PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 30843458-6 2019 CONCLUSION:: Patients treated with an ACE inhibitor can latently experience inappropriate secretion of antidiuretic hormone, and rapidly develop severe hyponatremia together with additional factors affecting water or salt homeostasis regardless of the length of the administration duration. Water 208-213 angiotensin I converting enzyme Homo sapiens 38-41 30790328-13 2019 The water extract derived from heat-killed cells with angiotensin-converting enzyme inhibitory activity, which is known as suppression of inflammation of skin, could protect normal human epidermal keratinocytes (NHEKs) from damage caused by UVB. Water 4-9 angiotensin I converting enzyme Homo sapiens 54-83 26475588-4 2016 The classic RAS comprises the ACE-ANG II-AT1R axis that promotes vasoconstriction; water intake; sodium retention; and increased oxidative stress, fibrosis, cellular growth, and inflammation. Water 83-88 angiotensin I converting enzyme Homo sapiens 30-33 30387422-19 2018 CONCLUSION: In our study, the hypertension-associated polymorphisms are linked to the renin-angiotensin-aldosterone axis (ACE I/D, ACE A2350G), as well as to salt and water management (ADD1 G460W, GNB3 C825T). Water 167-172 angiotensin I converting enzyme Homo sapiens 122-125 30206530-5 2018 Results: After thermoforming, the transparency of Duran and Essix A+ decreased, while the water absorption ability of all materials; the water solubility of Duran, Essix A+, and Essix ACE; and the surface hardness of Duran and Essix A+ increased. Water 137-142 angiotensin I converting enzyme Homo sapiens 184-187 29674143-6 2018 On the other hand, the bioactivity profile of each type of dry-fermented sausage was evaluated through the measurement of the ACE inhibitory and antioxidant activities in water-soluble peptide extracts fractionated by size-exclusion chromatography. Water 171-176 angiotensin I converting enzyme Homo sapiens 126-129 24015756-7 2013 By contrast, a series of positively selected amino acid residues identified in the ACE and AGT (two key members of the renin-angiotensin-aldosterone system, RAAS) proteins of cetaceans suggests that RAAS might have been adapted to maintain the water and salt balance in response to a hyperosmotic environment. Water 244-249 angiotensin I converting enzyme Homo sapiens 83-86 26242895-10 2015 Biofilm production was associated with the presence of esp (P < 0.001) and ace genes (P = 0.021), being higher in infecting (P < 0.001) and water (P 0.005) isolates as compared with colonizing ones. Water 146-151 angiotensin I converting enzyme Homo sapiens 78-81 26123666-3 2015 The results of MTLC confirmed that between the two hydrophobicity parameters km and Pm/w, for absorption prediction of 11 ACE inhibitors, the micelle-water partition coefficient Pm/w provided higher correlation (R(2) = 0.756), while for the km parameter R(2) = 0.612 was obtained. Water 150-155 angiotensin I converting enzyme Homo sapiens 122-125 25415596-4 2015 Only the Small Angle Neutron Scattering (SANS) of concentrated toluene ACE solutions reveals the existence of small reverse micelles (probably ACE dimers forming small cages hosting 1-2 water molecules). Water 186-191 angiotensin I converting enzyme Homo sapiens 143-146 21292273-7 2011 It was also observed that ACE butyl and ACE phenyl columns retained basic compounds when the columns were eluted with a mobile phase consisting of acetonitrile/water (95:5) containing 3.25 mM ammonium acetate. Water 160-165 angiotensin I converting enzyme Homo sapiens 26-29 24250503-7 2012 Very good correlation (r = 0.91; water-ethanol solvent system) between the chromatographically obtained hydrophobicity parameters and calculated log p values confirmed the selection of ACE inhibitors since lisinopril and quinapril were on the opposite sites of linear relationship. Water 33-38 angiotensin I converting enzyme Homo sapiens 185-188 22111323-6 2011 Diuretics more effectively contribute to the balance of sodium and volume of water, when used with ACE inhibitor and ARB. Water 77-82 angiotensin I converting enzyme Homo sapiens 99-102 21597156-1 2011 In this paper, we reported ultrasensitive lead ion detection in environmental water with pM sensitivity using aza-crown-ether-modified silver nanoparticles (ACE-Ag NPs) through dynamic light scattering (DLS). Water 78-83 angiotensin I converting enzyme Homo sapiens 157-160 23672666-4 2013 Similar to carboxypeptidase A and thermolysin, the promoted water mechanism is established for the catalysis of ACE. Water 60-65 angiotensin I converting enzyme Homo sapiens 112-115 23720263-4 2012 The