PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 33259116-0 2021 From Toy to Tool: Using Water Beads for Insulin Storage in Haiti. Water 24-29 insulin Homo sapiens 40-47 32829141-0 2020 Sub/supercritical fluid chromatography employing water-rich modifier enables the purification of biosynthesized human insulin. Water 49-54 insulin Homo sapiens 118-125 32790113-2 2020 Insulin treatment is associated with sodium and water retention, weight gain, and hypoglycaemia-all pathophysiological mechanisms related to HF decompensation. Water 48-53 insulin Homo sapiens 0-7 32619914-7 2020 RESULTS: Water, hair and nail arsenic concentrations showed significant positive associations with FBG, serum insulin and HOMA-IR and inverse associations with serum creatinine and LBM in a dose-dependent manner both in males and females. Water 9-14 insulin Homo sapiens 110-117 32258491-5 2020 We report how microemulsion composed of varying ratios of snail mucin and Tween 80 (1:9-9:1) using oil/water emulsion preparation method influenced insulin performance after oral administration. Water 104-109 insulin Homo sapiens 149-156 32377523-3 2020 Previous work indicated that low concentrations of carrageenan in drinking water caused marked glucose intolerance and insulin resistance in a mouse model. Water 75-80 insulin Homo sapiens 119-126 32258491-4 2020 The strategy in the novel system of using mucin loading insulin into the inner core of prepared water in oil microemulsion to provide sustained released, increased in vivo stability and enhanced drug absorption in the gastrointestinal tract. Water 96-101 insulin Homo sapiens 56-63 31711999-5 2020 The hydrophilicity and water-containing capacity of core-shell nanofibrous insulin/PLGA scaffolds significantly exceeded those of blended nanofibrous scaffolds. Water 23-28 insulin Homo sapiens 75-82 32082162-2 2019 Water Extract Ameliorates Palmitate Induced Insulin Resistance by Regulating IRS1/GSK3beta/FoxO1 Signaling Pathway in Human HepG2 Hepatocytes. Water 0-5 insulin Homo sapiens 44-51 31726824-0 2019 Destabilization of Insulin Hexamer in Water-Ethanol Binary Mixture. Water 38-43 insulin Homo sapiens 19-26 31721213-2 2020 Therefore, we investigated the potential that an increase in skeletal muscle mitochondrial H2 O2 emission, potentially as a result of decreased ADP sensitivity, contributes to cellular redox stress and the induction of insulin resistance during short-term bed rest in twenty healthy males. Water 91-96 insulin Homo sapiens 219-226 31726824-2 2019 X-ray crystal structures suggest that ethanol replaces water molecules inside the insulin hexamer cavity. Water 55-60 insulin Homo sapiens 82-89 31264419-1 2019 In the present work we illustrate the results of classical molecular dynamics simulations of model systems composed of six insulin molecules in water in the presence and in the absence of either epigallocatechin-3-gallate or melatonin molecules. Water 144-149 insulin Homo sapiens 123-130 31170414-8 2019 RESULTS: We found that a low-dose exposure (0.25 ppm iAs in drinking water) caused glucose intolerance in adult male C57BL/6 mice, likely by disrupting glucose-induced insulin secretion without affecting peripheral insulin sensitivity. Water 69-74 insulin Homo sapiens 168-175 30927942-3 2019 PURPOSE: To detect the association of insulin resistance with marrow adiposity in postmenopausal women with newly diagnosed type 2 diabetes (T2D) using chemical shift-encoded water-fat MRI. Water 175-180 insulin Homo sapiens 38-45 29948440-1 2018 The NMR derived translational diffusion coefficients were performed on unlabeled and uniformly labeled 13C,15N human insulin in water, both in neat, with zinc ions only, and in pharmaceutical formulation, containing only m-cresol as phenolic ligand, glycerol and zinc ions. Water 128-133 insulin Homo sapiens 117-124 29242971-2 2019 We tested if copeptin could be suppressed by increased water intake in healthy individuals, and if a water-induced change in copeptin was accompanied by altered concentrations of glucose, insulin or glucagon. Water 101-106 insulin Homo sapiens 188-195 30627556-16 2018 Furthermore, miR-15a-5p and miR-17-5p may function through "cell cycle, prostate cancer, and small cell lung cancer" while miR-19b-3p and miR-20a-5p function through "insulin resistance, hepatitis B, and viral carcinogenesis" and "vasopressin-regulated water reabsorption", respectively. Water 253-258 insulin Homo sapiens 167-174 30815830-8 2019 Immersing insulin under water after the vial has been pierced carries a high risk of contamination, leading to loss of potency and likelihood of causing injection abscesses. Water 24-29 insulin Homo sapiens 10-17 29916244-0 2018 The Role of Water in the Stability of Wild-type and Mutant Insulin Dimers. Water 12-17 insulin Homo sapiens 59-66 28554793-5 2017 The first formation equilibrium constants were calculated as Kf1: 5.48x103 1/M for Na(I)-insulin complex and Kf1: 4.87x103 1/M for K(I)-insulin in water. Water 147-152 insulin Homo sapiens 89-96 29413582-3 2018 After a simple step of solid-phase extraction, the chromatographic separation of human insulin was achieved by using InertSustain Bio C18 column with a mobile phase of acetonitrile containing 1% formic acid (A)-water containing 1% formic acid (B). Water 211-216 insulin Homo sapiens 87-94 29477225-3 2018 Moreover, water-soluble derivatives of vitamin E including some based on alphaTP are increasingly used as components of nanocarriers for enhanced and targeted delivery of drugs and other molecules (vitamins, including alphaT and alphaTP itself, vitamin D3, carnosine, caffeine, docosahexaenoic acid (DHA), insulin) and cofactors such as coenzyme Q10. Water 10-15 insulin Homo sapiens 306-313 29258604-7 2017 RESULTS: Plasma and serum water T2 exhibited strong bivariate correlations with markers of insulin, lipids, inflammation, coagulation and electrolyte balance. Water 26-31 insulin Homo sapiens 91-98 29258604-9 2017 Plasma water T2 exhibited 100% sensitivity and 87% specificity for detecting early insulin resistance in normoglycemic subjects, as defined by the McAuley Index. Water 7-12 insulin Homo sapiens 83-90 29147837-9 2017 These observations as well as the representative structures obtained by clustering analysis were in reasonable agreement not only with the structures of C-peptide that were determined in this study by NMR in 30% CD3CD in H2O at 298 K but also with the experimental and theoretical behaviors having been reported for protonated C-peptide. Water 221-224 insulin Homo sapiens 153-162 29514721-7 2018 Insulin sensitivity was higher with decaffeinated coffee than with water (P<0 05). Water 67-72 insulin Homo sapiens 0-7 29341613-7 2018 We combine molecular dynamics simulations, quantum calculations, and X-ray analyses to discover that a team of approximately 10 water molecules confined inside a barrel-shaped nanocavity at the center of insulin hexamer is one of the major causes that account for the unusual stability of the biomolecular assembly. Water 128-133 insulin Homo sapiens 204-211 29132429-7 2017 Correlation analysis elucidated that the water content was strongly correlated with local skin indices, such as the ceramide composition, redness, blood flow, and TNFalpha in the stratum corneum, whereas roughness was correlated with the systemic indices, such as serum insulin, leptin, and IL-6. Water 41-46 insulin Homo sapiens 270-277 28554793-5 2017 The first formation equilibrium constants were calculated as Kf1: 5.48x103 1/M for Na(I)-insulin complex and Kf1: 4.87x103 1/M for K(I)-insulin in water. Water 147-152 insulin Homo sapiens 136-143 28554793-7 2017 In case of a comparison together with Ca(II)-insulin and Mg(II)-insulin, the formation equilibrium constants (Kf1) are in order of Ca(II)-insulin>Mg(II)-insulin>Na(I)-insulin>K(I)-insulin in water. Water 200-205 insulin Homo sapiens 45-52 28554793-7 2017 In case of a comparison together with Ca(II)-insulin and Mg(II)-insulin, the formation equilibrium constants (Kf1) are in order of Ca(II)-insulin>Mg(II)-insulin>Na(I)-insulin>K(I)-insulin in water. Water 200-205 insulin Homo sapiens 64-71 28554793-7 2017 In case of a comparison together with Ca(II)-insulin and Mg(II)-insulin, the formation equilibrium constants (Kf1) are in order of Ca(II)-insulin>Mg(II)-insulin>Na(I)-insulin>K(I)-insulin in water. Water 200-205 insulin Homo sapiens 64-71 28554793-7 2017 In case of a comparison together with Ca(II)-insulin and Mg(II)-insulin, the formation equilibrium constants (Kf1) are in order of Ca(II)-insulin>Mg(II)-insulin>Na(I)-insulin>K(I)-insulin in water. Water 200-205 insulin Homo sapiens 64-71 28328176-0 2017 Glucose-Responsive Supramolecular Vesicles Based on Water-Soluble Pillar[5]arene and Pyridylboronic Acid Derivatives for Controlled Insulin Delivery. Water 52-57 insulin Homo sapiens 132-139 28145211-6 2017 In this group of patients, liberal doses of insulin, fluids and bicarbonate may lead to a decrease in the effective serum osmolarity which can lead to water shifts in the cerebrum. Water 151-156 insulin Homo sapiens 44-51 26826013-0 2017 Is insulin diluted when stored in water? Water 34-39 insulin Homo sapiens 3-10 26826013-2 2017 In Uganda, patients were noted to store insulin vials by submerging them in water. Water 76-81 insulin Homo sapiens 40-47 26826013-3 2017 OBJECTIVE: To examine whether withdrawing insulin from a vial without adding air back causes a vacuum which allows water to enter the vial, resulting in insulin dilution. Water 115-120 insulin Homo sapiens 42-49 28055215-4 2017 On the other hand, Salecan tuned the water content and the water release rate of the obtained hydrogel, leading to a controllable release rate of the insulin. Water 37-42 insulin Homo sapiens 150-157 28055215-4 2017 On the other hand, Salecan tuned the water content and the water release rate of the obtained hydrogel, leading to a controllable release rate of the insulin. Water 59-64 insulin Homo sapiens 150-157 27701016-4 2017 Insulin incorporation into the HII systems shrank the cylinders as it competed with the lipids in water-bonding. Water 98-103 insulin Homo sapiens 0-7 28107951-15 2017 Insulin underwent observable unfolding when water was used for dissolution. Water 44-49 insulin Homo sapiens 0-7 28024260-4 2017 The oligomerization process of insulin during development of pharmaceutical formulation with routinely used excipients has been studied using translation diffusion coefficient Dix10-10m2s-1 established in water solution. Water 205-210 insulin Homo sapiens 31-38 28054966-7 2017 Insulin AUC was higher for coffee and LFM versus OJ and water; (2) Glucose AUCs were not different among water and milks while insulin AUC was higher for milks versus water. Water 56-61 insulin Homo sapiens 0-7 28665380-10 2017 The beneficial therapeutic action of acupuncture and drinking mineral water is underlain by their impact on the mechanisms of resistance to insulin that manifests itself as a decrease of the fasting secretion of this hormone and optimization of carbohydrate and lipid metabolism. Water 70-75 insulin Homo sapiens 140-147 28665380-11 2017 The therapeutic effect of acupuncture and drinking mineral water is realized through the induction of the stress-initiating reactions which activate the processes of adaptation, with reflexotherapy largely acting on the cardiovascular system and drinking mineral water on the system responsible for insulin regulation of the metabolic processes. Water 59-64 insulin Homo sapiens 299-306 28665380-11 2017 The therapeutic effect of acupuncture and drinking mineral water is realized through the induction of the stress-initiating reactions which activate the processes of adaptation, with reflexotherapy largely acting on the cardiovascular system and drinking mineral water on the system responsible for insulin regulation of the metabolic processes. Water 263-268 insulin Homo sapiens 299-306 28003711-7 2016 Plasma water T2 can detect shifts in the blood proteome resulting from inflammation, insulin resistance and dyslipidemia. Water 7-12 insulin Homo sapiens 85-92 27907132-5 2016 In the second step the protein is applied at very high loadings on a cation exchange resin and eluted in a mixture of water and ethanol to obtain a concentrated insulin precursor, suitable for use directly in the transpeptidation reaction. Water 118-123 insulin Homo sapiens 161-168 25848248-7 2015 The commercial insulin-loaded TPGS-emulsified PEG-capped PLGA NPs (ISTPPLG NPs) were synthesized by water-oil-water emulsion solvent evaporation