PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 29670818-7 2018 Results: Incubation with fingolimod-phosphate increased levels of claudin-5 mRNA and protein as well as TEER values in HPnMECs. FTY 720P 25-45 claudin 5 Homo sapiens 66-75 25774903-6 2015 RESULTS: Incubation with fingolimod-phosphate increased the claudin-5 protein levels and TEER values in BMECs, although it did not change the amount of occludin, ICAM-1 or MelCAM proteins. FTY 720P 25-45 claudin 5 Homo sapiens 60-69 25774903-7 2015 Pretreatment with fingolimod-phosphate restored the changes in the claudin-5 and VCAM-1 protein/mRNA levels and TEER values in BMECs after exposure to MS sera. FTY 720P 18-38 claudin 5 Homo sapiens 67-76 25774903-8 2015 CONCLUSIONS: Pretreatment with fingolimod-phosphate prevents BBB disruption caused by both RRMS and SPMS sera via the upregulation of claudin-5 and downregulation of VCAM-1 in BMECs, suggesting that fingolimod-phosphate is capable of directly modifying the BBB. FTY 720P 31-51 claudin 5 Homo sapiens 134-143