classic RAS can be defined as the ACE-Ang II-AT1R axis that promotes vasoconstriction, water intake, sodium retention, and other mechanisms to maintain blood pressure, as well as increase oxidative stress, fibrosis, cellular growth, and inflammation in pathological conditions. Water 91-96 angiotensin I converting enzyme Homo sapiens 38-41 19267429-3 2009 We studied the cis-trans isomerization of the proline dipeptide (Ace-Pro-NMe) in explicit water by molecular dynamics simulations using a combined potential derived from ab initio quantum mechanics and empirical molecular mechanics. Water 90-95 angiotensin I converting enzyme Homo sapiens 65-68 20108263-0 2010 ACE applied to the quantitative characterization of benzo-18-crown-6-ether binding with alkali metal ions in a methanol-water solvent system. Water 120-125 angiotensin I converting enzyme Homo sapiens 0-3 20108263-1 2010 ACE was applied to the quantitative evaluation of noncovalent binding interactions between benzo-18-crown-6-ether (B18C6) and several alkali metal ions, Li(+), Na(+), K(+), Rb(+) and Cs(+), in a mixed binary solvent system, methanol-water (50/50 v/v). Water 233-238 angiotensin I converting enzyme Homo sapiens 0-3 20942455-1 2010 The influence of the salts KCl, NaCl, and NaI at molar concentrations on the alpha-helical folding kinetics of the alanine-based oligopeptide Ace-AEAAAKEAAAKA-Nme is investigated by means of (explicit-water) molecular dynamics simulations and a diffusional analysis. Water 201-206 angiotensin I converting enzyme Homo sapiens 142-145 20688233-8 2010 After 18 h of fermentation, the water extract of bean showed less ACE inhibitory activity than did the respective 80% ethanol extract. Water 32-37 angiotensin I converting enzyme Homo sapiens 66-69 20688233-9 2010 While the water extract of viscous material showed a higher ACE inhibitory activity than the respective ethanol extract. Water 10-15 angiotensin I converting enzyme Homo sapiens 60-63 20688233-10 2010 With respect to extraction yield, it was found that the ACE inhibitor in the fermented black soybean could be extracted more efficiently with water than 80% ethanol. Water 142-147 angiotensin I converting enzyme Homo sapiens 56-59 18689950-0 2008 Assay of angiotensin I-converting enzyme-inhibiting activity based on the detection of 3-hydroxybutyrate with water-soluble tetrazolium salt. Water 110-115 angiotensin I converting enzyme Homo sapiens 9-40 18689950-2 2008 In this study, an ACE-inhibiting assay was improved by the use of a water-soluble tetrazolium salt, 4-[3-(4-iodophenyl)-2-(4-nitrophenyl)-2H-5-tetrazolio]-1,3-benzene disulfonate sodium salt (WST-1), for the detection of 3-hydroxybutyrate, derived from 3HB-GGG. Water 68-73 angiotensin I converting enzyme Homo sapiens 18-21 16368010-0 2005 Computer simulation of partitioning of ten pentapeptides Ace-WLXLL at the cyclohexane/water and phospholipid/water interfaces. Water 86-91 angiotensin I converting enzyme Homo sapiens 57-60 16368010-0 2005 Computer simulation of partitioning of ten pentapeptides Ace-WLXLL at the cyclohexane/water and phospholipid/water interfaces. Water 109-114 angiotensin I converting enzyme Homo sapiens 57-60 15646128-5 2004 The albumin-linked non-etherified fatty acids affected the ACE activity neither in water solutions nor in presence of lipoprotein complexes. Water 83-88 angiotensin I converting enzyme Homo sapiens 59-62 15614025-1 2004 OBJECTIVE: Angiotensin II and aldosterone, generated by the angiotensin-converting enzyme (ACE) and aldosterone synthase (CYP11B2), respectively, not only regulate sodium and water homeostasis, but also influence vascular remodeling in response to high blood pressure. Water 175-180 angiotensin I converting enzyme Homo sapiens 60-89 15614025-1 2004 OBJECTIVE: Angiotensin II and aldosterone, generated by the angiotensin-converting enzyme (ACE) and aldosterone synthase (CYP11B2), respectively, not only regulate sodium and water homeostasis, but also influence vascular remodeling in response to high blood pressure. Water 175-180 angiotensin I converting enzyme Homo sapiens 91-94 12903404-2 2000 METHODS: The experiment was carried out under the low water activity condition, using tosylate chloride activating side-chain hydroxyl group of Sepharose CL-4B agarose to form a high active group which could react with the free amino-group of ACE to link the enzyme with agarose. Water 54-59 angiotensin I converting enzyme Homo sapiens 243-246 12557187-0 2003 Comparison of a QM/MM force field and molecular mechanics force fields in simulations of alanine and glycine "dipeptides" (Ace-Ala-Nme and Ace-Gly-Nme) in water in relation