method. Water 100-105 insulin Homo sapiens 15-22 26624532-0 2016 Surface interactions, thermodynamics and topography of binary monolayers of Insulin with dipalmitoylphosphatidylcholine and 1-palmitoyl-2-oleoylphosphatidylcholine at the air/water interface. Water 175-180 insulin Homo sapiens 76-83 26344698-0 2015 Water Proton NMR for In Situ Detection of Insulin Aggregates. Water 0-5 insulin Homo sapiens 42-49 26344698-6 2015 In this paper, human insulin preparations were used to demonstrate that the transverse relaxation rate of water protons R2 ((1) H2 O) can serve as a sensitive and reliable indicator to detect and quantify both visible and sub-visible protein aggregates. Water 106-111 insulin Homo sapiens 21-28 26058692-8 2015 We concluded that increased plasma glucose and insulin levels can cause the appearance of the AD-like pattern in both (18)F-FDG and (15)O-H2O images, and this phenomenon can occur even in subjects without insulin resistance. Water 138-141 insulin Homo sapiens 47-54 27774415-3 2016 This placebo-controlled double-blind trial tested the effects of a dried water extract of cinnamon (Cinnamomum cassia) on circulating glucose, lipids, insulin, and insulin resistance. Water 73-78 insulin Homo sapiens 164-171 27774415-10 2016 In conclusion, supplementation with 500 mg of water-extract of cinnamon for two months reduced fasting insulin, glucose, total cholesterol, and LDL cholesterol and enhanced insulin sensitivity of subjects with elevated blood glucose. Water 46-51 insulin Homo sapiens 103-110 27774415-10 2016 In conclusion, supplementation with 500 mg of water-extract of cinnamon for two months reduced fasting insulin, glucose, total cholesterol, and LDL cholesterol and enhanced insulin sensitivity of subjects with elevated blood glucose. Water 46-51 insulin Homo sapiens 173-180 26966319-0 2016 Cold Water Swimming Beneficially Modulates Insulin Sensitivity in Middle-Aged Individuals. Water 5-10 insulin Homo sapiens 43-50 27376416-1 2016 AIM: We examined whether cold water swimming for seven consecutive months changes basal leptin and insulin concentrations and insulin sensitivity in healthy non-obese women. Water 30-35 insulin Homo sapiens 99-106 27376416-9 2016 CONCLUSION: Regular cold water swimming may stimulate metabolic changes suggesting that leptin and insulin participate in adaptive metabolic mechanisms triggered by repeated cold exposure accompanied by mild exercise in healthy non-obese women. Water 25-30 insulin Homo sapiens 99-106 27491577-6 2016 RESULTS: We found an inverse association between the consumption of water (ml)/kg per weight with BMI, body fat, fat-free mass, waist circumference, insulin levels, HOMA-IR (p < 0.001), and with arterial pressure parameters, systolic (p < 0.010) and diastolic blood pressure (p < 0.028), and mean arterial pressure (p < 0.012), as well as direct associations with HDL cholesterol (p < 0.001). Water 68-73 insulin Homo sapiens 149-156 27491577-10 2016 CONCLUSIONS: Higher consumption of water (ml)/kg per weight was negatively associated with BMI, body fat, fat-free mass, waist circumference, insulin levels, HOMA-IR, and positively with HDL cholesterol in children independently of age, sex and cardiorespiratory fi tness. Water 35-40 insulin Homo sapiens 142-149 26729162-7 2016 Drinking water increases FO when blood carbohydrate and/or insulin concentrations are not elevated and when it is consumed instead of caloric beverages or in volumes that alter hydration status. Water 9-14 insulin Homo sapiens 59-66 25892399-3 2015 The oral insulin/DCK complex was prepared by making a physical complex of insulin aspart with DCK through ion-pair interaction in water. Water 130-135 insulin Homo sapiens 9-16 25767829-5 2015 Yet, unlike the empty HII systems, insulin perturbed the GMO-water interface while decreasing the movement of the GMO headgroup, and reducing T0 (296 K). Water 61-66 insulin Homo sapiens 35-42 25848248-7 2015 The commercial insulin-loaded TPGS-emulsified PEG-capped PLGA NPs (ISTPPLG NPs) were synthesized by water-oil-water emulsion solvent evaporation method. Water 110-115 insulin Homo sapiens 15-22 25380325-0 2014 The structure of insulin at the air/water interface: monomers or dimers? Water 36-41 insulin Homo sapiens 17-24 25576641-2 2015 When the INS-loaded liposome was dispersed in water (pH 7.4), the encapsulation efficiency (EE) obtained by the column-switching HPLC system was consistent with that obtained by a conventional ultracentrifugation method. Water 46-51 insulin Homo sapiens 9-12 25271009-8 2015 Total AUC of insulin and c-peptide was similar in aspartame, sucralose and water settings. Water 75-80 insulin Homo sapiens 13-20 25271009-8 2015 Total AUC of insulin and c-peptide was similar in aspartame, sucralose and water settings. Water 75-80 insulin Homo sapiens 25-34 25380325-1 2014 The hydrophobic character of the air/water interface affects the oligomeric composition of insulin. Water 37-42 insulin Homo sapiens 91-98 25380325-2 2014 By using interface-specific vibrational sum frequency spectroscopy and calculations of insulin monomer and dimer second-order nonlinear susceptibilities chi((2)), we show that insulin monomers segregate to the air/water interface. Water 214-219 insulin Homo sapiens 176-183 24007934-10 2014 CONCLUSIONS: The patients randomised to the carbohydrate oral fluid or the water prior to the surgery demonstrated a significant but similar decrease in insulin sensitivity. Water 75-80 insulin Homo sapiens 153-160 25383488-2 2014 By grinding the hydrophobic molecule with the amyloidogenic protein insulin, we obtained a water-soluble composite material. Water 91-96 insulin Homo sapiens 68-75 25348467-7 2014 For instance, at the water content of 1.77%, insulin without any protectants yields the highest RMSD value as 0.451 nm, then the RMSD of insulin in presence of trehalose only ca. Water 21-26 insulin Homo sapiens 45-52 25632375-2 2014 The quantitative recommendation to "drink enough water to dilute urine" might further facilitate weight loss by increasing fat oxidation via cell hydration-mediated changes in insulin. Water 49-54 insulin Homo sapiens 176-183 24976597-0 2014 epi-Fluorescence imaging at the air-water interface of fibrillization of bovine serum albumin and human insulin. Water 36-41 insulin Homo sapiens 104-111 24976597-3 2014 In this study, epi-fluorescence at the air-water interface was developed as an innovative technique for observing fibrillization of bovine serum albumin and human insulin. Water 43-48 insulin Homo sapiens 163-170 24090437-3 2013 In the ternary systems with the insulin-enhancing compounds, mixed species are observed with Hma, Hdhp, and Hpic with the formation of VOL2(holo-hTf), explained through the interaction of cis-[VOL2(H2O)] (L = ma, dhp) or cis-[VOL2(OH)](-) (L = pic) with an accessible His residue that replaces the monodentate H2O or OH(-) ligand. Water 198-201 insulin Homo sapiens 32-39 24641444-0 2014 Sensitivity of water dynamics to biologically significant surfaces of monomeric insulin: role of topology and electrostatic interactions. Water 15-20 insulin Homo sapiens 80-87 24641444-3 2014 In order to characterize the structural and dynamical behavior of interfacial water molecules near these two surfaces (DFS and HFS), we performed atomistic molecular dynamics simulations of insulin with explicit water. Water 78-83 insulin Homo sapiens 190-197 24583185-5 2014 There was a significant interaction between insulin sensitivity (sensitive vs resistant) and condition (water vs glucose). Water 104-109 insulin Homo sapiens 44-51 24607106-2 2014 The water-compatible molecularly imprinted polymers (MIPs) were prepared using methacrylic acid as a functional monomer, ethylene glycol dimethacrylate as a cross-linker, chloroform as a porogen and insulin as a template molecule. Water 4-9 insulin Homo sapiens 199-206 24580394-3 2014 The review is presented on the infusion of sterile water (hypotonic fluid) to lower serum sodium level in those circumstances when enteral supplementation of water is not possible, such as in postoperative patients or when other isotonic fluids (such as 5% dextrose in water infusion) are less than ideal-for example, hyperglycaemic patients on an insulin infusion. Water 51-56 insulin Homo sapiens 348-355 25355439-0 2014 Effect of Coptidis Rhizoma extracts in a water-based solution on insulin resistance in 3T3-L1 adipocytes. Water 41-46 insulin Homo sapiens 65-72 23815567-3 2014 Multiple pathogenic mechanisms have been proposed, including insulin-induced sodium and water retention. Water 88-93 insulin Homo sapiens 61-68 24090437-3 2013 In the ternary systems with the insulin-enhancing compounds, mixed species are observed with Hma, Hdhp, and Hpic with the formation of VOL2(holo-hTf), explained through the interaction of cis-[VOL2(H2O)] (L = ma, dhp) or cis-[VOL2(OH)](-) (L = pic) with an accessible His residue that replaces the monodentate H2O or OH(-) ligand. Water 310-313 insulin Homo sapiens 32-39 23596182-10 2013 Insulin infusion resulted in an increase in frontal NAA/Cr and NAA/H2O and frontal and temporal Glx/Cr and Glx/H2O and a decrease in frontal Cho/Cr and temporal Cho/H2O and myo-inositol/H2O (all P < 0.05, except temporal Glx/H2O, P = 0.054, NS) in the high-IS, but not in the low-IS, group. Water 67-70 insulin Homo sapiens 0-7 23596182-11 2013 Insulin sensitivity correlated positively with frontal NAA/Cr and NAA/H2O and temporal Glx/H2O and negatively with temporal myo-inositol/Cr and myo-inositol/H2O assessed during the second (1)H-MRS (all P < 0.05). Water 91-94 insulin Homo sapiens 0-7 23596182-10 2013 Insulin infusion resulted in an increase in frontal NAA/Cr and NAA/H2O and frontal and temporal Glx/Cr and Glx/H2O and a decrease in frontal Cho/Cr and temporal Cho/H2O and myo-inositol/H2O (all P < 0.05, except temporal Glx/H2O, P = 0.054, NS) in the high-IS, but not in the low-IS, group. Water 111-114 insulin Homo sapiens 0-7 23596182-10 2013 Insulin infusion resulted in an increase in frontal NAA/Cr and NAA/H2O and frontal and temporal Glx/Cr and Glx/H2O and a decrease in frontal Cho/Cr and temporal Cho/H2O and myo-inositol/H2O (all P < 0.05, except temporal Glx/H2O, P = 0.054, NS) in the high-IS, but not in the low-IS, group. Water 111-114 insulin Homo sapiens 0-7 23596182-10 2013 Insulin infusion resulted in an increase in frontal NAA/Cr and NAA/H2O and frontal and temporal Glx/Cr and Glx/H2O and a decrease in frontal Cho/Cr and temporal Cho/H2O and myo-inositol/H2O (all P < 0.05, except temporal Glx/H2O, P = 0.054, NS) in the high-IS, but not in the low-IS, group. Water 111-114 insulin Homo sapiens 0-7 23596182-10 2013 Insulin infusion resulted in an increase in frontal NAA/Cr and NAA/H2O and frontal and temporal Glx/Cr and Glx/H2O and a decrease in frontal Cho/Cr and temporal Cho/H2O and myo-inositol/H2O (all P < 0.05, except temporal Glx/H2O, P = 0.054, NS) in the high-IS, but not in the low-IS, group. Water 111-114 insulin Homo sapiens 0-7 23596182-11 2013 Insulin sensitivity correlated positively with frontal NAA/Cr and NAA/H2O and temporal Glx/H2O and negatively with temporal myo-inositol/Cr and myo-inositol/H2O assessed during the second (1)H-MRS (all P < 0.05). Water 70-73 insulin Homo sapiens 0-7 23596182-11 2013 Insulin sensitivity correlated positively with frontal NAA/Cr and NAA/H2O and temporal Glx/H2O and negatively with temporal myo-inositol/Cr and myo-inositol/H2O assessed during the second (1)H-MRS (all P < 0.05). Water 91-94 insulin Homo sapiens 0-7 23181759-2 2013 In the present study, in vivo experiments using a non-invasive method of chronic administration of corticosterone in drinking water demonstrated that chronic corticosterone administration led to cognitive impairment in the novel object recognition test and insulin resistance, as shown by significant increases in plasma insulin levels and the homeostatic model assessment index, and decreased insulin receptor phosphorylation. Water 126-131 insulin Homo sapiens 257-264 23875003-4 2013 3xTg-AD mice fed 0.23% w/v lipoic acid in drinking water for 4 weeks showed an insulin mimetic effect that consisted of increased brain glucose uptake, activation of the insulin receptor substrate and of the PI3K/Akt signaling pathway. Water 51-56 insulin Homo sapiens 79-86 23858976-2 2013 The insulin-loaded PCL nanoparticles were prepared by double emulsion method (water-in-oil-in-water) using Pluronic F68 as emulsifier. Water 78-83 insulin Homo sapiens 4-11 23858976-2 2013 The insulin-loaded PCL nanoparticles were