PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 10766803-2 2000 Binding of aquo-, cyano-, or azidocobalamin (Cbl.OH(2), Cbl.CN, and Cbl.N(3), respectively) to the recombinant human transcobalamin (TC) and haptocorrin from human plasma was investigated via stopped-flow spectroscopy. Water 49-54 Cbl proto-oncogene Homo sapiens 45-48 15913339-3 2005 Our magnetic circular dichroism and electron paramagnetic resonance spectroscopic studies reported here reveal that, in the absence of ATP, the interaction between Co2+Cbl and hATR promotes partial conversion of the cofactor to its "base-off" form in which a water molecule occupies the lower axial position. Water 259-264 Cbl proto-oncogene Homo sapiens 168-171 10766803-5 2000 The second step of Cbl.OH(2) binding was interpreted as a transformation of the initial "open" intermediate TC.Cbl.OH(2) to the "closed" conformation TC(Cbl) with displaced water. Water 23-28 Cbl proto-oncogene Homo sapiens 19-22 10766803-5 2000 The second step of Cbl.OH(2) binding was interpreted as a transformation of the initial "open" intermediate TC.Cbl.OH(2) to the "closed" conformation TC(Cbl) with displaced water. Water 23-28 Cbl proto-oncogene Homo sapiens 111-114 10766803-5 2000 The second step of Cbl.OH(2) binding was interpreted as a transformation of the initial "open" intermediate TC.Cbl.OH(2) to the "closed" conformation TC(Cbl) with displaced water. Water 23-28 Cbl proto-oncogene Homo sapiens 111-114 10766803-5 2000 The second step of Cbl.OH(2) binding was interpreted as a transformation of the initial "open" intermediate TC.Cbl.OH(2) to the "closed" conformation TC(Cbl) with displaced water. Water 115-120 Cbl proto-oncogene Homo sapiens 19-22 10766803-5 2000 The second step of Cbl.OH(2) binding was interpreted as a transformation of the initial "open" intermediate TC.Cbl.OH(2) to the "closed" conformation TC(Cbl) with displaced water. Water 115-120 Cbl proto-oncogene Homo sapiens 111-114 10766803-5 2000 The second step of Cbl.OH(2) binding was interpreted as a transformation of the initial "open" intermediate TC.Cbl.OH(2) to the "closed" conformation TC(Cbl) with displaced water. Water 115-120 Cbl proto-oncogene Homo sapiens 111-114 10766803-5 2000 The second step of Cbl.OH(2) binding was interpreted as a transformation of the initial "open" intermediate TC.Cbl.OH(2) to the "closed" conformation TC(Cbl) with displaced water. Water 173-178 Cbl proto-oncogene Homo sapiens 19-22 10766803-5 2000 The second step of Cbl.OH(2) binding was interpreted as a transformation of the initial "open" intermediate TC.Cbl.OH(2) to the "closed" conformation TC(Cbl) with displaced water. Water 173-178 Cbl proto-oncogene Homo sapiens 111-114 10766803-5 2000 The second step of Cbl.OH(2) binding was interpreted as a transformation of the initial "open" intermediate TC.Cbl.OH(2) to the "closed" conformation TC(Cbl) with displaced water. Water 173-178 Cbl proto-oncogene Homo sapiens 111-114 10766803-6 2000 The backward transition from the closed to the open conformation was the reason for the identical rate-limiting steps during substitution of H(2)O in TC.Cbl.OH(2) for cyanide or azide according to the reaction TC(Cbl) --> TC.Cbl.OH(2) + CN(-)/N(3)(-). Water 141-146 Cbl proto-oncogene Homo sapiens 153-156 10766803-6 2000 The backward transition from the closed to the open conformation was the reason for the identical rate-limiting steps during substitution of H(2)O in TC.Cbl.OH(2) for cyanide or azide according to the reaction TC(Cbl) --> TC.Cbl.OH(2) + CN(-)/N(3)(-). Water 141-146 Cbl proto-oncogene Homo sapiens 213-216 10766803-6 2000 The backward transition from the closed to the open conformation was the reason for the identical rate-limiting steps during substitution of H(2)O in TC.Cbl.OH(2) for cyanide or azide according to the reaction TC(Cbl) --> TC.Cbl.OH(2) + CN(-)/N(3)(-). Water 141-146 Cbl proto-oncogene Homo sapiens 213-216 10766803-6 2000 The backward transition from the closed to the open conformation was the reason for the identical rate-limiting steps during substitution of H(2)O in TC.Cbl.OH(2) for cyanide or azide according to the reaction TC(Cbl) --> TC.Cbl.OH(2) + CN(-)/N(3)(-). Water 