to the problem of modeling the unfolded peptide backbone in solution. Water 155-160 angiotensin I converting enzyme Homo sapiens 123-126 12557187-0 2003 Comparison of a QM/MM force field and molecular mechanics force fields in simulations of alanine and glycine "dipeptides" (Ace-Ala-Nme and Ace-Gly-Nme) in water in relation to the problem of modeling the unfolded peptide backbone in solution. Water 155-160 angiotensin I converting enzyme Homo sapiens 139-142 11858846-7 2002 Differences in the structures of BK and T-kinin in water may explain their susceptibility/resistance to the action of ACE. Water 51-56 angiotensin I converting enzyme Homo sapiens 118-121 11080323-12 2000 Water accumulations at a 45 degrees angle were: AeroVent 0.765 +/- 0.152 g; OptiVent 1.894 +/- 0.228 g; and ACE 4.043 +/- 0.665 g through 6 hours of use. Water 0-5 angiotensin I converting enzyme Homo sapiens 108-111 1382164-7 1992 A kinin induced increase in collecting duct PG synthesis may account for the water diuresis seen clinically with ACE inhibitors. Water 77-82 angiotensin I converting enzyme Homo sapiens 113-116 8957033-15 1996 It is concluded that in progressive chronic nephropathy ACE-inhibitor treatment was associated with different adaptive tubular changes in the handling of sodium, water, and protein compared with conventional antihypertensive therapy. Water 162-167 angiotensin I converting enzyme Homo sapiens 56-59 8676388-1 1996 Molecular dynamics simulations with umbrella sampling are used to perform free energy simulations of C-terminal and N-terminal helix propagation in small helices of Ace-(Ala)n-NMe, with n= (4,5,10,15), in water. Water 205-210 angiotensin I converting enzyme Homo sapiens 165-168 8931343-3 1996 Theoretically, administering of angiotensin converting enzyme inhibitors can enhance sodium and water retention in cirrhotic patients with ascites. Water 96-101 angiotensin I converting enzyme Homo sapiens 32-61 1327601-6 1992 By inhibiting this potent vasoconstrictor and suppressing its degradation of the powerful vasodilator bradykinin, and by promoting sodium and water excretion, ACE inhibitors contribute to the restoration of normal ventricular function. Water 142-147 angiotensin I converting enzyme Homo sapiens 159-162 10790965-0 2000 [Effects of angiotensin-converting enzyme (ACE) inhibitors on water-salt homeostasis in hypertensive patients living in Far North]. Water 62-67 angiotensin I converting enzyme Homo sapiens 12-41 10790965-0 2000 [Effects of angiotensin-converting enzyme (ACE) inhibitors on water-salt homeostasis in hypertensive patients living in Far North]. Water 62-67 angiotensin I converting enzyme Homo sapiens 43-46 10790965-1 2000 The aim of the study was evaluation of ACE inhibitors (captopril and ramipril) effect on water-salt homeostasis in the treatment of patients with arterial hypertension (AH) living in the Far North of Russia. Water 89-94 angiotensin I converting enzyme Homo sapiens 39-42 10520782-0 1999 Improvement of myocardial blood flow to ischemic regions by angiotensin-converting enzyme inhibition with quinaprilat IV: a study using [15O] water dobutamine stress positron emission tomography. Water 142-147 angiotensin I converting enzyme Homo sapiens 60-89 9729254-3 1998 The intake of 0.3 M NaCl and water was induced by combined administration of the diuretic, furosemide (FURO), and the angiotensin-converting enzyme inhibitor, captopril (CAP). Water 29-34 angiotensin I converting enzyme Homo sapiens 118-147 27392566-4 1998 The obtained (R)- and (S)-ACE were efficiently recrystallized from water, taking account of the solubility of (RS)-ACE, to give them in optically pure form. Water 67-72 angiotensin I converting enzyme Homo sapiens 26-29 27392566-4 1998 The obtained (R)- and (S)-ACE were efficiently recrystallized from water, taking account of the solubility of (RS)-ACE, to give them in optically pure form. Water 67-72 angiotensin I converting enzyme Homo sapiens 115-118 7634256-1 1994 At least theoretically, ACE-inhibitors may influence each of the factors involved in the regulation of salt and water metabolism. Water 112-117 angiotensin I converting enzyme Homo sapiens 24-27 2558792-6 1989 In the controls, angiotensin I-converting-enzyme (ACE) inhibition by enalapril significantly reduced the urinary output of sodium and water after ANP infusion. Water 134-139 angiotensin I converting enzyme Homo sapiens 17-48 2191853-2 1990 In patients with moderate to severe heart failure, therapeutic interventions incorporating diuretics, digoxin and selected vasodilators, specifically angiotensin-converting enzyme (ACE) inhibitors, are designed to