prepared by double emulsion method (water-in-oil-in-water) using Pluronic F68 as emulsifier. Water 94-99 insulin Homo sapiens 4-11 23858976-7 2013 These results suggest that insulin-loaded PCL nanoparticles prepared by water-in-oil-in-water emulsion method are biocompatible, efficient and safe insulin-delivering system with controlled insulin release, which indicates that it may be a powerful tool for insulin-dependent patients care. Water 72-77 insulin Homo sapiens 27-34 23858976-7 2013 These results suggest that insulin-loaded PCL nanoparticles prepared by water-in-oil-in-water emulsion method are biocompatible, efficient and safe insulin-delivering system with controlled insulin release, which indicates that it may be a powerful tool for insulin-dependent patients care. Water 72-77 insulin Homo sapiens 148-155 23858976-7 2013 These results suggest that insulin-loaded PCL nanoparticles prepared by water-in-oil-in-water emulsion method are biocompatible, efficient and safe insulin-delivering system with controlled insulin release, which indicates that it may be a powerful tool for insulin-dependent patients care. Water 72-77 insulin Homo sapiens 148-155 23858976-7 2013 These results suggest that insulin-loaded PCL nanoparticles prepared by water-in-oil-in-water emulsion method are biocompatible, efficient and safe insulin-delivering system with controlled insulin release, which indicates that it may be a powerful tool for insulin-dependent patients care. Water 88-93 insulin Homo sapiens 27-34 23181759-2 2013 In the present study, in vivo experiments using a non-invasive method of chronic administration of corticosterone in drinking water demonstrated that chronic corticosterone administration led to cognitive impairment in the novel object recognition test and insulin resistance, as shown by significant increases in plasma insulin levels and the homeostatic model assessment index, and decreased insulin receptor phosphorylation. Water 126-131 insulin Homo sapiens 321-328 22834785-1 2012 The human insulin (HI) protein was examined to elucidate its structure at the air-water interface. Water 82-87 insulin Homo sapiens 10-17 22975396-1 2012 We determined how glucose or insulin interacts with a phospholipid monolayer at the air/water interface and explained these mechanisms from a physico-chemical point of view. Water 88-93 insulin Homo sapiens 29-36 22842625-3 2012 Recombinant human Insulin was loaded into the lyophilized polymer matrix, which can be rehydrated by water. Water 101-106 insulin Homo sapiens 18-25 22833363-8 2012 The stability results showed that the complex was stable for 1 year at -20 C. The interaction mechanism of this formation is that the peptide bonds of insulin interact with the water-soluble head of phospholipids, forming a reverse micelle-like structure. Water 178-183 insulin Homo sapiens 152-159 23404086-0 2013 Biosynthetic engineered B28(K)-B29(P) human insulin monomer structure in water and in water/acetonitrile solutions. Water 73-78 insulin Homo sapiens 44-51 23404086-0 2013 Biosynthetic engineered B28(K)-B29(P) human insulin monomer structure in water and in water/acetonitrile solutions. Water 86-91 insulin Homo sapiens 44-51 22124766-4 2012 Novel water-in-water emulsion technique was used to prepare insulin-loaded nanoparticles. Water 6-11 insulin Homo sapiens 60-67 22124766-4 2012 Novel water-in-water emulsion technique was used to prepare insulin-loaded nanoparticles. Water 15-20 insulin Homo sapiens 60-67 22610603-5 2012 By adding water (1.00 +- 0.01) g into the vial containing the CRM, the C-peptide solution in 10 mM phosphate buffer saline (pH 6.6) is reconstituted. Water 10-15 insulin Homo sapiens 71-80 22356870-1 2012 The insulin loaded nanoparticles composed of poly (lactic-co-glycolic acid) (PLGA) and hydroxypropyl methylcellulose phthalate (HP55) were prepared via the emulsions solvent diffusion method with two different solvents, namely, DMSO and acetone/water. Water 245-250 insulin Homo sapiens 4-11 22704463-10 2012 Serum insulin was higher with the chews than both raisins and water (5.1 +- 2.0, 3.1 +- 0.8, 1.9 +- 0.6 uU ml-1 for chews, raisins and water respectively). Water 135-140 insulin Homo sapiens 6-13 22356870-7 2012 However, for the nanoparticles prepared with acetone/water, the release of insulin was pH-dependent. Water 53-58 insulin Homo sapiens 75-82 22263642-1 2012 The human insulin (HI) Langmuir monolayer at the air-water interface was systematically investigated in the presence and absence of Zn(II) ions in the subphase. Water 53-58 insulin Homo sapiens 10-17 22354326-10 2012 These observations suggested that the PLGA-PEG block copolymers nanomicelles have been prepared by a new synthetic route are potent nanocarrier for poorly water-soluble drugs as insulin. Water 155-160 insulin Homo sapiens 178-185 21704065-1 2011 NMR structure of biosynthetic engineered A22G-B31K-B32R human insulin monomer in water/acetonitrile solution. Water 81-86 insulin Homo sapiens 62-69 21945376-2 2011 By gradually decreasing the ambient RH of the insulin crystal, the content of the hydration water in the crystal was quantitatively controlled. Water 92-97 insulin Homo sapiens 46-53 21640997-1 2011 The mechanism of the enzymatic action of Savinase on an insulin substrate organized in a monolayer at the air-water interface was studied. Water 110-115 insulin Homo sapiens 56-63 21939115-0 2011 [The influence of single immersion in Dead Sea water on glucose, insulin, cortisol and C-peptide levels in type 2 diabetes mellitus patients]. Water 47-52 insulin Homo sapiens 65-72 21939115-0 2011 [The influence of single immersion in Dead Sea water on glucose, insulin, cortisol and C-peptide levels in type 2 diabetes mellitus patients]. Water 47-52 insulin Homo sapiens 87-96 21939115-3 2011 OBJECTIVE: To compare the effects of a single immersion in sweet or mineral water on blood glucose, insulin, cortisol and c-peptide levels in patients with type 2 DM. Water 76-81 insulin Homo sapiens 122-131 20688491-5 2010 It was verified that approximately 50% of the insulin was released to Milli-Q water in 800 h release experiments. Water 78-83 insulin Homo sapiens 46-53 21822379-4 2011 The particle size and entrapment efficiency of recombinant human insulin (rhINS)-loaded sodium glycocholate liposomes can be easily adjusted by tuning the homogenization parameters, phospholipid:sodium glycocholate ratio, insulin:phospholipid ratio, water:ether volume ratio, interior water phase pH, and the hydration buffer pH. Water 250-255 insulin Homo sapiens 65-72 21822379-4 2011 The particle size and entrapment efficiency of recombinant human insulin (rhINS)-loaded sodium glycocholate liposomes can be easily adjusted by tuning the homogenization parameters, phospholipid:sodium glycocholate ratio, insulin:phospholipid ratio, water:ether volume ratio, interior water phase pH, and the hydration buffer pH. Water 285-290 insulin Homo sapiens 65-72 20851146-1 2011 Chicks genetically selected for low juvenile body weight had a lower threshold of central insulin-induced decreased food and water intake and whole blood glucose concentration than those selected for juvenile high body weight. Water 125-130 insulin Homo sapiens 90-97 20359545-4 2010 It seems that bioadhesive delivery systems or water-insoluble powders with absorption enhancers are the most promising methods for intranasal delivery of insulin. Water 46-51 insulin Homo sapiens 154-161 20616745-6 2010 In particular, many experimental and clinical studies suggest that psyllium does lower serum and liver cholesterol concentrations and may increase HDL-cholesterol levels- Moreover,water soluble fibres, such as psyllium, moderate post prandial glucose and insulin concentrations in non-insulin dependent diabetic patients, if taken with meals and favour the reduction of body weight and hypertension. Water 180-185 insulin Homo sapiens 255-262 20616745-6 2010 In particular, many experimental and clinical studies suggest that psyllium does lower serum and liver cholesterol concentrations and may increase HDL-cholesterol levels- Moreover,water soluble fibres, such as psyllium, moderate post prandial glucose and insulin concentrations in non-insulin dependent diabetic patients, if taken with meals and favour the reduction of body weight and hypertension. Water 180-185 insulin Homo sapiens 285-292 20434317-5 2010 In this study, the adsorption of three proteins, bovine serum albumin (BSA), lysozyme and insulin, to oil/water interfaces is characterized by interfacial shear stress measurements using a sensitive rheometer equipped with a Du Nouy ring geometry. Water 106-111 insulin Homo sapiens 90-97 19385641-4 2009 According to atomic force microscopy images and dynamic light scattering measurements, the partial DMSO-induced dissection of insulin fibrils favors formation of smaller soluble oligomers, which retain a limited capacity to induce daughter generation of fibrils through seeding to the native insulin, as well as the ability to reassemble into fibrils upon removal of DMSO through dialysis against water. Water 397-402 insulin Homo sapiens 126-133 19889241-5 2010 After the second carbohydrate load, insulin AUC for CC was 49 % and 57 % greater (P < 0.01) than for DC and W, respectively. Water 111-112 insulin Homo sapiens 36-43 19770501-4 2009 The observed double conformation of GluB13 was essential to interpreting the charge balance and could be compared with the structure of a dried crystal of T(6) human insulin at 100 K. Differences in the dynamic behaviour of the water molecules coordinating the upper and lower Zn ions were observed and interpreted. Water 228-233 insulin Homo sapiens 166-173 19785566-0 2009 The effect of water-based exercise on glucose and insulin response in overweight women: a pilot study. Water 14-19 insulin Homo sapiens 50-57 19785566-1 2009 OBJECTIVE: The aim of this study was to investigate the effectiveness of a 12-week moderate intensity, water-based circuit-type training intervention on glucose and insulin responses in overweight women with normal or impaired glucose tolerance. Water 103-108 insulin Homo sapiens 165-172 19785566-8 2009 CONCLUSIONS: Moderate intensity, water-based circuit-type exercises appear to be an effective exercise modality to improve glucose and insulin response to a glucose challenge in overweight women with IGT. Water 33-38 insulin Homo sapiens 135-142 19414243-4 2009 The stability of InS in the complex in an organic/water (O/W) interface was verified via RP-HPLC. Water 50-55 insulin Homo sapiens 17-20 19947313-0 2009 [Insulin glargine and cancer: a storm in a glass of water?]. Water 52-57 insulin Homo sapiens 1-8 19353602-0 2009 Adsorption of insulin peptide on charged single-walled carbon nanotubes: significant role of ordered water molecules. Water 101-106 insulin Homo sapiens 14-21 18491415-0 2008 NMR structure of biosynthetic engineered human insulin monomer B31(Lys)-B32(Arg) in water/acetonitrile solution. Water 84-89 insulin Homo sapiens 47-54 19420793-4 2009 The pegylated insulin/CyD polypseudorotaxanes were less soluble in water. Water 67-72 insulin Homo sapiens 14-21 19639693-2 2009 The mineral water was found to activate regulation of carbohydrate metabolism by insulin and cortisol due to the formation of adaptive reactions during a course of its therapeutic intake. Water 12-17 insulin Homo sapiens 81-88 19639693-3 2009 The mineral water promoted realization of trophic effects of gastrin and insulin in animals with peptic ulcer the size of which significantly decreased. Water 12-17 insulin Homo sapiens 73-80 19149726-9 2009 The chitosan is modifiable chemically to produce water-soluble low molecular weight polymer which renders insulin able to be processed under mild conditions, and sulphated chitosan which markedly opens the paracellular channels for insulin transport. Water 49-54 insulin Homo sapiens 106-113 18674921-4 2008 The stability of At-insulin complex was checked by dialysis against deionized water and Ringer lactate (RL) solution. Water 78-83 insulin Homo sapiens 20-27 18674921-5 2008 It has been found that the half-life of At-insulin complex is about approximately 12h, when dialyzed against deionized water and is only 6h, when dialyzed against RL solution having the same composition as blood serum. Water 119-124 insulin Homo sapiens 43-50 18040865-0 2008 Structure of human insulin monomer in water/acetonitrile solution. Water 38-43 insulin Homo sapiens 19-26 18335029-3 2008 We wondered whether insulin-operated signaling pathways modulate mitochondrial