157-162 Cbl proto-oncogene Homo sapiens 153-156 10766803-6 2000 The backward transition from the closed to the open conformation was the reason for the identical rate-limiting steps during substitution of H(2)O in TC.Cbl.OH(2) for cyanide or azide according to the reaction TC(Cbl) --> TC.Cbl.OH(2) + CN(-)/N(3)(-). Water 157-162 Cbl proto-oncogene Homo sapiens 213-216 10766803-6 2000 The backward transition from the closed to the open conformation was the reason for the identical rate-limiting steps during substitution of H(2)O in TC.Cbl.OH(2) for cyanide or azide according to the reaction TC(Cbl) --> TC.Cbl.OH(2) + CN(-)/N(3)(-). Water 157-162 Cbl proto-oncogene Homo sapiens 213-216 10766803-6 2000 The backward transition from the closed to the open conformation was the reason for the identical rate-limiting steps during substitution of H(2)O in TC.Cbl.OH(2) for cyanide or azide according to the reaction TC(Cbl) --> TC.Cbl.OH(2) + CN(-)/N(3)(-). Water 232-237 Cbl proto-oncogene Homo sapiens 153-156 10766803-6 2000 The backward transition from the closed to the open conformation was the reason for the identical rate-limiting steps during substitution of H(2)O in TC.Cbl.OH(2) for cyanide or azide according to the reaction TC(Cbl) --> TC.Cbl.OH(2) + CN(-)/N(3)(-). Water 232-237 Cbl proto-oncogene Homo sapiens 213-216 10766803-6 2000 The backward transition from the closed to the open conformation was the reason for the identical rate-limiting steps during substitution of H(2)O in TC.Cbl.OH(2) for cyanide or azide according to the reaction TC(Cbl) --> TC.Cbl.OH(2) + CN(-)/N(3)(-). Water 232-237 Cbl proto-oncogene Homo sapiens 213-216 27864634-1 2017 Reactions of aquacobalamin (H2O-Cbl(III)) and its one-electron reduced form (cob(II)alamin, Cbl(II)) with chlorite (ClO2-) and chlorine dioxide (ClO 2 ) were studied by conventional and stopped-flow UV-Vis spectroscopies and matrix-assisted laser desorption/ionization-mass spectrometry (MALDI-MS). Water 28-31 Cbl proto-oncogene Homo sapiens 32-35 10502361-1 1999 This report describes an investigation aimed at preparation of radioiodinated cyanocobalamin (CN-Cbl) monomers and dimers with improved water solubility and decreased nonspecific binding. Water 136-141 Cbl proto-oncogene Homo sapiens 97-100 11670948-6 1999 The packing motif of CF(2)Cbl is very similar to that described for wet vitamin B(12), a distorted hexagonal close packing of the cobalamin, with channels of water running parallel to the crystallographic c axis through the crystal at x = (1)/(4), y = 0, and x = (3)/(4), y = (1)/(2), respectively. Water 158-163 Cbl proto-oncogene Homo sapiens 26-29 35337623-1 2022 Vitamin B12 (cobalamin, Cbl, B12) is a water-soluble micronutrient synthesized exclusively by a group of microorganisms. Water 39-44 Cbl proto-oncogene Homo sapiens 24-32 8781445-5 1996 In addition, electron paramagnetic resonance spectroscopy of H2O-Cbl preparations showed the presence of a small amount of Cob-(II)alamin that was capable of combining with NO. Water 61-64 Cbl proto-oncogene Homo sapiens 65-68 22568547-12 2012 The BP86 method shows more spectral features, and the best fit was found for a GS-Cbl model with 5,6-dimethylbenzimidazole at the BP86/6-311G(d,p) level with a water cpcm solvent model. Water 160-165 Cbl proto-oncogene Homo sapiens 82-85 27446930-1 2016 Vitamin B12 (cobalamin, Cbl, B12) is an indispensable water-soluble micronutrient that serves as a coenzyme for cytosolic methionine synthase (MS) and mitochondrial methylmalonyl-CoA mutase (MCM). Water 54-59 Cbl proto-oncogene Homo sapiens 24-27 25074859-6 2014 Intrinsic water-use efficiency scaled negatively with carbon isotope discrimination (Delta13Cbl) and positively with the ratio between mesophyll diffusion conductance (gm) and stomatal conductance. Water 10-15 Cbl proto-oncogene Homo sapiens 92-95 16961380-1 2006 The reaction between aquacobalamin, Cbl(H2O), and NO was studied at low pH. Water 40-43 Cbl proto-oncogene Homo sapiens 36-39 16961380-2 2006 As previously reported, the final product of the reaction is the same as that obtained in the reaction of NO and reduced Cbl(H2O), viz. Water 125-128 Cbl proto-oncogene Homo sapiens 121-124