PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 23419711-7 2013 S1P-induced migration was inhibited by the S1PR1 antagonist, VPC44116, and the S1PR1 functional antagonist, FTY720-P, but was potentiated by the S1PR2-specific antagonist, JTE013. FTY 720P 108-116 sphingosine-1-phosphate receptor 1 Homo sapiens 79-84 23926298-9 2013 Moreover, we show that Jak2(V617F) also utilizes an alternative sphingosine kinase-1-mediated pathway to inhibit PP2A and that FTY720-P, acting as a sphingosine-1-phosphate-receptor-1 agonist, elicits signals leading to the Jak2-PI-3Kgamma-PKC-SET-mediated PP2A inhibition. FTY 720P 127-135 sphingosine-1-phosphate receptor 1 Homo sapiens 149-183 23518370-2 2013 Following phosphorylation in vivo, the active agent, fingolimod phosphate (fingolimod-P), acts as a sphingosine 1-phosphate (S1P) receptor modulator, binding with high affinity to four of the five known S1P receptors (S1P1, S1P3, S1P4 and S1P5). FTY 720P 53-73 sphingosine-1-phosphate receptor 1 Homo sapiens 218-228 23518370-2 2013 Following phosphorylation in vivo, the active agent, fingolimod phosphate (fingolimod-P), acts as a sphingosine 1-phosphate (S1P) receptor modulator, binding with high affinity to four of the five known S1P receptors (S1P1, S1P3, S1P4 and S1P5). FTY 720P 75-87 sphingosine-1-phosphate receptor 1 Homo sapiens 218-228 23518370-3 2013 The mechanism of action of fingolimod in MS has primarily been considered as immunomodulatory, whereby fingolimod-P modulates S1P1 on lymphocytes, selectively retaining autoreactive lymphocytes in lymph nodes to reduce damaging infiltration into the central nervous system (CNS). FTY 720P 103-115 sphingosine-1-phosphate receptor 1 Homo sapiens 126-130 24281561-7 2012 In particular, FTY720-P strongly induces internalization and degradation of S1P1, inhibits S1P responsiveness of lymphocytes in the SLO, and acts as a functional antagonist at lymphocytic S1P1. FTY 720P 15-23 sphingosine-1-phosphate receptor 1 Homo sapiens 76-80 24281561-7 2012 In particular, FTY720-P strongly induces internalization and degradation of S1P1, inhibits S1P responsiveness of lymphocytes in the SLO, and acts as a functional antagonist at lymphocytic S1P1. FTY 720P 15-23 sphingosine-1-phosphate receptor 1 Homo sapiens 188-192 19430484-0 2009 Persistent signaling induced by FTY720-phosphate is mediated by internalized S1P1 receptors. FTY 720P 32-48 sphingosine-1-phosphate receptor 1 Homo sapiens 77-81 19430484-2 2009 The drug is phosphorylated in vivo, and most of the clinical effects of FTY720-phosphate (FTY720P) are thought to be mediated via S1P1 receptors on lymphocytes and endothelial cells, leading to sequestration of lymphocytes in secondary lymphoid organs. FTY 720P 72-88 sphingosine-1-phosphate receptor 1 Homo sapiens 130-134 19430484-2 2009 The drug is phosphorylated in vivo, and most of the clinical effects of FTY720-phosphate (FTY720P) are thought to be mediated via S1P1 receptors on lymphocytes and endothelial cells, leading to sequestration of lymphocytes in secondary lymphoid organs. FTY 720P 90-97 sphingosine-1-phosphate receptor 1 Homo sapiens 130-134 18088493-6 2007 The FTY720-P is a true agonist for S1P1, S1P3, S1P4, and S1P5, it affects the tissue distribution and functional activity of T cells, B cells, dendritic cells and regulatory T cells. FTY 720P 4-12 sphingosine-1-phosphate receptor 1 Homo sapiens 35-45 17237497-8 2007 Further, small interfering RNA-mediated down-regulation of G protein-coupled receptor kinase-2 and