respiration via NO, to alternatively release complete glucose oxidation to CO(2) and H(2)O or to drive glucose storage to glycogen. Water 164-169 insulin Homo sapiens 20-27 17576056-5 2008 The particles were prepared by spraying an acidic water/DMSO solution of insulin and polymer into supercritical carbon dioxide. Water 50-55 insulin Homo sapiens 73-80 19083400-10 2008 In conclusion, these results suggest that supplementation with hydrogen-rich water may have a beneficial role in prevention of T2DM and insulin resistance. Water 77-82 insulin Homo sapiens 136-143 18040865-2 2008 An NMR-derived human insulin monomer structure in H2O/CD3CN, 65/35 vol%, pH 3.6 is presented and compared with the available X-ray structure of a monomer that forms part of a hexamer (Acta Crystallogr. Water 50-53 insulin Homo sapiens 21-28 17970536-0 2007 Does bicarbonated mineral water rich in sodium change insulin sensitivity of postmenopausal women? Water 26-31 insulin Homo sapiens 54-61 17973055-9 2007 CONCLUSIONS: Use of continuous infusion of regular insulin associated with adequate water and electrolyte replacement using isotonic solutions, besides being an effective treatment for DKA, preserves plasma osmolarity and prevents cerebral edema. Water 84-89 insulin Homo sapiens 51-58 17970536-9 2007 Insulin concentrations showed a significant time effect (p < 0.0001) and a significant water x time interaction (p < 0.021). Water 90-95 insulin Homo sapiens 0-7 32680262-1 2007 Blood triglyceride, free fatty acid and insulin levels are lower after acute intake of an oil-water-monoglyceride gel versus an oil-water mixture, demonstrating that food matrix nanostructure and microstructure can be engineered to modulate the physiological response. Water 94-99 insulin Homo sapiens 40-47 16772346-5 2006 Perfusion and oxidative capacity were measured during insulin stimulation by [15O]H2O and [15O]O2. Water 82-85 insulin Homo sapiens 54-61 16307385-1 2006 The adsorption of insulin at an oil-water interface was studied with fluorescence correlation spectroscopy (FCS). Water 36-41 insulin Homo sapiens 18-25 16029032-3 2005 HSA-Fmoc-insulin is water-soluble and, upon incubation in aqueous buffers reflecting normal human serum conditions, slowly, spontaneously, and homogeneously hydrolyzes to release unmodified insulin with a t 1/2 of 25 +/- 2 h. A single subcutaneous or intraperitoneal administration of HSA-Fmoc-insulin to diabetic rodents lowers circulating glucose levels for about 4 times longer than an equipotent dose of Zn2+-free insulin. Water 20-25 insulin Homo sapiens 9-16 16254391-4 2005 Cooling of preheated human insulin-poly(ethylene glycol)-water solutions results in the facile formation of insulin particles. Water 57-62 insulin Homo sapiens 27-34 16254391-4 2005 Cooling of preheated human insulin-poly(ethylene glycol)-water solutions results in the facile formation of insulin particles. Water 57-62 insulin Homo sapiens 108-115 15797955-5 2005 Obese insulin-sensitive subjects had lower intramyocellular (1.64 +/- 0.68 vs.2.26 +/- 0.62% of water peak, P = 0.017) and visceral lipid deposition (45 +/- 23 vs. 77 +/- 52 cm(2), P = 0.04) and a higher level of adiponectin, compared with their obese-resistant counterparts (8.8 +/- 3.6 vs. 6.5 +/- 1.8 mug/dl, P = 0.015). Water 96-101 insulin Homo sapiens 6-13 19791416-1 2005 We present a hole burning study on insulin in a glycerol-water solvent by using the intrinsic amino acid tyrosine as a photochemical probe. Water 57-62 insulin Homo sapiens 35-42 19791416-2 2005 The focus of the experiments is on the comparative pressure response of the spectral holes for insulin in its native state, in its chemically denatured state and for tyrosine in the glycerol-water solvent. Water 191-196 insulin Homo sapiens 95-102 15773285-2 2005 The insulin nanoparticles were prepared by a water-in-oil-in-water emulsification and evaporation method. Water 45-50 insulin Homo sapiens 4-11 15773285-2 2005 The insulin nanoparticles were prepared by a water-in-oil-in-water emulsification and evaporation method. Water 61-66 insulin Homo sapiens 4-11 15271748-3 2004 For every 1 to 50-mg/dL increase in blood glucose concentration more than 100 mg/dL, 1 U of insulin was added to the injection port of a 100-mL measured volume set containing 5% dextrose in water. Water 190-195 insulin Homo sapiens 92-99 15620868-0 2005 Solid lipid micro-particles carrying insulin formed by solvent-in-water emulsion-diffusion technique. Water 66-71 insulin Homo sapiens 37-44 15620868-1 2005 The study aimed to produce solid lipid insulin-loaded micro-particles by the solvent-in-water emulsion-diffusion technique, using isobutyric acid as solvent phase, glyceryl monostearate or cetyl palmitate as lipid, soya lecithin and taurodeoxycholate as emulsifiers. Water 88-93 insulin Homo sapiens 39-46 15504987-6 2004 In contrast, the insulin-treated women did not lose body fat and gained 1.04 kg body wt due to a rise in extracellular water. Water 119-124 insulin Homo sapiens 17-24 15641356-0 2004 Human insulin and desamido human insulin isotherms in ethanol-water reversed phase systems. Water 62-67 insulin Homo sapiens 6-13 15641356-0 2004 Human insulin and desamido human insulin isotherms in ethanol-water reversed phase systems. Water 62-67 insulin Homo sapiens 33-40 15359580-4 2004 An excess of triacetin was added to the emulsion so that water could be extracted into the continuous phase, allowing the insulin-loaded microsphere precipitation. Water 57-62 insulin Homo sapiens 122-129 15359580-10 2004 CONCLUSIONS: The water extraction procedures successfully produced insulin-loaded hydrophilic microspheres allowing the preservation of peptide stability. Water 17-22 insulin Homo sapiens 67-74 14687662-12 2004 These data show that the insulin-stimulated oxidant signal differentially affects the two major downstream components of the insulin signaling pathway, PI 3"-kinase and MAP kinase, and cross-talk between insulin action, PLCgamma and, to a lesser extent, PKA modulates the net cellular effects of insulin-stimulated cellular H(2)O(2). Water 324-329 insulin Homo sapiens 25-32 15147807-1 2004 Formulation optimization of the water-in-oil-in-water multiple emulsion incorporating insulin was performed based on statistical methods such as the orthogonal experimental design and the response surface evaluation. Water 32-37 insulin Homo sapiens 86-93 15147807-1 2004 Formulation optimization of the water-in-oil-in-water multiple emulsion incorporating insulin was performed based on statistical methods such as the orthogonal experimental design and the response surface evaluation. Water 48-53 insulin Homo sapiens 86-93 14687662-12 2004 These data show that the insulin-stimulated oxidant signal differentially affects the two major downstream components of the insulin signaling pathway, PI 3"-kinase and MAP kinase, and cross-talk between insulin action, PLCgamma and, to a lesser extent, PKA modulates the net cellular effects of insulin-stimulated cellular H(2)O(2). Water 324-329 insulin Homo sapiens 125-132 14687662-12 2004 These data show that the insulin-stimulated oxidant signal differentially affects the two major downstream components of the insulin signaling pathway, PI 3"-kinase and MAP kinase, and cross-talk between insulin action, PLCgamma and, to a lesser extent, PKA modulates the net cellular effects of insulin-stimulated cellular H(2)O(2). Water 324-329 insulin Homo sapiens 125-132 14687662-12 2004 These data show that the insulin-stimulated oxidant signal differentially affects the two major downstream components of the insulin signaling pathway, PI 3"-kinase and MAP kinase, and cross-talk between insulin action, PLCgamma and, to a lesser extent, PKA modulates the net cellular effects of insulin-stimulated cellular H(2)O(2). Water 324-329 insulin Homo sapiens 125-132 15366973-14 2004 Additionally, glitazones may potentiate the renal effects of insulin on sodium and water retention. Water 83-88 insulin Homo sapiens 61-68 14645082-5 2003 DeltaS degrees cryst>0 indicates release of solvent, mostly water, molecules structured around the hydrophobic patches on the insulin molecules" surface in the solution. Water 63-68 insulin Homo sapiens 129-136 12911866-11 2003 - Results showed that in normal subjects distill water caused mild elevation of blood glucose level, mild lowering of plasma insulin, and significant reduction of plasma C-peptide. Water 49-54 insulin Homo sapiens 125-132 12705369-4 2003 MATERIALS AND METHODS: Balb/c mice received oral insulin supplementation in their drinking water (1 U/ml) from beyond weaning during 40 days (S group). Water 91-96 insulin Homo sapiens 49-56 12832299-6 2003 RESULTS: The dietary intake of total as well as water-insoluble and water-soluble fiber was inversely associated with insulin resistance: -0.17 (0.07), P = 0.012; -0.15 (0.07), P = 0.024; and -0.14 (0.07), P = 0.049 [regression coefficients (SE)]. Water 48-53 insulin Homo sapiens 118-125 12832299-6 2003 RESULTS: The dietary intake of total as well as water-insoluble and water-soluble fiber was inversely associated with insulin resistance: -0.17 (0.07), P = 0.012; -0.15 (0.07), P = 0.024; and -0.14 (0.07), P = 0.049 [regression coefficients (SE)]. Water 68-73 insulin Homo sapiens 118-125 12833111-12 2003 Increases in subcutaneous fat water content also correlated with improvements in insulin sensitivity at 6, 9 and 12 months of weight maintenance (r=0.34-0.54, P=0.094-0.006). Water 30-35 insulin Homo sapiens 81-88 12833111-14 2003 The increase in water content correlates with the increase in insulin sensitivity, suggesting that weight loss and consequent improved insulin sensitivity could mediate the increase in abdominal subcutaneous fat hydration. Water 16-21 insulin Homo sapiens 62-69 12833111-14 2003 The increase in water content correlates with the increase in insulin sensitivity, suggesting that weight loss and consequent improved insulin sensitivity could mediate the increase in abdominal subcutaneous fat hydration. Water 16-21 insulin Homo sapiens 135-142 11914752-3 2002 We present the development of a liquid formula that can be easily dispersed in water to produce particles named "nanocubicles" which efficiently encapsulate insulin. Water 79-84 insulin Homo sapiens 157-164 12162325-3 2002 At first these matrices were partially hydrolyzed and then the carboxyl groups were coupled with RGD or insulin in the presence of water-soluble carbodiimide. Water 131-136 insulin Homo sapiens 104-111 12167605-1 2002 Insulin is an important regulator of renal salt and water excretion, and hyperinsulinemia has been implicated to play a role in hypertension. Water 52-57 insulin Homo sapiens 0-7 12553944-4 2003 In contrast to its sodium retaining properties in normal, obese and diabetic subjects, insulin-glucose-potassium therapy may induce a sodium diuresis in catabolic patients with salt and water overload and in patients with congestive heart failure in whom haemodynamic improvement has also been observed. Water 186-191 insulin Homo sapiens 87-94 19003111-3 2002 Water-soluble or chloroform/methanol-extracted fractions from Kefram-Kefir were examined to evaluate the glucose uptake ability of L6 myotubes.As a result, the water-soluble fraction augmented the uptake of glucose in L6 myotubes both in the presence and absence of insulin stimulation. Water 160-165 insulin Homo sapiens 266-273 19003111-5 2002 Especially, glucose uptake was augmented up to six times with the addition of water-soluble fraction in the insulin-stimulated L6 myotubes. Water 78-83 insulin Homo sapiens 108-115 19003111-8 2002 Considering together with the reports that PI 3-kinase is locatedin the insulin signaling pathway and the participation in the translocation of glucose transporter 4 to the cell membrane, it is suggested that the water-soluble fraction of Kefram-Kefir activates PI 3-kinase or other upstream molecules in the insulin signaling pathway, which resulted in the augmentation of glucose uptake and its specific inhibition by wortmannin. Water 213-218 insulin Homo sapiens 72-79 19003111-8 2002 Considering together with the reports that PI 3-kinase is locatedin the insulin signaling pathway and the participation in the translocation of glucose transporter 4 to the cell membrane, it is suggested that the water-soluble fraction of Kefram-Kefir activates PI 3-kinase or other upstream molecules in the insulin signaling pathway, which resulted in the augmentation of glucose uptake and its specific inhibition by wortmannin. Water 213-218 