PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 12819228-11 2003 Although the active site residues differ between nm-HO and human HO-1, the close similarity in the H-bonded water network suggests a common mechanism shared by all heme oxygenases. Water 108-113 heme oxygenase 1 Homo sapiens 65-69 22879979-16 2012 Overexpression of HO-1 prevented the toxic effect induced by H(2)O(2) and NOC-18. Water 61-66 heme oxygenase 1 Homo sapiens 18-22 21412259-6 2011 Our study demonstrated that heme oxygenase-1 (HO-1) was the most induced antioxidant gene in PIG1 cells after treatment with H(2)O(2). Water 125-130 heme oxygenase 1 Homo sapiens 28-44 21412259-6 2011 Our study demonstrated that heme oxygenase-1 (HO-1) was the most induced antioxidant gene in PIG1 cells after treatment with H(2)O(2). Water 125-130 heme oxygenase 1 Homo sapiens 46-50 19590705-8 2009 Elevation of HO activity via induction of HO-1 expression within neighboring cells may provide protection from cytotoxicity caused by inflammatory oxidants like H(2)O(2). Water 161-166 heme oxygenase 1 Homo sapiens 42-46 18852027-2 2008 We found that nordihydroguaiaretic acid (NDGA), a powerful antioxidant from Larrea tridentate, activates the antioxidant pathway Nrf2/heme oxygenase-1 (HO-1) in cerebellar granule neurons and protects them against H(2)O(2) or 3-nitropropionic acid-induced neurotoxicity. Water 214-219 heme oxygenase 1 Homo sapiens 129-150 18852027-2 2008 We found that nordihydroguaiaretic acid (NDGA), a powerful antioxidant from Larrea tridentate, activates the antioxidant pathway Nrf2/heme oxygenase-1 (HO-1) in cerebellar granule neurons and protects them against H(2)O(2) or 3-nitropropionic acid-induced neurotoxicity. Water 214-219 heme oxygenase 1 Homo sapiens 152-156 17450221-7 2007 Additionally, the water-soluble fractions of UFPs were sufficient to induce the expression of F3, F2RL2, and heme oxygenase 1 (HMOX1). Water 18-23 heme oxygenase 1 Homo sapiens 109-125 17450221-7 2007 Additionally, the water-soluble fractions of UFPs were sufficient to induce the expression of F3, F2RL2, and heme oxygenase 1 (HMOX1). Water 18-23 heme oxygenase 1 Homo sapiens 127-132 20796278-13 2010 CONCLUSIONS: This exploratory study suggests that at a relatively high level of arsenic exposure, carriers of the short (GT)n allele (< 27 repeats) in the HO-1 gene promoter had a lower probability of developing carotid atherosclerosis than non-carriers of the allele after long-term arsenic exposure via ground water. Water 315-320 heme oxygenase 1 Homo sapiens 158-162 12498987-7 2003 This suggests that disruption of HO-1 protects against hyperoxia by diminishing the generation of toxic reactive intermediates in the lung via iron and H(2)O(2). Water 152-157 heme oxygenase 1 Homo sapiens 33-37 12452690-0 2002 1H NMR detection of immobilized water molecules within a strong distal hydrogen-bonding network of substrate-bound human heme oxygenase-1. Water 32-37 heme oxygenase 1 Homo sapiens 121-137 31810001-7 2020 HO-1 attenuated reactive oxygen species induced by H2O2 or pyocyanin treatment in PC-3 and DU145 cells. Water 51-55 heme oxygenase 1 Homo sapiens 0-4 8547275-0 1996 Heme oxygenase (HO-1): His-132 stabilizes a distal water ligand and assists catalysis. Water 51-56 heme oxygenase 1 Homo sapiens 16-20 31964423-13 2020 mRNA and protein analyses of PE-DBMSCs preconditioned with H2O2 at lower doses showed upregulation of HMOX1 expression. Water 59-63 heme oxygenase 1 Homo sapiens 102-107 31646664-4 2020 The dose-dependent protective effects against H2 O2 -induced oxidative stress of the rutin-Lys MRPs may involve the inhibition of reactive oxygen species generation, enhancement of the superoxide dismutase and catalase activities, along with the activation of the Nrf2-dependent pathway and upregulation of phase II antioxidant genes (including NQO1, HO-1, GCLG, and GCLM). Water 46-51 heme oxygenase 1 Homo sapiens 351-355 33898501-1 2021 Fubaiju Hot-Water Extracts Against ARPE-19 Cell Oxidative Damage by Activating PI3K/Akt-Mediated Nrf2/HO-1 Signaling Pathway. Water 12-17 heme oxygenase 1 Homo sapiens 102-106 33636332-7 2021 Taken all together, we demonstrate that plasma treated water-derived oxidants sensitize pancreatic cancer cells to ferroptotic cell death by targeting a NRF2-HMOX1-GPX4 specific kinase signaling network. Water 55-60 heme oxygenase 1 Homo sapiens 158-163 31865348-11 2020 In addition, EX4 markedly increased expression of NRF2, HO-1, and NQO-1 and significantly improved protein expression of NRF2 and HO-1 in H2O2-treated ARPE-19 cells, caused by increased nuclear NRF2 protein expression. Water 138-142 heme oxygenase 1 Homo sapiens 130-134 31810001-8 2020 HO-1 further reduced PC-3 and DU145 cell apoptosis induced by H2O2 or serum starvation. Water 62-66 heme oxygenase 1 Homo sapiens 0-4 25527214-1 2015 Pegylated zinc protoporphyrin (PEG-ZnPP) is a water-soluble inhibitor of heme oxygenase-1. Water 46-51 heme oxygenase 1 Homo sapiens 73-89 26611539-0 2015 Brazilian green propolis water extract up-regulates the early expression level of HO-1 and accelerates Nrf2 after UVA irradiation. Water 25-30 heme oxygenase 1 Homo sapiens 82-86 26566708-4 2016 We prospectively investigated the associations between HO-1 (GT)n polymorphism and cancer risk related to arsenic from drinking water. Water 128-133 heme oxygenase 1 Homo sapiens 55-59 26269017-27 2015 In H2O treated control group, compared to (GT)26 and (GT)36, the basal promoter activities of HO-1 gene carrying (GT)16 repeat increased (F =41. Water 3-6 heme oxygenase 1 Homo sapiens 94-98 24655000-7 2014 The water-soluble forms of the HO-1 inhibitor Zinc protoporphyrin (ZnPP) have seemed promising in different in-vivo models, in which it has induced growth arrest in tumour cells with few, if any, side effects. Water 4-9 heme oxygenase 1 Homo sapiens 31-35