PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
15317462-8	2004	Hydropathic analysis of the energetic contributions using HINT indicates a significant improvement of the correlation between HINT scores and the experimentally determined binding constants when the appropriate bridging water molecules are taken into account.	Water	220-225	histidine triad nucleotide binding protein 1	Homo sapiens	58-62	
24076743-6	2013	In particular, a detailed analysis of water molecules at the interfaces of high-resolution (<=2.30 A) X-ray crystal structures of protein-protein complexes, where 140 are biological protein-protein complex structures and 112 include non-biological protein-protein interfaces, was carried out using modeling tools based on the HINT forcefield.	Water	38-43	histidine triad nucleotide binding protein 1	Homo sapiens	329-333	
15317462-8	2004	Hydropathic analysis of the energetic contributions using HINT indicates a significant improvement of the correlation between HINT scores and the experimentally determined binding constants when the appropriate bridging water molecules are taken into account.	Water	220-225	histidine triad nucleotide binding protein 1	Homo sapiens	126-130	
15317462-10	2004	HINT was shown to be able to map quantitatively the contribution of individual structural waters to binding energy.	Water	90-96	histidine triad nucleotide binding protein 1	Homo sapiens	0-4	
11349819-3	2001	Particular emphasis is placed on: (1) demonstrating the relationship between the total empirical HINT score and free energy of association, deltaGinteraction; (2) showing that the HINT hydrophobic-polar interaction sub-score represents the energy cost of desolvation upon binding for interacting biomolecules; and (3) a new methodology for treating constrained water molecules as discrete independent small ligands.	Water	361-366	histidine triad nucleotide binding protein 1	Homo sapiens	97-101	
11349819-3	2001	Particular emphasis is placed on: (1) demonstrating the relationship between the total empirical HINT score and free energy of association, deltaGinteraction; (2) showing that the HINT hydrophobic-polar interaction sub-score represents the energy cost of desolvation upon binding for interacting biomolecules; and (3) a new methodology for treating constrained water molecules as discrete independent small ligands.	Water	361-366	histidine triad nucleotide binding protein 1	Homo sapiens	180-184	
33276572-0	2020	Metal-Polymer Complexes of Gallium/Gallium-68 with Copolymers of N-Vinylpyrrolidonewith N-Vinylformamideand N-Vinyliminodiacetic Acid: A Hint for Radiolabeling of Water-Soluble Synthetic Flexible Chain Macromolecules.	Water	163-168	histidine triad nucleotide binding protein 1	Homo sapiens	137-141	
2343089-4	1990	However, a hint at the group of halogenated hydrocarbons is only possible, if additional information about miscibility with water is accessible.	Water	124-129	histidine triad nucleotide binding protein 1	Homo sapiens	11-15	
28452756-4	2017	The data hint at a decreased electrostatic interaction at higher pressure, presumably due to the increase of the dielectric constant of water by 3% and the decrease of the free volume at 300 bar.	Water	136-141	histidine triad nucleotide binding protein 1	Homo sapiens	9-13	
27092011-3	2015	The findings hint that the air-water interface is a locale for synthetic reactions.	Water	31-36	histidine triad nucleotide binding protein 1	Homo sapiens	13-17