insulin Homo sapiens 309-316 12592900-6 2002 A course intake of mineral water raised tissue sensitivity to insulin at early stages of glucose test and lowered basal level of insulin and hydrocortisone. Water 27-32 insulin Homo sapiens 62-69 12592900-6 2002 A course intake of mineral water raised tissue sensitivity to insulin at early stages of glucose test and lowered basal level of insulin and hydrocortisone. Water 27-32 insulin Homo sapiens 129-136 12044564-10 2002 The insulin diffusion through the water-filled pores would be effectively prevented. Water 34-39 insulin Homo sapiens 4-11 11524020-2 2001 It was found that PT insulin has a highly flexible structure in pure water and is present in at least two different conformations, although with an overall tertiary structure similar to that of native insulin. Water 69-74 insulin Homo sapiens 21-28 12017983-4 2002 We report an 18-year-old diabetic female with rapid insulin-induced weight gain due to excessive body water retention, found by serial BIA measurement. Water 102-107 insulin Homo sapiens 52-59 12017983-10 2002 Rapid weight gain shortly after insulin therapy may be due to excessive but reversible water retention, detected by repeated BIA measurements. Water 87-92 insulin Homo sapiens 32-39 12391575-0 2002 Effect of water treatment on analyte and matrix ion yields in matrix-assisted time-of-flight secondary ion mass spectrometry: the case of insulin in and on hydroxycinnamic acid. Water 10-15 insulin Homo sapiens 138-145 12391575-8 2002 Water treatment resulted in a pronounced decrease in the 4HCCA yield, typically by a factor of five, in parallel with an increase of the insulin yield, by up to a factor of four. Water 0-5 insulin Homo sapiens 137-144 12391575-11 2002 The typically 20-fold increase in the insulin-to-4HCCA yield ratio, generated by water exposure of the samples, provides the explanation for the high yield ratios observed previously with water-treated samples. Water 81-86 insulin Homo sapiens 38-45 12391575-11 2002 The typically 20-fold increase in the insulin-to-4HCCA yield ratio, generated by water exposure of the samples, provides the explanation for the high yield ratios observed previously with water-treated samples. Water 188-193 insulin Homo sapiens 38-45 12391575-12 2002 Spraying with water or repeated exposure to water droplets caused a pronounced degradation of the insulin parent yields in combination with an increasing appearance of signals due to the B- and A-chains of insulin. Water 14-19 insulin Homo sapiens 98-105 12391575-12 2002 Spraying with water or repeated exposure to water droplets caused a pronounced degradation of the insulin parent yields in combination with an increasing appearance of signals due to the B- and A-chains of insulin. Water 14-19 insulin Homo sapiens 206-213 12391575-12 2002 Spraying with water or repeated exposure to water droplets caused a pronounced degradation of the insulin parent yields in combination with an increasing appearance of signals due to the B- and A-chains of insulin. Water 44-49 insulin Homo sapiens 98-105 12391575-12 2002 Spraying with water or repeated exposure to water droplets caused a pronounced degradation of the insulin parent yields in combination with an increasing appearance of signals due to the B- and A-chains of insulin. Water 44-49 insulin Homo sapiens 206-213 12391575-16 2002 With both methods of sample preparation, however, high secondary ion yields of insulin were only obtained after exposure of the samples to water. Water 139-144 insulin Homo sapiens 79-86 11981532-5 2002 Having identified several food allergies this "clinical ecologist" had placed the child on a spartan diet of bread, water and salt, and had reduced his insulin dosage by 68%. Water 116-121 insulin Homo sapiens 152-159 11785697-1 2001 PURPOSE: The aim of this study was to assess insulin stability by monitoring in situ time-course of insulin aggregation induced by a water-organic solvent (o/w) interface that occurs during the microencapsulation process. Water 133-138 insulin Homo sapiens 45-52 11524020-5 2001 In contrast, in TFE/water solution the mutant reveals a propensity of forming a well-defined structure at the secondary structure level, similar to monomeric native insulin. Water 20-25 insulin Homo sapiens 165-172 11524020-8 2001 The obtained results suggest that only an overall tertiary fold, as observed for PT insulin in pure water, is necessary for expressing the biological activity of insulin, as long as the molecule is flexible and retains the propensity to form the secondary structure required for its receptor binding. Water 100-105 insulin Homo sapiens 84-91 11524020-8 2001 The obtained results suggest that only an overall tertiary fold, as observed for PT insulin in pure water, is necessary for expressing the biological activity of insulin, as long as the molecule is flexible and retains the propensity to form the secondary structure required for its receptor binding. Water 100-105 insulin Homo sapiens 162-169 9648521-1 1998 This study deals with the production of chitosan microparticles containing insulin by interfacial crosslinkage of chitosan solubilized in the aqueous phase of a water/oil dispersion in the presence of ascorbyl palmitate. Water 161-166 insulin Homo sapiens 75-82 11269608-8 2001 In the second and third trimesters of pregnancy, insulin requirements were inversely associated with total, water soluble, and insoluble fiber intakes; the correlation coefficients ranged from -0.22 to -0.17 (P=.02 to .08). Water 108-113 insulin Homo sapiens 49-56 11063421-1 2000 Insulin-loaded microparticles were produced from blends of poly(ethylene glycol) (PEG) with poly (L-lactide) (PLA) homopolymer and poly (DL-lactide co-glycolide) copolymers (PLG) using a water-in-oil solvent extraction method. Water 187-192 insulin Homo sapiens 0-7 10905295-3 2000 Kinetic studies revealed that the aquation of iridium complexes activated them toward the oxidation of insulin in acidic solutions; e.g., the rate constant was equal to 25, 900, and 8,400 L mol(-1) s(-1) for the oxidation of insulin by the IrCl62-, Ir(H2O)CI5-, and Ir(H2O)2Cl4 complexes, respectively. Water 252-255 insulin Homo sapiens 103-110 10905295-3 2000 Kinetic studies revealed that the aquation of iridium complexes activated them toward the oxidation of insulin in acidic solutions; e.g., the rate constant was equal to 25, 900, and 8,400 L mol(-1) s(-1) for the oxidation of insulin by the IrCl62-, Ir(H2O)CI5-, and Ir(H2O)2Cl4 complexes, respectively. Water 252-255 insulin Homo sapiens 225-232 10909962-0 2000 Enhanced stimulation of glucose uptake by insulin increases exercise-stimulated glucose uptake in skeletal muscle in humans: studies using [15O]O2, [15O]H2O, [18F]fluoro-deoxy-glucose, and positron emission tomography. Water 153-156 insulin Homo sapiens 42-49 10803477-1 2000 Generalized edema due to water retention is a very rare complication of insulin therapy. Water 25-30 insulin Homo sapiens 72-79 10659969-5 2000 The insulin clamp treatments increased milk protein yield by 15 and 25% during abomasal infusion of water or casein plus branched-chain amino acids, respectively. Water 100-105 insulin Homo sapiens 4-11 16211669-5 1999 Water flow over the dam is analogous to glucose leaving the blood for tissues, which is controlled by insulin. Water 0-5 insulin Homo sapiens 102-109 10358994-6 1999 65 patients with dumping-syndrome following a course of drinking mineral water demonstrated improvement in clinical symptoms of the disease and changed hormonal response to glucose which manifested with activation of insulin secretion early phase and reduced rise of hydrocortisone levels. Water 73-78 insulin Homo sapiens 217-224 11858448-4 2000 Water-soluble fiber appears to have a greater potential to reduce postprandial blood glucose, insulin, and serum lipid levels than insoluble fiber. Water 0-5 insulin Homo sapiens 94-101 10547529-5 1999 In this study, we use molecular dynamics simulations of 2-Zn insulin in water solvent to explore the further effect of vicinal polar or charged groups on hydrophobic hydration at a biomolecular surface. Water 72-77 insulin Homo sapiens 61-68 10547529-6 1999 In contrast to the case for solvent more isolated from such polar solute influences, the binding energies of the water that is proximal to the hydrophobic dimeric interface of insulin and vicinal to polar and charged groups are comparable to the bulk solvent value, a result of compensating interaction primarily with the solute counterions. Water 113-118 insulin Homo sapiens 176-183 10097254-6 1999 During the experimental period, body weight gain was greater in the insulin-treated groups than in the control groups whereas water intake was considerably decreased in the insulin-treated groups. Water 126-131 insulin Homo sapiens 173-180 9868963-1 1998 We treated two cases of diabetes mellitus who developed acute pulmonary edema following accidental aspiration of sweetened water for emergency treatment, when they had fallen into hypoglycemic coma following an overdose of injectable insulin. Water 123-128 insulin Homo sapiens 234-241 9766251-1 1998 Insulin (Ins) spontaneously and easily complexed with the hydrogel nanoparticle of hydrophobized cholesterol-bearing pullulan (CHP) in water. Water 135-140 insulin Homo sapiens 0-7 9546200-0 1998 NMR triple-quantum filtered relaxation analysis of 17O-water in insulin solutions: an insight into the aggregation of insulin and the properties of its bound water. Water 55-60 insulin Homo sapiens 64-71 9546200-0 1998 NMR triple-quantum filtered relaxation analysis of 17O-water in insulin solutions: an insight into the aggregation of insulin and the properties of its bound water. Water 55-60 insulin Homo sapiens 118-125 9546200-0 1998 NMR triple-quantum filtered relaxation analysis of 17O-water in insulin solutions: an insight into the aggregation of insulin and the properties of its bound water. Water 158-163 insulin Homo sapiens 64-71 9546200-1 1998 Transverse triple-quantum filtered NMR spectroscopy (TTQF) of 17O-water was used to study the properties of water in insulin solutions at different Zn2+ concentrations and pH values. Water 108-113 insulin Homo sapiens 117-124 9546200-2 1998 It was established that strongly bound water molecules are already present in Zn-free insulin. Water 39-44 insulin Homo sapiens 86-93 9546200-3 1998 On the assumption that the effective correlation time of a strongly bound water molecule, tau sb, is 10 ns, the apparent number of strongly bound water molecules was approximately 3 to 4 per insulin monomer. Water 74-79 insulin Homo sapiens 191-198 9546200-3 1998 On the assumption that the effective correlation time of a strongly bound water molecule, tau sb, is 10 ns, the apparent number of strongly bound water molecules was approximately 3 to 4 per insulin monomer. Water 146-151 insulin Homo sapiens 191-198 9423146-4 1997 Because of its low solubility in water and aqueous ethanol solution, zinc insulin was dissolved in 10% acetic acid-water solution for eye devices preparation. Water 33-38 insulin Homo sapiens 74-81 9572809-7 1998 With water ingestion, plasma catecholamines increased significantly, whereas insulin fell (P < 0.05). Water 5-10 insulin Homo sapiens 77-84 9423146-4 1997 Because of its low solubility in water and aqueous ethanol solution, zinc insulin was dissolved in 10% acetic acid-water solution for eye devices preparation. Water 115-120 insulin Homo sapiens 74-81 9188045-5 1997 In amorphous solids at low water content (glassy state), the cyclic anhydride intermediate of insulin reacts predominantly with water to form deamidated insulin, whereas the intermolecular reaction with another insulin molecule to form a covalent dimer accounts for < or = 15% of the total degradation. Water 27-32 insulin Homo sapiens 94-101 9301120-0 1997 Long-term effects of water-soluble corn bran hemicellulose on glucose tolerance in obese and non-obese patients: improved insulin sensitivity and glucose metabolism in obese subjects. Water 21-26 insulin Homo sapiens 122-129 9194511-3 1997 The drinking water contained 10% glucose to prevent hypoglycemia in the insulin-injected rats. Water 13-18 insulin Homo sapiens 72-79 9188045-5 1997 In amorphous solids at low water content (glassy state), the cyclic anhydride intermediate of insulin reacts predominantly with water to form deamidated insulin, whereas the intermolecular reaction with another insulin molecule to form a covalent dimer accounts for < or = 15% of the total degradation. Water 