) is usually metabolized by CYP1A1/1A2 and CYP3A4 to the 2-hydroxy estradiol (2-OHE2) and 4-hydroxy estradiol (4-OHE2) in human liver.	2-hydroxyestradiol	91-97	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	56-62	
11454902-10	2001	The activity of testosterone 6beta-hydroxylation (a selective probe for CYP3A4/5 activity) strongly correlated with the rate of formation of 2-OH-E2, 4-OH-E2, and several other hydroxyestrogen metabolites by both male and female liver microsomes.	2-hydroxyestradiol	141-148	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	72-78	
11454902-10	2001	The activity of testosterone 6beta-hydroxylation (a selective probe for CYP3A4/5 activity) strongly correlated with the rate of formation of 2-OH-E2, 4-OH-E2, and several other hydroxyestrogen metabolites by both male and female liver microsomes.	2-hydroxyestradiol	150-157	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	72-78	
11067738-4	2000	Among the nine enzymes (CYP1A1, 1A2, 2A6, 2C8, 2C9, 2C19, 2D6, 2E1, and 3A4) tested, CYP3A4 having a V(max)/K(m) (ml/min/nmol P450) value of 0.32 for production of 2-OH-E2 was shown to be the most suitable enzyme as the reagent.	2-hydroxyestradiol	164-171	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	85-91