beta-arrestins abolished FTY720-P-induced S1P1 receptor degradation. FTY 720P 124-132 sphingosine-1-phosphate receptor 1 Homo sapiens 141-145 17237497-12 2007 We propose that the ability of FTY720-P to target the S1P1 receptor to the ubiquitinylation and proteasomal degradation pathway may at least in part underlie its immunosuppressive and anti-angiogenic properties. FTY 720P 31-39 sphingosine-1-phosphate receptor 1 Homo sapiens 54-58 34937912-4 2022 Here, we report the cryo-electron microscopy (cryo-EM) structures of Gi-bound S1PR1 in complex with S1P, fingolimod-phosphate (FTY720-P) and siponimod (BAF312). FTY 720P 105-125 sphingosine-1-phosphate receptor 1 Homo sapiens 78-83 34937912-4 2022 Here, we report the cryo-electron microscopy (cryo-EM) structures of Gi-bound S1PR1 in complex with S1P, fingolimod-phosphate (FTY720-P) and siponimod (BAF312). FTY 720P 127-135 sphingosine-1-phosphate receptor 1 Homo sapiens 78-83 20061941-3 2010 There are at least 5 S1P receptor subtypes, known as S1P subtypes 1-5 (S1P1-5), 4 of which bind fingolimod-phosphate. FTY 720P 96-116 sphingosine-1-phosphate receptor 1 Homo sapiens 71-75 20061941-5 2010 Fingolimod-phosphate initially activates lymphocyte S1P1 via high-affinity receptor binding yet subsequently induces S1P1 down-regulation that prevents lymphocyte egress from lymphoid tissues, thereby reducing autoaggressive lymphocyte infiltration into the central nervous system (CNS). FTY 720P 0-20 sphingosine-1-phosphate receptor 1 Homo sapiens 52-56 20061941-5 2010 Fingolimod-phosphate initially activates lymphocyte S1P1 via high-affinity receptor binding yet subsequently induces S1P1 down-regulation that prevents lymphocyte egress from lymphoid tissues, thereby reducing autoaggressive lymphocyte infiltration into the central nervous system (CNS). FTY 720P 0-20 sphingosine-1-phosphate receptor 1 Homo sapiens 117-121 16549044-9 2006 (S)-FTY720-P acting as a potent agonist of S1P receptor type 1 (S1P1), induces long-term down-regulation of S1P1 on lymphocytes, and thereby inhibits the migration of lymphocytes toward S1P. FTY 720P 0-12 sphingosine-1-phosphate receptor 1 Homo sapiens 43-62 16549044-9 2006 (S)-FTY720-P acting as a potent agonist of S1P receptor type 1 (S1P1), induces long-term down-regulation of S1P1 on lymphocytes, and thereby inhibits the migration of lymphocytes toward S1P. FTY 720P 0-12 sphingosine-1-phosphate receptor 1 Homo sapiens 64-68 16549044-9 2006 (S)-FTY720-P acting as a potent agonist of S1P receptor type 1 (S1P1), induces long-term down-regulation of S1P1 on lymphocytes, and thereby inhibits the migration of lymphocytes toward S1P. FTY 720P 0-12 sphingosine-1-phosphate receptor 1 Homo sapiens 108-112 30366961-0 2018 S1P1 receptor phosphorylation, internalization, and interaction with Rab proteins: effects of sphingosine 1-phosphate, FTY720-P, phorbol esters, and paroxetine. FTY 720P 119-127 sphingosine-1-phosphate receptor 1 Homo sapiens 0-4 30366961-1 2018 Sphingosine 1-phosphate (S1P) and FTY720-phosphate (FTYp) increased intracellular calcium in cells expressing S1P1 mCherry-tagged receptors; the synthetic agonist was considerably less potent. FTY 720P 34-50 sphingosine-1-phosphate receptor 1 Homo sapiens 110-114 30366961-1 2018 Sphingosine 1-phosphate (S1P) and FTY720-phosphate (FTYp) increased intracellular calcium in cells expressing S1P1 mCherry-tagged receptors; the synthetic agonist was considerably less potent. FTY 720P 52-56 sphingosine-1-phosphate receptor 1 Homo sapiens 110-114