128-133 insulin Homo sapiens 153-160 9188045-6 1997 Increasing water content reduces the glass transition temperature of insulin to < 35 degrees C, and covalent dimer formation becomes increasingly favored relative to deamidation. Water 11-16 insulin Homo sapiens 69-76 9188045-5 1997 In amorphous solids at low water content (glassy state), the cyclic anhydride intermediate of insulin reacts predominantly with water to form deamidated insulin, whereas the intermolecular reaction with another insulin molecule to form a covalent dimer accounts for < or = 15% of the total degradation. Water 128-133 insulin Homo sapiens 94-101 9188045-9 1997 The kinetics and product distribution of human insulin in lyophilized powders between pH 3 and 5 illustrate the differential sensitivities of various solid-state reaction types to the effects of water activity and solid-phase behavior. Water 195-200 insulin Homo sapiens 47-54 9188045-5 1997 In amorphous solids at low water content (glassy state), the cyclic anhydride intermediate of insulin reacts predominantly with water to form deamidated insulin, whereas the intermolecular reaction with another insulin molecule to form a covalent dimer accounts for < or = 15% of the total degradation. Water 128-133 insulin Homo sapiens 153-160 9188188-2 1997 To this end, the oxidized chain B from insulin (INS) (S = 5% in demineralized water) was subjected to tryptic proteolysis (E/S = 1/50; pH 5; 37 degrees C; 24 h). Water 78-83 insulin Homo sapiens 39-46 9095349-0 1997 Mitogenic activities of water-soluble and -insoluble insulin conjugates. Water 24-29 insulin Homo sapiens 53-60 9095349-1 1997 Insulin was covalently bound to water-soluble polymers such as poly(oxyethylene) and poly(acrylic acid). Water 32-37 insulin Homo sapiens 0-7 9095349-3 1997 Insulin was also bound to a poly(acrylic acid)-grafted polystyrene film, to form a water-insoluble multivalent conjugate. Water 83-88 insulin Homo sapiens 0-7 9095349-6 1997 A concentration of immobilized insulin much lower than that of native insulin and the water-soluble insulin conjugates accelerated cell growth. Water 86-91 insulin Homo sapiens 31-38 9095349-8 1997 The findings suggest that the mitogenic effect of the water-insoluble, multivalent insulin conjugate lasts longer than that of the water-soluble conjugates, owing to the absence of internalization into the cell. Water 54-59 insulin Homo sapiens 83-90 8731216-2 1996 In this study, insulin was covalently attached to two water-soluble polymers containing N-(2-hydroxypropyl)methacrylamide using the mixed anhydride method. Water 54-59 insulin Homo sapiens 15-22 9100605-4 1997 The time-restricted food and water intakes were associated with variations of gastric pH, plasma gastrin, insulin, glucose, and calcium documented on a circadian basis. Water 29-34 insulin Homo sapiens 106-113 8980165-2 1996 Both insulin and lack of natriuretic counteracting response lead to water expansion, while hyperglycemica-induced osmotic diuresis leads to water depletion. Water 68-73 insulin Homo sapiens 5-12 8865303-12 1996 CONCLUSIONS: The decomposition of human insulin in lyophilized powders between pH 3-5 is a water induced solid-state reaction accelerated by the plasticization effect of sorbed water. Water 91-96 insulin Homo sapiens 40-47 8865303-12 1996 CONCLUSIONS: The decomposition of human insulin in lyophilized powders between pH 3-5 is a water induced solid-state reaction accelerated by the plasticization effect of sorbed water. Water 177-182 insulin Homo sapiens 40-47 9098972-3 1997 The C18 silica rods gave minimum plate heights of 10-15 microns for aromatic hydrocarbons in 80% methanol and of 20-30 microns for insulin in acetonitrile-water mixtures in the presence of trifluoroacetic acid. Water 155-160 insulin Homo sapiens 131-138 9241582-4 1997 In this report we describe enclosure of insulin-releasing cells into water-insoluble poly(2-hydroxyethyl methacrylate) and poly(2-hydroxyethyl methacrylate-co-methyl methacrylate) membranes using X-ray contrast medium as a solvent without use of any special apparatus. Water 69-74 insulin Homo sapiens 40-47 8914428-4 1996 Several mechanisms mediated by hyperinsulinemia can be entertained as follows: 1) sodium and water retention, 2) increased sympathetic nerve activity and reduced catecholamine clearance, 3) increased intracellular calcium concentration and reduced magnesium concentration, 4) increased coagulant activity and impaired fibrinolytic activity, 5) impaired endothelium-dependent NO synthesis and release, 6) increased vascular responsiveness for the vasoactive substrates, 7) increased proliferation of vascular smooth muscle cell by activation of protein kinase C or mediated by insulin and IGF-1 action. Water 93-98 insulin Homo sapiens 36-43 11666389-0 1996 Oxidation Kinetics of the Potent Insulin Mimetic Agent Bis(maltolato)oxovanadium(IV) (BMOV) in Water and in Methanol. Water 95-100 insulin Homo sapiens 33-40 8611526-12 1996 This effect is attributed to loss of water from the hydration shell of the insulin hexamer with increasing temperature and consequently reduces the entropic contributions to the T <--> R transition in the phenol/2Zn(II)-insulin hexamer system. Water 37-42 insulin Homo sapiens 75-82 8611526-12 1996 This effect is attributed to loss of water from the hydration shell of the insulin hexamer with increasing temperature and consequently reduces the entropic contributions to the T <--> R transition in the phenol/2Zn(II)-insulin hexamer system. Water 37-42 insulin Homo sapiens 226-233 8927035-2 1995 Several compounds including those currently used as insulin-mimetic agents in animal and human studies are stable upon dissolution in distilled water but lack such stability in distilled water at pH 7. Water 144-149 insulin Homo sapiens 52-59 7671346-4 1995 Metabolism of BaP to water-soluble metabolites by HepG2 cells in culture was 50% lower in fluorescein isothiocyanate (FITC)-insulin-CYP1A1-antibody-conjugate-treated cells than in control cells. Water 21-26 insulin Homo sapiens 124-131 7851230-2 1994 DeFronzo et al has used the analogy that insulin resistance can be viewed as a large iceberg submerged just below the water. Water 118-123 insulin Homo sapiens 41-48 7789625-6 1995 Infusion of 1.2 pmol.kg-1.min-1 GLP-I with 20 g glucose (10% dextrose in water) injected intravenously over 60 min enhanced plasma responses of immunoreactive CP; the mean incremental areas under concentration curves (0-60 min) increased sixfold, but the glycemic excursion was not affected. Water 73-78 insulin Homo sapiens 159-161 7742317-0 1995 Structure and rotational dynamics of fluorescently labeled insulin in aqueous solution and at the amphiphile-water interface of reversed micelles. Water 109-114 insulin Homo sapiens 59-66 8139483-3 1994 In control rats receiving PB in drinking water (0.5 mg/mL), serum insulin and triglyceride levels were diminished without any change in glucose and cholesterol concentrations in the fed state. Water 41-46 insulin Homo sapiens 66-73 8140052-5 1994 This process is accelerated by increasing the temperature and water content of the insulin powder or by performing lyophilization and/or dissolution of insulin in alkaline media. Water 62-67 insulin Homo sapiens 83-90 8140052-7 1994 The water sorption isotherm for insulin reveals that the extent of aggregation directly correlates with the water uptake by the lyophilized insulin powder, thus pointing to the critical role of protein conformational mobility in the aggregation process. Water 4-9 insulin Homo sapiens 32-39 8140052-7 1994 The water sorption isotherm for insulin reveals that the extent of aggregation directly correlates with the water uptake by the lyophilized insulin powder, thus pointing to the critical role of protein conformational mobility in the aggregation process. Water 4-9 insulin Homo sapiens 140-147 8140052-7 1994 The water sorption isotherm for insulin reveals that the extent of aggregation directly correlates with the water uptake by the lyophilized insulin powder, thus pointing to the critical role of protein conformational mobility in the aggregation process. Water 108-113 insulin Homo sapiens 32-39 8140052-7 1994 The water sorption isotherm for insulin reveals that the extent of aggregation directly correlates with the water uptake by the lyophilized insulin powder, thus pointing to the critical role of protein conformational mobility in the aggregation process. Water 108-113 insulin Homo sapiens 140-147 8338615-3 1993 The transfer of the expression plasmid of human insulin pSW3 by natural transformation and by transduction with phage P1 was investigated in laboratory media and in surface water samples. Water 173-178 insulin Homo sapiens 48-55 8136324-3 1993 Maps of the water distribution in the cubic insulin crystal show some well-ordered waters, which are bound to surrounding protein atoms by multiple hydrogen bonds, and an ill-defined solvent structure at a greater distance from the protein surface. Water 12-17 insulin Homo sapiens 44-51 1874176-1 1991 A water-soluble quinone, coenzyme Q0 (CoQ0), was shown to stimulate insulin release, and dicumarol, an inhibitor of quinone reductase, inhibited glucose-induced insulin release in pancreatic islets. Water 2-7 insulin Homo sapiens 68-75 8327648-9 1993 Insulin-mediated modulation of capillary permeability to water and electrolytes may also be involved. Water 57-62 insulin Homo sapiens 0-7 1332612-2 1992 Fractionation of organic extracts by thin layer chromatography in chloroform/acetone/methanol/acetic acid/water (50/20/10/10/5, v/v) revealed two insulin-sensitive glucosaminyl lipid fractions, the TLC origin (the Rf 0.0 fraction) and a fraction that migrated with Rf 0.18-0.2 (the Rf 0.2 fraction). Water 106-111 insulin Homo sapiens 146-153 1806308-0 1991 [Effect of water extract of 4 Chinese herbal drugs on the binding of insulin with human erythrocyte insulin receptor]. Water 11-16 insulin Homo sapiens 69-76 1806308-0 1991 [Effect of water extract of 4 Chinese herbal drugs on the binding of insulin with human erythrocyte insulin receptor]. Water 11-16 insulin Homo sapiens 100-107 1988957-0 1991 Water structure in cubic insulin crystals. Water 0-5 insulin Homo sapiens 25-32 1646259-1 1991 Insulin resistance associated with a hyperinsulinemic response to oral glucose intake has been found in patients with essential hypertension and is believed to play a role in inducing hypertension by causing renal sodium and water retention. Water 225-230 insulin Homo sapiens 0-7 2017469-4 1991 Water intake was higher after insulin than saline at 60" and 90". Water 0-5 insulin Homo sapiens 30-37 2268141-0 1990 Insulin stimulation of water intake in humans. Water 23-28 insulin Homo sapiens 0-7 2268141-2 1990 Water intake was significantly higher after insulin than after saline administration during the 90-min period studied. Water 0-5 insulin Homo sapiens 44-51 2268141-3 1990 Plasma glucose decreased significantly in individuals receiving insulin and the time of the maximum decrease (30 min) was concurrent with the beginning of water intake. Water 155-160 insulin Homo sapiens 64-71 2203255-0 1990 Water volume and consumption time: influence on the glycemic and insulinemic responses in non-insulin-dependent diabetic subjects. Water 0-5 insulin Homo sapiens 65-72 33800074-0 2021 Water Extract of Mungbean (Vigna radiata L.) Inhibits Protein Tyrosine Phosphatase-1B in Insulin-Resistant HepG2 Cells. Water 0-5 insulin Homo sapiens 89-96 2155002-7 1990 Insulin may increase absorption of sodium in the diluting segment of the distal nephron with consequent water retention. Water 104-109 insulin Homo sapiens 0-7 33800074-1 2021 The present study aimed to investigate the effects of mungbean water extract (MWE) on insulin downstream signaling in insulin-resistant HepG2 cells. Water 63-68 insulin Homo sapiens 86-93 33800074-1 2021 The present study aimed to investigate the effects of mungbean water extract (MWE) on insulin downstream signaling in insulin-resistant HepG2 cells. Water 63-68 insulin Homo sapiens 118-125 33486948-9 2021 The device was fabricated and its applicability has been demonstrated by delivering ~1.8 mL of water at a 10 +- 2 muLmin-1 flow rate at 2 V constant applied voltage over a period of 3 h. Such a wearable device can be programed to deliver model insulin or pain medication drugs for chronic diseases. Water 95-100 insulin Homo sapiens 244-251 22382020-2 2012 The amyloid-like fibrils are prepared in a two step procedure, where insulin and magnetic nanoparticles