correct pathophysiological mechanisms such as left ventricular dysfunction, excessive vasoconstriction and renal reabsorption of sodium and water. Water 354-359 angiotensin I converting enzyme Homo sapiens 150-179 2191853-2 1990 In patients with moderate to severe heart failure, therapeutic interventions incorporating diuretics, digoxin and selected vasodilators, specifically angiotensin-converting enzyme (ACE) inhibitors, are designed to correct pathophysiological mechanisms such as left ventricular dysfunction, excessive vasoconstriction and renal reabsorption of sodium and water. Water 354-359 angiotensin I converting enzyme Homo sapiens 181-184 34946614-2 2021 S-nitrosocaptopril monohydrate (Cap-NO H2O) is a novel crystal form of S-nitrosocaptopril (Cap-NO), and is not only a nitric oxide (NO) donor, but also an angiotensin-converting enzyme inhibitor (ACEI). Water 39-42 angiotensin I converting enzyme Homo sapiens 155-184 2558792-6 1989 In the controls, angiotensin I-converting-enzyme (ACE) inhibition by enalapril significantly reduced the urinary output of sodium and water after ANP infusion. Water 134-139 angiotensin I converting enzyme Homo sapiens 50-53 2442780-2 1987 Captopril has two possible mechanisms for the inhibitory action on the water flow, one is its stimulative effect on prostaglandin E2 (PGE2) biosynthesis by inhibition of kininase II activity, the other, is a direct effect on water flow independent of PGE2. Water 71-76 angiotensin I converting enzyme Homo sapiens 170-181 2864682-8 1985 ACE inhibition reduces symptoms, enhances exercise capacity, and favorably affects sodium, water, and potassium homeostasis in patients with heart failure. Water 91-96 angiotensin I converting enzyme Homo sapiens 0-3 32645216-8 2020 Additionally, the lyophilized water extract inhibited the in vitro activity of alpha-amylase, alpha-glucosidase, and angiotensin converting enzyme and showed cytotoxic effects towards Caco-2, A549, and HepG2 cancer cells, but no cytotoxicity towards IMR90 cells. Water 30-35 angiotensin I converting enzyme Homo sapiens 117-146 3017059-0 1986 Effects of ACE inhibition on renal regulation of salt and water. Water 58-63 angiotensin I converting enzyme Homo sapiens 11-14 6165739-3 1981 Kinin potentiation by the kininase II inhibitor captopril (SQ 14225) significantly decreased vasopressin and 8-Br-cAMP-stimulated water flow. Water 130-135 angiotensin I converting enzyme Homo sapiens 26-37 33735773-0 2021 Identification of water-soluble peptides in distilled spent grain and its angiotensin converting enzyme (ACE) inhibitory activity based on UPLC-Q-TOF-MS and proteomics analysis. Water 18-23 angiotensin I converting enzyme Homo sapiens 74-103 33735773-0 2021 Identification of water-soluble peptides in distilled spent grain and its angiotensin converting enzyme (ACE) inhibitory activity based on UPLC-Q-TOF-MS and proteomics analysis. Water 18-23 angiotensin I converting enzyme Homo sapiens 105-108 33438805-0 2022 Investigation of inhibitio effect of butanol and water extracts of Matricaria chamomilla L. on Angiotensin-Converting Enzyme purified from human plasma. Water 49-54 angiotensin I converting enzyme Homo sapiens 95-124 33438805-2 2022 Impact of water and butanol extracts of Matricaria chamomilla L. (M. chamomilla) on purity ACE was examined. Water 10-15 angiotensin I converting enzyme Homo sapiens 91-94 33438805-9 2022 Water and butanol extracts of M. chamomilla demonstrated inhibitor impact on ACE activity. Water 0-5 angiotensin I converting enzyme Homo sapiens 77-80 33438805-13 2022 These results indicate that butanol and water extracts of M. chamomilla may have an ACE inhibitor potential. Water 40-45 angiotensin I converting enzyme Homo sapiens 84-87 33254514-8 2020 These medications are readily available and testing this theory involves determination of the correct dosage of angiotensin receptor blockers or ACE inhibitors (via dilution in water) that can be used as nasal lavage and performing efficacy trials. Water 177-182 angiotensin I converting enzyme Homo sapiens 145-148 32945658-6 2020 The interactions inhibiting heme dissociation were then seen to be (i) either a direct or a water molecule mediated interaction between distal histidine and heme iron; and (ii) stacking between heme and the alphaCE1/betaCD1 phenylalanine residue. Water 92-97 angiotensin I converting enzyme Homo sapiens 207-223 32180974-10 2020 In vitro, the water residue showed the highest antioxidant capacity and angiotensin-converting enzyme (ACE) inhibitory activity, due to more reducing sugars and peptides. Water 14-19 angiotensin I converting enzyme Homo sapiens 103-106