are mixed simply by grinding in the solid state, resulting in a water soluble hybrid material. Water 168-173 insulin Homo sapiens 69-76 34510301-0 2021 Deuterium-depleted water stimulates GLUT4 translocation in the presence of insulin, which leads to decreased blood glucose concentration. Water 19-24 insulin Homo sapiens 75-82 33800074-8 2021 This is the first study to show that mungbean water extract increased cellular glucose uptake and improved insulin sensitivity of insulin-resistant HepG2 cells through PTP-1B inhibition and modulating the expression of genes related to glucose metabolism. Water 46-51 insulin Homo sapiens 107-114 33800074-8 2021 This is the first study to show that mungbean water extract increased cellular glucose uptake and improved insulin sensitivity of insulin-resistant HepG2 cells through PTP-1B inhibition and modulating the expression of genes related to glucose metabolism. Water 46-51 insulin Homo sapiens 130-137 34746944-9 2021 It is found from our calculations that the first solvation shell of insulin is readily occupied by choline and geranate ions in the presence of water. Water 144-149 insulin Homo sapiens 68-75 34746944-10 2021 Moreover, the geranate ions strongly interacted with the water molecules and thereby, eliminating the intermolecular hydrogen bonding (H-bonding) interactions towards the insulin at 0.30-0.50 mole fraction of CAGE ILs. Water 57-62 insulin Homo sapiens 171-178 34746944-11 2021 The most desirable 0.30-0.50 mole fraction of CAGE invigorates water-mediated H-bonding interactions with geranate ions, which also enhances the electrostatic behavior around the vicinity of the insulin dimer. Water 63-68 insulin Homo sapiens 195-202 34674526-0 2021 Structural Stability of Insulin Oligomers and Protein Association-Dissociation Processes: Free Energy Landscape and Universal Role of Water. Water 134-139 insulin Homo sapiens 24-31 34674526-3 2021 We focus on the solvation of the insulin monomer in water, stability and dissociation of its dimer, and structural integrity of the hexamer. Water 52-57 insulin Homo sapiens 33-40 34674526-5 2021 Ten water molecules inside the central cavity stabilize the structure of the insulin hexamer. Water 4-9 insulin Homo sapiens 77-84 34455318-2 2022 In this study, we encapsulated insulin and quercetin using a self-assembled water-in-oil-in-water (W/O/W) double emulsion. Water 76-81 insulin Homo sapiens 31-38 34455318-2 2022 In this study, we encapsulated insulin and quercetin using a self-assembled water-in-oil-in-water (W/O/W) double emulsion. Water 92-97 insulin Homo sapiens 31-38 34510301-12 2021 Based on our experimental data, deuterium-depleted water could be used to treat patients with metabolic syndrome (MS) by increasing insulin sensitivity. Water 51-56 insulin Homo sapiens 132-139 34406771-1 2021 We calculate the rate of dissociation of an insulin dimer into two monomers in water. Water 79-84 insulin Homo sapiens 44-51 34266892-1 2021 We used stable isotope-labeled glucose and palmitate tracer infusions, a hyperinsulinemic-euglycemic clamp, positron-emission tomography of muscles and adipose tissue after (18F)fluorodeoxyglucose and (15O)water injections, and subcutaneous adipose tissue (SAT) biopsy to test the hypotheses that: i) increased glucose uptake in SAT is responsible for high insulin-stimulated whole-body glucose uptake in people with obesity who are insulin-sensitive, and ii) putative SAT factors thought to cause insulin resistance are present in people with obesity who are insulin-resistant but not in those who are insulin-sensitive. Water 206-211 insulin Homo sapiens 357-364 34301147-8 2021 Meanwhile, through the study of insulin centroid trajectory, we have claimed two different diffusion mechanisms of insulin in polymer solution: The movement of insulin in the HA and water solution follows the Brownian motion rule. Water 182-187 insulin Homo sapiens 32-39 34452273-8 2021 Lipophilicity of insulin in terms of log Poctanol/water was improved from -1.8 to 2.1. Water 50-55 insulin Homo sapiens 17-24 34301147-8 2021 Meanwhile, through the study of insulin centroid trajectory, we have claimed two different diffusion mechanisms of insulin in polymer solution: The movement of insulin in the HA and water solution follows the Brownian motion rule. Water 182-187 insulin Homo sapiens 115-122 34301147-8 2021 Meanwhile, through the study of insulin centroid trajectory, we have claimed two different diffusion mechanisms of insulin in polymer solution: The movement of insulin in the HA and water solution follows the Brownian motion rule. Water 182-187 insulin Homo sapiens 160-167 34301147-9 2021 In comparison, the hopping effect of insulin has been observed in the PVA solution due to poor intermolecular affinity as well as lower polymer water solubility. Water 144-149 insulin Homo sapiens 37-44 35470695-5 2022 Accordingly, we further hypothesized that, in T2D individuals, seven days of passive heat treatment via hot water immersion to waist-level would improve leg blood flow responses to an oral glucose load (i.e., endogenous insulin stimulation) via induction of endothelial HSP72. Water 108-113 insulin Homo sapiens 220-227 34111968-0 2021 Inspecting Insulin Products Using Water Proton NMR. Water 34-39 insulin Homo sapiens 11-18 34111968-4 2021 METHODS: Four insulin products for patient self-injection presented as prefilled pens have been noninvasively and quantitatively inspected using the water proton NMR technology. Water 149-154 insulin Homo sapiens 14-21 34111968-9 2021 CONCLUSIONS: Water proton NMR can noninvasively and quantitatively inspect insulin pens. Water 13-18 insulin Homo sapiens 75-82 34084477-1 2021 Metabolic alkalosis induced by ingestion of alkaline water may enhance insulin sensitivity in type 1 diabetes mellitus. Water 53-58 insulin Homo sapiens 71-78 34323033-2 2021 Methods: The formulation of insulin-loaded water-in-oil-in-water solid lipid nanoparticles (INS-SNPs) was prepared by using a methanol-chloroform mixed solvent. Water 43-48 insulin Homo sapiens 28-35 34323033-2 2021 Methods: The formulation of insulin-loaded water-in-oil-in-water solid lipid nanoparticles (INS-SNPs) was prepared by using a methanol-chloroform mixed solvent. Water 59-64 insulin Homo sapiens 28-35 34105321-1 2021 OBJECTIVES: The present study aimed to explore the effect of water-based rhythmic exercise training on fasting blood sugar (FBS), homeostatic model assessment (HOMA), insulin, thyroid stimulating hormone (TSH), and T4 in postmenopausal women with metabolic syndrome. Water 61-66 insulin Homo sapiens 167-174 34178828-1 2021 Background: Water pre-load affects insulin secretion by altering the level of copeptin (C-terminal component of the arginine vasopressin hormone (AVP)) and preventing obesity by reducing food intake. Water 12-17 insulin Homo sapiens 35-42 35476966-5 2022 Pursuing this objective, we first investigated the therapeutic effect of intranasal insulin on Abeta oligomer (AbetaO)-induced memory impairment in male rats using the Morris water maze task. Water 175-180 insulin Homo sapiens 84-91 35587736-6 2022 The HGs embody more than 70% water amenable for hosting insulin in the matrix. Water 29-34 insulin Homo sapiens 56-63 35549028-4 2022 The adsorption of insulin onto the different materials is characterized through the conformational changes with respect to its conformation in water and the interfacial regions, which are described by specific arrangements of polymer chains, water, insulin, and plasticizer molecules. Water 143-148 insulin Homo sapiens 18-25 35549028-4 2022 The adsorption of insulin onto the different materials is characterized through the conformational changes with respect to its conformation in water and the interfacial regions, which are described by specific arrangements of polymer chains, water, insulin, and plasticizer molecules. Water 242-247 insulin Homo sapiens 18-25 35291774-0 2022 Insulin aspart dimer dissociation in water. Water 37-42 insulin Homo sapiens 0-7 35359364-3 2022 By conjugating heavy water (D2O) probed Raman scattering with label-free two-photon fluorescence (TPF) microscopy, we observed altered de novo lipogenesis, 3D lipid droplet morphology, and lipid peroxidation under various methionine and insulin concentrations. Water 21-26 insulin Homo sapiens 237-244 35006485-2 2022 Human insulin (Actrapid ) was labelled with fluorescein isothiocyanate (FITC) and the synthesised conjugate identified using reverse phase high performance liquid chromatography (RP-HPLC) on a C18 column and a gradient method with mobile phase A containing 0.1% trifluoroacetic acid (TFA) in Millipore water and mobile phase B containing 90% Acetonitrile, 10% Millipore water and 0.1% TFA. Water 302-307 insulin Homo sapiens 6-13 35006485-2 2022 Human insulin (Actrapid ) was labelled with fluorescein isothiocyanate (FITC) and the synthesised conjugate identified using reverse phase high performance liquid chromatography (RP-HPLC) on a C18 column and a gradient method with mobile phase A containing 0.1% trifluoroacetic acid (TFA) in Millipore water and mobile phase B containing 90% Acetonitrile, 10% Millipore water and 0.1% TFA. Water 370-375 insulin Homo sapiens 6-13 35291774-8 2022 Additionally, water plays a vital role in the dissociation of the insulin aspart by stabilizing the monomers in the dissociated state. Water 14-19 insulin Homo sapiens 66-73 2557291-1 1989 investigation of the hydrogen exchange in H2O of the peptide fragment B23-B29 of insulin. Water 42-45 insulin Homo sapiens 81-88 35023456-6 2022 METHODS: Water in oil in water (W-O-W) microemulsion solvent evaporation technique was used for the preparation of nanoparticles consisting from positively charged poly (D, L-lactide-co-glycolide) coated with chitosan and loaded with insulin. Water 9-14 insulin Homo sapiens 234-241 35023456-6 2022 METHODS: Water in oil in water (W-O-W) microemulsion solvent evaporation technique was used for the preparation of nanoparticles consisting from positively charged poly (D, L-lactide-co-glycolide) coated with chitosan and loaded with insulin. Water 25-30 insulin Homo sapiens 234-241 35059257-0 2022 Electrolyzed hydrogen-rich water for oxidative stress suppression and improvement of insulin resistance: a multicenter prospective double-blind randomized control trial. Water 27-32 insulin Homo sapiens 85-92 2557291-2 1989 Detailed and precise information on the exchanges in water of the peptide hydrogens of the insulin fragment B23-B29 (Gly23-Phe24-Phe25-Tyr26-Thr27-Pro28 -Lys29) has been obtained from magnetization-transfer measurements, and nonlinear least-squares fits of the experimental spectra using the expression for the discrete Fourier transform of a sum of exponentially damped sinusoids. Water 53-58 insulin Homo sapiens 91-98 2736199-4 1989 The stimulation of tumour growth by insulin was counteracted by the inclusion of 3-hydroxybutyrate in the drinking water without any alteration in the extent of weight loss. Water 115-120 insulin Homo sapiens 36-43 2689836-16 1989 Calcium chloride infusion, dextrose and insulin in water, and correction of acidosis with sodium bicarbonate are helpful in controlling the acute, life-threatening cardiac arrhythmias. Water 51-56 insulin Homo sapiens 40-47 2671776-8 1989 Similarly, in the oral water-loaded group serum DLF increased from 49 +/- 15 at time 0 to 127 +/- 24 pg digoxin Eq/ml at peak (p less than 0.01) after they received insulin.2= Water 23-28 insulin Homo sapiens 165-172 2505349-0 1989 Effect of insulin administration on water drinking in children. Water 36-41 insulin Homo sapiens 10-17 2505349-1 1989 The effect of insulin administration on water intake, was studied in children submitted to standard protocols for stimulation of secretion of hypophyseal hormones by i.v. Water 40-45 insulin Homo sapiens 14-21 2505349-4 1989 Water intake was significantly higher in both groups of patients receiving insulin than in the control group (no insulin). Water 0-5 insulin Homo sapiens 75-82 2505349-4 1989 Water intake was significantly higher in both groups of patients receiving insulin than in the control group (no insulin). Water 0-5 insulin Homo sapiens 113-120 2759361-3 1989 Water addition increased the peak blood glucose (p less than 0.02) and serum insulin (p less than 0.02) levels in healthy subjects, and the blood glucose concentration in well-controlled diabetic patients (p less than 0.02). Water 0-5 insulin Homo sapiens 77-84 2881643-3 1987 As the internal Na concentration was raised from 5 mmol/kg muscle water to 18 mmol/kg muscle water, the magnitude of the insulin-induced increase in the ouabain-sensitive Na efflux (an index of the Na,K-pump activity) rose by 5-fold and the magnitude of the insulin-induced hyperpolarization rose by 8.5-fold. Water 66-71 insulin Homo sapiens 121-128 2505889-2 1989 Surface potential (delta V) measurements were performed to assess information on insulin penetration/interaction with dipalmitoylphosphatidylcholine (DPPC) monolayers spread at the water-air interface. Water 181-186 insulin Homo sapiens 81-88 3061458-6 1988 In the second part, we introduce a simple fluorescence technique by which adsorption isotherms of water-soluble and fluorescent-labeled substrates, such as insulin, to membranes may be determined. Water 98-103 insulin Homo sapiens 156-163 3323466-6 1987 The water solubility of both molecules, CF and insulin, was considerably increased with the addition of increasing concentrations of salicylate to the solutions: at 37 degrees C, 2.5 M sodium salicylate solution increases the CF solubility 532 times from 12.2 to 6.5 mg.mL-1, and 1.5 M salicylate increases the solubility of insulin 7875 times, thus an aqueous solution containing 630 mg.mL-1 of insulin may be prepared. Water 4-9 insulin Homo sapiens 47-54 3323466-6 1987 The water solubility of both molecules, CF and insulin, was considerably increased with the addition of increasing concentrations of salicylate to the solutions: at 37 degrees C, 2.5 M sodium salicylate solution increases the CF solubility 532 times from 12.2 to 6.5 mg.mL-1, and 1.5 M salicylate increases the solubility of insulin 7875 times, thus an aqueous solution containing 630 mg.mL-1 of insulin may be prepared. Water 4-9 insulin Homo sapiens 325-332 3323466-6 1987 The water solubility of both molecules, CF and insulin, was considerably increased with the addition of increasing concentrations of salicylate to the solutions: at 37 degrees C, 2.5 M sodium salicylate solution increases the CF solubility 532 times from 12.2 to 6.5 mg.mL-1, and 1.5 M salicylate increases the solubility of insulin 7875 times, thus an aqueous solution containing 630 mg.mL-1 of insulin may be prepared. Water 4-9 insulin Homo sapiens 325-332 3314457-5 1987 Fructose, 75 g/300 ml of water, elicited--in contrast to the same amount of glucose--only a small increase in insulin and glucose levels. Water 25-30 insulin Homo sapiens 110-117 6422764-4 1984 Insulin (500 ng/ml) further augmented follicle-stimulating hormone (FSH)-induced aromatase activity, as evidenced both by an increase in 17 beta-estradiol production and by the release of tritiated water from [1 beta-3H]testosterone by granulosa cells. Water 198-203 insulin Homo sapiens 0-7 2881643-3 1987 As the internal Na concentration was raised from 5 mmol/kg muscle water to 18 mmol/kg muscle water, the magnitude of the insulin-induced increase in the ouabain-sensitive Na efflux (an index of the Na,K-pump activity) rose by 5-fold and the magnitude of the insulin-induced hyperpolarization rose by 8.5-fold. Water 93-98 insulin Homo sapiens 121-128 3546211-2 1986 Dichloramine-T, a water insoluble derivative of chloramine-T showed excellent properties as an iodination reagent, for the preparation of radiolabeled insulin for use in radioimmunoassay. Water 18-23 insulin Homo sapiens 151-158 3710313-2 1986 SHR treated with 10% sucrose solution as drinking water for 3 months exhibited an impaired glucose tolerance with higher serum insulin levels and a reduction of sigma delta IRI/sigma delta BS. Water 50-55 insulin Homo sapiens 127-134 3894123-2 1985 While insulin treatment restores plasma AA pattern, proline, methionine, valine, isoleucine, and total BCAA remain elevated in skeletal muscle intracellular water. Water 157-162 insulin Homo sapiens 6-13 6143305-2 1984 The addition of naloxone to a meal consisting of 50 g sucrose dissolved in 200 ml water augmented the rise of plasma insulin levels significantly during the first 30 min after its ingestion and reduced the rise in plasma insulin and pancreatic polypeptide and elevated glucagon levels during the last 30 min of the experimental period. Water 82-87 insulin Homo sapiens 117-124 6318856-1 1984 Injection of insulin to the CSF in the presence of spontaneous diuresis and hydration gives rise to the growth of reabsorption of osmotically free water accompanied by high tubular transport, as well as to the development of antinatriuresis and inhibition of diuresis. Water 147-152 insulin Homo sapiens 13-20 6111357-4 1981 Reduced insulin and DOI lose their ordered structure in water, but their helical conformation is restored in surfactant solutions. Water 56-61 insulin Homo sapiens 8-15 6342378-7 1983 The bound insulin could be removed by washing with water and detergent, but soaking in detergent did not remove a small residual quantity of the bound insulin, suggesting that minimal chemical binding or diffusion of the insulin into the plastic may occur. Water 51-56 insulin Homo sapiens 10-17 6377337-4 1984 This indicates that insulin possesses a markedly lower quantity of water of hydration than has been observed for globular proteins containing a higher proportion of hydrophilic groups on the surface of the molecule. Water 67-72 insulin Homo sapiens 20-27 6346673-1 1983 17 mineral water on insulin, histamine and pentagastrin stimulated gastric secretion]. Water 11-16 insulin Homo sapiens 20-27 7009285-1 1981 Insulin is insoluble in water at physiological pH, but dissolves relatively rapidly in plasma. Water 24-29 insulin Homo sapiens 0-7 6987372-2 1980 Insulin diffusivity in the membranes was determined to be 1.0 x 10(-6) cm2/sec, which is in reasonable agreement with literature values for insulin diffusivity in water. Water 163-168 insulin Homo sapiens 0-7 6987372-2 1980 Insulin diffusivity in the membranes was determined to be 1.0 x 10(-6) cm2/sec, which is in reasonable agreement with literature values for insulin diffusivity in water. Water 163-168 insulin Homo sapiens 140-147 5787105-0 1969 The effect of glucola, diet cola and water ingestion on blood glucose and plasma insulin. Water 37-42 insulin Homo sapiens 81-88 488464-0 1979 [Sensitivity to insulin during adaptation to mineral water taken internally]. Water 53-58 insulin Homo sapiens 16-23 910906-9 1977 These results indicate that insulin-requiring diabetics absorb glucose, Na, and H2O normally. Water 80-83 insulin Homo sapiens 28-35 1120786-2 1975 In studies on six water-loaded normal subjects in a steady state of water diuresis, insulin was administered i.v. Water 18-23 insulin Homo sapiens 84-91 4542575-3 1973 After a 90 min period of efflux, the insulin-treated muscles contained approximately 11% less intracellular water than did their controls. Water 108-113 insulin Homo sapiens 37-44 4542069-0 1973 The effect of diabetes mellitus and insulin on the absorption of glucose, water and electrolytes by the small intestine in man. Water 74-79 insulin Homo sapiens 36-43 920500-2 1977 Oxidation of partially thiolated insulin (0.5-0.7 SH group/mole), formed by reacting insulin with AHTL, with, (a) potassium ferricyanide, (b) Cu++-oxygen gave water soluble macromolecules containing 20-26 and 410-708 monomer units respectively which had rod-random coil shape (light scattering). Water 159-164 insulin Homo sapiens 33-40 1033127-0 1976 [Effect of mineral water on the secretion of insulin in an acute experiment]. Water 19-24 insulin Homo sapiens 45-52 4464859-9 1974 The solubility of native insulin in aqueous polyethylene glycol and in water showed a pH-dependence similar to that observed for the distribution in the dextran-polyethylene glycol system. Water 71-76 insulin Homo sapiens 25-32 4464859-10 1974 Iodination of insulin decreased the solubility of the hormone in polyethylene glycol and in water in parallel, and decreased the pH value at which solubility was a minimum. Water 92-97 insulin Homo sapiens 14-21 4339189-0 1972 Water of co-ordination in insulin. Water 0-5 insulin Homo sapiens 26-33 5557813-0 1971 [Formation and stability of water-soluble complexes of insulin with polyacrylic and polymethacrylic acids]. Water 28-33 insulin Homo sapiens 55-62 5792362-3 1969 Insulin in low concentrations inhibits the uptake of Ca(++) by the monooctadecyl (stearyl) phosphate monolayer (at air-water interface) and facilitates the release of Ca(++) adsorbed to the monolayer. Water 119-124 insulin Homo sapiens 0-7 4883828-0 1968 Direct isolation of thiol-containing peptides from insulin using a water-insoluble organomercurial copolymer of ethylene and maleic acid. Water 67-72 insulin Homo sapiens 51-58 5673348-0 1968 Insulin: intestinal absorption as water-in-oil-in-water emulsions. Water 34-39 insulin Homo sapiens 0-7 5673348-0 1968 Insulin: intestinal absorption as water-in-oil-in-water emulsions. Water 50-55 insulin Homo sapiens 0-7 5615061-0 1967 [Identification of insulin fractions in water solutions by starch-gel electrophoresis method]. Water 40-45 insulin Homo sapiens 19-26 13772880-0 1961 Deuterium-hydrogen exchange between water and insulin. Water 36-41 insulin Homo sapiens 46-53 13771912-0 1960 Neutralization of cod insulin with antiserum: precipitation of insulin-anti-insulin complex with ethanol-water. Water 105-110 insulin Homo sapiens 22-29 13771912-0 1960 Neutralization of cod insulin with antiserum: precipitation of insulin-anti-insulin complex with ethanol-water. Water 105-110 insulin Homo sapiens 63-70 13771912-0 1960 Neutralization of cod insulin with antiserum: precipitation of insulin-anti-insulin complex with ethanol-water. Water 105-110 insulin Homo sapiens 63-70 13479489-0 1957 [Dissociation of insulin in pyridine-water and acetic acid-water solutions]. Water 37-42 insulin Homo sapiens 17-24 13479489-0 1957 [Dissociation of insulin in pyridine-water and acetic acid-water solutions]. Water 59-64 insulin Homo sapiens 17-24 13464569-0 1957 [Changes in distribution of body water during hypoglycemic shock caused by insulin]. Water 33-38 insulin Homo sapiens 75-82 14938438-0 1952 A metabolic study of a diabetic patient: the effect of variations in the dosage of insulin upon adrenal cortical activity and upon water, electrolyte and nitrogen excretion. Water 131-136 insulin Homo sapiens 83-90 18149461-0 1949 Kinetics of distribution of insulin between two body water compartments. Water 53-58 insulin Homo sapiens 28-35 18878810-0 1948 The adsorption of water vapour on insulin and plasma albumin. Water 18-23 insulin Homo sapiens 34-41 33545104-4 2021 Amyloid aggregation is accompanied by zinc release and the suppression of water-sustained insulin dynamics, as shown by particle-induced X-ray emission and X-ray absorption spectroscopy and by neutron spectroscopy, respectively. Water 74-79 insulin Homo sapiens 90-97 5758012-0 1968 [Effects of the Mateczny II spring water in Cracow on the action of insulin]. Water 35-40 insulin Homo sapiens 68-75 33511440-3 2021 METHODS: We measured insulin-stimulated whole-body glucose disposal and glucose uptake and perfusion rates in five major muscle groups (erector spinae, obliques, rectus abdominis, hamstrings, quadriceps) in 15 healthy lean people and 37 people with obesity by using the hyperinsulinaemic-euglycaemic clamp procedure in conjunction with [2H]glucose tracer infusion (to assess whole-body glucose disposal) and positron emission tomography after injections of [15O]H2O (to assess muscle perfusion) and [18F]fluorodeoxyglucose (to assess muscle glucose uptake). Water 462-465 insulin Homo sapiens 21-28 33639734-4 2021 Insulin, when tested with these solutions, was found to show rigid conformations, relative to that in pure water. Water 107-112 insulin Homo sapiens 0-7 33639734-7 2021 Our study reveals that the loss of configurational entropy of insulin in arginine solution, as compared to that in pure water, is more as compared to the entropy loss in the other two amino acid solutions, which, moreover, was found to be due to the presence of motionally bound less entropic hydration water of insulin in arginine solution than in histidine or lysine solution. Water 120-125 insulin Homo sapiens 62-69 33639734-7 2021 Our study reveals that the loss of configurational entropy of insulin in arginine solution, as compared to that in pure water, is more as compared to the entropy loss in the other two amino acid solutions, which, moreover, was found to be due to the presence of motionally bound less entropic hydration water of insulin in arginine solution than in histidine or lysine solution. Water 303-308 insulin Homo sapiens 62-69